Clinical trials: Malabsorption
Bile Acid Diarrhea, Bile Acid Malabsorption
Treatment of Bile Acid Diarrhoea With Atorvastatin
Bile acid diarrhoea (BAD) is a socially debilitating disease with stomach pain, high stool frequency, urgency, and faecal incontinence as the main symptoms. Studies estimate that 1-2% of the population suffers from the disease.
- Trial name
- BASTA (NCT07042165)
- Testing
- Atorvastatin
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Asger Lund, MD
Endothelial Dysfunction, Hyperhomocysteinemia
Effects of Oral Supplementation With Creatine on Systemic Microvascular Endothelial Function in Vegetarian Individuals
The present study aims at investigating the effects of the oral supplementation with creatine on the systemic microvascular reactivity and plasma levels of homocysteine in vegetarian individuals of the vegan type.
- Trial name
- NCT02961972
- Testing
- monohydrate and micronized creatine
- Where
- Brazil
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Diabete Type 1
Strategy For Assessing The Risk Of Type 1 Diabetes In Pediatric Celiac Patients
Celiac disease (CD) and type 1 diabetes mellitus (T1D) are chronic autoimmune disorders that frequently co-occur, largely due to shared genetic susceptibility, particularly HLA-DQ2 and HLA-DQ8 alleles.
- Trial name
- CARES-T1D (NCT07862101)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- University of Bari
Education of Patients, Counseling
Celiac Disease School for Women Living on a Gluten-free Diet
Swedish celiac disease women living on a gluten-free diet for years report poorer subjective health and more bowel complaints than Swedish women of same age in general population.
- Conditions
- Education of Patients, Counseling, Problem-Based Learning
- Trial name
- CDST (NCT01088152)
- Testing
- Celiac school, Usual care of celiac disease women
- Where
- Sweden
- Volunteers
- 106 people
- Sponsor
- Medical Research Council of Southeast Sweden
Celiac Disease in Children, Celiac Disease in Adolescents
Effect of Adherence to a Gluten-Free Diet on Cognitive and Motor Dual-Task Performance in Adolescents Diagnosed With Celiac Disease
The aim of this cross-sectional observational study is to comprehensively examine the effects of adherence to a gluten-free diet on cognitive, motor, and psychosocial functions in adolescents aged 8-18 years diagnosed with celiac…
- Trial name
- NCT07382999
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Inonu University
Celiac Disease
Multicenter Study on the Toxicity of Gluten Traces in the Treatment of Celiac Disease
The purpose of this study is to evaluate the toxicity of minute doses of gluten in the treatment of celiac disease, a disorder characterized by permanent intolerance to dietary gluten.
- Trial name
- NCT00250146
- Testing
- Gluten (behaviour)
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- Università Politecnica delle Marche
Mortality, Hyperhomocysteinemia
5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients
A randomized prospective study was done to determine whether i.v. 5-methyltetrahydrofolate vs oral folate improved survival in ESRD patients. Homocysteine, CRP, Lp(a), albumin, folates, vitamin B6 and B12 were checked.
- Conditions
- Mortality, Hyperhomocysteinemia, Inflammation
- Trial name
- NCT00626223
- Testing
- 5-MTHF (5-methyltetrahydrofolate), folic acid
- Where
- Italy
- Volunteers
- 341 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Celiac Disease
Effects of Omega-3 Fatty Acids on Inflammation and Gut Microbiota in Celiac Disease
The goal of this clinical trial is to learn if omega-3 fatty acid supplements (n-3 PUFAs) can help reduce inflammation and promote intestinal healing in adults newly diagnosed with celiac disease (CD).
- Trial name
- OMEGA-CD (NCT07585669)
- Testing
- n-3 Polyunsaturated Fatty Acids (PUFAs)
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- University of Chile
Severe Acute Malnutrition, Persistent Diarrhea
Trial of Rice-Based F-75 in Severe Malnutrition & Persistent Diarrhea in Children (SAM-RICE Study)
The goal of this study is to find out if a rice-based version of the F-75 therapeutic food helps children with severe acute malnutrition (SAM) and persistent diarrhea recover better than the standard commercial F-75.
- Conditions
- Severe Acute Malnutrition, Persistent Diarrhea, Children
- Trial name
- SAM-RICE (NCT07070856)
- Testing
- WHO-recommended standard therapeutic milk used for stabilization phase in SAM), HO-recommended Rice based therapeutic milk used for stabilization phase in SAM)
- Where
- 2 sites in Pakistan
- Volunteers
- 320 people
- Sponsor
- Children's Hospital and Institute of Child Health, Multan
Short Bowel Syndrome
A Study of Teduglutide (Revestive®) in Children, Teenagers and Adults With Short Bowel Disease
The main aims of the study are to assess the safety profile of Teduglutide (Revestive®) in people with Short Bowel Disease as well as how well people respond to the treatment with Teduglutide (Revestive®).
- Trial name
- NCT04877431
- Where
- Argentina
- Volunteers
- 45 people
- Sponsor
- Takeda
Short Bowel Syndrome
Use of Pancreatic Enzymes in Short Bowel Syndrome
Patients with short bowel syndrome have a high mortality rate that is mainly attributed to complications from central lines and long-term intravenous (IV) nutrition.
- Trial name
- SBS (NCT03097029)
- Testing
- Pancreatic Enzyme
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital of Philadelphia
Hyperhomocysteinemia, Thrombotic, Cbs-Related, Ischemic Stroke
Methylenetetrahydrofolate Reductase Deficiency in Ischemic Stroke
Adult onset epileptic seizures is rare and often associated with metabolic disorders, drugs and intracranial pathologies such as ischemia, hemorrhage or space-occupying lesions.
- Conditions
- Hyperhomocysteinemia, Thrombotic, Cbs-Related, Ischemic Stroke, Epilepsy
- Trial name
- NCT04287881
- Testing
- Methylenetetrahydrofolate reductase (MTHFR) deficiency
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul Medeniyet University
Celiac Disease
Celiac Disease Database
The focus of this study is to create a database containing information about patients with celiac disease. This database will allow us to examine clinical and epidemiologic features of the University of Chicago Medical Center…
- Trial name
- NCT01172665
- Where
- United States
- Volunteers
- 1,090 people
- Sponsor
- University of Chicago
Celiac Disease
Effect of Addition of Short Course of Prednisolone to Gluten Free Diet in Naive Celiac Disease Patients
Withdrawal of gluten, the culprit antigen, is the definite treatment for celiac disease. Weeks to months after gluten withdrawal from the diet before the clinical manifestations, histological features start improving.
- Trial name
- CD (NCT01045837)
- Testing
- Prednisolone and Gluten free diet, Gluten free diet
- Where
- India
- Volunteers
- 33 people
- Sponsor
- All India Institute of Medical Sciences
Short Bowel Syndrome, Infection, Bacterial
Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome
The purpose of this study is to assess the drug absorption of oral antibiotics in patients with short bowel syndrome.
- Trial name
- GRAAL (NCT05302531)
- Testing
- Amoxicillin, Levofloxacin, Ofloxacin
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Central Hospital, Nancy, France
Celiac Disease, Villous Atrophy of Intestine
Persistent Villous Atrophy in Celiac Disease Patients Following an Intentionally Strict Gluten-free Diet
Celiac disease (CD) is an immune-mediated disease characterized by small intestinal inflammation from gluten ingestion, a group of proteins present in various cereals, including wheat, rye, barley, spelt, and kamut.
- Trial name
- CADER2 (NCT06500754)
- Testing
- Ultra-strict gluten-free diet
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Mutua de Terrassa
Intestinal Malabsorption
Efficacy and Safety of ELGN-2112 on Intestinal Malabsorption in Preterm Infants
The study will evaluate the effect of ELGN-2112 on intestinal malabsorption in preterm infants.
- Trial name
- NCT05670951
- Testing
- ELGN-2112
- Where
- Israel
- Volunteers
- 360 people
- Sponsor
- Elgan Pharma Ltd.
Coeliac Disease, Celiac Disease
A Phase 2a/b Study of the Efficacy and Safety of Subcutaneous Amlitelimab in Adults With Nonresponsive Celiac Disease
This is a Phase 2a/b, randomized, double-blind, placebo-controlled, parallel-group, 6-arm study to evaluate the efficacy and safety of amlitelimab in adult participants with non-responsive celiac disease (NRCD) who are on a…
- Trial name
- NCT06557772
- Testing
- Amlitelimab, SIGE, Gluten-free product (GFP)
- Where
- 118 sites in United States, Argentina and 19 more
- Volunteers
- 229 people
- Sponsor
- Sanofi
Irritable Bowel Syndrome, Bacterial Overgrowth Syndrome
Atrantil for Intestinal Bacterial Overgrowth
Intestinal Bacterial Overgrowth (IBO) is a common functional condition due to excessive amounts of bacteria in the gastrointestinal tract.
- Conditions
- Irritable Bowel Syndrome, Bacterial Overgrowth Syndrome, SIBO
- Trial name
- NCT04755673
- Testing
- Atrantil (Medical Food)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Celiac Disease
Behavioral Intervention for Celiac Disease
Celiac disease (CD) is a chronic autoimmune condition whose only currently available treatment is a strict, burdensome gluten-free diet (GFD).
- Trial name
- NCT05204446
- Testing
- GROW Project, GROW+ Project
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Children's National Research Institute