Clinical trials: Malaria, Uncomplicated
Malaria
Safety and Efficacy Dose of Artesunate Used in Combination With LAPDAP Treatment of Uncomplicated Falciparum Malaria
Drug resistance to a range of antimalarial treatments has become widespread in Africa, South East Asia and South America. Because the rapid spread of drug resistance threatens a public health disaster in these areas of the world…
- Trial name
- NCT00519467
- Testing
- Chlorproguanil-dapsone-artesunate (CDA)
- Where
- 2 sites in Malawi, The Gambia
- Volunteers
- 120 people
- Sponsor
- GlaxoSmithKline
Falciparum Malaria
Effectiveness of the Association Artesunate and Mefloquine in the Treatment of Malaria by Plasmodium Falciparum
The purpose of this study was to evaluate the effectiveness of the fixed combination of artesunate+mefloquine in the treatment of uncomplicated malaria caused by Plasmodium falciparum in the municipality of Cruzeiro do Sul, Juruá…
- Trial name
- NCT01144702
- Testing
- artesunate & mefloquine combination
- Where
- 2 sites in Brazil
- Volunteers
- 163 people
- Sponsor
- Oswaldo Cruz Foundation
Malaria
Tolerability and Efficacy of CD+A Compared to AQ+SP for the Treatment of P.Falciparum Malaria in Rwandan Children
In 2005-2006, a clinical trial was carried out to test safety, tolerability and efficacy of the combination chlorproguanil-dapsone+artesunate (CD+A): 800 children aged 12-59 months with uncomplicated P.
- Trial name
- NCT00461578
- Testing
- Chlorproguanil-dapsone + artesunate
- Where
- Rwanda
- Volunteers
- 800 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Uncomplicated Falciparum Malaria
Pharmacokinetics and Pharmacodynamics of the Gametocytocidal and Post-treatment Chemoprotective Effects of Antimalarials
Single-center phase II/III clinical investigation of the pharmacokinetics and pharmacodynamics of artemether-lumefantrine and dihydroartemisinin-piperaquine for gametocyte clearance and post-treatment chemoprotection in Zambian…
- Trial name
- NCT04009343
- Testing
- Artemether-lumefantrine, Dihydroartemisinin-piperaquine
- Where
- Zambia
- Volunteers
- 182 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Malaria
Compliance to Artesunate-Amodiaquine Therapy for Uncomplicated Malaria in Rural Ghana
With a change in malaria treatment policy to use combination antimalaria therapy, it is envisaged that compliance to combination therapy would be less than that of monotherapy that was being used for case management in Ghana.
- Trial name
- Compliance (NCT00873938)
- Where
- Ghana
- Volunteers
- 411 people
- Sponsor
- Kintampo Health Research Centre, Ghana
Uncomplicated Malaria
Pharmacokinetics of Dihydroartemisinin-Piperaquine in the Treatment of Uncomplicated Malaria in Children in Burkina Faso
This will be an open-label trial in Burkina Faso assessing the pharmacokinetics of the antimalarial combination of dihydroartemisinin/piperaquine (DP, Duocotexcin) in children.
- Trial name
- NCT00845533
- Testing
- Dihydroartemisinin-Piperaquine
- Sponsor
- University of California, San Francisco
Malaria,Falciparum
Therapeutic Efficacy Study of AL and DP in Western Kenya
Artemether-lumefantrine (AL) was adopted as first-line antimalarial therapy in Kenya in 2006, and dihydroartemisinin-piperaquine (DP) as the second-line therapy in 2010.
- Trial name
- NCT05060198
- Testing
- Artemether-lumefantrine (AL), Dihydroartemisinin-piperaquine (DP)
- Volunteers
- 340 people
- Sponsor
- Kenya Medical Research Institute
Uncomplicated Malaria
Treatment of Uncomplicated Malaria in Benin
Malaria is a life-threatening disease especially in small children. A high degree of Plasmodium falciparum resistance to chloroquine has already spread to South-Benin where this study is taking place.
- Trial name
- NCT00460369
- Testing
- sulfadoxine-pyrimethamine, artemether-lumefantrine, amodiaquine-artesunate coformulation
- Where
- Benin
- Volunteers
- 240 people
- Sponsor
- Institut de Recherche pour le Developpement
Malaria Fever, Plasmodium Falciparum Malaria
Efficacy and Safety of Pyronaridine-Artesunate Versus Artemether-Lumefantrine
In Nigeria, malaria is the commonest reason for outpatient clinic attendance in childhood and is responsible for about 20% of childhood deaths. The emergence of strains of P.
- Conditions
- Malaria Fever, Plasmodium Falciparum Malaria, Uncomplicated Malaria
- Trial name
- NCT05192265
- Testing
- Antimalarials, pyronaridine-artesunate, Antimalarials, Artemether + Lumefantrine
- Where
- Nigeria
- Volunteers
- 172 people
- Sponsor
- University of Ibadan
Acute Uncomplicated P. Falciparum Malaria
Efficacy, Safety and Tolerability of Co-artemether in Non-immune Travelers
This study will assess the safety and efficacy of co-artemether in the treatment of acute uncomplicated P. falciparum malaria in returning non-immune travellers THIS STUDY IS NOT ENROLLING PATIENTS IN THE UNITED STATES
- Trial name
- NCT00233337
- Testing
- Co-artemether
- Sponsor
- Novartis Pharmaceuticals
Malaria, Falciparum
Efficacy and Safety of Pyronaridine-artesunate for the Treatment in Uncomplicated Falciparum Malaria
This study is a prospective, single arm, open-labelled clinical trial. The total number subjects will be 145 patients to receive Pyronaridine-artesunate once daily for 3 days. Dosing will be according to the body weight.
- Trial name
- NCT02389439
- Testing
- Pyronaridine-artesunate
- Where
- 3 sites in Cambodia
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Artemisinin-Based Antimalarial Combinations and Clinical Response in Cameroon
To assess the efficacy of artesunate-amodiaquine, dihydroartemisinin-piperaquine, in comparison with artemether-lumefantrine during 42 days follow up period in 720 children with acute uncomplicated P.
- Trial name
- NCT01845701
- Testing
- Artesunate-Amodiaquine, Dihydroartemisinine-Piperaquine, Artemether-lumefantrine combination
- Where
- 2 sites in Cameroon
- Volunteers
- 720 people
- Sponsor
- University of Yaounde 1
Vivax Malaria
Primaquine Pharmacokinetics in Lactating Women and Their Infants
The weight of malaria falls most heavily on young children and pregnant women but studies of the safety of antimalarials in pregnancy and lactation are few.
- Trial name
- NCT01780753
- Testing
- Primaquine
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- University of Oxford
Malaria
Azithromycin Plus Chloroquine Versus Mefloquine In the Treatment of Uncomplicated P. Falciparum Malaria.
To compare Azithromycin plus Chloroquine versus Mefloquine to treat uncomplicated plasmodium falciparum malaria.
- Trial name
- NCT00367653
- Testing
- Azithromycin plus Chloroquine, Mefloquine
- Where
- 8 sites in Burkina Faso, Ghana and 4 more
- Volunteers
- 397 people
- Sponsor
- Pfizer
Plasmodium Falciparum Malaria
Phase II Dose-ranging Study of Pyronaridine/Artesunate in Adults Patients With Plasmodium Falciparum Malaria
The primary trial objective is to determine the clinically effective dose of orally administered pyronaridine/artesunate (Pyramax®, PA) with a 3:1 ratio to treat adults with acute, symptomatic, uncomplicated P.
- Trial name
- NCT01594931
- Testing
- pyronaridine/artesunate
- Where
- 6 sites in Cambodia, Indonesia and 4 more
- Volunteers
- 477 people
- Sponsor
- Medicines for Malaria Venture
Malaria, Falciparum, Malaria, Vivax
Efficacy, Tolerability, PK of OZ439 in Adults With Acute, Uncomplicated P.Falciparum or Vivax Malaria Mono-infection
A Phase IIa Exploratory, Open label, Single Dose Regimen, Multiple Dose Testing Clinical Study to Assess the Preliminary Efficacy, Tolerability and Pharmacokinetics of OZ439 in adult patients with acute, uncomplicated Plasmodium…
- Trial name
- NCT01213966
- Testing
- OZ439
- Volunteers
- 82 people
- Sponsor
- Medicines for Malaria Venture
Plasmodium Falciparum Malaria
Efficacy and Safety of Artesunate + Amodiaquine With SLD of Primaquine for Treatment of Falciparum Malaria in Zanzibar
The general objective of this study is to assess the therapeutic efficacy and safety of artesunate + amodiaquine combined with a single low dose of primaquine (0.25 mg/kg) for the treatment of uncomplicated P.
- Trial name
- AcoV (NCT03773536)
- Testing
- Artesunate-amodiaquine given with single low dose primaquine
- Where
- Tanzania
- Volunteers
- 146 people
- Sponsor
- Professor Anders Björkman
Malaria, Falciparum
Efficacy Study of Amodiaquine-Artesunate and Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria
In the Democratic Republic of Congo (DRC), malaria is an important cause of morbidity and mortality. It is estimated that malaria is responsible for 30% of admissions to hospital averaged throughout the country and for 25-30%…
- Trial name
- NCT01567423
- Testing
- ASAQ Winthrop® Sanofi Aventis, Coartem®, Novartis
- Where
- Democratic Republic of the Congo
- Volunteers
- 301 people
- Sponsor
- Epicentre
Uncomplicated Falciparum Malaria
Efficacy and Safety of ASAQ and PD for the Treatment of Uncomplicated Falciparum Malaria in Mainland Tanzania
The World Health Organization recommends regular surveillance of antimalarial efficacy to monitor the performance of different drugs.
- Trial name
- GF-TES-2017 (NCT03431714)
- Testing
- Artesunate amodiaquine
- Where
- Tanzania
- Volunteers
- 333 people
- Sponsor
- National Institute for Medical Research, Tanzania
Uncomplicated Plasmodium Falciparum Malaria
Rapid Diagnostic Testing and Artemisinin-Based Combination Therapy for Uncomplicated Malaria by Community Health Workers
The purpose of this study is to evaluate the efficiency of a rapid diagnostic test (Paracheck Pf) for the diagnosis of uncomplicated Plasmodium falciparum malaria by community health workers at village level in Tanzania and how…
- Trial name
- NCT00301015
- Testing
- Rapid diagnostic test for malaria
- Where
- Tanzania
- Volunteers
- 3,005 people
- Sponsor
- Karolinska University Hospital