Clinical trials: Malaria, completed
Malaria, Filariasis
Medical Implications of Coinfection With Malaria and Filariasis Parasites
This study will examine the clinical, immunological and epidemiological effects of concurrent infections with P. falciparum and W. bancrofti or M.
- Trial name
- NCT00471666
- Where
- Mali
- Volunteers
- 1,039 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Plasmodium Falciparum
Plasmodium Falciparum Artemisinin Resistance Vietnam
Resistance of Plasmodium falciparum toward Artemisinins, the most important drug for the successful treatment of malaria, has been confirmed in Cambodia.
- Trial name
- NCT01775592
- Testing
- Arterakin (DHA-PPQ)
- Where
- Vietnam
- Volunteers
- 95 people
- Sponsor
- National Institute of Malariology, Parasitology and Entomology, Vietnam
Malaria
Improved Clinical and Microscopy Diagnosis at Primary Health Care in Tanzania
General objective: To improve the quality of fever case management in children in government health facilities in Tanzania Hypothesis:The training of health workers, as well as provision, training and use of microscopes for…
- Trial name
- NCT00687895
- Testing
- Clinical algorithm and microscopy diagnosis of malaria
- Where
- Tanzania
- Volunteers
- 3,131 people
- Sponsor
- Muhimbili University of Health and Allied Sciences
Malaria
Micronutrients and Child Health Study
The purpose of this study is to determine to what extent supplementation with zinc and other micronutrients are efficacious in preventing malaria in young Tanzanian children.
- Trial name
- MACH (NCT00623857)
- Testing
- Zinc, Vitamins and minerals other than zinc, Vitamins plus zinc and other minerals
- Where
- Tanzania
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Malaria, Falciparum
Chloroquine and Coartem for Treatment of Symptomatic Children With Plasmodium Falciparum in Guinea Bissau
This study will evaluate the efficacy of treatment with artemether-lumefantrine as compared to chloroquine in the dose of 50 mg/kg for treatment of malaria in children in Guinea-Bissau.
- Trial name
- NCT00426439
- Testing
- Chloroquine, Artemether-lumefantrine (Coartem)
- Where
- Guinea-Bissau
- Volunteers
- 300 people
- Sponsor
- Bandim Health Project
Vector Transmission
Attractive Targeted Sugar Bait Trial in Mali
Globally, the female mosquitoes to be effective at transmitting malaria parasites, must have a number of characteristics including: abundance, longevity (individual mosquitoes must survive long enough after feeding on infected…
- Trial name
- NCT04149119
- Testing
- Attractive Target Sugar Baits (ATSB)
- Where
- Mali
- Volunteers
- 6,068 people, healthy volunteers welcome
- Sponsor
- University Clinical Research Center, Mali
Plasmodium Falciparum Malaria
Human Immunity to MSP-1 in Western Kenya
This is a study of 125 healthy male and female Kenyan adults aged 18 years and above, and 300 healthy male and female Kenyan infants enrolled at 1 month of age and followed to 3 years of age.
- Trial name
- NCT00138372
- Where
- Kenya
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Malaria,Falciparum, Anemia in Children
Comparing Chemoprevention Approaches for School-based Malaria Control
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent screening and treatment (IST) - students will receive treatment if they have a…
- Trial name
- NCT05244954
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine
- Where
- Malawi
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Malaria, Plasmodium Falciparum
A Study of Blood-stage Controlled Human Plasmodium Falciparum Malaria Infection in Tanzania
This will be a single-centre, open label trial to determine the safety and feasibility of CHMI model using Plasmodium falciparum-infected cryopreserved erythrocytes administered to healthy Tanzanian adults with varying prior…
- Trial name
- NCT04788862
- Testing
- P. falciparum infected erythrocytes
- Where
- Tanzania
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria,Falciparum
First-in-Human Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV367
This three-part, first-in-human, healthy volunteer study aims to assess the safety and tolerability of the test medicine as well as how it is taken up by the body when given as single and multiple doses.
- Trial name
- NCT05507970
- Testing
- MMV367, MMV367 (Fed 440mg), MMV367 (Fasted 440mg)
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Bioavailability of the Fixed Combination of Amodiaquine and Artesunate Under Fed & Fasted Conditions
Primary Objective: to evaluate the interaction with food after a single oral dose of a fixed combination of amodiaquine (AQ) and artesunate (AS) (COARSUCAM™) in healthy male subjects Secondary Objective: to assess the clinical…
- Trial name
- NCT00386503
- Testing
- Artesunate + Amodiaquine
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Sanofi
Malaria in Pregnancy
Safe and Efficacious Artemisinin-based Combination Treatments for African Pregnant Women With Malaria
Malaria is the most important human parasitic disease and is responsible of high morbidity and mortality in resource-poor countries.
- Trial name
- PREGACT (NCT00852423)
- Testing
- Dihydroartemisinin-piperaquine, Artesunate-mefloquine, Artesunate-amodiaquine
- Where
- 7 sites in Burkina Faso, Ghana and 2 more
- Volunteers
- 3,428 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria, Severe Malaria
Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria
Background: Malaria is caused by small parasites carried by some mosquitoes. People can get malaria if an infected mosquito bites them. Malaria destroys red blood cells.
- Trial name
- NCT01955382
- Testing
- Actidose Aqua, Artesunate, Amodiaquine
- Where
- Mali
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Phase II Artesunate Study in Severe Malaria
The primary objective of the study is to evaluate the effectiveness of 2 intravenous artesunate dosing regimens (2.4 mg/kg initially and at 12, 24, 48, and 72 hours or 4.0 mg/kg initially and at 24 and 48 hours) in clearing P.
- Trial name
- NCT00522132
- Testing
- Artesunate
- Where
- 3 sites in Gabon, Malawi
- Volunteers
- 200 people
- Sponsor
- Medicines for Malaria Venture
Malaria, Falciparum
Time to Become Negative of Three Rapid Diagnostic Tests for Malaria
Background: Antigen-detecting rapid diagnostic tests (RDTs) for malaria provide the possibility of a parasite-based diagnosis in areas where good quality microscopy can not be achieved. P.
- Trial name
- NCT01325974
- Where
- 2 sites in Uganda
- Volunteers
- 424 people
- Sponsor
- Epicentre
Malaria
Azithromycin + Artesunate v Artemether-lumefantrine in Uncomplicated Malaria.
This trial sets out to determine whether the combination of azithromycin and artesunate (AZ+AS) is as good as the current standard treatment for uncomplicated malaria in Tanzania, artemether-lumefantrine (AL).
- Trial name
- CAZAMS (NCT00694694)
- Testing
- azithromycin + artesunate, artemether-lumefantrine
- Where
- Tanzania
- Volunteers
- 261 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Comparison of Three Plasmodium Falciparum Isolates in a Controlled Human Malaria Infection
An effective vaccine against malaria is urgently needed to combat the scourge of this disease. Before candidate vaccines can be tested in endemic countries, they are first tested in human volunteers in so-called Controlled Human…
- Trial name
- TIP3 (NCT01627951)
- Testing
- NF54, NF135, NF166
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria, Plasmodium Falciparum Malaria
Phase I/II Trial of a Malaria Vaccine in Adults Living in the United States of America
Phase I/II Trial of a Malaria Vaccine, FMP011/AS01B, in Adults Living in the United States of America.
- Trial name
- NCT00312702
- Testing
- Falciparum Malaria Protein 11 with AS02A adjuvant
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Healthy Subjects
Study to Investigate the Safety, Tolerability and Pharmacokinetics of AD 452 [(+)-Mefloquine] Compared With Racemic Mefloquine
Mefloquine is a quinolinemethanol antimalarial that is effective as therapy and prophylaxis for all species of malaria infecting humans, including multi-drug resistant Plasmodium falciparum.
- Trial name
- NCT00931697
- Testing
- AD 452 (+) mefloquine, Racemic Mefloquine
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Treague Ltd
Malaria
Quinine vs. Artemether/Lumefantrine in Uncomplicated Malaria During Pregnancy
A) for the treatment of uncomplicated malaria during second and third trimester pregnancy to oral Quinine hydrochloride. The PCR-corrected adequate clinical and parasitological response (ACPR) on day 42 is considered as the…
- Trial name
- NCT00495508
- Testing
- Quinine, artemether / lumefantrine
- Where
- Uganda
- Volunteers
- 300 people
- Sponsor
- Epicentre
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