Clinical trials: Malaria, completed
Malaria
Experimental Falciparum Transmission to Anopheles
This is a single-centre, open-label study using P. falciparum-induced blood stage malaria (IBSM) infection to assess the infectivity of sexual life cycle stages of the malaria parasite (gametocytes) to mosquito vectors.
- Trial name
- EFITA (NCT02431637)
- Testing
- Administration of the malaria inoculum, Piperaquine Phosphate 480 mg
- Where
- Australia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria, Plasmodium Falciparum Malaria
Phase I/II Trial of a Malaria Vaccine in Adults Living in the United States of America
Phase I/II Trial of a Malaria Vaccine, FMP011/AS01B, in Adults Living in the United States of America.
- Trial name
- NCT00312702
- Testing
- Falciparum Malaria Protein 11 with AS02A adjuvant
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria
Community Dynamics of Malaria Transmission and Mosquito Feeding in Bancoumana, Mali
Background: Half of the world's population is at risk of malaria. Malaria is a disease that affects many people in Mali and other parts of Africa. It is caused by germs spread by mosquito bites. Malaria may be mild.
- Trial name
- NCT03304704
- Where
- 3 sites in Mali
- Volunteers
- 1,928 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria,Falciparum
Effectiveness and Safety of Artesunate-Amodiaquine and Artemether-Lumefantrine for the Treatment of Malaria in Yaounde
Artesunate-amodiaquine and artemether-lumfantrine are currently being used for the treatment of uncomplicated Plasmodium falciparum in Cameroon.
- Trial name
- NCT04565184
- Testing
- Artesunate-amodiaquine combination, Artemether, Lumefantrine Drug Combination
- Where
- Cameroon
- Volunteers
- 242 people
- Sponsor
- University of Yaounde 1
Malaria
Effectiveness of Malaria Camps as Part of the Odisha State Malaria Elimination Drive
The Odisha State Malaria Control Program (India) has introduced 'malaria camps' where teams of health workers visit villages to educate the population, enhance vector control with long-lasting insecticide nets (LLINs) and indoor…
- Trial name
- CSCMi20 (NCT03963869)
- Testing
- Malaria Camps
- Where
- India
- Volunteers
- 2,463 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Plasmodium Falciparum Malaria, Vaccines
Experimental Vaccine for Plasmodium Falciparum Malaria
This study will evaluate the safety of two experimental malaria vaccines in healthy volunteers and examine their immune response to them.
- Trial name
- NCT00340431
- Testing
- MSP1(42)-FVO & MSP1(42)-3D7
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Falciparum Malaria
Clinical Investigation of In-vivo Susceptibility of P.Falciparum to Artesunate in Western Cambodia
There are worrying signs that parasitological responses to the artemisinin drugs for uncomplicated falciparum malaria are slower than elsewhere in the world.If responses to artesunate are poor it is essential to have…
- Trial name
- NCT00493363
- Testing
- Artesunate, Artesunate + Mefloquine
- Where
- Cambodia
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Malaria, Malaria,Falciparum
Malawi International Center of Excellence in Malaria Research School-based Cohort
A school-based, prospective, cohort study was conducted to evaluate the epidemiology of P. falciparum (Pf) infections in school-age children and determine the impact of the screen-and-treat approach on Pf infection and anemia…
- Conditions
- Malaria, Malaria,Falciparum, Anemia
- Trial name
- NCT04858087
- Testing
- Screening and treatment
- Volunteers
- 786 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Malaria
Safety, Tolerability and Pharmacokinetic Profile of Ascending Oral Doses of MMV390048, Part A
This Phase I study will evaluate the safety, tolerability and pharmacokinetic properties of escalating single doses of reformulated MMV390048 when administered to healthy men and women of non-childbearing potential (WNCBP) under…
- Trial name
- NCT02783820
- Testing
- MMV390048 40 mg, MMV390048 80 mg, MMV390048 120 mg
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
MALARIA
Efficacy of Antimalarial Drugs Used for the Treatment of Uncomplicated Malaria, Plasmodium Falciparum, at the Agadez, Gaya and Tessaoua Sentinel Sites
In Niger, malaria is a major public health problem. It is the main cause of morbidity and mortality among children. The management of malaria cases is based on the principle of early diagnosis and rapid treatment with effective…
- Trial name
- NCT05070520
- Testing
- Artemether-lumefantrine
- Where
- Niger
- Volunteers
- 259 people
- Sponsor
- Programme National de Lutte contre le Paludisme, Niger
Malaria
Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers, Study 1
To investigate the comparative tolerability, metabolism and pharmacokinetics of individual enantiomers of PQ in healthy human volunteers.
- Trial name
- NCT02898779
- Testing
- Primaquine, R-Primaquine, S-Primaquine, SR Primaquine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Mississippi, Oxford
Malaria
Spatial Repellent Products for Control of Vector Borne Diseases - Malaria - Indonesia
The primary objective of the study is to demonstrate and quantify the protective efficacy (PE) of spatial repellent products in reducing the incidence of malaria infection in human cohorts.
- Trial name
- SR-M-IDR (NCT02294188)
- Testing
- Spatial Repellent product with active ingredient (SHIELD), Active ingredient, Spatial Repellent product without active ingredient (SHIELD)
- Where
- Indonesia
- Volunteers
- 1,519 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Malaria
Trial to Compare Effectiveness of 2 Insecticides in Preventing Malaria
Twenty-four (24) clusters, each containing between 250-300 houses were selected throughout Bioko Island to be sprayed with either a long lasting pyrethroid insecticide, K-Othrine SC 62.5, or a bendiocarb insecticide, FICAM.
- Trial name
- NCT02458066
- Testing
- IRS: bendiocarb, IRS: deltamethrin
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Medical Care Development, Inc.
Malaria
Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...
Background: Malaria is a severe infection caused by a parasite. People can get malaria if a mosquito that carries the parasite bites them.
- Trial name
- NCT02511054
- Testing
- Chloroquine (CQ), Pyrimethamine (PYR), Sanaria PfSPZ Challenge (NF54)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Safety and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria
This first-in-human clinical trial, was a dose escalation multi-center trial designed to assess the safety, tolerability, and immunogenicity of the vaccine component, BNT165b1, a ribonucleic acid (RNA)-lipid nanoparticle (LNP)…
- Trial name
- NCT05581641
- Testing
- BNT165b1
- Where
- 5 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Parasitology, Entomology
Malaria Genetic Surveillance in Cambodia
This study is to determine the prevalence and geographical distribution of antimalarial drug resistance-linked genetic mutations in clinical P. falciparum infections in Cambodia
- Conditions
- Parasitology, Entomology, Malaria
- Trial name
- NCT03384472
- Volunteers
- 185 people
- Sponsor
- University of Oxford
Pregnant Women, Malaria
Ultrasound Study in Pregnant Women With Malaria
Most of the neonatal deaths that occur worldwide every year are associated with low birth weight (LBW), caused by intrauterine growth restriction (IUGR) and/or preterm delivery.
- Trial name
- UPS (NCT00840502)
- Where
- Thailand
- Volunteers
- 1,887 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Plasmodium Falciparum Infection, Plasmodium Vivax Infection
Efficacy and Safety of Dihydroartemisinin-piperaquine (DHP) for the Treatment of Uncomplicated Malaria
This is an observational safety and efficacy study on dihydroartemisinin-piperaquine in Timika, Indonesia with a 42 day follow up period.
- Trial name
- NCT02353494
- Testing
- Dihydroartemisinin-Piperaquine
- Where
- Indonesia
- Volunteers
- 130 people
- Sponsor
- Menzies School of Health Research
Malaria
The Role of Rapid Diagnostic Tests for Malaria for Targeting of ACTs at Community Level
This study aims to test directly by means of a cluster randomized controlled trial, the impact of the introduction of RDTs for malaria on dispensing behaviour of chemical sellers, the main non-formal outlet for drugs locally, at…
- Trial name
- GhanaCommRDT (NCT01907672)
- Testing
- Rapid Diagnostic Test
- Where
- Ghana
- Volunteers
- 4,748 people
- Sponsor
- Ghana Health Services
Uncomplicated Malaria
Treatment Efficacy and Malaria TRANSmission After Artemisinin Combination Therapy (TRANSACT)
Artemisinin combination therapy (ACT) with artemether lumefantrine (AL) is currently the first line treatment policy in Tanzania. AL is an efficacious drug that also has the capacity to reduce malaria transmission to mosquitoes.
- Trial name
- TRANSACT (NCT00868465)
- Testing
- Artemether-Lumefantrine, Dihydroartemisinin-piperaquine
- Where
- 2 sites in Kenya, Tanzania
- Volunteers
- 600 people
- Sponsor
- Radboud University Medical Center
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