Clinical trials: Malaria, completed
Vivax Malaria, G6PD Deficiency
Short Course Primaquine for the Radical Cure of P. Vivax Malaria - Indonesia
The proportion of malaria that is the Plasmodium vivax species is increasing in Indonesia. Reducing vivax malaria will require innovative solutions to cure both the blood and liver stages of the disease.
- Trial name
- SCOPE (NCT05879224)
- Testing
- Revised case management package
- Where
- 6 sites in Indonesia
- Volunteers
- 2,999 people
- Sponsor
- Menzies School of Health Research
Malaria
A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh
This is a study assessing safety and efficacy of current national guidelines for the treatment of uncomplicated malaria in Bangladesh as well as to assess the G6PD status among the enrolled patients.
- Trial name
- NCT02389374
- Testing
- chloroquine, Artemether-lumefantrine combination, Primaquine
- Volunteers
- 181 people
- Sponsor
- Menzies School of Health Research
Malaria
Improving Knowledge, Attitudes and Practices for Malaria Prevention in the Embera Katio Population
Objective: To evaluate the effectiveness of an educational intervention compared to regular education in improving knowledge, attitudes and practices (KAP) for the prevention of malaria among indigenous people of the Embera Katío…
- Trial name
- NCT06590597
- Testing
- EDUCATIONAL INTERVENTION FOR MALARIA PREVENTION
- Where
- Colombia
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Malaria,Falciparum, Malaria Recrudescence
TES of Artemether-lumefantrine for Pf in the Philippines in 2017-2018
The emergence and spread of drug resistance is a major obstacle to combating malaria. The World Health Organization (WHO) recommends that regular efficacy monitoring should be undertaken by all malaria endemic countries that have…
- Trial name
- TES (NCT05958810)
- Testing
- Artemether-lumefantrine, Primaquine
- Volunteers
- 80 people
- Sponsor
- Research Institute for Tropical Medicine, Philippines
Plasmodium Falciparum
Study of Malaria Vaccine RTS,S/AS01E in Plasmodium Falciparum-infected and Uninfected Adults Pre-treated With Anti-malarial Therapy
The main goal of this study is to assess the efficacy of RTS,S/AS01E, a candidate vaccine against malaria caused by Plasmodium falciparum (P. falciparum), in adults positive for P.
- Trial name
- NCT04661579
- Testing
- Malaria Vaccine RTS,S/AS01E, Abhayrab rabies vaccine, Dihydroartemisinin-piperaquine (DHA/Pip)
- Where
- Kenya
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- PATH
Vivax Malaria
Incidence of Vivax Along the Thai Burma Border
This is a continuous cohort study consisting of 200 participants (one third 6 months old to 5 years, one third 6 to 15 years old, one third ≥ 15 years old) i.e.
- Trial name
- VHC (NCT01076868)
- Testing
- Primaquine
- Where
- Thailand
- Volunteers
- 403 people
- Sponsor
- University of Oxford
Malaria in Pregnancy, Sexually Transmitted Infections
Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea
The purpose of this study is to determine whether repeated courses of sulphadoxine-pyrimethamine (SP) in combination with azithromycin given at Antenatal Clinic, leads to lower rates of low birth weight deliveries (<2.5 kg) among…
- Conditions
- Malaria in Pregnancy, Sexually Transmitted Infections, Anaemia
- Trial name
- IPTp in PNG (NCT01136850)
- Testing
- chloroquine, sulphadoxine pyrimethamine, LLIN, azithromycin, sulphadoxine pyrimethamine, LLIN
- Where
- Papua New Guinea
- Volunteers
- 2,793 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Malaria
Immune Parameters in the Cord Blood of Newborns Exposed to Malaria in the Womb
This study, conducted by the Malaria Research and Training Center at the University of Bamako, Mali, and the NIAID, will examine how exposure to the malaria parasite in the womb affects the developing immune system of newborns.
- Trial name
- NCT00772642
- Where
- Mali
- Volunteers
- 120 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Vivax
Study of Controlled Human Plasmodium Vivax Infection
This is a sporozoite-challenge clinical study with the primary aim of assessing the safety and feasibility of controlled human P. vivax malaria infection in two healthy volunteers.
- Trial name
- VAC068 (NCT03377296)
- Testing
- Plasmodium vivax infection, Collection of 250mL blood from each volunteer (N=2)
- Where
- 2 sites in United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Falciparum
Efficacy Study of Amodiaquine-Artesunate and Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria
In the Democratic Republic of Congo (DRC), malaria is an important cause of morbidity and mortality. It is estimated that malaria is responsible for 30% of admissions to hospital averaged throughout the country and for 25-30%…
- Trial name
- NCT01567423
- Testing
- ASAQ Winthrop® Sanofi Aventis, Coartem®, Novartis
- Where
- Democratic Republic of the Congo
- Volunteers
- 301 people
- Sponsor
- Epicentre
Malaria, Vivax
Pilot Human Study of Tinidazole Efficacy For Radical Cure Of Plasmodium Vivax
Assess the efficacy of 2 grams of tinidazole given for 5 days with standard dose chloroquine to achieve radical cure of Plasmodium vivax within a 90 day follow-up period sufficient to justify an IND and formal phase II evaluation.
- Trial name
- NCT00811096
- Testing
- Tinidazole, chloroquine
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Malaria
Reducing the Burden of Malaria by Targeting Hotspots of Malaria Transmission
In this study, the investigators propose to determine the value of rolling out four targeted malaria control efforts in reducing overall malaria transmission.
- Trial name
- REDHOT (NCT01575613)
- Testing
- Artemether-lumefantrine combination, Bacillus thuringiensis, Long lasting insecticide treated net (LLINs)
- Where
- Kenya
- Volunteers
- 17,506 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria Falciparum
Health Systems Implementation and Molecular Surveillance of Multiple First-Line Treatments for Uncomplicated Malaria in Western Kenya
This implementation study evaluated the health systems feasibility, economic costs, and stakeholder acceptability of deploying multiple first-line therapies (MFTs) that were of the artemisinin-based combination therapies (ACTs)…
- Trial name
- NCT07362498
- Testing
- Artemether + Lumefantrine, Dihydroartemisin-piperaquine, Artesunate-Amodiaquine (AS-AQ)
- Where
- 2 sites in Kenya
- Volunteers
- 316 people
- Sponsor
- Strathmore University
Malaria, Falciparum
Study to Compare the Triple ACT AL+AQ With the ACT AL in Cambodia and Vietnam
This study is a multi-centre, open-label randomised trial to assess the efficacy, safety and tolerability of the Triple ACT artemether-lumefantrine+amodiaquine (AL+AQ) compared to the ACT artemether-lumefantrine (AL) in…
- Trial name
- TACT-CV (NCT03355664)
- Testing
- ACT, TACT
- Where
- 4 sites in Cambodia, Vietnam
- Volunteers
- 310 people
- Sponsor
- University of Oxford
Malaria
Safety And Immunogenicity Of Novel Candidate Blood-Stage Malaria Vaccine P27A : Phase Ia/Ib
P27A study is designed as a randomized phase Ia/Ib trial to evaluate the safety and immunogenicity of the blood stage candidate vaccine P27A against P.
- Trial name
- P27A (NCT01949909)
- Testing
- CH-Alum50, CH-GLA2.5/50, TZ Ver
- Where
- 2 sites in Switzerland, Tanzania
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Plasmodium Falciparum Malaria
Time to Infection With Malaria Parasites
This study will attempt to find out what effect mosquito insecticides have on the transmission of malaria in The Gambia. Eight hundred healthy men and women, aged 18 to 40 years, living in selected villages east of Farafenni town…
- Trial name
- NCT00322738
- Where
- The Gambia
- Volunteers
- 2,558 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria Infection, Malaria Incidence
Malaria Incidence in Infants in Bancoumana, Mali
This study, conducted by the Malaria Research and Training Center at the Faculty of Medicine in Bamako and the NIAID will measure the frequency of occurrence of malaria in infants in Bancoumana, Mali.
- Conditions
- Malaria Infection, Malaria Incidence, Anemia
- Trial name
- NCT00508417
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria,Falciparum
Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali
The purpose of this study is to compare the gametocytocidal and transmission reducing activity of artesunate-amodiaquine (ASAQ) and artemether-lumefantrine-amodiaquine (ALAQ) with and without a single dose of 0.25mg/kg primaquine…
- Trial name
- NECTAR4 (NCT05550909)
- Testing
- Artesunate-amodiaquine combination, Primaquine Phosphate, Artemether-lumefantrine
- Where
- Mali
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Sanaria™ PfSPZ Challenge Vaccine
This study will randomize 30 healthy adult participants to one of three cohorts comprised of six groups of 5 individuals per group to simultaneously receive PfSPZ Challenge via the ID route.
- Trial name
- NCT01546389
- Testing
- Sanaria™ PfSPZ Vaccine, Chloroquine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Pregnancy
Efficacy and Safety of IPTp-DP Versus IPTp-SP in Malawi
This study aims to compare the efficacy of monthly IPTp-DP with monthly IPTp-SP to determine if IPTp-DP is associated with a reduction in malaria infection at delivery among HIV-negative women in an area with high levels of SP…
- Trial name
- STOPMIP-MW (NCT03009526)
- Testing
- Sulfadoxine-pyrimethamine, dihydroartemisinin-piperaquine
- Where
- Malawi
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- Kamuzu University of Health Sciences
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