Clinical trials: Malaria, completed
Malaria, Malaria, Vivax
Short Course Radical Cure of P. Vivax Malaria in Nepal
This study is designed as a multicentre randomized, open label trial to assess the safety and efficacy of a low dose short course PQ treatment (3.5mg/kg total dose given over 7 days) in glucose-6-phosphate dehydrogenase (G6PD)…
- Conditions
- Malaria, Malaria, Vivax, Malaria,Falciparum
- Trial name
- NCT04079621
- Testing
- primaquine
- Where
- 2 sites in Nepal
- Volunteers
- 27 people
- Sponsor
- Menzies School of Health Research
Malaria
Evaluation of the Implementation and Effectiveness of Intermittent Preventive Treatment for Malaria Using Dihydroartemisinin-piperaquine on Reducing Malaria Burden in School Aged Children in Tanzania
In Tanzania, according to the National Malaria Control Programme (NMCP), malaria prevalence has declined from an average of 18.1% in 2008 to 7% in 2017, marked as an epidemiological transition from meso-endemic to hypo-endemic…
- Trial name
- IPTsc (NCT04245033)
- Testing
- Dihydroartemisinin-Piperaquine (DP)
- Where
- Tanzania
- Volunteers
- 4,100 people, healthy volunteers welcome
- Sponsor
- National Institute for Medical Research, Tanzania
Malaria
Artemether-Lumefantrine Effectiveness in Guinea-Bissau 2
The routine treatment of children with antimalarials will be monitored. Children with a positive malaria film and/or a positive rapid diagnostic test (RDT) will have a capillary blood sample taken to verify the diagnosis and to…
- Trial name
- NCT01133314
- Where
- Guinea-Bissau
- Volunteers
- 600 people
- Sponsor
- Bandim Health Project
Severe Malaria
Very Severe Malaria Treated by Intravenous Artesunate
In endemic areas, Plasmodium falciparum malaria exacts a huge public health toll, causing close to half a million deaths each year. In non-endemic industrialized areas, imported malaria may develop.
- Trial name
- Palustar (NCT04516317)
- Testing
- None (Observational study Group intravenous artesunate), None (Observational study Group intravenous quinine)
- Where
- France
- Volunteers
- 578 people
- Sponsor
- Dr Fabrice BRUNEEL
Vitamin A Deficiency, Malaria
Assessing Model Parameters for Applying the Retinol Isotope Dilution (RID) Method
For assessing body retinol pools in preschool children, it is recommended that a blood sample is taken 14-21 days after isotope dosing. During this period, dietary intake of vitamin A should be controlled.
- Conditions
- Vitamin A Deficiency, Malaria, Inflammation
- Trial name
- SUPERKID (NCT02996513)
- Testing
- Retinol Isotope Dilution (RID)
- Where
- Nigeria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Vaccine
Impact of Vaccines on Antimicrobial Microbial Resistance
Vaccination is a potentially critical component of efforts to arrest development and dissemination of antimicrobial resistance (AMR), though little is known about vaccination impact within low-income and middle-income countries.
- Trial name
- IVAR (NCT06450379)
- Where
- Malawi
- Volunteers
- 13,200 people, healthy volunteers welcome
- Sponsor
- Malawi Liverpool Wellcome Programme
Malaria, Falciparum
Arginine Malaria Trial: Study of Adjunctive Arginine in Falciparum Malaria
Acute falciparum malaria is associated with low plasma arginine and impaired nitric oxide (NO) production. Both are associated with poor outcome.
- Trial name
- NCT00147368
- Testing
- intravenous (IV) arginine
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Menzies School of Health Research
Malaria
Study of Factors Involved in Resistance to Severe Malaria
This study will examine whether resistance to severe malaria is associated with weakening of a specific immune response (TLR-mediated pro-inflammatory cytokine response).
- Trial name
- NCT00368810
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Pharmacokinetic Study of Multi-dose Chloroquine
Chloroquine (CQ) remains an alternative cheap, safe and widely available drug. Our previous research has shown that double (50 mg/kg) standard dose CQ given in split doses had a 95% efficacy and was well tolerated and safe.
- Trial name
- NCT01814423
- Testing
- Chloroquine-base 50 mg, Chloroquine-base 70 mg
- Where
- Guinea-Bissau
- Volunteers
- 30 people
- Sponsor
- Bandim Health Project
Malaria
Phase I Study of Ascending Doses of MMV390048 in Healthy Adult Volunteers
This is a first-in-human study of MMV390048. The study will evaluate the safety, tolerability and pharmacokinetic properties of escalating single and multiple doses of MMV390048 when administered to healthy male volunteers and…
- Trial name
- NCT02230579
- Testing
- MMV390048 5mg, MMV390048 20mg, MMV390048 40mg
- Where
- South Africa
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria,Falciparum
First-in-Human Study to Assess the Safety, Tolerability and Pharmacokinetics of MMV367
This three-part, first-in-human, healthy volunteer study aims to assess the safety and tolerability of the test medicine as well as how it is taken up by the body when given as single and multiple doses.
- Trial name
- NCT05507970
- Testing
- MMV367, MMV367 (Fed 440mg), MMV367 (Fasted 440mg)
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Plasmodium Falciparum Infection, Plasmodium Vivax Infection
Efficacy and Safety of Dihydroartemisinin-piperaquine (DHP) for the Treatment of Uncomplicated Malaria
This is an observational safety and efficacy study on dihydroartemisinin-piperaquine in Timika, Indonesia with a 42 day follow up period.
- Trial name
- NCT02353494
- Testing
- Dihydroartemisinin-Piperaquine
- Where
- Indonesia
- Volunteers
- 130 people
- Sponsor
- Menzies School of Health Research
Malaria
Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites in Healthy African Adults in Mali
Background: Malaria is still a health problem in Sub-Saharan Africa. Death rates are stable and have even increased in some areas. There are malaria vaccines.
- Trial name
- NCT02627456
- Testing
- PfSPZ Vaccine, PfSPZ Challenge Material, PBS and HSA Diluent
- Where
- Mali
- Volunteers
- 409 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Safety and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria
This first-in-human clinical trial, was a dose escalation multi-center trial designed to assess the safety, tolerability, and immunogenicity of the vaccine component, BNT165b1, a ribonucleic acid (RNA)-lipid nanoparticle (LNP)…
- Trial name
- NCT05581641
- Testing
- BNT165b1
- Where
- 5 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Malaria, Malaria,Falciparum
A Study to Assess the Safety and Effectiveness of Two Experimental Malaria Vaccines
Malaria is a major public health problem. There were around 240 million cases of malaria and 627,000 deaths worldwide in 2020. There is a great need for a safe, effective malaria vaccine and the team at University of Oxford is…
- Conditions
- Malaria, Malaria,Falciparum, Parasitic Disease, Vector Borne Diseases
- Trial name
- NCT05978037
- Testing
- RH5.1 and/or RH5.2-VLP with Matrix-M
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Malaria Prophylaxis
Boosting the Impact of SMC Through Simultaneous Screening and Treatment of Roommates
Malaria represents a major public health concern in sub-Sahara Africa. Seasonal malaria chemoprevention (SMC) is one of the largest preventive measures.
- Conditions
- Malaria, Malaria Prophylaxis, Mass Testing and Treatment
- Trial name
- SMC-RST (NCT04816461)
- Testing
- Amodiaquine Sulfadoxine-Pyrimethamin administration, Dihydroartemisinin-Piperaquine, Standard HRP2-RDT
- Where
- Burkina Faso
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Malaria, Falciparum
Safety and Immunogenicity of Recombinant Pichia Pastoris AMA1-DiCo Candidate Malaria Vaccine With GLA-SE and Alhydrogel ® as Adjuvant in Healthy Malaria Non-Exposed European and Malaria Exposed African Adults
The primary objective is to evaluate the safety of 3 doses given at D0, W4, and W26 of 50 µg dosage of AMA1-DiCo adjuvanted either with GLA-SE or Alhydrogel® in healthy European adults not previously exposed to the parasite…
- Trial name
- AMA1-DiCo (NCT02014727)
- Testing
- Group A1 : 50µg AMA1-DiCo + Alhydrogel, Group A2 : 50 µg AMA1-DiCo+ GLA-SE
- Where
- 2 sites in Burkina Faso, France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Malaria
Intermittent Preventive Treatment During Pregnancy in Benin
Malaria in pregnancy is one of the most important preventable causes of low birthweight worlwide and a major cause of severe maternal anaemia contributing to maternal mortality.
- Trial name
- NCT00274235
- Testing
- sulfadoxine-pyrimethamine / mefloquine
- Where
- Benin
- Volunteers
- 1,600 people
- Sponsor
- Institut de Recherche pour le Developpement
Asymptomatic P.Falciparum Malaria
Effect of Antimalarial Treatment on Gametocyte Carriage in Asymptomatic P. Falciparum
Treatment of uncomplicated P.falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a marked increase in the density of gametocytes.
- Trial name
- NCT00289250
- Testing
- Sulfadoxine-pyrimethamine, Sulfadoxine-pyrimethamine plus artesunate
- Where
- The Gambia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Glucose 6 Phosphate Dehydrogenase Deficiency
Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers Receiving a Seven Day Dose Regimen
To investigate the comparative tolerability, metabolism and pharmacokinetics of individual enantiomers of PQ in healthy human volunteers, receiving study drug over the course of 7 days.
- Trial name
- NCT03934450
- Testing
- RPQ, SPQ, Primaquine Phosphate
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Mississippi, Oxford
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