Clinical trials: Malaria, completed
Malaria
Controlled Human Malaria Infection by Intradermal Injection of Plasmodium Falciparum Sporozoites in Tanzanian Adults
The proposed trial will evaluate whether relatively non immune populations in endemic countries can be effectively infected with aseptic, purified, cryopreserved sporozoites (PfSPZ Challenge) given intradermally.
- Trial name
- NCT01540903
- Testing
- PfSPZ Challenge, Saline
- Where
- Tanzania
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Malaria, Malaria, Cerebral
Study of the Safety of Intravenous Artesunate
The purpose of this study is to establish the safety, tolerability, and pharmacokinetics of a multiple dose of the antimalarial drug artesunate.
- Trial name
- NCT00292942
- Testing
- Intravenous Artesunate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria, Falciparum Malaria
ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan
Chloroquine resistant falciparum malaria in Pakistan is prevalent in every malarious area examined. Resistance to the favoured second-line treatment, sulphadoxine-pyrimethamine S/P is rising fast.
- Conditions
- Malaria, Falciparum Malaria, Vivax Malaria
- Trial name
- NCT00158548
- Testing
- SP, chloroquine, amodiaquine, primaquine, artesunate
- Where
- Pakistan
- Volunteers
- 650 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Malaria Surveillance in Rakai, Uganda
Background: Malaria is a leading cause of morbidity and mortality in Uganda, accounting for more than a quarter of all outpatient visits at health facilities, 20 percent of hospital admissions, and about 10 percent of inpatient…
- Trial name
- NCT01265407
- Where
- Uganda
- Volunteers
- 1,650 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Anaemia
Seasonal Malaria Chemoprevention Versus Home Management of Malaria in Children Under 5 Years in Ghana
In areas of Africa where malaria is only a problem during a short rainy season, monthly courses of antimalarial drugs can provide very effective prevention of malaria in children.
- Trial name
- NCT01651416
- Testing
- Artemether-lumefantrine combination, Dihydroartemisinin Piperaquine combination, Amodiaquine plus sulphadoxine-pyrimethamine combination
- Where
- Ghana
- Volunteers
- 2,400 people
- Sponsor
- Centre for Global Health Research, Ghana
Malaria, Malaria Vaccine
Knowledge and Attitude Among Healthcare Workers Towards Malaria Vaccine, Sudan 2025.
This study assesses Sudanese healthcare workers' knowledge and attitudes toward the malaria vaccine in 2025, considering demographic and professional factors.
- Trial name
- NCT07194499
- Testing
- No interventions
- Where
- Sudan
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Research and Publication office
Malaria, Non-malarial Febrile Illness
Non-malarial Febrile Illness in Children in Areas of Perennial Malaria Transmission
To evaluate the causes of non-malarial febrile illness in children living in an area of perennial malaria transmission and to determine if these children who test negative for malaria by rapid diagnostic test receive any benefit…
- Trial name
- NCT01043744
- Testing
- Artemether-Lumefantrine
- Where
- 2 sites in Tanzania
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Febrile Illness, Malaria
Rapid Diagnostic Tests (RDTs) for Malaria in Kampala, Uganda
Malaria remains a disease that causes much death and sickness, especially in sub-Saharan Africa. An accurate, simple, and inexpensive method of diagnosing malaria is urgently needed.
- Trial name
- NCT00327964
- Where
- Uganda
- Volunteers
- 600 people
- Sponsor
- University of California, San Francisco
Malaria
A Trial of Improved Financial Access to Healthcare in Ghana
Effective control strategies for malaria depend both on preventing disease and on treating those who become infected to prevent significant morbidity and mortality.
- Trial name
- NCT00146692
- Testing
- Free medical treatment
- Where
- Ghana
- Volunteers
- 2,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Effectiveness of OZ439 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Volunteers
A single centre, open, controlled study using Blood Stage Plasmodium falciparum challenge inoculum (BSPC) as a model to assess the effectiveness of three dose levels of the experimental anti-malarial product, OZ439.
- Trial name
- NCT02453581
- Testing
- OZ439
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Efficacy and Safety of Dihydroartemisinin/Piperaquine (Artekin®) for the Treatment of Uncomplicated Malaria in Peru
In Peru, Mefloquine plus Artesunate (MAS3), is the current first line treatment for P. falciparum malaria in the Amazonian Region, and has proved its efficacy against multi-resistant P.
- Trial name
- NCT00373607
- Testing
- Dihydroartemisin-piperaquine, Mefloquine + Artesunate
- Volunteers
- 522 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria
Prenatal Iron and Malaria Study
The purpose of this study is to compare the presence of Plasmodium infection in parturient women who antenatally received a combination of iron-fortified foods with iron supplements versus iron-fortified foods only.
- Trial name
- PIMAL (NCT01308112)
- Testing
- iron
- Where
- Kenya
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Pyronaridine Artesunate 3:1 Granule Formulation vs. Coartem© Crushed Tablets in P. Falciparum Malaria Pediatric Patients
The primary objective of this Phase III clinical study is to demonstrate the efficacy of the fixed combination of pyronaridine artesunate (PA) granule formulation (60:20 mg; pediatric PYRAMAX®) by showing a PCR-corrected adequate…
- Trial name
- NCT00541385
- Testing
- pyronaridine artesunate, arthemeter lumefantrine
- Where
- 8 sites in Burkina Faso, Côte d’Ivoire and 6 more
- Volunteers
- 535 people
- Sponsor
- Medicines for Malaria Venture
Malaria, Bacteremia
Empirical ANtibiotic THErapy in Adults Hospitalised With Malaria
While World Health Organization (WHO) guidelines recommend empirical antibacterial therapy as the standard of care in all African children with severe falciparum malaria, there are fewer data to guide the management of adults…
- Conditions
- Malaria, Bacteremia, Sepsis
- Trial name
- ANTHEM (NCT03224052)
- Where
- Burma
- Volunteers
- 20 people
- Sponsor
- Menzies School of Health Research
P Vivax, Malaria, Vivax
Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P. Vivax Malaria, Cruzeiro do Sul, Acre, Brazil
We plan to assess the efficacy of 3 different regimens of chloroquine and primaquine for the treatment of P. vivax infections in Cruzeiro do Sul, Acre, Brazil.
- Trial name
- NCT03610399
- Testing
- Primaquine
- Where
- Brazil
- Volunteers
- 257 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria
Trial to Evaluate CIS43LS in Healthy Adults
Background: People get malaria when they are bitten by an infected mosquito. Malaria can be serious and sometimes deadly. Although there are medicines to treat malaria, there is no vaccine that fully prevents infection.
- Trial name
- NCT04206332
- Testing
- VRC-MALMAB0100-00-AB, Plasmodium falciparum (P. falciparum) sporozoite challenge
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Falciparum
Efficacy and Safety of the Pediatric Formulation of Artemether- Lumefantrine in Children With Uncomplicated P. Falciparum Malaria.
This study will evaluate the safety and efficacy of artemether-lumefantrine against uncomplicated malaria caused P. falciparum in children of 5-35 kg bodyweight.
- Trial name
- NCT00386763
- Testing
- Artemether-lumefantrine
- Where
- 5 sites in Benin, Kenya and 3 more
- Volunteers
- 890 people
- Sponsor
- Novartis
Sickle Cell Anemia, Sickle Cell Disease
Novel Use Of Hydroxyurea in an African Region With Malaria
Multiple studies have shown that hydroxyurea has clinical efficacy in preventing acute painful episodes and reducing the need for blood transfusions in children with sickle cell anemia (SCA), but no study has been conducted in…
- Conditions
- Sickle Cell Anemia, Sickle Cell Disease, Malaria
- Trial name
- NOHARM (NCT01976416)
- Testing
- Hydroxyurea
- Where
- Uganda
- Volunteers
- 208 people
- Sponsor
- Indiana University
Malaria, Malaria Vaccines
Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Given at 6, 7.5 and 9 Months of Age in Co-administration With Measles, Rubella and Yellow Fever (YF) Vaccines Followed by a Booster of the Malaria Vaccine.
The purpose of this study is to assess the immunogenicity, safety, and reactogenicity of the SB257049 candidate malaria vaccine when co-administered with Vitamin A, measles, rubella and yellow fever vaccines to children aged 6…
- Trial name
- NCT02699099
- Testing
- Vitamin A, Candidate Plasmodium falciparum malaria vaccine, MR-Vac
- Where
- 2 sites in Ghana
- Volunteers
- 699 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria
In Vivo and In Vitro Efficacy of Artemisinin Combination Therapy
This study aims to assess the degree of artemisinin resistance in adult and pediatric subjects presenting with uncomplicated falciparum malaria in Western Kenya.
- Trial name
- NCT01976780
- Testing
- Artesunate, Artemether Lumefantrine, Mefloquine
- Where
- Kenya
- Volunteers
- 118 people
- Sponsor
- Global Emerging Infections Surveillance and Response System
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