Clinical trials: Malaria, completed
Malaria
ANC & Malaria Diagnostic in Pregnancy
The program's overall objective is to assess the impact of a package of interventions aimed at reducing malaria-related mortality and morbidity in pregnant women and newborns by ensuring access to a package of interventions…
- Trial name
- AQUAMOD (NCT01703884)
- Testing
- ASAQ
- Where
- Burkina Faso
- Volunteers
- 5,254 people
- Sponsor
- Centre Muraz
Malaria
Harmonized AS/MQ Efficacy Study - Thailand
The purposes of this study is to determine parasitological clearance rates by microscopy for the 72-hour period after first artesunate dose in subjects with uncomplicated P. falciparum malaria.
- Trial name
- NCT02052323
- Testing
- Artesunate/mefloquine (AS/MQ)
- Where
- Thailand
- Volunteers
- 48 people
- Sponsor
- Armed Forces Research Institute of Medical Sciences, Thailand
Malaria, Falciparum
Assessment of Artesunate/Mefloquine in the Peruvian Amazon
There is growing evidence of the emergence of P. falciparum resistance to artesunate (a derivative of artemisin) in Southeast Asia.
- Trial name
- Artesunate (NCT02084602)
- Testing
- Artesunate, Mefloquine
- Where
- Peru
- Volunteers
- 45 people
- Sponsor
- Instituto Nacional de Salud. Peru
Malaria
Healthy Volunteer Study of the Pharmacokinetics of Oral Piperaquine With OZ439 + TPGS Formulation in the Fasted State
Piperaquine tablets (coated) + OZ439 granules + TPGS granules will be co-administered in Phase IIb (adults). However, safety and PK data (for OZ439 plus piperaquine) were obtained using piperaquine tablets plus OZ439 as Powder in…
- Trial name
- NCT01853475
- Testing
- PQP tablets 960mg, PQP tablets 1440mg, OZ439+TPGS 800mg
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Single Oral Dose Study of Atovaquone/Proguanil Hydrochloride Combination Tablets and Atovaquone Suspension
This study will be a single-center, phase I, randomized, open, in fed condition, parallel, single dose study to evaluate the pharmacokinetics and the safety, tolerability of Atovaquone/proguanil combination tablets and atovaquone…
- Trial name
- NCT01858831
- Testing
- Atovaquone/proguanil HCL, Atovaquone
- Where
- Japan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria
Efficacy and Tolerability of Artesunate Amodiaquine Versus Chloroquine in the Treatment of Uncomplicated Plasmodium Vivax Malaria
Primary Objective: To demonstrate the non-inferiority of corrected adequate clinical and parasitological response at Day 28 of Artesunate Amodiaquine (ASAQ) versus chloroquine Secondary Objectives: To assess the non inferiority…
- Trial name
- NCT01378286
- Testing
- ARTESUNATE + AMODIAQUINE, Chloroquine
- Where
- Brazil
- Volunteers
- 380 people
- Sponsor
- Sanofi
Malaria
A Study to Evaluate the Safety, Immunogenicity and Efficacy of GlaxoSmithKline (GSK) Biologicals' Candidate Malaria Vaccine RTS,S/AS02A, When Administered to Children Aged 1 to 4 Years Living in a Malaria-endemic Region of Mozambique.
Malaria is an important cause of death and serious illness among Mozambican children. Although the risk of malaria can be reduced by drugs and by impregnated bed nets, it would be helpful if children could be protected against…
- Trial name
- NCT00197041
- Testing
- RTS,S/AS02A
- Where
- Mozambique
- Volunteers
- 2,022 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria, Falciparum
Chloroquine and Coartem for Treatment of Symptomatic Children With Plasmodium Falciparum in Guinea Bissau
This study will evaluate the efficacy of treatment with artemether-lumefantrine as compared to chloroquine in the dose of 50 mg/kg for treatment of malaria in children in Guinea-Bissau.
- Trial name
- NCT00426439
- Testing
- Chloroquine, Artemether-lumefantrine (Coartem)
- Where
- Guinea-Bissau
- Volunteers
- 300 people
- Sponsor
- Bandim Health Project
Malaria in Pregnancy, HIV Infections
Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine
The purpose of this study is to evaluate the efficacy of cotrimoxazole prophylaxis in prevention of malaria during pregnancy in HIV-infected women, compared to intermittent preventive treatment with mefloquine.
- Trial name
- PACOME (NCT00970879)
- Testing
- cotrimoxazole, mefloquine
- Where
- 5 sites in Benin
- Volunteers
- 430 people
- Sponsor
- Institut de Recherche pour le Developpement
Malaria, Vivax
Safety and Immunogenicity Study of Plasmodium Vivax CS Derived Synthetic Peptides Formulated in Two Adjuvants
This was a phase I double blind controlled vaccine trial, evaluating safety, tolerability and immunogenicity of mixtures of N, R and C LSP derived from the P.
- Trial name
- Fase1B (NCT01081847)
- Testing
- Peptides (N,R&C) formulated in Montanide ISA 720, Peptides (N,R&C) formulated in Montanide ISA 51
- Where
- 2 sites in Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Malaria Vaccine and Drug Development Center
Malaria
Relapses in Plasmodium Ovale and Efficacy of Artemether-lumefantrine for Mixed Species and Non-falciparum Malaria
Malaria is a protozoan infection transmitted by anopheline mosquitoes. The most severe forms are caused by Plasmodium (P) falciparum and to a much lesser extent by P. vivax.
- Trial name
- REPLAMO (NCT02528279)
- Testing
- Coartem
- Where
- 2 sites in Gabon
- Volunteers
- 50 people
- Sponsor
- Albert Schweitzer Hospital
Malaria, Anaemia
Evaluation of a Novel Long Lasting Insecticidal Net and Indoor Residual Spray Product
The proposed study is a four-arm randomized control trial (RCT) in 48 villages in the Lakes region in Tanzania comparing the relative effectiveness of 4 vector control interventions for reducing malaria transmission and…
- Trial name
- NCT02288637
- Testing
- Olyset Plus LLIN, Conventional Olyset LLIN, IRS
- Where
- Tanzania
- Volunteers
- 3,840 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Combination Antimalarials in Uncomplicated Malaria
The purpose of this study is to study the efficacy of sulfadoxine-pyrimethamine on its own and compare this with efficacy of a new combination antimalarial therapy, either sulphadoxine-pyrimethamine plus artesunate or…
- Trial name
- NCT00203801
- Testing
- Sulfadoxine-pyrimethamine, Artesunate plus sulfadoxine-pyrimethamine, Artemether-lumefantrine
- Where
- 7 sites in Eswatini, Mozambique and 1 more
- Volunteers
- 700 people
- Sponsor
- University of Cape Town
Uncomplicated Falciparum Malaria
Efficacy and Safety of ASAQ and PD for the Treatment of Uncomplicated Falciparum Malaria in Mainland Tanzania
The World Health Organization recommends regular surveillance of antimalarial efficacy to monitor the performance of different drugs.
- Trial name
- GF-TES-2017 (NCT03431714)
- Testing
- Artesunate amodiaquine
- Where
- Tanzania
- Volunteers
- 333 people
- Sponsor
- National Institute for Medical Research, Tanzania
Malaria, Anemia
Intermittent Treatment With Sulfadoxine-pyrimethamine for Malaria Control in Infants
The purpose of this study is to assess the effectiveness of Intermittent Preventive Treatment in Infants (IPTi) with Sulfadoxine-Pyrimethamine to reduce the numbers of malaria attacks, episodes of anemia, and the overall…
- Trial name
- NCT00206739
- Testing
- Sulfadoxine (12.5 mg)/Pyrimethamine (250 mg)
- Where
- Ghana
- Volunteers
- 1,070 people, healthy volunteers welcome
- Sponsor
- Bernhard Nocht Institute for Tropical Medicine
Vivax Malaria
Pharmacokinetic Study of Primaquine and Chloroquine in Healthy Subjects
This is a standard pharmacokinetic interaction study. Subjects will be randomized to be either group A or B. Group A. Subjects will have 3 hospitalizations to complete.
- Trial name
- PQCQ (NCT01218932)
- Testing
- A, B
- Where
- Thailand
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Proof-of-Concept Study of MSP3-LSP Vaccine to Protect Against Malaria in Africa
Hypothesis: The MSP3-LSP/Alum vaccine, administered to children will have a protective efficacy of at least 30% (lower bound of confidence interval of 0) against malaria disease occurring during a period beginning from 14 days…
- Trial name
- MSP3-POC (NCT01341704)
- Testing
- MSP3-LSP/AlOH, Verorab Vaccine, 0.9% NaCl/Normal Saline
- Where
- Mali
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Vac4All
Malaria
Malaria Transmission in Humans and Mosquitoes at the Area of Sabou, Burkina Faso
Background: Malaria is a disease that affects many people in Burkina Faso. It is caused by germs that are spread by mosquito bites. A vaccine that blocks the spread of malaria is important to get rid of the disease.
- Trial name
- NCT04650815
- Where
- 2 sites in Burkina Faso
- Volunteers
- 608 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uncomplicated Plasmodium Falciparum Malaria
Efficacy, Safety and Tolerability of KAF156 in Combination With Lumefantrine Solid Dispersion Formulation (LUM-SDF) in Pediatric Population With Uncomplicated Plasmodium Falciparum Malaria
This study aimed to determine the efficacy, safety and tolerability of the investigational drug KAF156 in combination with a solid dispersion formulation of lumefantrine (LUM-SDF) in pediatric patients (6 months to < 18 years of…
- Trial name
- KALUMI (NCT04546633)
- Testing
- KAF156, LUM-SDF, Coartem
- Where
- 9 sites in Burkina Faso, Côte d’Ivoire and 3 more
- Volunteers
- 295 people
- Sponsor
- Novartis Pharmaceuticals
Malaria, Uncomplicated
Adherence to Lumefantrine-Artemether
This is a study of how well caregivers of children with malaria adhere to the recommended regimen for lumefantrine-artemether (LA).
- Trial name
- NCT00153491
- Testing
- artemether-lumefantrine
- Where
- Tanzania
- Volunteers
- 300 people
- Sponsor
- Centers for Disease Control and Prevention
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