Clinical trials: Malaria, completed
Sickle Cell Anemia, Sickle Cell Disease
Optimizing Hydroxyurea Therapy in Children With SCA In Malaria Endemic Areas
The Novel use Of Hydroxyurea in an African Region with Malaria (NOHARM) study is the first placebo-controlled randomized clinical trial of hydroxyurea treatment in a malaria endemic region.
- Conditions
- Sickle Cell Anemia, Sickle Cell Disease, Malaria
- Trial name
- NOHARM-MTD (NCT03128515)
- Testing
- Hydroxyurea
- Where
- Uganda
- Volunteers
- 187 people
- Sponsor
- Indiana University
Malaria Asymptomatic Parasitaemia
Determining the Impact of Scaling up Mass Testing, Treatment and Tracking on Malaria Prevalence in Ghana
Globally, malaria prevalence in 2016 was reported to have increased with 445,000 deaths, 91% of which occurred in sub-Sahara Africa with more than 75% being children.
- Trial name
- DetI-MTTT (NCT04301531)
- Testing
- Mass testing using RDTs, Treatment for all cases confirmed positive malaria cases with ACTs, Determination of Hb
- Where
- Ghana
- Volunteers
- 5,861 people, healthy volunteers welcome
- Sponsor
- Noguchi Memorial Institute for Medical Research
Malaria,Falciparum
A Study to Test Experimental Blood Stage Malaria Vaccine in Burkina Faso.
This is a Phase IIb randomised controlled trial of the safety, immunogenicity and efficacy of the blood-stage malaria vaccine candidates RH5.1 in Matrix-MTM and RH5.2-VLP in Matrix-MTM in infants aged 5-17 months in Burkina Faso
- Trial name
- NCT05790889
- Testing
- Rabies vaccine, RH5.1 10μg adjuvated with 50μg Matrix-M, RH5.2 5μg adjuvated with 50μg Matrix-M
- Where
- Burkina Faso
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Assessment of Safety and Immunogenicity of a Single Vial Presentation of R21/Matrix-M and Co-Administration With EPI Vaccines
This is a Phase Ib trial conducted in Bougouni, Mali to evaluate the safety and immunogenicity of R21/Matrix-M in a single and two vial presentation, with different immunisation schedules, and when co-administered with EPI…
- Trial name
- NCT05155579
- Testing
- R21/Matrix-M - single vial formulation, R21/Matrix-M - two vial formulation, Licensed vaccine - Measles-rubella
- Where
- 2 sites in Mali, United Kingdom
- Volunteers
- 594 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Fever, Malaria
Introducing Rapid Diagnostic Tests Into the Private Health Sector
Most malaria deaths occur within 48 hours of onset of symptoms, and in rural areas with poor access to health facilities, home management of malaria (HMM) can improve the timeliness of treatment and reduce malaria mortality by up…
- Conditions
- Fever, Malaria, Diagnosis, Referral
- Trial name
- NCT01194557
- Testing
- Rapid diagnostic test, Lumartem
- Where
- Uganda
- Volunteers
- 2,600 people
- Sponsor
- DBL -Institute for Health Research and Development
Malaria
Cohort Event Monitoring in Sub Saharan Africa
This cohort event monitoring will document real-life safety experiences following the intake of Injectable AS. Specifically, the study will record common adverse events that are associated with the use of Inj.
- Trial name
- CEMISA (NCT02817919)
- Where
- 4 sites in Ghana
- Volunteers
- 1,126 people
- Sponsor
- African Collaborating Centre for Pharmacovigilance
Seizure, Epilepsy
A Safety and Feasibility Study of Enteral LVT vs. Standard of Care for Seizure Control in Pediatric CM
Pediatric cerebral malaria (CM) affects more than 3 million children each year killing ~20% and leaving one third of survivors with long term neurologic and psychiatric sequelae.
- Conditions
- Seizure, Epilepsy, Cerebral Malaria
- Trial name
- LVT2 (NCT01982812)
- Testing
- Oral Levetiracetam, Standard AED
- Where
- Malawi
- Volunteers
- 44 people
- Sponsor
- University of Rochester
Malaria
Epidemiology Study of Malaria Transmission Intensity in Sub-Saharan Africa
This study is designed to characterise P. falciparum transmission intensity in subjects aged ≥6 months and <10 years by measurement of P.
- Trial name
- NCT01954264
- Testing
- Capillary blood sample, Data collection
- Where
- 3 sites in Burkina Faso, Senegal
- Volunteers
- 2,421 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Malaria, Falciparum, HIV Infections
Prevention of Malaria During Pregnancy Using Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine: Malawi
In Malawi, the standard of care to prevent malaria during pregnancy at the time of the study was a two dose sulfadoxine-pyrimethamine intermittent protective treatment (SP IPT) regimen administered in the second and third…
- Trial name
- NCT00126906
- Testing
- Monthly sulfadoxine/pyrimethamine, 2-dose sulfadoxine/pyrimethamine
- Where
- Malawi
- Volunteers
- 700 people
- Sponsor
- Centers for Disease Control and Prevention
Hemoglobin Mutations, Erythrocyte Variants
Collection of Blood From Persons With Hemoglobin and Erythrocyte Polymorphisms for Laboratory Malaria Research
This study will collect blood samples for use in laboratory studies of malaria. The World Health Organization reports that 40 percent of the world's population is at risk for malaria, mostly in the poorest countries.
- Trial name
- NCT00277849
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria in Pregnancy, Adherence, Treatment
Acceptability and Feasibility in the Context of the IMPROVE Trial in Kenya
This multi-centre study will compare the acceptability, feasibility, cost and incremental cost-effectiveness of intermittent preventive treatment (IPTp) with dihydroartemisinin-piperaquine (DP) with or without azithromycin to the…
- Trial name
- NCT04160026
- Testing
- Monthly intermittent preventive treatment with dihydroartemisnin-piperaquine, Monthly intermittent preventive treatment with sulfadoxine-pyrimethamine, Monthly intermittent preventive treatment with dihydroartemisnin-piperaquine with targeted information transfer
- Where
- Kenya
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Malaria
Quinine vs. Artemether/Lumefantrine in Uncomplicated Malaria During Pregnancy
A) for the treatment of uncomplicated malaria during second and third trimester pregnancy to oral Quinine hydrochloride. The PCR-corrected adequate clinical and parasitological response (ACPR) on day 42 is considered as the…
- Trial name
- NCT00495508
- Testing
- Quinine, artemether / lumefantrine
- Where
- Uganda
- Volunteers
- 300 people
- Sponsor
- Epicentre
Malaria
Absolute BA and OZ439 PK Effect of Different OZ439 Dose Volumes and Cobicistat Co-administration Study
This study is an open-label, two-part study to determine the absolute bioavailability (BA) of OZ439 using simultaneous intravenous [14C]-OZ439 microdose/800mg oral dosing and to investigate the pharmacokinetics (PK) of OZ439…
- Trial name
- NCT04069221
- Testing
- Single oral dose of 800 mg OZ439, Single oral dose of 400 mg OZ439, Single oral dose of cobicistat
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Trial to Evaluate CIS43LS in Healthy Adults
Background: People get malaria when they are bitten by an infected mosquito. Malaria can be serious and sometimes deadly. Although there are medicines to treat malaria, there is no vaccine that fully prevents infection.
- Trial name
- NCT04206332
- Testing
- VRC-MALMAB0100-00-AB, Plasmodium falciparum (P. falciparum) sporozoite challenge
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Reducing the Effects of Malaria in Children by Administering Repeated Preventive Doses
The general goal of the project is to assess the infectious status and immunity of mothers and children living in a malaria region.
- Trial name
- NCT00167843
- Testing
- sulfadoxine-pyrimethamine
- Where
- Gabon
- Volunteers
- 1,189 people, healthy volunteers welcome
- Sponsor
- Albert Schweitzer Hospital
Malaria
Study to Assess Safety, Tolerability and Phamacokinetics of KAE609 Administered Intravenously in Healthy Subjects
This was a randomized, subject and investigator-blinded, placebo-controlled, single and multiple ascending intravenous (iv) dose study in healthy subjects to assess the safety and tolerability of KAE609 given in the vein.
- Trial name
- NCT04321252
- Testing
- KAE609
- Where
- Belgium
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Malaria, Vivax Malaria
Eight Week Primaquine Regimen for the Treatment of Vivax Malaria
Plasmodium vivax represents a major health problem throughout the tropics. Outside Africa it accounts for over 50% of cases, affecting an estimated 70-80 million people per year.
- Trial name
- NCT00158587
- Testing
- primaquine
- Volunteers
- 150 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
A Safety and Efficacy Study of R21 +/- ChAd63/MVA ME-TRAP
The purpose of this study is to assess the safety and efficacy of adjuvanted R21 alone and in combination with a viral-vectored vaccine regimen (constituting adjuvanted R21 + ChAd63 and MVA encoding ME-TRAP) against malaria…
- Trial name
- NCT02905019
- Testing
- R21 with Matrix-M1, ChAd63 ME-TRAP, MVA ME-TRAP
- Where
- 3 sites in United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Plasmodium Falciparum, Pregnancy Malaria
Clinical Performance of the HRP2 HS-RDT for Malaria Diagnosis in Pregnant Women
This is a cross-sectional and multicentre clinical trial to study the performance of the Histidine Rich Protein 2 (HRP2) highly sensitive rapid diagnostic test (HS-RDT) for the detection of malaria during pregnancy in low…
- Conditions
- Plasmodium Falciparum, Pregnancy Malaria, Diagnoses Disease
- Trial name
- HSRDT MiP (NCT03172221)
- Testing
- HS-RDT
- Where
- 2 sites in Colombia
- Volunteers
- 880 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Anemia, Malaria
Perennial Malaria Chemoprevention (PMC) in Cameroon
The Plus Project will assess the impact, operational feasibility, efficacy, effectiveness, and cost-effectiveness of PMC. Specifically, the impact evaluation will involve monitoring a passive cohort of all children in the study…
- Trial name
- NCT05889052
- Testing
- Sulfadoxine pyrimethamine
- Where
- Cameroon
- Volunteers
- 2,138 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
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