Clinical trials: Malaria, completed
Falciparum Malaria
Pyronaridine - Artesunate (3:1) Versus Mefloquine Plus Artesunate in Plasmodium Falciparum Malaria Patients
The primary objective of this phase III clinical study is to compare the efficacy and safety of the fixed combination of pyronaridine artesunate (Pyramax®, PA) with that of the combination of mefloquine plus artesunate (MQ + AS)…
- Trial name
- NCT00403260
- Testing
- Pyronaridine - artesunate, Mefloquine plus artesunate
- Where
- 9 sites in Burkina Faso, Cambodia and 5 more
- Volunteers
- 1,271 people
- Sponsor
- Medicines for Malaria Venture
Malaria,Falciparum, Plasmodium Falciparum
Safety and Protective Efficacy of Pb(PfCS@UIS4)
In the underlying study, a genetically modified P. berghei parasite is used. P. berghei is one of the four Plasmodium species that causes malaria in rodents. The hypothesis is that immunization of humans with P.
- Conditions
- Malaria,Falciparum, Plasmodium Falciparum, Plasmodium Berghei, Controlled Human Malaria Infection (CHMI)
- Trial name
- PbVac (NCT03138096)
- Testing
- Pb(PfCS@UIS4)-infected mosquitoes, Challenge infection P. falciparum
- Where
- 2 sites in Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria, Falciparum, Plasmodium Falciparum
Pilot Study to Estimate the Burden and Distribution of Plasmodium Falciparum Malaria in Kalifabougou, Mali in Preparation for a Prospective Cohort Study of Naturally-Acquired Malaria Immunity
Plasmodium falciparum malaria remains a global public health threat. Leading malaria vaccine candidates confer only partial short-lived protection at best.
- Trial name
- NCT01160562
- Where
- Mali
- Volunteers
- 1,719 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
A Trial of the Efficacy of Artesunate and Three Quinine Regimens in the Treatment of Severe Malaria in Children at the Ebolowa Regional Hospital - Cameroon
The purpose of the study is to evaluate and compare the efficacy of parenteral artesunate with three quinine regimens in the treatment of severe malaria in children at the Ebolowa Regional Hospital located in the South region of…
- Trial name
- NCT02563704
- Testing
- Artesunate, Quinine
- Volunteers
- 238 people
- Sponsor
- University of Yaounde 1
Malaria, Falciparum
Evaluation of Potential Effect of Artemether - Lumefantrine and Malaria Drugs on Auditory Function
To evaluate the potential effects of artemether- lumefantrine on the auditory function
- Trial name
- NCT00444106
- Testing
- Artesunate-mefloquine, Atovaquone-proguanil, Artemether-lumefantrine
- Where
- Colombia
- Volunteers
- 265 people
- Sponsor
- Novartis
Malaria
A Comparative Safety and Activity Study With Ferroquine Associated With Artesunate Versus Amodiaquine Associated With Artesunate in African Adult Patients With Uncomplicated Malaria
The primary objective is to assess the safety of different doses of ferroquine with artesunate (AS) in adult African patients with uncomplicated malaria.
- Trial name
- NCT00563914
- Testing
- ferroquine (SSR97193), amodiaquine
- Where
- 2 sites in Gabon, Kenya
- Volunteers
- 72 people
- Sponsor
- Sanofi
Vivax Malaria
G6PD Assessment Before Primaquine for Radical Treatment of Vivax Malaria
This will be a single-arm observational cohort study. Malaria patients with Plasmodium vivax and meeting study inclusion criteria, who give consent to be enrolled in the study, will have their G6PD status measured by the…
- Trial name
- GAP (NCT02876549)
- Testing
- Chloroquine, Primaquine 0.25 mg/kg/day, Primaquine 0.75 mg/kg weekly
- Where
- Afghanistan
- Volunteers
- 1,000 people
- Sponsor
- University of Oxford
Malaria,Falciparum
Safety and Immunogenicity of SUM-101 Malaria Vaccine in Children and Infants Living in Burkina Faso
This clinical trial aims to learn about the safety and immunogenicity of the blood-stage malaria vaccine candidate SUM-101 in infants and children, paving the way for its incorporation into a multi-stage malaria vaccine.
- Trial name
- SUM-101 (NCT06618885)
- Testing
- SUM-101
- Where
- Burkina Faso
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Malaria, Diarrhea
Clinical Evaluation of the Use of an mHealth Intervention on Quality of Care
Under the World Health Organization's (WHO) integrated community case management (iCCM) Rapid Access Expansion Program (RAcE), World Vision Niger and Canada supported the Niger Ministry of Public Health to implement iCCM in four…
- Conditions
- Malaria, Diarrhea, Acute Respiratory Infection
- Trial name
- NCT03874143
- Testing
- mHealth Intervention for Quality of Care
- Volunteers
- 520 people
- Sponsor
- World Vision Canada
Acute Malaria
Phase IIa Proof of Concept Study of M5717-Pyronaridine in Adults and Adolescents With Acute Uncomplicated Plasmodium Falciparum Malaria (CAPTURE 1)
The purpose of this study was to evaluate the safety, efficacy, and pharmacokinetic of the combination M5717 plus pyronaridine in participants with acute uncomplicated Plasmodium falciparum malaria.
- Trial name
- NCT05689047
- Testing
- M5717 330 mg, M5717 500 mg, M5717 660 mg
- Where
- 5 sites in Burkina Faso, Gabon and 2 more
- Volunteers
- 38 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Malaria
Plasmodium Vivax Efficacy Trial in Cruzeiro do Sul, Acre, Brazil
Background: The World Health Organization recommends that antimalarial treatment policies be evaluated every few years to check their efficacy. P.
- Trial name
- NCT02043652
- Testing
- Chloroquine, Primaquine
- Where
- Brazil
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Malaria
An Extension to Study MALARIA-055 PRI (NCT00866619) to Evaluate the Long-term Efficacy, Safety and Immunogenicity of GSK Biologicals' Candidate Malaria Vaccine in Infants and Children in Africa
The purpose of this study is to conduct long-term surveillance for efficacy, safety and immunogenicity of the GSK Biologicals RTS,S/AS01E candidate Plasmodium falciparum malaria vaccine in infants and children in Africa following…
- Trial name
- NCT02207816
- Testing
- Blood sampling, Malaria Vaccine 257049 (MALARIA-055 PRI), Meningococcal C Conjugate Vaccine (MALARIA-055 PRI)
- Where
- 3 sites in Burkina Faso, Kenya and 1 more
- Volunteers
- 3,084 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Plasmodium Falciparum Malaria
EP1300 Polyepitope DNA Vaccine Against Plasmodium Falciparum Malaria
Malaria, a disease responsible for over one million deaths per year, is caused by a germ spread by mosquito bites. The purpose of this study is to evaluate a vaccine designed for the prevention of malaria caused by the parasite…
- Trial name
- NCT01169077
- Testing
- EP-1300
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Antimalarial Drug Resistance in Mali
Resistance of Plasmodium falciparum (malaria) to current antimalarial drugs and the continuing development of resistance to new antimalarial formulations is one of the major obstacles to effective malaria control and case…
- Trial name
- NCT00127998
- Testing
- chloroquine, sulfadoxine-pyrimethamine, amodiaquine
- Where
- 3 sites in Mali
- Volunteers
- 1,011 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria
The Effect of Folic Acid on Efficacy of Sulfadoxine-pyrimethamine in Pregnant Women in Western Kenya
The purpose of this study is to determine whether folic acid, which is often routinely given to pregnant women to prevent birth defects and anemia, affects the efficacy of sulfadoxine-pyrimethamine, another drug that is routinely…
- Trial name
- NCT00130065
- Testing
- Sulfadoxine-pyrimethamine/folic acid
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- Centers for Disease Control and Prevention
Plasmodium Falciparum Malaria
Immunization With Different Doses of Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis
Malaria is one of the major infectious diseases in the world with a tremendous impact on the quality of life significantly contributing to the ongoing poverty in endemic countries.
- Trial name
- ZonMw1 (NCT01218893)
- Testing
- Chloroquine prophylaxis, Immunization, Plasmodium falciparum challenge
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria
Community Dynamics of Malaria Transmission and Mosquito Feeding in Bancoumana, Mali
Background: Half of the world's population is at risk of malaria. Malaria is a disease that affects many people in Mali and other parts of Africa. It is caused by germs spread by mosquito bites. Malaria may be mild.
- Trial name
- NCT03304704
- Where
- 3 sites in Mali
- Volunteers
- 1,928 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Pan-Malaria Transmission-Blocking Vaccine AnAPN1
Malaria is still responsible for more than 627,000 deaths each year, predominantly among children under 5 years old. Current reductions in deaths have stagnated, and additional setbacks for malaria control programs due to the…
- Trial name
- PamTBVac (NCT05905432)
- Testing
- Vaccine AnAPN1
- Where
- Gabon
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Malaria
Evaluation of Weekly Tafenoquine
This study is a phase 2b, placebo controlled, randomized, blinded study of the efficacy of WR 238605, a new primaquine analog, compared to placebo as chemosuppression of P. falciparum malaria in Nyanza Province, western Kenya.
- Trial name
- NCT02491606
- Testing
- Tafenoquine
- Volunteers
- 249 people
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria, Cerebral
Treating Brain Swelling in Pediatric Cerebral Malaria
This study evaluates the effectiveness of two interventions in Malawian children with cerebral malaria at high risk of death. One-third of the participants will receive treatment as usual, one-third will receive treatment as…
- Trial name
- TBS (NCT03300648)
- Testing
- Mechanical ventilation, Hypertonic saline
- Where
- Malawi
- Volunteers
- 57 people
- Sponsor
- Michigan State University
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