Clinical trials: Malaria, completed
Malaria
A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003)
The purpose of this study is to assess the antimalarial activity, pharmacokinetics, and safety of MK-7602 in healthy adults following Plasmodium falciparum (P. falciparum) infection.
- Trial name
- NCT06294912
- Testing
- Plasmodium falciparum, MK-7602, Artemether/lumefantrine
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Malaria
Assessment of Safety and Immunogenicity of R21/Matrix-M™ in African Children Living With HIV
A Phase Ib trial to evaluate the safety and immunogenicity of R21/Matrix-M™ in African children living with HIV
- Trial name
- NCT05385510
- Testing
- R21/Matrix-M™
- Where
- Uganda
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
P. Falciparum Infection Dynamics and Transmission to Inform Elimination (INDIE-1a)
In the current randomized trial, the investigators will test the ability of two experimental approaches to malaria infection management to reduce malaria transmission potential.
- Trial name
- NCT03705624
- Testing
- Enhanced Community Case Management (CCM), Monthly Screening and Treatment (MSAT)
- Where
- Burkina Faso
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Fever
Treatment of Fever Due to Malaria With Ibuprofen
Drugs to treat fever are widely used in children with fever. But there is a controversy about the benefit of reducing fever in children with malaria. Ibuprofen is often used to treat malarial fever.
- Trial name
- NCT00167713
- Testing
- Ibuprofen
- Where
- Gabon
- Volunteers
- 50 people
- Sponsor
- Albert Schweitzer Hospital
Malaria, Surveillance
VectorCAM: A Digital Innovation to Advance Entomological Surveillance
Mosquitoes spread diseases such as malaria, but tracking mosquito populations is often slow and depends on a small number of highly trained specialists.
- Conditions
- Malaria, Surveillance, Entomology, Vector-Borne Diseases
- Trial name
- NCT07909746
- Testing
- VectorCam, Routine Entomological Surveillance
- Where
- Uganda
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Malaria
Effectiveness of Malaria Treatment in Mexico
In the context of malaria elimination in the Americas, solid evidence is necessary of the effectiveness of anti-malarial control measures delivered to the affected individuals. In the Americas, most P.
- Trial name
- EMTM (NCT02394197)
- Testing
- Chloroquine phosphate, primaquine
- Volunteers
- 153 people
- Sponsor
- LILIA GONZALEZ CERON
Severe Malaria
Monitoring of Molecular Markers of Artemisinin Resistance Through Repeated Cross-sectional Assessments in DR Congo, Nigeria and Uganda
Currently, 16 African countries include the use of pre-referral rectal artesunate (RAS) in their treatment policies. However, guidelines for RAS use vary widely across countries and inappropriate use of RAS as a monotherapy and…
- Trial name
- Caramal DRM (NCT04037332)
- Testing
- Blood sample (combined with malaria RDT) followed by gentoyping analysis
- Where
- 7 sites in Democratic Republic of the Congo, Nigeria and 1 more
- Volunteers
- 916 people
- Sponsor
- Swiss Tropical & Public Health Institute
Plasmodium Falciparum Malaria
Efficacy of Artesunate + Amodiaquine Versus Artemether-lumefantrine for Falciparum Malaria in Zanzibar, 2005
The primary objective of the study was to determine the PCR-APCR up to day 42 in children <60 months of age, weighing ≥5kg with uncomplicated malaria, treated with either artesunate+ amodiaquine (ASAQ) or artemether-lumefantrine…
- Trial name
- ACOII (NCT03768908)
- Testing
- Artemether-lumefantrine, Artesunate + Amodiaquine
- Volunteers
- 359 people
- Sponsor
- Professor Anders Björkman
Malaria,Falciparum, Parasitemia
Study in Blood Stage Malaria Infection After DVI of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites
This is a single-centre, open-label, Phase Ib study designed to assess if intravenous injection of approximately 3200 P. falciparum (NF54 strain) sporozoites can be safely administered to achieve blood-stage parasitaemia with a…
- Conditions
- Malaria,Falciparum, Parasitemia, Protozoan Infections, Parasitic Disease
- Trial name
- NCT04310085
- Testing
- Artemether-Lumefantrine 20 Mg-120 Mg Oral Tablet, PfSPZ-DVI Challenge
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
L9LS MAb in Malian Infants
The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of L9LS in infants in Mali and to evaluate the impact of L9LS on subsequent R21/Matrix-MTM vaccine immunogenicity.
- Trial name
- NCT06461026
- Testing
- L9LS, R21/Matrix-MTM
- Where
- 3 sites in Mali
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Malaria in Pregnancy
Prevention of Intrauterine Growth Retardation in Burkina Faso: the Malaria Component
Our objective was to investigate the importance of malaria infection/disease during pregnancy and more particularly during the first trimester; we also looked at the maternal-foetal interactions and their influence on the…
- Trial name
- NCT00680732
- Testing
- Multiple micronutrients supplements (MMS), Iron and folic acid (IFA), Chloroquine (CQ)
- Where
- Burkina Faso
- Volunteers
- 1,370 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria, HIV
Antimalarial Pharmacology in Children and Pregnant Women in Uganda
The burden of malaria is greatest in children and pregnant women in sub-Saharan Africa. Malaria is one of the most important infectious diseases in the world.
- Trial name
- NCT01717885
- Where
- Uganda
- Volunteers
- 473 people
- Sponsor
- University of California, San Francisco
Malaria
Artesunate Plus Amodiaquine in Malaria in Cote d'Ivoire
The primary objective of this study is to demonstrate the non-inferiority of Polymerase Chain Reaction (PCR)-adjusted adequate clinical and parasitological response to artesunate plus amodiaquine at Day 28 in two groups of…
- Trial name
- NCT01023399
- Testing
- Artesunate + Amodiaquine
- Where
- Côte d’Ivoire
- Volunteers
- 580 people
- Sponsor
- Sanofi
Malaria
Determining a Tolerable Dose of Primaquine in G6PD-deficient Persons Without Malaria in Mali
The purpose of this study is to determine the highest tolerable dose of primaquine within 0.75 mg/kg. A tolerable dose is defined as one in which: Two or fewer participants (< 30%) experience hemolysis; No participant experiences…
- Trial name
- PQSAFETY (NCT02535767)
- Testing
- Primaquine
- Where
- Mali
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Fever, Suspected Malaria
ACT for the Home Management in Malagasy Children
The purpose of this study is to assess the feasibility, the acceptability and the effectiveness of the use of the Artesunate + Amodiaquine Fixed Dose Combination for the home management of presumed malaria in Malagasy children by…
- Trial name
- NCT00612547
- Testing
- Artesunate + Amodiaquine Fixed Dose Combination (CoArsucam)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- National Malaria Control Programme, Madagascar
Malaria, HIV/AIDS
Improving Maternal heAlth by Reducing Malaria in African HIV Women
Trial to evaluate the safety and efficacy of DHA-PPQ for Intermittent Preventive Treatment (IPTp) in HIV-infected pregnant women receiving cotrimoxazole prophylaxis (CTXp) and antiretroviral (ARV) drugs and using long lasting…
- Conditions
- Malaria, HIV/AIDS, Pregnancy Related
- Trial name
- MAMAH (NCT03671109)
- Testing
- Dihydroartemisinin-piperaquine (DHA-PPQ)
- Where
- 2 sites in Gabon, Mozambique
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Falciparum Malaria
Effectiveness of the Association Artesunate and Mefloquine in the Treatment of Malaria by Plasmodium Falciparum
The purpose of this study was to evaluate the effectiveness of the fixed combination of artesunate+mefloquine in the treatment of uncomplicated malaria caused by Plasmodium falciparum in the municipality of Cruzeiro do Sul, Juruá…
- Trial name
- NCT01144702
- Testing
- artesunate & mefloquine combination
- Where
- 2 sites in Brazil
- Volunteers
- 163 people
- Sponsor
- Oswaldo Cruz Foundation
Fever
Filter Paper Blood Spots Collected During Fever as a Source for Post-travel Diagnosis in Travelers
This study is part of a larger prospective cohort study (JOKA), designed to study febrile illness occurring during a travel to the tropics, as well as the evaluation of the clinical use of malaria rapid diagnostic tests (RDT) by…
- Trial name
- JOKA-II (NCT02900066)
- Where
- Belgium
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria, Falciparum
Food Interaction Study on the Pharmacokinetics of Eurartesim™ (DHA and PQP)in Healthy Male Adult Volunteers
The study was designed to assess the effect of food on the extent and rate of absorption of Dihydroartemisinin (DHA) and Piperaquine Phosphate (PQP) administered as a fixed dose combination (Eurartesim™).
- Trial name
- NCT01222962
- Testing
- Eurartesim
- Where
- Australia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- sigma-tau i.f.r. S.p.A.
Malaria
Bioavailability Study of Oral OZ439 Prototype Granule Formulations Administered With Piperaquine Phosphate (PQP) Tablets
This is a single-centre, 2-part, randomised, single-dose parallel group study in healthy male subjects and female subjects of non-childbearing potential.
- Trial name
- NCT02387580
- Testing
- OZ439 + TPGS, OZ439 Prototype 1, OZ439 Prototype 3
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
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