Clinical trials: Malaria
Malaria, Severe Acute Malnutrition
Efficacy and Bio-availability of Artemether-Lumefantrine in Severely Malnourished Children
The general objective of the study is to answer to the question: "Is the current dose of AL less efficacious in the severely malnourished compared to the non-severely malnourished children, and is PK in cause?" We aim to assess…
- Trial name
- MAL-NUT (NCT01958905)
- Testing
- Artemether-lumefantrine fixed combination
- Where
- 2 sites in Mali, Niger
- Volunteers
- 399 people
- Sponsor
- Epicentre
Fever, Malaria
Innovative Public-private Partnership to Target Subsidized Antimalarials in the Retail Sector
There are compelling medical and public health reasons to reduce unnecessary consumption of antimalarials and strong evidence to support the use of RDTs in malaria case management.
- Trial name
- NCT02199977
- Testing
- Free Malaria Rapid Diagnostic Test, Conditional ACT voucher, Malaria Rapid Diagnostic test for a charge
- Where
- Kenya
- Volunteers
- 444 people
- Sponsor
- Duke University
Malaria
Evaluation of the Riamet® Versus Malarone® in the Treatment of Uncomplicated Malaria
Riamet® or Malarone® are both recommended as the first line treatment for uncomplicated malaria in France, according to the French consensus Conference revised in 2007 on the treatment of imported malaria.
- Trial name
- MalaRia (NCT01150344)
- Testing
- Malarone (atovaquone + proguanil combination), RIAMET (artemether + LUMEFANTRIN combination)
- Where
- France
- Volunteers
- 317 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Malaria
An Extended Follow up of a RTS,S/AS01E Malaria Vaccine Trial
Malaria is one of the leading causes of deaths in children below five years old. Despite antimalarial drugs and insecticide treated bed nets, the established means of treatment and protection, malaria still continues to affect…
- Trial name
- MAL059 (NCT00872963)
- Testing
- RTS,S/AS01E
- Where
- Kenya
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
Malaria
A Phase I Study to Assess the Safety and Immunogenicity of ChAd63 ME-TRAP - MVA ME-TRAP Heterologous Prime-boost Vaccination Co-administered With EPI Vaccines in Gambian Infants
Two vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, are being tested to see if they will form a safe and effective vaccination strategy against malaria.
- Trial name
- VAC058 (NCT02083887)
- Testing
- ChAd63 ME-TRAP / MVA ME-TRAP
- Where
- The Gambia
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Plasmodium Falciparum
A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of New Plasmodium Falciparum Malaria Vaccine Candidates ChAd63 RH5 Alone and With MVA RH5
The purpose of this study is to assess two new malaria vaccines, ChAd63 RH5 and MVA RH5, at different doses and alone or in combination.
- Trial name
- NCT02181088
- Testing
- ChAd63 RH5 low dose, ChAd63 RH5 full dose, MVA RH5 low dose
- Where
- 2 sites in United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Plasmodium Falciparum Malaria
A Safety and Efficacy Study of Concomitant Administration of ChAd63/MVA ME-TRAP + RTS,S
The purpose of this study is to assess two types of new malaria vaccines in different combinations. The study will enable us to assess: 1. The ability of the vaccines to prevent malaria infection. 2.
- Trial name
- NCT02252640
- Testing
- RTS,S/AS01B (50mcg of RTS,S and standard adult dose of AS01), RTS,S/AS01B (10mcg of RTS,S and one fifth of the standard dose of AS01), ChAd63 ME-TRAP (5 x 10^10 vp)
- Where
- 4 sites in United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
Bio-availability of Rectal Artesunate in Children With Severe Falciparum Malaria
The study aims at describing the pharmacokinetic properties of rectal artesunate in well characterized severely ill patients using intravenous artesunate as a comparator.
- Trial name
- REACH (NCT02492178)
- Testing
- Intrarectal artesunate, Intravenous artesunate, Intravenous quinine
- Where
- Democratic Republic of the Congo
- Volunteers
- 82 people
- Sponsor
- University of Oxford
Malaria, Falciparum
Time to Become Negative of Three Rapid Diagnostic Tests for Malaria
Background: Antigen-detecting rapid diagnostic tests (RDTs) for malaria provide the possibility of a parasite-based diagnosis in areas where good quality microscopy can not be achieved. P.
- Trial name
- NCT01325974
- Where
- 2 sites in Uganda
- Volunteers
- 424 people
- Sponsor
- Epicentre
Iron Deficiency, Malaria
Acute vs. Delayed Iron: Effect on Red Cell Iron Incorporation in Severe Malaria
The purpose of this study is to determine whether iron therapy given to iron-deficient Ugandan children with moderate-to-severe anemia and clinical malaria is better absorbed and incorporated into red blood cells if it is given…
- Conditions
- Iron Deficiency, Malaria, Nutrition, Global Health
- Trial name
- NCT01754701
- Testing
- Immediate iron, Delayed iron
- Where
- Uganda
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Malaria
Efficacy of Three ACTs for the Treatment of Falciparum Malaria in Maradi Niger
Study treatments: Artemether-lumefantrine Artesunate-amodiaquine Dihydroartemisinin-piperaquine Location: Maradi, Niger Principal Objective: To measure the clinical and parasitological efficacy of the three artemisinin…
- Trial name
- NCT01755559
- Testing
- Artesunate-amodiaquine, Dihydroartemisinin-piperaquine, Artemether-lumefantrine
- Where
- Niger
- Volunteers
- 663 people
- Sponsor
- Epicentre
Malaria
Chemopreventive Therapy for Malaria in Ugandan Children
Young African children living in high transmission areas suffer the greatest burden of malaria. In most African countries, such as Uganda, the only current preventive measure against malaria in high transmission settings is the…
- Trial name
- PROMOTE-Chemop (NCT00948896)
- Testing
- trimethoprim-sulfamethoxazole (TS; TMP/SMX), sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine (DP)
- Where
- Uganda
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
Safety, Attenuation and Immunogenicity of GAP3KO Administered Via A Stephensi Mosquitoes
Study designed to evaluate safety and tolerability of a genetically attenuated P. falciparum (GAP3KO) that arrests early in the liver stage of the parasite life cycle.
- Trial name
- NCT02313376
- Testing
- GAP3KO
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Hyper-reactive Malarial Splenomegaly, Malaria
Prednisone Plus Chloroquine for the Treatment of Hyper-reactive Malarial Splenomegaly
This randomized clinical trial will address a complication related to recurrent episodes of malaria in endemic areas - hyper-reactive malarial splenomegaly.
- Conditions
- Hyper-reactive Malarial Splenomegaly, Malaria, Anaemia
- Trial name
- LiHMS (NCT01785979)
- Testing
- prednisone induction - chloroquine, Chloroquine
- Where
- Papua New Guinea
- Sponsor
- Lihir Medical Centre
Uncomplicated Falciparum Malaria, Artemisinin-resistant
Arterolane-PQP Versus DHA-PQP in Uncomplicated Falciparum Malaria in Eastern Myanmar
Emerging resistance to artemisinins and their partner drugs severely threatens the treatment of falciparum malaria in Myanmar with artemisinin combination therapies.
- Trial name
- NCT02461186
- Testing
- Arterolane maleate-piperaquine phosphate (Synriam), Dihydroartemisinin-piperaquine phosphate (Duocotexin)
- Sponsor
- University of Oxford
Plasmodium Vivax
Investigation of Short Course, High Dose Primaquine Treatment for Liver Stages of Plasmodium Vivax Infection
This study specifically seeks to provide data on the safety, tolerability and pilot efficacy of short course, high dose primaquine treatment in Papua New Guinean children aged 5-10 years, in a cross-sectional study design.
- Trial name
- NCT02364583
- Testing
- Primaquine
- Where
- Papua New Guinea
- Volunteers
- 150 people
- Sponsor
- Papua New Guinea Institute of Medical Research
Malaria
A Phase Ib Induced Malaria Infection Study With the Combination of OZ439 and DSM265
This is a single-centre, open-label, dose finding study using induced blood stage malaria (IBSM) infection to characterize the pharmacodynamic interaction between OZ439 and DSM265, administered around 120 minutes apart for…
- Trial name
- OZ/DSMCombo (NCT02389348)
- Testing
- DSM265, OZ439
- Where
- Australia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
A Trial of the Efficacy of Artesunate and Three Quinine Regimens in the Treatment of Severe Malaria in Children at the Ebolowa Regional Hospital - Cameroon
The purpose of the study is to evaluate and compare the efficacy of parenteral artesunate with three quinine regimens in the treatment of severe malaria in children at the Ebolowa Regional Hospital located in the South region of…
- Trial name
- NCT02563704
- Testing
- Artesunate, Quinine
- Volunteers
- 238 people
- Sponsor
- University of Yaounde 1
Malaria
School-Based Treatment With ACT to Reduce Transmission
We propose to evaluate the community-level impact of intermittent preventive treatment (IPT) for malaria in schoolchildren on clinical outcomes and malaria transmission, using a cluster-randomised design in Jinja, Uganda.
- Trial name
- START-IPT (NCT02009215)
- Testing
- Dihydroartemisinin-piperaquine (DP)
- Where
- Uganda
- Volunteers
- 10,746 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
The Synergistic Effects of Home-management and Intermittent Preventive Treatment of Malaria in Children
This cluster randomised trial is proposed to assess the clinical impact of adding a seasonal intermittent preventive treatment (IPTc) schedule for children aged 3 -59 months to a home management of malaria (HMM) programme using…
- Trial name
- KNUST-COMDIS (NCT00550160)
- Testing
- Amodiaquine plus Artesunate co-administration
- Where
- Ghana
- Volunteers
- 1,490 people, healthy volunteers welcome
- Sponsor
- Kwame Nkrumah University of Science and Technology