Clinical trials: Malaria, completed
Malaria,Falciparum
Safety and Immunogenicity of SUM-101 Malaria Vaccine in Children and Infants Living in Burkina Faso
This clinical trial aims to learn about the safety and immunogenicity of the blood-stage malaria vaccine candidate SUM-101 in infants and children, paving the way for its incorporation into a multi-stage malaria vaccine.
- Trial name
- SUM-101 (NCT06618885)
- Testing
- SUM-101
- Where
- Burkina Faso
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Malaria, Falciparum
Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Malaria in Africa
The primary objective is to confirm the hypothesis that azithromycin plus chloroquine is non-inferior to mefloquine for the treatment of symptomatic, uncomplicated malaria due to P. falciparum.
- Trial name
- NCT00082576
- Testing
- Azithromycin/Chloroquine, Mefloquine
- Where
- 6 sites in Ghana, Mali and 2 more
- Volunteers
- 238 people
- Sponsor
- Pfizer
Malaria, Falciparum, Plasmodium Falciparum
Pilot Study to Estimate the Burden and Distribution of Plasmodium Falciparum Malaria in Kalifabougou, Mali in Preparation for a Prospective Cohort Study of Naturally-Acquired Malaria Immunity
Plasmodium falciparum malaria remains a global public health threat. Leading malaria vaccine candidates confer only partial short-lived protection at best.
- Trial name
- NCT01160562
- Where
- Mali
- Volunteers
- 1,719 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uncomplicated P. Falciparum Malaria in Children
Artemether-lumefantrine (AL) Versus Artesunate + Amodiaquine (ASAQ) for the Treatment of Uncomplicated Falciparum Malaria in Burkina Faso
Several countries in Africa have changed their first-line treatment for uncomplicated malaria to an ACT. Burkina Faso has changed its policy to Artemether-Lumefantrine (AL) and Artesunate-Amodiaquine (AQ+AS).
- Trial name
- ACTE (NCT01017770)
- Testing
- Artesunate-amodiaquine, Artemether-lumefantrine
- Where
- 4 sites in Burkina Faso
- Volunteers
- 340 people
- Sponsor
- Centre Muraz
Malaria
Safety and Immunogenicity of GSK Biologicals' Malaria Vaccine 257049 When Administered on 7 Schedules to African Infants
The aim of the malaria vaccine program of the MVI/GSK partnership is to develop an efficacious malaria vaccine that is deliverable through the existing system, the Expanded Program on Immunization (EPI) of WHO.
- Trial name
- NCT01231503
- Testing
- GSK Biological's Investigational Malaria Vaccine 257049, Engerix-B, Tritanrix HepB Hib
- Where
- Malawi
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Transfusion-Transmitted Infectious Disease
Mirasol Evaluation of Reduction in Infections Trial
This is a prospective, randomized, double-blind, controlled study to determine the effectiveness of Mirasol-treated fresh whole blood (FWB) versus Standard-issue FWB for preventing transmission of transfusion-transmitted…
- Trial name
- MERIT (NCT03737669)
- Testing
- Mirasol-treated Fresh Whole Blood, Standard Fresh Whole Blood
- Where
- Uganda
- Volunteers
- 2,000 people
- Sponsor
- Johns Hopkins University
Malaria, Anemia
Evaluation of Seasonal Malaria Chemoprevention in Kita
Seasonal malaria chemoprevention (SMC) is a new strategy recommended by World Health Organization in 2012 for areas of highly seasonal transmission such as the Sahel.
- Trial name
- NCT02894294
- Testing
- implementation of seasonal malaria chemoprevention
- Volunteers
- 1,162 people, healthy volunteers welcome
- Sponsor
- University of Bamako
Malaria
Plasmodium Falciparum Clearance Rates in Response to Artesunate in Eastern Cambodia
Plasmodium falciparum parasite clearance rates (PCRs) after oral artesunate treatment of patients with uncomplicated malaria were recently found to be significantly slower in Pailin (Western Cambodia) compared to Wang Pha…
- Trial name
- NCT01240603
- Where
- Cambodia
- Volunteers
- 415 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Surveillance of Effectiveness/Safety of Artemether-lumefantrine in Patients With Malaria
The purpose of this study is to describe the pediatric and adult patients (U.S. and foreign residents) diagnosed with malaria and treated with artemether-lumefantrine with regard to their demographics, including evaluation of…
- Trial name
- NCT01228344
- Testing
- Artemether-lumefantrine
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Novartis Pharmaceuticals
Malaria
ANC & Malaria Diagnostic in Pregnancy
The program's overall objective is to assess the impact of a package of interventions aimed at reducing malaria-related mortality and morbidity in pregnant women and newborns by ensuring access to a package of interventions…
- Trial name
- AQUAMOD (NCT01703884)
- Testing
- ASAQ
- Where
- Burkina Faso
- Volunteers
- 5,254 people
- Sponsor
- Centre Muraz
Malaria, Bacteremia
Empirical ANtibiotic THErapy in Adults Hospitalised With Malaria
While World Health Organization (WHO) guidelines recommend empirical antibacterial therapy as the standard of care in all African children with severe falciparum malaria, there are fewer data to guide the management of adults…
- Conditions
- Malaria, Bacteremia, Sepsis
- Trial name
- ANTHEM (NCT03224052)
- Where
- Burma
- Volunteers
- 20 people
- Sponsor
- Menzies School of Health Research
Uncomplicated Plasmodium Falciparum Malaria
Rapid Diagnostic Testing and Artemisinin-Based Combination Therapy for Uncomplicated Malaria by Community Health Workers
The purpose of this study is to evaluate the efficiency of a rapid diagnostic test (Paracheck Pf) for the diagnosis of uncomplicated Plasmodium falciparum malaria by community health workers at village level in Tanzania and how…
- Trial name
- NCT00301015
- Testing
- Rapid diagnostic test for malaria
- Where
- Tanzania
- Volunteers
- 3,005 people
- Sponsor
- Karolinska University Hospital
Malaria, RDT
Abbott NxTekTM Malaria RDT WHO Prequalification Study
Since their introduction in the late 90's, rapid diagnostic tests (RDTs) have dramatically improved our ability to control malaria but proved insufficient to support elimination efforts because of their limited sensitivity…
- Conditions
- Malaria, RDT, Diagnoses Disease
- Trial name
- NCT05444790
- Testing
- Rapid Diagnostic Test
- Where
- 3 sites in Indonesia, Peru and 1 more
- Volunteers
- 4,563 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Malaria
Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Naïve Adults
The proposed study is a Phase 1 study with controlled human malaria infection (CHMI) designed primarily to evaluate the safety of the FMP012 combined with AS01B adjuvant system.
- Trial name
- NCT02174978
- Testing
- FMP012 with AS01B adjuvant system, P falciparum Controlled Human Malaria Infection (CHMI)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Asymptomatic P.Falciparum Malaria
Effect of Antimalarial Treatment on Gametocyte Carriage in Asymptomatic P. Falciparum
Treatment of uncomplicated P.falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a marked increase in the density of gametocytes.
- Trial name
- NCT00289250
- Testing
- Sulfadoxine-pyrimethamine, Sulfadoxine-pyrimethamine plus artesunate
- Where
- The Gambia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Plasmodium Vivax Malaria
Clinical Trial for the Development of a Safe Malaria Challenge Model That Can be Reproduced in Humans
The purpose of this study is to demonstrate that volunteers can be safely and reproducibly infected with Plasmodium vivax (P. vivax) by the bites of experimentally infected Anopheles dirus (An. dirus) mosquitoes carrying P.
- Trial name
- Pvivax (NCT00935623)
- Testing
- Malaria Challenge
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Accute Falciparum Malaria
Artemether-lumefantrine Resistance Monitoring in Children With Uncomplicated Plasmodium Falciparum Malaria in Mali
Background: Malaria is a disease caused by a parasite. People get malaria if they are bitten by an parasite-infected mosquito. A drug called artemether-lumefantrine (AL) can treat malaria.
- Trial name
- NCT02645604
- Where
- Mali
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Fever, Suspected Malaria
ACT for the Home Management in Malagasy Children
The purpose of this study is to assess the feasibility, the acceptability and the effectiveness of the use of the Artesunate + Amodiaquine Fixed Dose Combination for the home management of presumed malaria in Malagasy children by…
- Trial name
- NCT00612547
- Testing
- Artesunate + Amodiaquine Fixed Dose Combination (CoArsucam)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- National Malaria Control Programme, Madagascar
Weight Loss, Weight Gain
Effect of Ready to Use Therapeutic Food (RUTF) Supplement After an Episode of Malaria Falciparum on Weight
The primary objective of this study is to determine to what extent provision with RUTF will promote catch up growth in children following an acute uncomplicated episode of P. falciparum malaria.
- Conditions
- Weight Loss, Weight Gain, Convalescence, Malaria
- Trial name
- NCT00819858
- Testing
- RUTF (Plumpynut®)
- Where
- Republic of the Congo
- Volunteers
- 180 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
HIV
Daily Trimethoprim-sulfamethoxazole or Weekly Chloroquine Among Adults on ART in Malawi
The purpose of this study is to determine if there is a benefit to taking trimethoprim-sulfamethoxazole (TS) as prophylaxis among HIV positive adults who have viral load suppression and a good clinical response on anti-retroviral…
- Trial name
- TSCQ (NCT01650558)
- Testing
- Standard of Care prophylaxis, Chloroquine (CQ) prophylaxis
- Where
- 2 sites in Malawi
- Volunteers
- 1,499 people
- Sponsor
- University of Maryland, Baltimore
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