Clinical trials: Male
Prostatic Neoplasms, Castration-Resistant
Study of 225Ac-PSMA-617 in Men With PSMA-positive Prostate Cancer
This is a Phase 1, open-label, international, dose escalation study to evaluate the safety of [225Ac]Ac-PSMA-617 (225Ac-PSMA-617) in men with PSMA-positive prostate cancer who have and have not had prior exposure to…
- Trial name
- NCT04597411
- Testing
- 225^Ac-PSMA-617, 68^Ga-PSMA-11
- Where
- 2 sites in Australia, South Africa
- Volunteers
- 101 people
- Sponsor
- Endocyte
Healthy Adult Male
Study on the Mass Balance of [14C]HRS-9190 for Injection in Healthy Participants
To evaluate the absorption, metabolism and excretion after a single intravenous bolus of [14C]HRS-9190 in healthy Participants
- Trial name
- NCT07494175
- Testing
- [14C] HRS-9190
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy Male Adults, Food Effect in Healthy Volunteers
A Study to Evaluate the Effect of Food on the Bioavailability of AJ201, and Safety, Tolerability, and Pharmacokinetics of AJ201 in Japanese and White Healthy Male Participants
This is a Phase 1, randomized, single-dose, open-label, two-way crossover study to evaluate the effect of food on AJ201, and to evaluate the safety, tolerability, and pharmacokinetics of AJ201 in Japanese and White healthy male…
- Trial name
- NCT07549919
- Testing
- AJ201
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AnnJi Pharmaceutical Co., Ltd.
Healthy Male Adults
To Evaluate the Mass Balance Recovery, Metabolite Profile and Metabolite Identification in Healthy Male Subjects
To Evaluate the Mass Balance Recovery, Metabolite Profile and Metabolite Identification in Healthy Male Subjects
- Trial name
- NCT07036458
- Testing
- 14C Epaminurad Oral Solution
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- JW Pharmaceutical
Non-obstructive Azoospermia, Male Infertility
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Couples With Non-obstructive Azoospermia (NOA)
Objective: To examine the rate of embryo aneuploidy in patients with non-obstructive azoospermia (NOA) who utilize in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) and compare live birth rates with the…
- Trial name
- NCT06566599
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Inception Fertility Research Institute, LLC
Healthy Volunteers - Male and Female
A Study of ORN252 in Healthy Participants
The purpose of this study is to assess the safety and tolerability of ORN252 in healthy adult participants.
- Trial name
- NCT07439796
- Testing
- ORN252
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orna Therapeutics, Inc.
Healthy Adult Male, Healthy Adult Females
Examining Olive Oil Extract on Knee Comfort and Function
The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults. The main questions it aims to answer are: 1) Does the olive oil extract improve the perceptions of knee pain and…
- Conditions
- Healthy Adult Male, Healthy Adult Females, Joint Discomfort
- Trial name
- NCT07514013
- Testing
- Olive Oil Extract
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Applied Food Sciences Inc.
mCRPC (Metastatic Castration-resistant Prostate Cancer), Genital Diseases, Male
Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer
This is a Phase 1/2, open-label, randomized, dose finding and dose expansion study to evaluate the safety, preliminary efficacy, and PK of gedatolisib in combination with darolutamide in subjects with mCRPC.
- Conditions
- mCRPC (Metastatic Castration-resistant Prostate Cancer), Genital Diseases, Male, Urogenital Diseases, Male, Prostatic Disease
- Trial name
- NCT06190899
- Testing
- Gedatolisib, Darolutamide
- Where
- 13 sites in United States, France and 2 more
- Volunteers
- 54 people
- Sponsor
- Celcuity Inc
Telogen Effluvium, Female Pattern Hair Loss
Clinical Study of DA-001 as a Treatment for Hair Shedding Reduction and Hair Re-Growth
The primary objective of the study is to assess the safety and efficacy of DA-001 as a treatment for Hair Shedding Reduction and Hair Re-Growth
- Conditions
- Telogen Effluvium, Female Pattern Hair Loss, Female Pattern Hair Loss, Androgenic Alopecia, Male Pattern Baldness
- Trial name
- NCT06648850
- Testing
- DA-001, Phenylephrine, DA-001 Topical + DA-005 Oral (HIF-1α supplement)
- Volunteers
- 1,120 people
- Sponsor
- Applied Biology, Inc.
Healthy Participants, Healthy Adult Females
A Study to Evaluate the Safety of Increasing Doses of DF5112 in Healthy Adults
This is a double-blind, randomized, placebo-controlled, single ascending dose (SAD) study to evaluate safety, tolerability, pharmacokinetics (PK), immunogenicity and pharmacodynamics (PD) of DF5112 in healthy adult participants.
- Conditions
- Healthy Participants, Healthy Adult Females, Healthy Adult Male, Healthy
- Trial name
- DF5112 (NCT07232121)
- Testing
- DF5112
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dragonfly Therapeutics
Healthy Adult Male
Evaluation of MTX-463 Administered Subcutaneously in Healthy Adult Males
A randomized, double-blind, placebo-controlled, study to assess the safety, tolerability, and PK of MTX-463 when administered via SC injection in healthy adult males.
- Trial name
- NCT07450521
- Testing
- MTX-463
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Mediar Therapeutics
Infertility, Male
Assessment of TetraSOD® Efficacy to Improve Semen Parameters in Men With Idiopathic Infertility
TetraSOD® is a unique marine phytoplankton (Tetraselmis chuii) SOD-rich ingredient that is grown under patent-protected technology exclusively designed by the company Fitoplancton Marino, S.L. (Spain).
- Trial name
- NCT04864314
- Testing
- Marine microalgae Tetraselmis chuii with high Superoxide Dismutase (SOD) activity
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Fitoplancton Marino, S.L.
Healthy Adult Male
A Study to Evaluate the Safety, PK, and Immunogenicity of Recombinant Human Hyaluronidase in Healthy Subjects
The study is being conducted to evaluate the safety, pharmacokinetics, and immunogenicity of recombinant human hyaluronidase in healthy Chinese adult male subjects.
- Trial name
- NCT07484893
- Testing
- recombinant human hyaluronidase
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Shanghai Henlius Biotech
Male Infertility
SpermQT Prospective Observational Trial
The goal of the study is to validate the ability of the Epigenetic Sperm Quality Test (SpermQT) to assess a man's sperm quality and corresponding success of infertility treatments.
- Trial name
- SPOT (NCT05966883)
- Where
- 6 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Inherent Biosciences
Male Contraception, Healthy Male Adults
A First in Human Study, Evaluating the Safety and Efficacy of ADAM™ 1.0
This study will evaluate the safety and feasibility of the ADAM System for implantation into the vas deferens in 25 healthy males at 3 sites. This is a prospective, non-randomized, open label interventional trial.
- Trial name
- NCT05134428
- Testing
- ADAM System
- Where
- 3 sites in Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Contraline, Inc
Healthy Male Subjects
A Study to Evaluate the PK Similarity of AK112 in Healthy Chinese Male Subjects
The purpose of this study is to evaluate the pharmacokinetic (PK) similarity of AK112 (an anti-PD-1/VEGF bispecific antibody) from the proposed new manufacturing site and the approved original site in healthy male subjects.
- Trial name
- NCT07340476
- Testing
- AK112 (New Site), AK112 (Original Site)
- Where
- China
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Akeso
Healthy Male Adult Volunteers
Study to Demonstrate Pharmacokinetic and Pharmacodynamic Similarity Between NKF-INS(L), US-Humalog®, and EU-Humalog®
Study to demonstrate pharmacokinetic and pharmacodynamic similarity between NKF-INS(L), US-Humalog®, and EU-Humalog®
- Trial name
- NCT07165652
- Testing
- NKF-INS(L), US-Humalog®, EU-Humalog®
- Where
- South Africa
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Xentria, Inc.
Male Pattern of Hair Loss, Androgenic Alopecia, Androgenetic Alopecia (AGA)
Clinical Trial to Evaluate CG2001 in Chinese Adult Male Participants With Androgenetic Alopecia
The main objectives of this study are to preliminarily evaluate the effectiveness of CG2001 in treating Chinese adult male AGA participants, determine the recommended dose for Phase III clinical studies, and evaluate the safety…
- Trial name
- NCT07076706
- Testing
- minoxidil + finasteride
- Where
- 8 sites in China
- Volunteers
- 110 people
- Sponsor
- Beijing Dayspring Pharmaceutical Technology Co., Ltd
Healthy Adult Male and Female Volunteers
Pharmacokinetic Comparison of Vonafexor Acid and Its Lysine Salt and Evaluation of Potential Drug-Drug Interactions
The purpose of this study is to define and compare the pharmacokinetic (PK) and pharmacodynamic (PD) profile of EYP651 at two dose levels and compare it with Vonafexor Acid PK and PD profile, the Part A.
- Trial name
- NCT07251153
- Testing
- EYP651/Vonafexor low dose, EYP651/Vonafexor high dose, EYP651/CYP3A4 inhibitor
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Enyo Pharma
Non Obstructive Azoospermia, Cryptozoospermia
Identifying Candidates for Limited Dissection at Microdissection TESE.
The goal of this retrospective observational study is to learn whether certain clinical characteristics can help predict which infertile men may successfully have sperm retrieved using a less-invasive "mini-incision" version of…
- Conditions
- Non Obstructive Azoospermia, Cryptozoospermia, Oligoasthenoteratozoospermia, Male Infertility
- Trial name
- NCT07286279
- Where
- Canada
- Volunteers
- 248 people
- Sponsor
- Clinique Ovo