Clinical trials: Male Hypogonadism
Hypogonadism
Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men
Type 2 diabetes is one of the most common metabolic disorders in the U.S, estimated to affect 16 million Americans. Established risk factors for this disease include obesity, increased waist/hip ratio, high insulin levels in the…
- Trial name
- NCT00470990
- Testing
- GnRH antagonist (Acyline)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Functional Hypogonadism
Use of D-Chiro-inositol in Male Functional Hypogonadism Associated With Sexual Dysfunction
A prospective, uncontrolled, non-pharmacological interventional study conducted on men with functional or borderline hypogonadism, aimed at evaluating, after 3 months of supplementation with D-Chiro-inositol, changes in hormonal…
- Trial name
- HERO_2025 (NCT07584772)
- Testing
- D-chiro-inositol
- Volunteers
- 35 people
- Sponsor
- Cardarelli Hospital
Ejaculatory Dysfunction, Hypogonadism
A Study of Ejaculatory Dysfunction in Men With Low Testosterone Levels
The purpose of this study is to see if testosterone solution 2% can impact symptoms of ejaculatory dysfunction in men with low testosterone.
- Trial name
- NCT01419236
- Testing
- Testosterone Solution 2%
- Where
- 7 sites in United States, Canada
- Volunteers
- 76 people
- Sponsor
- Eli Lilly and Company
Acquired Hypogonadotropic Hypogonadism
Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men
Objectives: The overall clinical question is whether LH supplementation to men in indication for FSH according to the AIFA note 74, or with HH, will improve spermatogenesis and pregnancy rate (spontaneous or after ART) over FSH…
- Trial name
- RHYTHM (NCT04189133)
- Testing
- Lutropin alfa, Human chorionic gonadotropin
- Where
- 5 sites in Italy
- Volunteers
- 32 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Colorectal Cancer, Sarcopenia
Perioperative Testosterone Replacement Therapy in Sarcopenic Male Colorectal Cancer Patients
With increasing age and the additional impact from the bowel cancer and the chemotherapy and/ or radiotherapy it has been described that testosterone (a male hormone produced naturally in the body) levels are reduced.
- Conditions
- Colorectal Cancer, Sarcopenia, Hypogonadism, Male, Perioperative Care
- Trial name
- TERESA (NCT05367284)
- Testing
- Testosterone
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- London North West Healthcare NHS Trust
Spinal Cord Injury, Spinal Cord Injuries
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injury
- Trial name
- NCT04460872
- Testing
- Testosterone Enanthate, Locomotor Training
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- North Florida Foundation for Research and Education
Kallmann Syndrome, Congenital Hypogonadotropic Hypogonadism
Health Needs of Patients With Kallmann Syndrome
Kallmann syndrome (KS), also known as congenital hypogonadotropic hypogonadism (CHH), is a rare endocrine disorder that is characterized by failure to undergo puberty combined with infertility.
- Conditions
- Kallmann Syndrome, Congenital Hypogonadotropic Hypogonadism, Idiopathic Hypogonadotropic Hypogonadism
- Trial name
- NCT01914172
- Testing
- online questionairres
- Where
- Switzerland
- Volunteers
- 249 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Hypothalamic Obesity
A Study to Assess Efficacy and Safety of LB54640 in Patients With Hypothalamic Obesity
The goal of this study was to determine how well LB54640 (also known as bivamelagon) worked and how safe it was in participants with Hypothalamic Obesity (HO).
- Trial name
- NCT06046443
- Testing
- Bivamelagon
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 28 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Hypogonadism
Subcutaneous Testosterone Replacement Efficacy and Safety in Adult Men Diagnosed With Hypogonadism
Evaluation of efficacy and safety of testosterone enanthate administered subcutaneously using an auto-injector
- Trial name
- STEADY (NCT02159469)
- Testing
- Testosterone enanthate auto-injector
- Where
- 28 sites in United States
- Volunteers
- 150 people
- Sponsor
- Antares Pharma Inc.
Hypogonadism, Hypogonadism, Male
A Phase 1/2a Study to Determine the Dose Response Pharmacokinetics of TSX-011 (Testosterone Undecanoate) in Hypogonadal Males
This will be a phase 1/2a, open-label, single-center study with 3 periods. The aims of the study are to: 1. evaluate the dose-response curve following ascending single doses of TSX-011; 2. confirm optimum dosing conditions; 3.
- Conditions
- Hypogonadism, Hypogonadism, Male, Gonadal Disorders, Endocrine System Diseases
- Trial name
- NCT03335254
- Testing
- TSX-011
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- TesoRx Pharma, LLC
Male Infertility, Hypogonadism, Male
The Impact of Sinopharm COVID-19 Vaccination on Male Fertility
The investigators shall study the effect of Sinopharm vaccination on semen parameters and serum testosterone
- Trial name
- NCT04946565
- Testing
- Semen analysis
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gonadotropin Deficiency
ITT-5 Mechanisms of Spermatogenesis in Man
The purpose of this investigational drug study is to determine how much male hormone, testosterone, is needed to maintain sperm production in the testis.
- Trial name
- ITT-5 (NCT02147964)
- Testing
- Testosterone 1% Gel, Acyline, Dutasteride
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Washington
Testicular Cancer, Survivorship
Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors
Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant
- Conditions
- Testicular Cancer, Survivorship, ASCVD, Coronary Artery Disease
- Trial name
- NCT05611307
- Testing
- Lipid profile, Coronary artery assessment, Hormone levels for hypogonadism
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Down Syndrome, Edwards Syndrome
Whole Blood Specimen Collection From Pregnant Subjects
To obtain whole blood specimens from pregnant subjects to be used for research and development and clinical validation studies of prenatal assays.
- Conditions
- Down Syndrome, Edwards Syndrome, Patau Syndrome, Klinefelter Syndrome
- Trial name
- NCT02430584
- Testing
- Observational - no intervention
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Progenity, Inc.
Hypothalamic Obesity
Study of Tesomet With Open-label Extension in Subjects With Hypothalamic Obesity (HO)
This study will evaluate the safety and efficacy of Tesomet (tesofensine + metoprolol) in subjects 18 years of age or older, with HO
- Trial name
- NCT05147415
- Testing
- Tesomet
- Where
- United States
- Sponsor
- Saniona
Prostate Cancer
HRT-PC Trial: Hormone Recovery After Treatment for Prostate Cancer Trial. An Open-label Phase II Study of Clomiphene Citrate in Patients With Persistent Hypogonadism After ADT for Treatment of Localized Prostate Cancer
The purpose of this phase II trial is to assess the clinical utility of clomiphene citrate for the augmentation of testosterone in prostate cancer survivors who complete androgen deprivation therapy (ADT), including the efficacy…
- Trial name
- NCT07882862
- Testing
- Clomiphene Citrate 25mg
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Nebraska
Hypogonadism, Hypogonadism, Male
A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial
The overall objective of this randomized trial is to investigate the effects of treatment of AAS- induced male hypogonadism with combined therapy of letrozole and hCG compared with placebo on reproductive hormone levels…
- Conditions
- Hypogonadism, Hypogonadism, Male, Hypogonadotropic Hypogonadism
- Trial name
- NCT05205837
- Testing
- Letrozole 2.5mg, hCG
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypogonadism, Male, Secondary Hypogonadism
AIM-TEST: Microbiome-Targeted Nutrition for Functional Secondary Hypogonadism
AIM-TEST is a randomized, double-blind, placebo-controlled clinical trial evaluating whether an AI-guided, microbiome-targeted nutritional intervention can increase the body's own testosterone production in men aged 30-65 years…
- Trial name
- AIM-TEST (NCT07761546)
- Testing
- Fixed-Formula Microbiome-Targeted Oral Nutritional Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Varol TUNALI
Turner Syndrome, Hypogonadism; Ovarian
Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome
This 14-month, phase IV, randomized controlled crossover trial aims to compare the effects of oral versus transdermal estrogen replacement therapy (ERT) in women with Turner syndrome (TS).
- Conditions
- Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy
- Trial name
- NCT06570460
- Testing
- 17-beta estradiol
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Klinefelter Syndrome
Adaptation Among Adolescents and Adults With Klinefelter Syndrome
This study aims to understand the impact of living with Klinefelter syndrome (KS) and the factors that contribute to adaptation in adolescents and adults.
- Trial name
- NCT00896272
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- National Human Genome Research Institute (NHGRI)