Clinical trials: Male Infertility
Klinefelter Syndrome
Fertility Preservation in Cases of Klinefelter Syndrome.
Klinefelter Syndrome (KS) is the most common sex chromosomal abnormalities (1/600 newborn males), and is characterized by a hypergonadism hypogonadism.
- Trial name
- FERTIPRESERVE (NCT01918280)
- Testing
- Seminal analyses and testicular biopsy
- Where
- 4 sites in France
- Volunteers
- 141 people
- Sponsor
- Hospices Civils de Lyon
Male Infertility
A Novel Sperm Selection Method Provides Advantages Over Conventional Approaches
The goal of this clinical trial is to know if a novel sperm selection device (CA0) has a similar performance than the standard selection method in teratozoospermic and azoospermic men.
- Trial name
- NCT06545318
- Testing
- Density Gradient Centrifugation, CA0 chamber
- Where
- Mexico
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Center of Innovation Technology & Reproductive Medicine
Infertility Unexplained
Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway
Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia…
- Trial name
- NCT03361618
- Testing
- Zinc Sulfate
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Babylon University
Male Infertility
Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study
Korean Red ginseng (KRG) has long been applied to various diseases as a health-promoting herbal medicine in Korea. Many clinical studies of ginseng have been performed to elucidate its therapeutic characteristics.
- Trial name
- NCT02204826
- Testing
- Korean Red Ginseng (KRG), Varicocelectomy
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Pusan National University Hospital
Reproductive Issues, Fertility Issues
Towards Optimal Fertility, Fathering and Fatherhood studY
This case-control study involving fertile and subfertile couples aims to identify male factors related to pregnancy likelihood, create a fertility index measure combining male and female factors to predict pregnancy likelihood…
- Trial name
- TOFFFY (NCT06293235)
- Testing
- Lifestyle and metabolic indicators
- Where
- Singapore
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Infertility
Magnetic Nanoparticle Sperm Separation for Teratozoospermia Male and Women Older Than 35 Years
Women over 35 years old are likely to suffer from impaired oocyte repair capacity. Teratozoospermia is a condition reflects morphological affection of sperm. These spermatozoa would add an extra burden on the oocyte after ICSI.
- Trial name
- NCT03666364
- Testing
- Sperm preparation for ICSI
- Where
- 3 sites in Egypt
- Volunteers
- 1,400 people
- Sponsor
- Ibn Sina Hospital
Non-obstructive Azoospermia, Male Infertility
Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Couples With Non-obstructive Azoospermia (NOA)
Objective: To examine the rate of embryo aneuploidy in patients with non-obstructive azoospermia (NOA) who utilize in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) and compare live birth rates with the…
- Trial name
- NCT06566599
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Inception Fertility Research Institute, LLC
Infertility, Male
Varicocele Repair for Men Undergoing IVF/ICSI
For infertile men undergoing intracytoplasmic sperm injection (ICSI), data from retrospective studies suggested that varicocele repair may be beneficial and associated with improved livebirth and pregnancy rates, however, its…
- Trial name
- Varicocele (NCT04608864)
- Testing
- varicocelectomy
- Volunteers
- 2,000 people
- Sponsor
- Al-Yasmeen Fertility and Gynecology Center
Male Infertility
Valuation of Variable Dose of Docosahexanoic Acid for the Improvement of the Parameters of Male Fertility
Sperm parameters will be examined before DHA (DHA=Docosahexanoic Acid) consumption, after one months and after 2 months taken Docosahexanoic Acid or placebo.
- Trial name
- DHA (NCT02889341)
- Testing
- DHA
- Volunteers
- 60 people
- Sponsor
- Vida Recoletas Sevilla
Infertility, Male
The Effect of Supplementation With Fish Oil (EPAX EVOLVE 05) on Sperm Quality
The study will enrol men that have a poor sperm quality. They will take either a placebo or fish oil capsule (2 per day) for 3 months.
- Trial name
- NCT06950203
- Testing
- Very Long Chain Polyunsaturated Fatty Acids, Comparator arm (DHA)
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Epax Norway AS
Erectile Dysfunction, Azoospermia
Trial to Evaluate Erectile Function, Fertility and Sperm Count in Male Cyclists Compared to Age Matched Controls
Bicycle riding is associated with related diverse urogenital symptoms ranging from genital numbness to erectile dysfunction (ED).
- Trial name
- NCT00282477
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Infertility, Male, Oligozoospermia
The Role of Artery-Preserving Varicocelectomy in Subfertile Men With Severe Oligozoospermia.
A male factor is responsible for almost half the cases of subfertility. Varicocele is a major cause of impaired spermatogenesis and potentially a correctable cause.
- Conditions
- Infertility, Male, Oligozoospermia, Varicocelectomy
- Trial name
- NCT03344588
- Testing
- artery preserving varicocelectomy, artery ligation varicocelectomy
- Where
- Egypt
- Volunteers
- 330 people
- Sponsor
- Mansoura University
Infertility, Male, Infertility Unexplained
Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity
Infertility was reported in approximately 15% of all heterozygous couples, with male factor accounting for nearly half the cases.
- Conditions
- Infertility, Male, Infertility Unexplained, Infertility Due to Complete Spermatogenic Arrest, Oligospermia
- Trial name
- NCT05506722
- Testing
- Testes shocker
- Where
- Iraq
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Reduced Sperm Motility, IVF
Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods
Purpose: To compare the effects of the density gradient centrifugation and microfluidic chip sperm preparation methods on embryo development in a study population with astheno-teratozoospermia.
- Conditions
- Reduced Sperm Motility, IVF, ICSI, Astheno Teratozoospermia
- Trial name
- NCT04962074
- Testing
- Microfluidic sperm sorting chip, Density gradient
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Maltepe University
Male Infertility
Genetic Causes of Male Infertility
This study is being conducted at the University Hospital of Lund University in Malmo, Sweden, in collaboration with the U.S. National Institute of Child Health and Human Development.
- Trial name
- NCT00341120
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conventional IVF, ICSI
Child Follow-up in Women Treated With Conventional IVF or ICSI
To compare the physical, mental and motor development of babies born from pregnancy using ICSI technique and and conventional IVF in non-male factor infertile couples.
- Trial name
- NCT04866524
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 322 people
- Sponsor
- Mỹ Đức Hospital
Sub Fertility, Male, Fertility Disorders
Effects of a Fasting Mimicking Diet on Sperm Quality
This study investigates the effect of repetitive cycles of a Fasting Mimicking Diet (3x5 days in six months) on sperm quality in men
- Conditions
- Sub Fertility, Male, Fertility Disorders, Sperm Count, Low
- Trial name
- KiWu-B (NCT04908774)
- Testing
- Fasting Mimicking Diet
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Charite University, Berlin, Germany
Male Infertility, Unexplained Infertility
Swim up and Gradient Methods Used in Assisted Reproduction Techniques on DNA Fragmentation of Spermatozoa
Sperms are prepared by sperm washing techniques before used in assisted reproductive technologies. Most commonly used sperm preparation methods are the swim up and the density gradient.
- Trial name
- NCT01859520
- Testing
- swim-up, density gradient sperm preparation techniques
- Volunteers
- 65 people
- Sponsor
- Gazi University
Obesity, Oligospermia
Aromatase Inhibitors in the Treatment of Male Infertility
Obesity is associated with an increase in blood levels of estrogen. Estrogen or "female hormone" is believed to have a negative effect on sperm production.
- Trial name
- NCT00440180
- Testing
- Anastrozole
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Infertility, Male
NAPO - Novel Approach for Oligospermia
This randomized controlled trial aims to assess whether treatment with denosumab can improve semen quality in infertile men selected by serum anti-mullerian hormone (AMH) as a positive predictive biomarker, and with severely…
- Trial name
- NAPO (NCT06300229)
- Testing
- Denosumab, sodium chloride
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Martin Blomberg Jensen