Clinical trials: Male Infertility
Cancer, Infertility
Late Effects of Cancer Therapies on Gonadal Function, Fertility, Efficiency of Fertility Preservation Procedures and Pregnancy Outcomes
In the past two decades, evidence-based knowledge on the prevalence and risk factors for fertility impairment, including infertility, following cancer and numerous cancer treatment regimens has significantly increased.
- Conditions
- Cancer, Infertility, Late Effects, Female Fertility
- Trial name
- Follow-AYA (NCT07622537)
- Volunteers
- 4,000 people
- Sponsor
- Karolinska Institutet
Infertility
In Vitro Fertilisation Versus Intracytoplasmic Sperm Injection in Patients Without Severe Male Factor Infertility
Over recent decades, the use of intracytoplasmic sperm injection (ICSI) has increased, even among patients without severe male factor infertility.
- Trial name
- INVICSI (NCT04128904)
- Testing
- IVF, ICSI
- Where
- 6 sites in Denmark
- Volunteers
- 824 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Varicocele, Male Infertility
Intratesticular Artery Resistive Index Changes After Varicocelectomy
This study aims to evaluate how blood flow inside the testicles changes after surgery to correct a varicocele, and whether these changes correlate with improvements in semen quality and testosterone levels.
- Conditions
- Varicocele, Male Infertility, Secondary Hypogonadism
- Trial name
- NCT07517952
- Testing
- Microscopic Sub-inguinal Varicocelectomy
- Volunteers
- 40 people
- Sponsor
- Assiut University
Male Infertility
Males, Antioxidants, and Infertility Trial
The objective of the Males, Antioxidants, and Infertility (MOXI) Trial is to examine whether treatment of infertile males with an antioxidant formulation improves male fertility.
- Trial name
- MOXI (NCT02421887)
- Testing
- Antioxidant Supplement
- Where
- 10 sites in United States
- Volunteers
- 171 people
- Sponsor
- Yale University
Male Idiopathic Infertility
A Trial to Compare Efficacy and Safety of Follitropin Delta Versus Placebo (Inactive Treatment) in the Treatment of Men With Idiopathic Infertility (Unexplained Reduction of Semen Quality) (ADAM)
The primary purpose of this trial is to investigate whether men with idiopathic infertility (unexplained reduction of semen quality), after being treated with a daily dose of 12 µg recombinant follicle stimulating hormone (rFSH)…
- Trial name
- NCT05403476
- Testing
- FE 999049
- Where
- 22 sites in United States, Belgium and 5 more
- Volunteers
- 4 people
- Sponsor
- Ferring Pharmaceuticals
Infertility, Male
Role of Nutritional Support in Idiopathic Male Infertility
Approximately 100 males with idiopathic infertility and oligo- and/or astheno- and/or and/or teratozoospermia and fertile woman will take a Test dietary supplement (TDS), containing carnitine, vitamins and trace elements (active…
- Trial name
- NCT03588949
- Testing
- Dietary Supplement with L-carnitine (FertilHom), Control Dietary Supplement
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- NATURAmedicatrix Sàrl
Obesity, Sub Fertility, Male
Weight Loss Impact on Male Fertility
This is a prospective non-randomized unicentric clinical trial, characterized by the inclusion of obese (BMI> 35) male with subfertility (sperm count showing low sperm counts and / or motility and / or morphology and / or DNA…
- Conditions
- Obesity, Sub Fertility, Male, Metabolic Syndrome
- Trial name
- NCT04186767
- Testing
- Very Low Carb Ketogenic Diet
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Varicocele
Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled Trial
Varicocele is the most common surgical disease which could lead to male infertility. It is found in approximately 15% adult males, and in about 40% infertile males. And the incidence is up to 80% in secondary infertility.
- Trial name
- NCT01463787
- Testing
- microsurgical varicocelectomy in inguinal approach, microsurgical varicocelectomy in subinguinal approach
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Feng Pan
Asthenozoospermia
Study the Effect of Oral Zinc Supplementation on High Molecular Weight Zinc Binding Protein in Semen
There are several causes leading to male infertility, like oxidative stress, and nutritional deficiency of trace elements like zinc.
- Trial name
- supplement (NCT01612403)
- Testing
- zinc sulfate
- Where
- 2 sites in Iraq
- Volunteers
- 37 people
- Sponsor
- mahmoud hussein hadwan
Male Infertility, Epigenetic Disorder
Human Sperm Epigenetics in Embryonic Development.
A total of 60 men (40 with a history of infertility and treatment with assisted reproduction and 20 infertile controls achieving conception naturally) will be asked to provide at least one semen sample each for conventional semen…
- Trial name
- EPI (NCT04256668)
- Testing
- Obtaining one or semen samples
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Non-obstructive Azoospermia
Use of Semen TEX101 to Improve Sperm Retrieval Rates for Men With Non-obstructive Azoospermia
The investigators hypothesize that sperm production varies with time in men with no sperm in semen (non-obstructive azoospermia, NOA) and that the semen protein, TEX101, is able to monitor these changes.
- Trial name
- NCT02851966
- Testing
- mTESE
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- Mount Sinai Hospital, Canada
Primary Ovarian Insufficiency, Azoospermia
Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)
Background: Infertility affects 1 in 6 people. Often, the causes of infertility are unknown. Treatments are successful in only about 50% of cases.
- Conditions
- Primary Ovarian Insufficiency, Azoospermia, Oligospermia
- Trial name
- NCT07357701
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Male Subfertility
The Impact of a Nutritional Supplement (Impryl®) on Male Fertility
Infertility is a worldwide problem and about 10%-15% of all couples will be affected by the inability to have children. In approximately 50% of infertile couples a male factor is involved.
- Trial name
- SUMMER (NCT03337360)
- Testing
- Impryl
- Where
- 21 sites in Netherlands
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Male Infertility
CMV IGG Antibodies in Semen as a Predictor for Blood Testis Barrier Damage
To assess whether the presence of Cytomegalovirus (CMV) Immunoglobulin G (IGG) antibodies in semen is a reliable predictor of male subfertility or infertility.
- Trial name
- NCT05302856
- Testing
- Blood test (CMV IGG, Anti sperm antibody, Testosterone levels)
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Non Obstructive Azoospermia, Cryptozoospermia
Identifying Candidates for Limited Dissection at Microdissection TESE.
The goal of this retrospective observational study is to learn whether certain clinical characteristics can help predict which infertile men may successfully have sperm retrieved using a less-invasive "mini-incision" version of…
- Conditions
- Non Obstructive Azoospermia, Cryptozoospermia, Oligoasthenoteratozoospermia, Male Infertility
- Trial name
- NCT07286279
- Where
- Canada
- Volunteers
- 248 people
- Sponsor
- Clinique Ovo
Azoospermia, Nonobstructive, Infertility, Male
Retrieval of Sperm From Men With Azoospermia Using Ultrasound-guided Rete Testis Aspiration
The objective of this study is to use ultrasound-guided rete testis flushing and aspiration technique to retrieve sperm, non-surgically, from the testes of azoospermic men.
- Trial name
- NCT03291522
- Testing
- Ultrasound-guided rete testis flushing and aspiration
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pittsburgh
Endocrine Disease, Infertility
Hormonal Regulation of Puberty and Fertility
Background: The body produces gonadotropin-releasing hormone (GnRH) about every 2 hours. GnRH travels through the bloodstream to the pituitary gland, where it stimulates the gland to produce hormones called gonadotropins.
- Conditions
- Endocrine Disease, Infertility, Hypogonadism, Amenorrhea
- Trial name
- NCT01511588
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Male Infertility
Regulation of Stem Spermatogonia in the Mature Testis
Investigative trial to evaluate the role of a glial cell lined derived neurotrophic factor (GDNF) in regulation of spermatogonial renewal and testicular function.
- Trial name
- NCT02756923
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Weill Medical College of Cornell University