Clinical trials: Malignant Colorectal Neoplasm
Colon Cancer, Lymph Node Metastasis
Italian Study on the Right Hemicolectomy: How the Lymphadenectomy is Performed
The objective of the study is the analysis of lymphadenectomy in the course of right hemicolectomy, in relation to the radicality of the surgical resection that is performed.
- Conditions
- Colon Cancer, Lymph Node Metastasis, Surgical Procedure, Unspecified
- Trial name
- CoDIG-2 (NCT05943951)
- Testing
- Right hemicolectomy
- Where
- 62 sites in Italy
- Volunteers
- 788 people
- Sponsor
- Gabriele Anania
Colorectal Cancer
Doctor-Recommended Home-Based Exercise Program or Relaxation Training in Improving Physical Function and Controlling Symptoms in Patients With Stage IV or Recurrent Colon Cancer That Cannot Be Removed By Surgery
The goal of this study is to compare the effects of exercise with the effects of relaxation training on physical function (how well participants perform normal daily activities) and symptoms related to your cancer diagnosis (such…
- Trial name
- NCT00985400
- Testing
- Exercise Program, Telephone-based intervention, Counseling intervention
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- M.D. Anderson Cancer Center
Colon Cancer
Complete Mesocolic Excision With Central Vessel Ligation Compared With Conventional Surgery for Colon Cancer
The aim of this study is to compare between complete mesocolic excision with central vascular ligation and conventional surgery of colon cancer regarding number of harvested lymph nodes, surgical outcome and complications.
- Trial name
- NCT02526836
- Testing
- Conventional Surgery, Complete mesocolic excision with central vascular ligation
- Where
- 2 sites in Egypt, Italy
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Hypoxemia, Esophageal Cancer
High-flow Nasal Cannula Oxygenation in Sedated Endoscopy for High-risk Obstructive Sleep Apnea Patients
Hypoxia is the most common adverse event during propofol sedation for gastrointestinal endoscopy. The STOP-BANG questionnaire is a widely used, simple assessment tool for screening obstructive sleep apnea (OSA) risk.
- Conditions
- Hypoxemia, Esophageal Cancer, Gastric Cancer (Diagnosis), Colon Cancer
- Trial name
- NCT07155330
- Testing
- High-flow nasal cannula
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang University
Colorectal Cancer
Chemotherapy With Raltitrexed and Fluorouracil in Treating Patients With Advanced Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002828
- Testing
- fluorouracil, raltitrexed
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer
SCar-biopsies After Malignant Colorectal Polypectomy of Uncertain RAdicality
After endoscopic removal of a colorectal polyp that harbors (unexpected) adenocarcinoma, pathology usually can not guarantee a radical resection from an oncological point of view.
- Trial name
- SCAPURA (NCT02328664)
- Testing
- Flexible sigmoidoscopy or colonoscopy
- Where
- 36 sites in Netherlands
- Volunteers
- 246 people
- Sponsor
- Dr. Frank ter Borg MD PhD
Gastric Cancer, Colon Cancer
Postoperative Oral Nutritional Supplementation After Major Gastrointestinal Surgery
Patients who underwent major gastrointestinal surgery is potentially at risk of malnutrition due to reduced oral intake, increased nutritional need, reduced gastrointestinal absorption function, and/or metabolic changes after…
- Conditions
- Gastric Cancer, Colon Cancer, Pancreatic Cancer, Duodenal Cancer
- Trial name
- NCT01838109
- Testing
- oral nutritional supplement
- Where
- South Korea
- Volunteers
- 174 people
- Sponsor
- Seoul National University Hospital
Colon Carcinoma, Liver and Intrahepatic Bile Duct Carcinoma
Characterization of Mechanical Tissue Properties in Patients With Pancreatic, Liver, or Colon Cancer
This pilot research trial studies characterization of mechanical tissue properties in patients with pancreatic, liver, or colon cancer.
- Conditions
- Colon Carcinoma, Liver and Intrahepatic Bile Duct Carcinoma, Pancreatic Carcinoma
- Trial name
- NCT03137706
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis, Laboratory Procedure
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Southern California
Overall Survival, Postoperative Complications
Standardization of Laparoscopic Surgery for Right Hemi Colon Cancer (SLRC)
To standardize the surgery for advanced right hemi colon cancer with laparoscopy and investigate whether extended lymphadenectomy (CME) could improve disease-free survival in patients with right colon cancer, compared with D3…
- Conditions
- Overall Survival, Postoperative Complications, Metastasis, Stage, Colon Cancer
- Trial name
- NCT02942238
- Testing
- CME, D3
- Volunteers
- 582 people
- Sponsor
- Ruijin Hospital
Colon Cancer Stage
Celecoxib as Adjuvant Therapy to Chemotherapy in Patients With Metastatic Colorectal Cancer
The study aimed at evaluation of anticancer effect of celecoxib as adjuvant therapy to chemotherapy in patients with metastatic colorectal cancer
- Trial name
- NCT03645187
- Testing
- FOLFERI, Folferi and celecoxib
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sherief Abd-Elsalam
Breast Carcinoma, Colorectal Carcinoma
A Self-Monitoring Platform for Tracking Medication Safety and Concerns in Cancer Patients
This clinical trial evaluates the usefulness of a self-monitoring platform for tracking medication safety events and concerns in patients with lung, colorectal, breast, and prostate cancer.
- Conditions
- Breast Carcinoma, Colorectal Carcinoma, Lung Carcinoma, Malignant Solid Neoplasm
- Trial name
- NCT07291414
- Testing
- Educational Intervention, Electronic Health Record Review, Follow-Up
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan Rogel Cancer Center
Liver Neoplasms
Vaccine Therapy and Radiation to Liver Metastasis in Patients With CEA-Positive Solid Tumors
This study will evaluate the safety and effects of vaccine treatment plus radiation to the liver in patients with solid tumors that have spread to the liver.
- Trial name
- NCT00081848
- Testing
- rV-CEA(6D)/TRICOM-rF-CEA(6D)/TRICOM, rF-CEA(6D)/TRICOM, Recombinant Fowlpox-GM-CSF
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Colon Cancer Screening, Colon Cancer Surveillance
Enchasing Polyp Detection: The Effect of Adding Polyp Detection Attachment Device to Computer Aid Detection System.
Despite the widespread use of colonoscopy, the ongoing challenge of potentially missing polyps remains. Previous studies have independently shown that both Endocuff, a colonoscope attachment device for polyp detection, and…
- Trial name
- NCT06116864
- Testing
- Endocuff and GI Genius, GI Genius
- Where
- United States
- Volunteers
- 1,766 people, healthy volunteers welcome
- Sponsor
- Marshall University
Cholestasis, Icterus
FGF19 in Obstructive Cholestasis: "Unveil the Signal"
Rationale: Bile salts are potent signalling molecules influencing various metabolic and functional processes. Bile salts exert these functions by activating nuclear (e.g. FXR ) and plasma cell membrane-bound receptors (e.g.
- Conditions
- Cholestasis, Icterus, Cholangiocarcinoma, Pancreatic Neoplasms
- Trial name
- FOCUS (NCT05718349)
- Testing
- Biospecimen sampling
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Nicole Hildebrand
Colorectal Cancer, Neurotoxicity
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery
RATIONALE: Calcium gluconate and magnesium sulfate may prevent or lessen neurotoxicity caused by oxaliplatin. It is not yet known whether calcium gluconate and magnesium sulfate are more effective than a placebo in preventing…
- Trial name
- NCT00316914
- Testing
- calcium gluconate, magnesium sulfate
- Where
- 14 sites in United States
- Volunteers
- 104 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Appendix Carcinoma, Carcinomatosis
Psychological, Psychophysical and Epigenetic Determinants of Chronic Pain After Cytoreductive - Hyperthermic Intraoperative Chemotherapy
This study learns if depression, anxiety, and catastrophizing (thought patterns that prompt people to expect the worst) are associated with chronic pain after surgery among patients who are scheduled to have cytoreductive surgery…
- Conditions
- Appendix Carcinoma, Carcinomatosis, Colorectal Carcinoma, Gastric Carcinoma
- Trial name
- NCT05083338
- Testing
- Biospecimen Collection, Pain Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
DNA Changes That Affect Vitamin D Metabolism in Patients With Colorectal Cancer Receiving Vitamin D Supplements
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00550563
- Testing
- cholecalciferol, polymerase chain reaction, polymorphism analysis
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Roswell Park Cancer Institute
Colon Cancer
Compare Outcomes After High and Low Ligation of Inferior Mesenteric Artery in Colorectal Cancer
We aim comparing different outcomes between high and low tie ligation of inferior mesenteric artery in left colorectal cancer operable and elective surgeries.
- Trial name
- NCT06253949
- Testing
- ligation of inferior mesenteric artery in colorectal cancer
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Colon Cancer
Follow-up After Surgery for Colon Cancer. General Practice vs. Surgical-based Follow-up?
The purpose of this study is to clarify cost effectiveness and quality of life issues among colon cancer patients followed up in a hospital setting or by their GP's.Statement of study hypothesis:Postoperative follow up of colon…
- Trial name
- ONKOLINK (NCT00572143)
- Testing
- ca coli follow-up by GP
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- University Hospital of North Norway
Lynch Syndrome, Colon Cancer
Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome
Multicenter, multinational, randomized, 2-arm, double-blind, phase II clinical study with 2000mg mesalamine, or placebo for prevention of colorectal neoplasia in Lynch Syndrome patients during and following daily intake for 2…
- Conditions
- Lynch Syndrome, Colon Cancer, Colon Neoplasm
- Trial name
- MesaCAPP (NCT04920149)
- Testing
- Mesalamine
- Where
- 8 sites in Denmark, Sweden
- Volunteers
- 150 people
- Sponsor
- Ann-Sofie Backman
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