Clinical trials: Malignant Colorectal Neoplasm
Colorectal Cancer, Metastatic Cancer
Vaccine Therapy in Treating Patients With Colorectal Cancer Metastatic to the Liver
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. PURPOSE: Phase II trial to study the effectiveness of vaccine therapy in treating patients who have colorectal cancer that has spread to the…
- Trial name
- NCT00033748
- Testing
- monoclonal antibody 11D10 anti-idiotype, monoclonal antibody 3H1 Alu Gel
- Where
- 75 sites in United States
- Volunteers
- 56 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Right Hemicolectomy
Fluorescence Lymph Node Mapping for Colon Cancer Surgery
Fluorescence-guided surgery using indocyanine green can visualize the complex and diverse lymph node drainage structures for each patient and help determine the extent of dissection of the D3 lymph node tailored to the patient.
- Trial name
- CONSTELLARE (NCT07060443)
- Testing
- Indocyanine green (ICG) injection for intraoperative lymph node imaging, Standard Right Hemicolectomy (Non-ICG)
- Where
- 13 sites in South Korea
- Volunteers
- 186 people
- Sponsor
- Pusan National University Yangsan Hospital
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Recurrent or Persistent Metastatic Colorectal Cancer
Phase I trial to study the effectiveness of radiolabeled monoclonal antibody therapy in treating patients who have recurrent or persistent metastatic colorectal cancer.
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00023933
- Testing
- iodine I 131 monoclonal antibody CC49-deltaCH2
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
Cetuximab and Irinotecan in Treating Patients With Advanced Colorectal Cancer
RATIONALE: Monoclonal antibodies, such as cetuximab, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00005076
- Testing
- cetuximab, irinotecan hydrochloride
- Volunteers
- 110 people
- Sponsor
- University of Alabama at Birmingham
Secondary Malignant Neoplasm of Liver
Comparison of Hepatectomy and Local Ablation for Resectable Synchronous and Metachronous Colorectal Liver Metastasis
The surgical and local ablation strategy for the treatment of resectable synchronous and metachronous colorectal liver metastases(CRLM) has not still been defined.
- Trial name
- HELARC (NCT02886104)
- Testing
- CRLM resection group, CRLM ablation group
- Where
- China
- Volunteers
- 548 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colon Cancer, Colon Polyp
Comparison of Two Preparations for the Study of the Colon Through Colonoscopy
Compare the quality of bowel preparation between two groups of patients, who will undergo two different preparations: 1. Moviprep + diet; 2. Plenvu + diet
- Conditions
- Colon Cancer, Colon Polyp, Colon Adenoma, Colon Rectal Cancer
- Trial name
- NCT04497935
- Testing
- PLENVU, MoviPrep
- Where
- Portugal
- Volunteers
- 613 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde do Alto Ave, EPE
Colorectal Cancer, Metastatic Colorectal Cancer
Regorafenib and Nivolumab in Mismatch Repair (MMR) Refractory Colorectal Cancer
The main purpose of this study is to test the safety, tolerable side effects, and determine the highest tolerable dose of the combination of Regorafenib and Nivolumab.
- Conditions
- Colorectal Cancer, Metastatic Colorectal Cancer, Colon Cancer
- Trial name
- NCT03712943
- Testing
- Regorafenib, Nivolumab
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Microsatellite Stable (MSS) Colon Cancer, Locally Advanced Colon Cancer
Node-Sparing Short-Course Radiation With CAPOX and Sintilimab for MSS Locally Advanced Colon Cancer: A Randomized, Prospective, Multicenter Study
This study aims to evaluate the use of node-sparing short-course radiotherapy combined with chemotherapy and Sintilimab, or chemotherapy alone, as neoadjuvant therapy for MSS-type locally advanced colon cancer.
- Trial name
- mRCAT-C (NCT06594692)
- Testing
- Node-Sparing Short-Course Radiotherapy Combined with CAPOX and Sintilimab, CAPOX Chemotherapy
- Where
- 2 sites in China
- Volunteers
- 140 people
- Sponsor
- Sir Run Run Shaw Hospital
Colon Cancer
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer
Cancer of the colon and rectum are the third most common cancers in Canadian males and females. The initial therapy of colorectal cancer is surgery to remove the cancer and nearby lymph glands.
- Trial name
- NCT00131599
- Testing
- 5FU/LV
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- AHS Cancer Control Alberta
Colon Cancer
Preoperative Chemosensitivity Testing to Predict Treatment Benefit in Adjuvant Stage III Colon Cancer
The primary working hypothesis is that preoperative chemo-sensitivity testing using fluorodeoxyglucose positron emission tomography (FDG-PET) performed before and after one course of FOLFOX (folinic acid, fluorouracil…
- Trial name
- PePiTA (NCT00994864)
- Testing
- FOLFOX
- Where
- 21 sites in Belgium
- Volunteers
- 235 people
- Sponsor
- Jules Bordet Institute
Colorectal Cancer
Vaccine Therapy and Chemotherapy With or Without Tetanus Toxoid Compared With Chemotherapy Alone in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00027833
- Testing
- ALVAC-CEA-B7.1 vaccine, tetanus toxoid, FOLFIRI regimen
- Where
- 13 sites in United States, Canada
- Sponsor
- Herbert Irving Comprehensive Cancer Center
Colonic Neoplasms, Effects of Chemotherapy
microRNAs Tool for Stratifying Stage II Colon Cancer
The investigators discover the investigators' miRNA tool can be a useful tool to predict the patients with stage II colon who can benefit from chemotherapy.Then the investigators plan to make an observation study that may…
- Trial name
- NCT02635087
- Testing
- miRNA tool
- Where
- China
- Volunteers
- 630 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Colorectal Carcinoma
A Study of IMC-1121B (Ramucirumab) in Colorectal Cancer
The purpose of this study is to test how long participants with colorectal cancer live without progressive disease when being treated with IMC-1121B (ramucirumab) and the modified FOLFOX-6 chemotherapy.
- Trial name
- NCT00862784
- Testing
- IMC-1121B (ramucirumab), Oxaliplatin, Folinic acid
- Where
- 7 sites in Canada, Spain
- Volunteers
- 48 people
- Sponsor
- Eli Lilly and Company
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Colorectal Cancer
A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer.
This single arm study will evaluate the safety profile of Xeloda as monotherapy for adjuvant treatment of colon cancer. All patients will receive Xeloda 1250mg/m2 p.o.
- Trial name
- NCT00502671
- Testing
- capecitabine [Xeloda]
- Where
- 46 sites in Russia
- Volunteers
- 228 people
- Sponsor
- Hoffmann-La Roche
Caregiver, Malignant Neoplasm
Patient Portal and Navigation Program in Providing Information for Asian American Cancer Patients
This phase I/II trial studies how well patient portal and navigation program work in providing information for Asian American cancer patients.
- Conditions
- Caregiver, Malignant Neoplasm, Physician, Stage I Colorectal Cancer AJCC v8
- Trial name
- NCT03867916
- Testing
- Patient Navigation Program, Quality-of-Life Assessment, Survey Administration
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cancer
Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions
RATIONALE: Using BG00001 to insert the gene for interferon-beta into a person's pleural cavity may improve the body's ability to fight cancer.
- Trial name
- NCT00066404
- Testing
- recombinant adenovirus-hIFN-beta
- Where
- United States
- Sponsor
- Abramson Cancer Center at Penn Medicine
Malignant Neoplasm of Large Intestine TNM Staging Primary Tumor (T) T4, Peritoneal Carcinomatosis
Surgery With HIPEC in Treating Patients With a High Risk of Developing Colorectal Peritoneal Carcinomatosis
Multicentric randomised trial. The goal of this clinical research study is to learn if hyperthermic intraperitoneal chemotherapy (HIPEC) will help to decrease the rate of peritoneal carcinomatosis(PC) in patients with high risk…
- Trial name
- NCT02179489
- Testing
- Surgery and Hyperthermic Intraperitoneal Chemotherapy with MMC
- Where
- 9 sites in China
- Volunteers
- 271 people
- Sponsor
- Zhejiang University
Colorectal Cancer
Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which regimen of chemotherapy is more effective for metastatic colorectal cancer.
- Trial name
- NCT00008281
- Testing
- FOLFOX regimen, fluorouracil, leucovorin calcium
- Where
- 134 sites in United States, Canada
- Sponsor
- Sanofi
Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma
Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer
This phase I/II trial studies the side effects and how well encorafenib, binimetinib, and nivolumab work in treating patients with microsatellite stable, BRAFV600E gene-mutated colorectal cancer that has spread to other places in…
- Conditions
- Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma, Metastatic Rectal Adenocarcinoma
- Trial name
- NCT04044430
- Testing
- Binimetinib, Encorafenib, Nivolumab
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco
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