Clinical trials: Malignant Colorectal Neoplasm
Colorectal Neoplasms, Adenocarcinoma of the Colon
Study of Colorectal Cancer Patients (Stage IIIC) With Either Regorafenib or Standard of Care (No Treatment) After Adjuvant FOLFOX
This study, for patients who have Stage IIIC colorectal cancer and who underwent 5-fluorouracil/leucovorin with oxaliplatin (FOLFOX) chemotherapy after surgery, will test to see if regorafenib given after the completion of FOLFOX…
- Conditions
- Colorectal Neoplasms, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
- Trial name
- NCT02425683
- Testing
- Regorafenib
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- US Oncology Research
Recurrent Colon Cancer, Recurrent Rectal Cancer
Sorafenib, Cetuximab, and Irinotecan in Treating Patients With Advanced or Metastatic Colorectal Cancer
This phase I/II trial is studying the side effects and best dose of sorafenib when given together with cetuximab and irinotecan and to see how well they work in treating patients with advanced or metastatic colorectal cancer.
- Conditions
- Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage III Colon Cancer, Stage III Rectal Cancer
- Trial name
- NCT00134069
- Testing
- sorafenib tosylate, cetuximab, irinotecan hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute (NCI)
Colon Cancer
PrehabPal: A Digital Tool to Help Older Adults Prepare for Cancer Surgery
This is a multi-center, randomized trial investigating the use of PrehabPal web app versus a written surgery prehabilitation instructions among individuals aged 65 years and older preparing for colon cancer surgery.
- Trial name
- NCT05520866
- Testing
- PrehabPal
- Where
- 3 sites in United States
- Volunteers
- 132 people
- Sponsor
- University of California, San Francisco
Oropharyngeal Cancer, Neck Cancer
A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers
Background: Often, metastatic human papillomavirus (HPV) associated cancers cannot be cured. They also do not respond well to treatment. Some forms of colon cancer also have poor responses to treatment.
- Conditions
- Oropharyngeal Cancer, Neck Cancer, Human Papillomavirus, HPV
- Trial name
- NCT04708470
- Testing
- Bintrafusp Alfa, PDS01ADC, Entinostat
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer, Intestinal Obstruction
Randomized Trial of Colonic Stents as a Bridge to Surgery
The objective of this randomized controlled trial was to evaluate the role colonic self-expanding metal stent (SEMS) placement as a bridge to surgery in patients with acute malignant left-sided colonic obstruction.
- Trial name
- NCT00758186
- Testing
- Emergency endoscopic colonic stenting, Emergency surgery
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Singapore General Hospital
Clinical Stage IV Esophageal Adenocarcinoma AJCC v8, Clinical Stage IV Esophageal Squamous Cell Carcinoma AJCC v8
Enhanced Outpatient Symptom Management to Reduce Acute Care Visits Due to Chemotherapy-Related Adverse Events
This clinical trial studies if enhanced outpatient symptom management with telemedicine and remote monitoring can help reduce acute care visit due to chemotherapy-related adverse events.
- Conditions
- Clinical Stage IV Esophageal Adenocarcinoma AJCC v8, Clinical Stage IV Esophageal Squamous Cell Carcinoma AJCC v8, Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8
- Trial name
- NCT05038254
- Testing
- Best Practice, Patient Monitoring, Questionnaire Administration
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
Neoadjuvant Radiation Therapy and Capecitabine in Treating Patients With Stage III or Stage IV Colorectal Adenocarcinoma
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy, such as capecitabine, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00075556
- Testing
- capecitabine, conventional surgery, neoadjuvant therapy
- Where
- 12 sites in France
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Colon Cancer, Neoadjuvant Therapies
Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Arm, Phase II Trial
Most colorectal cancers belong to the microsatellite stable (MSS) or proficient mismatch repair (pMMR) subtypes, with limited response to PD-1 inhibitors.
- Conditions
- Colon Cancer, Neoadjuvant Therapies, Immune Checkpoint Therapy, Radiation Therapy
- Trial name
- MODIFI-L (NCT07279077)
- Testing
- Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colon Cancer Screening
Colonoscopy Bowel Prep Comparison Among Diabetic Patients
The goal of this clinical trial is to learn if the Golytely or SUPREP bowel preparation works more effectively in bowel cleansing for colorectal cancer screening with colonoscopy in patients with diabetes.
- Trial name
- NCT07351019
- Testing
- Golytely, SUPRPEP
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Eisenhower Army Medical Center
Colon Cancer
Study Investigating the Role of Oxaliplatin Duration in Modified FOLFOX-6 or CAPOX Regimen as Adjuvant Colon Cancer Therapy
This study is designed to confirm that first 3 months of oxaliplatin in 6 months of modified FOLFOX-6 or CAPOX treatment is not inferior to 6 months of oxaliplatin in modified FOLFOX-6 or CAPOX treatment in terms of disease free…
- Trial name
- NCT01092481
- Testing
- oxaliplatin
- Where
- 17 sites in South Korea
- Volunteers
- 1,580 people
- Sponsor
- Samsung Medical Center
Colorectal Cancer
Traditional Print Communication Methods, Simple Electronic Communication Methods, or Usual Care in Increasing How Often Older Women Undergo Colorectal Cancer Screening
RATIONALE: Finding out which communication method affects a participant's decision to undergo colorectal cancer screening may help increase the number of participants who undergo screening.
- Trial name
- NCT00459030
- Testing
- educational intervention via internet, educational intervention mailed, No additional educational intervention
- Where
- United States
- Volunteers
- 904 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Metastatic Colorectal Carcinoma, Recurrent Colon Carcinoma
TAS-102 and Oxaliplatin for the Treatment of Refractory Stage IV Colon Cancer
This phase II trial studies how well TAS-102 and oxaliplatin work in treating patients with stage IV colon cancer. Drugs used in chemotherapy, such as TAS-102 and oxaliplatin, work in different ways to stop the growth of tumor…
- Conditions
- Metastatic Colorectal Carcinoma, Recurrent Colon Carcinoma, Refractory Colorectal Carcinoma, Stage IV Colon Cancer AJCC v7
- Trial name
- NCT04294264
- Testing
- Oxaliplatin, Trifluridine and Tipiracil Hydrochloride
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Rutgers, The State University of New Jersey
Adult Giant Cell Glioblastoma, Adult Glioblastoma
18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy
The purpose of the study is to conduct research of a new PET radiopharmaceutical in cancer patients. The uptake of the novel radiopharmaceutical 18F-FPPRGD2 will be assessed in study participants with glioblastoma multiforme…
- Conditions
- Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Male Breast Cancer
- Trial name
- NCT01806675
- Testing
- 18F-fludeoxyglucose (18F-FDG), 18F-FPPRGD2
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Sanjiv Sam Gambhir
Colorectal Cancer
Genetic Study of Young Patients With Colorectal Cancer
RATIONALE: Identifying gene mutations (microsatellite instability) may allow doctors to plan effective treatment for patients who develop colorectal cancer at an early age.
- Trial name
- NCT00044967
- Testing
- microsatellite instability analysis
- Where
- 73 sites in United States, Canada
- Volunteers
- 651 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Prostate Cancer, Carcinoma of the Rectum
Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium
Postoperative cognitive dysfunction (POCD) and postoperative delirium occurs mainly in aged patients. POCD and POD may increase the mortality and morbidity.
- Conditions
- Prostate Cancer, Carcinoma of the Rectum, Colon Cancer, Renal Carcinoma
- Trial name
- MAPOCD (NCT02928692)
- Testing
- Minocycline
- Where
- 5 sites in China
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Colonic Neoplasms
Cetuximab in Combination With Anti-PD-1 and mFOLFOX Treat For RAS/BRAF wt Right-Sided Colon Cancer
We plan to evaluate the efficacy and safety of cetuximab combined with anti-PD-1 and mFOLFOX6 in the treatment of RAS/BRAF WT locally advanced or metastatic right colon cancer
- Trial name
- CIFOXRC (NCT05468177)
- Testing
- neoadjuvant chemotherapy
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Tongji Hospital
Malignant Neoplasm, Malignant Neoplasm of Rectum
Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial
The investigators hypothesize that an increase in dietary fiber intake during radiation therapy may provide better long-term intestinal health for the cancer survivor.
- Conditions
- Malignant Neoplasm, Malignant Neoplasm of Rectum, Malignant Neoplasm of Anus, Malignant Neoplasm of Urinary Bladder
- Trial name
- FIDURA (NCT04534075)
- Where
- Sweden
- Volunteers
- 354 people
- Sponsor
- Sahlgrenska University Hospital
Colorectal Cancer
Combination Chemotherapy With or Without Cetuximab in Treating Patients With Stage III Colon Cancer That Was Completely Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, or fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00265811
- Testing
- Folfox, Cetuximab
- Where
- 8 sites in France
- Volunteers
- 2,559 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Colorectal Cancer
Cetuximab With or Without Brivanib in Treating Patients With K-Ras Wild Type Tumours and Metastatic Colorectal Cancer
RATIONALE: Brivanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00640471
- Testing
- cetuximab, brivanib alaninate
- Where
- 37 sites in Canada
- Volunteers
- 750 people
- Sponsor
- NCIC Clinical Trials Group
Metastatic Colon Cancer
A Phase Ⅱ Study of XELOX Chemotherapy With or Without Surgery of Primary Lesion for Colon Cancer Patients
The primary endpoint is to evaluate the TFS (time to failure of strategy).
- Trial name
- NCT02291744
- Testing
- resection of primary lesion, XELOX
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Fudan University
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