Clinical trials: Malignant Colorectal Neoplasm
Stage I Colon Cancer AJCC v8, Stage I Rectal Cancer AJCC v8
Designing a Dyad-Based mHealth Intervention to Improve Adherence to Lifestyle Recommendations in Colorectal Cancer Survivors and Their Family Caregivers
This clinical trial develops and tests a mobile health (mHealth) intervention to improve adherence to lifestyle recommendations in colorectal cancer (CRC) survivors and their family caregivers.
- Conditions
- Stage I Colon Cancer AJCC v8, Stage I Rectal Cancer AJCC v8, Stage II Colon Cancer AJCC v8, Stage II Rectal Cancer AJCC v8
- Trial name
- NCT06746012
- Testing
- Discussion, Educational Activity, Internet-Based Intervention
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colon Cancer, Rectum Cancer
Self-monitoring and Reminder Texts to Increase Physical Activity After Cancer: a Pilot Randomized Controlled Trial
Epidemiologic data consistently indicate that colorectal cancer survivors can improve their quality-of-life and prognosis by engaging in physical activity.
- Trial name
- Smart Pace (NCT02966054)
- Testing
- Digital Health Physical Activity Intervention Group
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Francisco
Solid Tumor, Adult, Colorectal Cancer
A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
The goal of this study is to test A2B395, an allogeneic logic-gated Tmod™ CAR T-cell product in subjects with solid tumors including colorectal cancer (CRC), non-small cell lung cancer (NSCLC), head and neck squamous cell…
- Conditions
- Solid Tumor, Adult, Colorectal Cancer, Non-Small Cell Lung, NSCLC (Non-small Cell Lung Cancer)
- Trial name
- DENALI-1 (NCT06682793)
- Testing
- A2B395, xT CDx with HLA-LOH assay
- Where
- 10 sites in United States
- Volunteers
- 240 people
- Sponsor
- A2 Biotherapeutics Inc.
Liver Metastasis Colon Cancer
Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer
After a patient is diagnosed with colon cancer, they receive a CT of the chest, abdomen, and pelvis to see if the cancer has spread (metastasized) to other parts of the body.
- Trial name
- NCT05314400
- Testing
- Full Gadoxetate-enhanced liver MRI, Shortened Gadoxetate-enhanced liver MRI
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Metastatic Colon Cancer, Liver Cancer
Hepatic Artery Infusion (HAI) Program at Duke University
The Duke HAI program was implemented in November 2018 and treated 30 patients in its first 17 months using the Medtronic Synchromed II device (only commercially available device suitable for HAI for cancer patients).
- Conditions
- Metastatic Colon Cancer, Liver Cancer, Intrahepatic Cholangiocarcinoma
- Trial name
- NCT04511793
- Testing
- Medtronic Synchromed II pump
- Sponsor
- Michael Lidsky, M.D.
Colon Cancer
Improving Quality of Life for Colon Cancer Patients and Their Caregivers
By joining this study, participants, including patients and their caregivers, will be provided useful information about colon cancer that may help alleviate anxiety surrounding treatment, improve communications with the medical…
- Trial name
- NCT04713007
- Testing
- Quality of Life Ted Talks, Quality of Life Supportive Resources
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Hawaii
Patients With Uncertain Difficult Airway, Colon Cancer
Safety and Feasibility of Reversible Induction Strategy
This study would explore the safety and feasibility of a reversible induction strategy for uncertain difficult airway. This reversible induction strategy would include high flow nasal canular oxygenation support, short-term…
- Conditions
- Patients With Uncertain Difficult Airway, Colon Cancer, Gastric Cancer, Prostatic Cancer
- Trial name
- NCT04434963
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Colorectal Cancer
S9923 R115777 in Treating Patients With Advanced Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of R115777 in treating patients who have recurrent or…
- Trial name
- NCT00005833
- Testing
- R115777
- Where
- 12 sites in United States
- Volunteers
- 62 people
- Sponsor
- SWOG Cancer Research Network
Peritoneal Carcinomatosis
Cytoreduction Followed by Normothermic Versus Hyperthermic Intraperitoneal Intraoperative Chemoperfusion (HIPEC): a Study in Peritoneal Carcinomatosis
Peritoneal carcinomatosis from appendix or colon (large bowel) cancer is treated in suitable patients with surgery followed by instillation of heated chemotherapy inside the abdominal cavity.
- Trial name
- NCT01575730
- Testing
- Hyperthermic intraoperative Peritoneal Chemoperfusion
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- University Hospital, Ghent
Solid Tumor, Adult, Advanced Solid Tumor
A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors
Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of SNS-101, a novel anti VISTA IgG1 monoclonal antibody as monotherapy or in combination with cemiplimab in patients with…
- Conditions
- Solid Tumor, Adult, Advanced Solid Tumor, Head and Neck Cancer, Breast Cancer
- Trial name
- NCT05864144
- Testing
- SNS-101 (anti-VISTA), Cemiplimab
- Where
- 10 sites in United States
- Volunteers
- 98 people
- Sponsor
- Sensei Biotherapeutics, Inc.
Advanced Breast Cancer, Advanced or Metastatic Breast Cancer
A Study to Learn About the Study Medicine Called PF-08165784 in People With PIK3CA-Mutated Advanced or Metastatic Solid Tumors
The purpose of this study is to learn about the safety and effects of the study medicine (called PF-08165784) when given alone or together with other anti-cancer therapies.
- Conditions
- Advanced Breast Cancer, Advanced or Metastatic Breast Cancer, Metastatic Breast Cancer (HR+/ HER2-), Metastatic Colorectal Adenocarcinoma
- Trial name
- NCT07897721
- Testing
- PF-08165784, Fulvestrant, Atirmociclib
- Volunteers
- 268 people
- Sponsor
- Pfizer
Colorectal Cancer
Personalized Screening Plans to Increase Colorectal Cancer Screening in Healthy Participants
RATIONALE: Developing a personalized screening plan may be more effective than usual care in increasing the number of healthy participants who regularly undergo screening for colorectal cancer.
- Trial name
- NCT00617071
- Testing
- medical chart review, survey administration, fecal occult blood test
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Pain, Postoperative, Pain, Abdominal
Optimal Peripheral Nerve Block After Minimally Invasive Colon Surgery
The purpose of the trial is to identify the "most simple non-inferior of three different methods", placebo, laparoscopic assisted transverse abdominal plane block (L-TAP) and ultrasound guided TAP block (US-TAP), using…
- Conditions
- Pain, Postoperative, Pain, Abdominal, Analgesia, Surgery
- Trial name
- OPMICS (NCT04311099)
- Testing
- Active drug, Injection of Ropivacaine - Ultrasound-guided transverse abdominal plane block, Injection of Ropivacaine - Laparoscopic assisted transverse abdominal plane block
- Where
- 5 sites in Denmark
- Volunteers
- 360 people
- Sponsor
- Claus Anders Bertelsen, PhD, MD
Colon Cancer, Rectal Cancer
Clinical Trial in Patients With Metastatic Colorectal Cancer
The objective of this trial is to compare efficacy and safety of CoFactor and 5-fluorouracil (5-FU) versus leucovorin and 5-FU in treatment of metastatic colorectal cancer.
- Trial name
- NCT00235898
- Testing
- CoFactor, 5-FU, Leucovorin
- Where
- 30 sites in India, Poland and 3 more
- Volunteers
- 300 people
- Sponsor
- Mast Therapeutics, Inc.
Colon Cancer, Malnutrition
The Patient in Laparoscopic Colon Surgery:Impact of Comorbidities,Frailty,Malnutrition and Sarcopenia on Short-term Mortality
There are many factors involved in outlining the patient's profile and in defining which factors can be configured as risks related to the surgical act; for the modern surgeon it is no longer possible to identify the patient at…
- Conditions
- Colon Cancer, Malnutrition, Sarcopenia, Comorbidities and Coexisting Conditions
- Trial name
- NCT04729738
- Where
- Italy
- Volunteers
- 420 people
- Sponsor
- University Hospital of Ferrara
Colorectal Cancer, Metastatic Cancer
Surgery With or Without Radiofrequency Ablation Followed by Irinotecan in Treating Patients With Colorectal Cancer That is Metastatic to the Liver
RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. Combining radiofrequency ablation with surgery may kill more tumor cells.
- Trial name
- NCT00030563
- Testing
- irinotecan hydrochloride, adjuvant therapy, conventional surgery
- Where
- 3 sites in United States, Canada
- Sponsor
- University of Washington
Colorectal Cancer, Colorectal Neoplasms
Effect of Patient Portal Messaging Before Mailing Fecal Immunochemical Testing Kit on Colorectal Cancer Screening Rates
Behavioral economics principles have increasingly been shown to improve health outcomes in the United States. They offer the ability to implement simple, low-cost and effective interventions to address key health issues without…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Cancer Screening
- Trial name
- NCT05115916
- Testing
- MyChart Priming Message
- Where
- United States
- Volunteers
- 3,880 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Colorectal Cancer
BMS-247550 in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of BMS-247550 in treating patients who have metastatic…
- Trial name
- NCT00033306
- Testing
- ixabepilone, Fluoropyrimidine, Irinotecan
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- University of Alabama at Birmingham
Colorectal Cancer
Primary Tumor Sidedness Associated With Clinical Characteristic and Postoperative Outcomes in Colon Cancer: a Propensity Score Matching Study
Background: Recent investigations have suggested that sidedness is associated with the prognosis of colon cancer patients. The role of sidedness in surgical outcome is unclear.
- Trial name
- NCT06184555
- Volunteers
- 24,436 people
- Sponsor
- Chang Gung Memorial Hospital
Colorectal Cancer
Genetic Study in Patients With Stage II or Stage III Colon Cancer
RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer. PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.
- Trial name
- NCT00003833
- Testing
- DNA stability analysis, gene mapping
- Where
- 59 sites in United States, Canada
- Volunteers
- 598 people
- Sponsor
- Alliance for Clinical Trials in Oncology
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