Clinical trials: Malignant Colorectal Neoplasm
Colorectal Cancer, Stage III Colon Cancer
French Assessment of MRD by Liquid Biopsies in Stage III CRC Patients (FRENCH.MRD.CRC)
Improving personalized cancer treatments and finding the best strategies to treat each patient relies on using new diagnostic technologies.
- Conditions
- Colorectal Cancer, Stage III Colon Cancer, Minimal Residual Disease, Liquid Biopsy
- Trial name
- NCT06287814
- Testing
- Blood sample/lliquid biopsy
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Colorectal Cancer, Liver Metastases
Conversion Therapy of RAS/BRAF Wild-Type Right-sided Colon Cancer Patients With Initially Unresectable Liver Metastases
The prognosis of patients with metastatic right-sided colon cancer is worse than that of patients with metastatic left-sided cancer.
- Trial name
- NCT04525326
- Testing
- Cetuximab, Bevacizumab, mFOLFOX/FOLFIRI ( Standard Chemotherapy)
- Volunteers
- 584 people
- Sponsor
- Fudan University
Hepatocellular Carcinoma
Non-Interventional Registry Study to Evaluate the Effectiveness of TheraSphere® in the Treatment of Hepatocellular Carcinoma (HCC)
The purpose of this registry study is to gather effectiveness, QoL, safety and procedural information on TheraSphere® for the treatment of participants with Hepatocellular Carcinoma (HCC), Intrahepatic Cholangiocarcinoma (iCC)…
- Trial name
- PROACTIF (NCT04069468)
- Testing
- TheraSphere
- Where
- 37 sites in France
- Volunteers
- 1,247 people
- Sponsor
- Boston Scientific Corporation
Colorectal Polyp, Colorectal Adenoma
Standard Colonoscopy Versus Colonoscopy With Endocuff Vision
This study seeks to compare colonoscopy results between a standard method and one using a distal scope attachment (Endocuff Vision).
- Conditions
- Colorectal Polyp, Colorectal Adenoma, Colon Cancer
- Trial name
- NCT03361917
- Testing
- Endocuff Vision
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
Colonic Neoplasms, Effects of Chemotherapy
A 6 microRNA Tool for Stratifying Stage II Colon Cancer of Receiving Adjuvant Chemotherapy
Whether patients with stage II colon cancer should receive adjuvant chemotherapy or not is still on debate.MicroRNA(miRNA) is a promising tool.
- Trial name
- NCT02466113
- Testing
- A 6 microRNA stratified tool, A classic stratified tool
- Volunteers
- 430 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Peritoneal Neoplasms
Pharmacokinetic, Safety and Efficacy Study of Nanoparticle Paclitaxel in Patients With Peritoneal Cancers
The purpose of this study is to evaluate the safety, pharmacokinetics and preliminary efficacy of an intraperitoneally administered suspension of nanoparticulate paclitaxel in patients with refractory malignancies principally…
- Trial name
- NCT00666991
- Testing
- nanoparticulate paclitaxel
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- CritiTech, Inc.
Colon Cancer, Robotic Surgery
Effectiveness of Robotic Surgery for Right Colon Cancer
This study aims to explore through a multi-center, randomized controlled clinical study whether robot-assisted radical resection of right colon cancer is superior to laparoscopic surgery in terms of surgical quality and…
- Trial name
- NCT06421974
- Testing
- DaVinci si or xi system, laparoscopic radical resection
- Where
- China
- Volunteers
- 610 people
- Sponsor
- Sir Run Run Shaw Hospital
Colon Cancer, Benign Colon Diseases
Evaluation of Microcirculation in Colon Wall and Bowel Anastomosis by Laser Induced Fluorescence Video Angiography
The aim of the study is to describe utility of dynamic fluorescence videoangiography of indocyanine green (ICG) in gastrointestinal surgery, for evaluation of microcirculation in colon wall and anastomosis before and after…
- Trial name
- NCT01419860
- Testing
- Elective colon resection
- Where
- Norway
- Volunteers
- 4 people
- Sponsor
- Ostfold Hospital Trust
Colon Adenocarcinoma, ERBB2 Gene Amplification
S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery
This randomized phase II trial studies how well trastuzumab and pertuzumab work compared to cetuximab and irinotecan hydrochloride in treating patients with HER2/neu amplified colorectal cancer that has spread from where it…
- Conditions
- Colon Adenocarcinoma, ERBB2 Gene Amplification, Rectal Adenocarcinoma, Recurrent Colon Carcinoma
- Trial name
- NCT03365882
- Testing
- Cetuximab, Irinotecan Hydrochloride, Laboratory Biomarker Analysis
- Where
- 798 sites in United States, Puerto Rico
- Volunteers
- 240 people
- Sponsor
- SWOG Cancer Research Network
ColoRectal Cancer, Liver Metastases
Simultaneous Resection of Colorectal Cancer With Synchronous Liver Metastases
Synchronous colorectal cancer with liver metastases, defined as the diagnosis of a primary colorectal tumour and liver metastases within 12 months, is a common problem faced by colorectal and hepatobiliary surgeons.(Adam) The…
- Conditions
- ColoRectal Cancer, Liver Metastases, Liver Metastasis Colon Cancer, Surgery
- Trial name
- RESECT (NCT02954913)
- Testing
- Simultaneous Resection
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- Hamilton Health Sciences Corporation
Colorectal Cancer
Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma
This study is designed primarily to establish efficacy and estimate resource utilization. The short-term hypothesis is that the dose of capecitabine (825 mg/m2 twice/day 5 days per week) during the course of radiation therapy is…
- Trial name
- NCT00216424
- Testing
- Capecitabine (Xeloda)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- James A. Haley Veterans Administration Hospital
Rectal Neoplasms Malignant, Rectum Carcinoma
Neoadjuvant Chemotherapy in Patients With Moderate Risk Mid Rectal Cancer
The purpose of this study is to determine whether 3 months of neoadjuvant CapOx is non-inferior to neoadjuvant radiotherapy in patients with moderate risk CRM"-" mid rectal cancer.
- Conditions
- Rectal Neoplasms Malignant, Rectum Carcinoma, Rectal Cancer
- Trial name
- RuCorT-02 (NCT04134897)
- Testing
- Capecitabine, Oxaliplatin, Radiotherapy
- Where
- Russia
- Volunteers
- 316 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Colon Mucinous Adenocarcinoma, Colon Signet Ring Cell Adenocarcinoma
Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery
This phase II trial studies how well v-akt murine thymoma viral oncogene homolog 1 (Akt) inhibitor MK2206 works in treating patients with previously treated colon or rectal cancer that has spread from the primary site to other…
- Conditions
- Colon Mucinous Adenocarcinoma, Colon Signet Ring Cell Adenocarcinoma, Rectal Mucinous Adenocarcinoma, Rectal Signet Ring Cell Adenocarcinoma
- Trial name
- NCT01802320
- Testing
- Akt Inhibitor MK2206, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Malignant Solid Neoplasm
Testing Trastuzumab and Pertuzumab in Patients With Higher Than Normal Copies of the HER2 Gene Found in Their Tumors (MATCH - Subprotocol J)
This phase II MATCH treatment trial tests how well trastuzumab and pertuzumab work in treating patients with HER2-amplified non-breast, non-gastric/gastroesophageal junction, and non-colorectal cancers.
- Trial name
- NCT06136897
- Testing
- Biopsy Procedure, Biospecimen Collection, Echocardiography Test
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Cancer Institute (NCI)
Colon Cancer, Post Operative Pain
Propofol With Clonidine and Ketamine Throughout Colon Cancer Surgery
The Study Showed that combining clonidine and ketamine together can increase the likelihood of achieving a sufficient level of anaesthesia while minimizing post-operative discomfort and inflammation.
- Trial name
- NCT05536362
- Testing
- TCI Propofol Injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Egymedicalpedia
Colonic Neoplasms
MOSAIC - Multicenter International Study of Oxaliplatin/ 5FU-LV in the Adjuvant Treatment of Colon Cancer
To evaluate the FOLFOX regimen versus LV5FU2 in the adjuvant treatment of stage II and III colon cancer. Primary objective: Disease Free Survival (DFS) Secondary objective: Overall Survival (OS), safety (including long term…
- Trial name
- NCT00275210
- Testing
- Oxaliplatin (SR96669)
- Where
- 19 sites in Australia, Austria and 17 more
- Volunteers
- 2,246 people
- Sponsor
- Sanofi
Colon Cancer
A Clinico-biological Database in Cachexia in Patients With Colon Cancer
Creation of a prospective clinico-biological database dedicated to cachexia and undernutrition in order to carry out future research projects, to improve our knowledge of colon cancer and cachexia and to optimize the therapeutic…
- Trial name
- BCBCachexie (NCT05257135)
- Testing
- Biological collection
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Colon Cancer
MRI Staging in Colon Cancer
The main purpose of this study is to investigate whether magnetic ressonance imaging (MRI) can be used in treatment planning with assessment of diagnostic accuracy.
- Trial name
- NCT04391933
- Testing
- MRI 3 tesla
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Vejle Hospital
Colon Cancer
Safe D3 Right Hemicolectomy for Cancer Through Multidetector Computed Tomography (MDCT) Angio
When performing a resection of the right colon due to cancer one aims not only to remove the tumor bearing bowel segment, but also lymph nodes draining the affected area.
- Trial name
- NCT01351714
- Testing
- D3 resection
- Where
- 2 sites in Norway
- Volunteers
- 700 people
- Sponsor
- Sykehuset i Vestfold HF
Recurrent Colon Carcinoma, Recurrent Rectal Carcinoma
Sorafenib Tosylate, Bevacizumab, Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer
This phase I trial studies the side effects and best dose of sorafenib tosylate when given together with bevacizumab, irinotecan hydrochloride, leucovorin calcium, and fluorouracil in treating patients with colorectal cancer that…
- Conditions
- Recurrent Colon Carcinoma, Recurrent Rectal Carcinoma, Stage IVA Colon Cancer, Stage IVA Rectal Cancer
- Trial name
- NCT01383343
- Testing
- Bevacizumab, Fluorouracil, Irinotecan Hydrochloride
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- National Cancer Institute (NCI)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.