Clinical trials: Malignant Liver Tumor
Secondary Malignant Neoplasm of Liver
Combination of Cryosurgery and NK Immunotherapy for Advanced Liver Cancer
The aim of this study is the safety and efficacy of cryosurgery plus NK immunotherapy to advanced liver cancer.
- Trial name
- NCT02843802
- Testing
- Cryosurgery, NK Immunotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Liver Tumor, Hepatic Fibrosis
Assessment of Hepatic Fibrosis by Shear Wave Elastography in Patients With Liver Malignancy: A Prospective Single-center Study
To evaluate the diagnostic performance of two-dimensional shear-wave elastography (SWE) for staging hepatic fibrosis in the background liver parenchyma in patients with liver tumors before hepatic resection, using resected tissue…
- Trial name
- NCT02958592
- Testing
- two-dimensional shear-wave elastography (SWE)
- Volunteers
- 121 people
- Sponsor
- Sun Yat-sen University
Liver Tumor
Exploration of Noninvasive Differential Diagnosis of Benign and Malignant Liver Tumors
To explore an effective noninvasive method for differential diagnosis of liver tumors.
- Trial name
- NCT06524557
- Testing
- with chronic liver disease
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital
HHV8, HHV8 Infection
HHV8 and Solid Organ Transplantation
Solid organ transplant candidates will undergo serological screening for HHV8 at time of listing and transplantation. In the event of a recipient/donor mismatch R-/D+ or in the presence of a seropositive recipient (R+), blood…
- Conditions
- HHV8, HHV8 Infection, HHV8-Related Malignant Neoplasm, Kaposi Sarcoma
- Trial name
- NCT05081141
- Testing
- Diagnostic test for HHV8 exposure
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ventilation, Ablation Techniques
Use of Flow-Controlled Ventilation During CT-Guided Percutaneous Liver Tumor Ablation
Tumors in the liver can be treated using percutaneous ablation. At the Amsterdam UMC, this procedure is often performed under CT guidance by an interventional radiologist.
- Trial name
- EVOLVE (NCT07291271)
- Testing
- Flow controlled ventilation
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Liver Cancer
Fluorescent-labeled IgG for Liver Tumor Detection
This study is to evaluate whether intraoperative fluorescence imaging using fluorescent-labeled IgG probe (FluoAB) can help distinguish the tumor and the liver cirrhosis (or the liver parenchyma).
- Trial name
- NCT05394246
- Testing
- FluoAB
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese Academy of Sciences
HCC, Liver Tumor
Safety Margin Assessment After RFA Using the Registration of Pre-ablation MRI and Post-ablation CT
Magnetic resonance imaging (MRI) has been widely used for small liver lesion detection and characterization. In patients who undergo RFA, MRI is often performed before RFA, whereas immediate technical success is usually assessed…
- Trial name
- NCT02985034
- Testing
- RFA
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Seoul National University Hospital
Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver
Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial
This phase III trial compares hepatic arterial infusion (HAI) (pump chemotherapy) in addition to standard of care chemotherapy versus standard of care chemotherapy alone in treating patients with colorectal cancer that has spread…
- Conditions
- Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver, Stage IV Colorectal Cancer AJCC v8, Unresectable Colorectal Carcinoma
- Trial name
- NCT05863195
- Testing
- Bevacizumab, Capecitabine, Cetuximab
- Where
- 62 sites in United States
- Volunteers
- 408 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Liver Carcinoma
CIRSE Registry for SIR-Spheres Therapy
The administration of SIR-Spheres microspheres (yttrium-90 resin microspheres) is a form of selective internal radiation therapy (SIRT) for the treatment of patients with primary and secondary liver tumours.
- Trial name
- CIRT (NCT02305459)
- Testing
- Yttrium-90 loaded SIR-Spheres microspheres, QLQ-C30 with HCC module
- Where
- Austria
- Volunteers
- 1,051 people
- Sponsor
- Cardiovascular and Interventional Radiological Society of Europe
Liver Neoplasm Malignant Primary, Cholangiocarcinoma
Lenvatinib Combined Pembrolizumab in Advanced Hepatobiliary Tumors
The investigators design a phase IIB clinical study to explore the efficacy and safety of lenvatinib plus pembrolizumab as a second-line treatment in patients with advanced hepatobiliary malignant tumors and to analyze potential…
- Conditions
- Liver Neoplasm Malignant Primary, Cholangiocarcinoma, Combinational Immunotherapy, Biomarker
- Trial name
- NCT03895970
- Testing
- Lenvatinib plus Pembrolizumab
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Carcinoma, Liver Metastases
Radiofrequency Ablation Versus Stereotactic Radiotherapy in Colorectal Liver Metastases
This randomized clinical phase III trial is testing the efficacy of radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) in the treatment of colorectal carcinoma liver metastases.
- Trial name
- RAS01 (NCT01233544)
- Testing
- SBRT or RFA
- Where
- 2 sites in Denmark, Sweden
- Volunteers
- 300 people
- Sponsor
- University of Aarhus
Secondary Malignant Neoplasm of Liver
Computertomography-guided Wire Marking of the Liver
The aim of the study is to evaluate if it is possible to mark with a wire colorectal hepatic metastases after complete response to a neoadjuvant chemotherapy.Primary the investigators want to investigate if the wire marking is a…
- Trial name
- NCT01457599
- Testing
- Computertomography-guided marking of colorectal liver metastases
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Advanced Solid Tumor, Castration-Resistant Prostatic Cancer
A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors
Study CP-MGC018-02 is a study of vobramitamab duocarmazine (MGC018) in combination with lorigerlimab (MGD019). The study is designed to characterize safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics…
- Conditions
- Advanced Solid Tumor, Castration-Resistant Prostatic Cancer, Malignant Melanoma, Pancreatic Ductal Carcinoma
- Trial name
- NCT05293496
- Testing
- vobramitamab duocarmazine, lorigerlimab
- Where
- 10 sites in United States
- Volunteers
- 31 people
- Sponsor
- MacroGenics
Advanced Cholangiocarcinoma, Advanced Hepatocellular Carcinoma
AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease
This phase I trial tests the safety, side effects, and best dose of a new intervention, AU409, in treating patients with primary liver cancers that may have spread from where it first started to nearby tissue, lymph nodes, or…
- Conditions
- Advanced Cholangiocarcinoma, Advanced Hepatocellular Carcinoma, Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Liver
- Trial name
- NCT05791448
- Testing
- Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Southern California
Hepatocellular Carcinoma, Hilar Cholangiocarcinoma
Optimization of Health Expenditure in Liver Surgery
The aim of this study is to reduce the length of stay after liver surgery by taking account of objective quantitative clinical variables, subjective qualitative clinical variables and non clinical variables.
- Conditions
- Hepatocellular Carcinoma, Hilar Cholangiocarcinoma, Intra Hepatic Cholangiocarcinoma, Liver Metastasis
- Trial name
- NCT01715402
- Testing
- liver surgery
- Where
- 11 sites in France
- Volunteers
- 3,000 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Liver Tumor
Physiologic Assessment Following Gadoxetic Acid and Gadobenate Dimeglumine Administration
The purpose of this study is to prospectively compare the physiologic response of patients who receive either intravenous gadoxetic acid (Eovist) or intravenous gadobenate dimeglumine (MultiHance).
- Trial name
- NCT02226666
- Testing
- MRI with Multihance, MRI with Eovist
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Michigan
Liver Cancer
A Clinical Study to Evaluate the Clinical Outcomes of Hepatectomy With Nutritional Risk After Preoperative Nutritional Support
Objective:to Study the clinical outcomes of hepatectomy with Nutritional risk After Preoperative Nutritional Support. Study design: 1.Prospective，randomized, controlled clinical study;2.Patients: The subjects were from Peking…
- Trial name
- NCT01292330
- Testing
- nutritional support before operation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Adrenal Cortical Carcinoma, Alveolar Soft Part Sarcoma
Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors
This phase II trial studies how well cabozantinib-s-malate works in treating younger patients with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to therapy, or are newly diagnosed.
- Conditions
- Adrenal Cortical Carcinoma, Alveolar Soft Part Sarcoma, Central Nervous System Neoplasm, Childhood Clear Cell Sarcoma of Soft Tissue
- Trial name
- NCT02867592
- Testing
- Cabozantinib, Cabozantinib S-malate, Pharmacological Study
- Where
- 142 sites in United States
- Volunteers
- 109 people
- Sponsor
- National Cancer Institute (NCI)
Malignant Biliary Obstruction, Hepatocellular Carcinoma
Efficacy and Safety of a Fully Covered Self-Expandable Metal Stent for Unresectable HCC
The effectiveness and safety of fully covered metal stent in malignant biliary obstruction caused by HCC are still unknown. These would be clarified in this prospective cohort study.
- Trial name
- NCT05729867
- Testing
- Endoscpic biliary drainage using fully covered metal stent
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Portal Vein Pressure
Effect of Terlipressinum on the Portal Vein Pressure of Patients With Liver Tumor After Liver Resection
In this study, investigators aim to screen out the patients with portal hypertension by monitoring intraoperative PVP, and to decide the effect of Terlipressinum on the portal pressure after liver resection.
- Trial name
- NCT03352349
- Testing
- Terlipressinum
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital