Clinical trials: Malignant Neoplasm of Bronchus and Lung
NSCLC (Advanced Non-small Cell Lung Cancer), Breast Cancer
A Study of CEA-Targeted CAR-T Therapy in Patients With CEA-Positive Advanced Solid Tumors
This study is a single-arm, open-label, dose-escalating + dose-expansion clinical study, aiming to evaluate the safety and efficacy of CEA-targeted CAR-T cell preparations, and to preliminarily observe the study drug in…
- Trial name
- PBC102 (NCT07250386)
- Testing
- CEA-targeted CAR-T (Intravenous), CEA-targeted CAR-T (Intrapleural)
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lung Cancer, Lung Neoplasm Malignant
Confocal Laser Endomicroscopy VERification
The goal of this multi-center randomized clinical trial is to evaluate the added value of needle based confocal laser endomicroscopy (nCLE)-imaging to regular diagnostic bronchoscopic peripheral lung lesion analysis on the…
- Conditions
- Lung Cancer, Lung Neoplasm Malignant, Carcinoma, Non-Small-Cell Lung, Neoplasm of Lung
- Trial name
- CLEVER (NCT06079970)
- Testing
- Neelde Based Confocal Laser Endomicroscopy, Conventional diagnostic bronchoscopy
- Where
- 5 sites in United States, Austria and 3 more
- Volunteers
- 208 people
- Sponsor
- Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Soft Tissue Sarcoma, Non-small Cell Lung Cancer
Evaluation of the I-phase Clinical Trial of 177Lu-HX02 Injection in Patients With Advanced Malignant Solid Tumors
This study is a single-center, open-label, phase I dose-escalation clinical trial, aiming to evaluate the safety and tolerability, radiation dosimetry and pharmacokinetic characteristics, as well as the preliminary efficacy of…
- Trial name
- NCT07920822
- Testing
- 177Lu-HX02 injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Hexin (Suzhou) Pharmaceutical Technology Co., Ltd
Carcinoma, Non-Small-Cell Lung, Lung Cancer
Dose Escalating Study With BAY43-9006 With Carboplatin, Paclitaxel and Bevacizumab in Untreated Stage IIIb Non-small Cell Lung Cancer (NSCLC)
To determine the tolerability, maximum tolerated dose and pharmacokinetics of this drug.
- Trial name
- NCT01069328
- Testing
- Nexavar (Sorafenib, BAY43-9006), Bevacizumab, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Bayer
Non Small Cell Lung Cancer, Non-squamous Non-small-cell Lung Cancer
Cabozantinib With Pemetrexed in Advanced Non-small Cell Lung Cancer, Urothelial Cancer and Malignant Mesothelioma
This study will combine cabozantinib with pemetrexed to treat patients with non-small cell lung cancer, urothelial cancer and advanced malignant mesothelioma.
- Conditions
- Non Small Cell Lung Cancer, Non-squamous Non-small-cell Lung Cancer, Urothelial Carcinoma, Malignant Mesothelioma
- Trial name
- NCT04173338
- Testing
- Cabozantinib, Pemetrexed
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Augusta University
Lung Cancer, Malignant Mesothelioma
Vaccine Therapy in Treating Patients With Stage I, Stage II, or Stage IIIA Non-small Cell Lung Cancer or With Stage I or Stage II Mesothelioma
RATIONALE: Vaccines made from a person's tumor may help the body build an immune response to kill tumor cells. PURPOSE: Phase I trial to study the effectiveness of vaccine therapy in treating patients who have undergone surgery…
- Trial name
- NCT00003974
- Testing
- lung tumor associated antigen, DetoxPC, chemotherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roswell Park Cancer Institute
Lung Neoplasms, Carcinoma, Non-Small-Cell Lung
Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers
CK-301 (cosibelimab) is a fully human monoclonal antibody of IgG1 subtype that directly binds to Programmed Death-Ligand 1 (PD-L1) and blocks its interactions with the Programmed Death-1 (PD-1) and B7.1 receptors.
- Conditions
- Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell, Malignant Mesothelioma, Advanced
- Trial name
- NCT03212404
- Testing
- CK-301 (cosibelimab)
- Where
- 48 sites in Australia, France and 7 more
- Volunteers
- 272 people
- Sponsor
- Checkpoint Therapeutics, Inc.
Non Small Cell Lung Cancer, Nasopharyngeal Cancer
Evaluating Endostatin Plus TC Regimen in Secondary Malignant Neoplasm of Liver Using Contrast Enhancement Ultrasonography
Contrast enhancement ultrasonography（CEUS）could be used to evaluate the blood flow perfusion liver cancer. In this clinical trial, CEUS was used to evaluated the changes of blood flow perfusion of Secondary Malignant Neoplasm of…
- Conditions
- Non Small Cell Lung Cancer, Nasopharyngeal Cancer, Liver Metastasis
- Trial name
- NCT01347424
- Testing
- Paclitaxel , carboplatin, endostatin, Paclitaxel and Carboplatin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-sen University