Clinical trials: Malignant Neoplasm of Female Breast
Breast Cancer, Lung Cancer
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
This study will investigate the effects of atezolizumab on select cancer types in people whose analysis of tumour DNA and RNA indicates they may be sensitive to atezolizumab.
- Conditions
- Breast Cancer, Lung Cancer, Gastrointestinal Cancer, Genitourinary Cancer
- Trial name
- CAPTIV-8 (NCT04273061)
- Testing
- Atezolizumab
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- British Columbia Cancer Agency
Breast Cancer Female
In Vitro Detection of Tissue Abnormality
Intraoperative ex-vivo use of the ClearEdge Imaging Device in Breast Conserving Surgery to image the excised tissue surgical margins.
- Trial name
- NCT01209182
- Testing
- Testing a new device (LS BioPath TOUCH) on excised tissue
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- LS BioPath
Breast Neoplasm Malignant Female
Omission of Local Therapies in Women Patients With HER2-positive or Triple-negative Breast Cancer
HER2-positive and Triple-negative are subtypes of breast cancer more sensitive to systemic therapies, where the complete pathological response rate may be higher than 50%.
- Trial name
- OLT (NCT06938724)
- Testing
- Omission of local therapies
- Where
- Italy
- Volunteers
- 152 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Female Breast Cancer, Depression
An Intervention for Female Breast CANcer: Acceptance and Commitment Therapy (I-CAN-ACT) for Depression and Physical Pain
As a result of the cancer diagnosis and medical therapies, women with breast cancer often encounter debilitating cooccurring psychological and physical symptoms.
- Conditions
- Female Breast Cancer, Depression, Pain
- Trial name
- I-CAN-ACT (NCT05374161)
- Testing
- Acceptance and Commitment Therapy, Waitlist Control Group
- Where
- Cyprus
- Volunteers
- 88 people
- Sponsor
- University of Cyprus
Breast Cancer Female, Insomnia
Comparative Effectiveness Feasibility Trial for Insomnia Among Breast Cancer Survivors
Women with breast cancer who report insomnia that started or worsened during breast cancer diagnosis and treatment will be enrolled in a group behavioral trial to one of two arms testing cognitive behavioral therapy for insomnia…
- Trial name
- NCT03328169
- Testing
- Mindfulness-Based Therapy, Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- George Washington University
Advanced Cancers
Lenalidomide in Combination With Bevacizumab, Sorafenib, Temsirolimus, or 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX)
The goal of this clinical research study is to find the highest tolerable doses of the combinations of lenalidomide and other drugs that can be given to patients with advanced cancer.
- Trial name
- NCT01183663
- Testing
- Lenalidomide, Bevacizumab, Sorafenib
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- M.D. Anderson Cancer Center
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Social Health, Activity Behaviors, and Quality of Life Among Young Adult Cancer Survivors
This longitudinal observational study examines how social health, including social support, social roles, loneliness, social anxiety, and social network characteristics, relates to physical activity, sedentary time, and quality…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT07259304
- Testing
- Medical Device Usage and Evaluation, Quality-of-Life Assessment, Survey Administration
- Where
- 3 sites in United States
- Volunteers
- 173 people
- Sponsor
- University of Southern California
Breast Cancer Female, Breast Cancer Recurrent
18F-FDG PET/CT Imaging for Breast Cancer
Purpose To investigate the ability of 18F-FDG PET/CT imaging to detect metastases not detected by conventional imaging (CT and bone scintigraphy) in patients diagnosed with stage II/III and locoregional recurrent breast cancer…
- Trial name
- NCT05730608
- Testing
- 18F-FDG PET/CT
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Vestre Viken Hospital Trust
Breast Cancer Female
The Role of Magnetic Resonance Imaging in Assessment of Axillary Lymph Nodes Metastasis in Breast Cancer Patients.
Breast cancer is the most common cancer among women worldwide.The main cause of cancer related death is the invasion and metastasis. The usual site of spread outside the breast is to lymph nodes in the axilla.
- Trial name
- NCT03163316
- Testing
- Unenhanced magnetic resonance imaging.
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Advanced Solid Tumor, Unresectable Solid Tumor
A Beta-only IL-2 ImmunoTherapY Study
This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a…
- Conditions
- Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer
- Trial name
- ABILITY-1 (NCT05086692)
- Testing
- MDNA11, Pembrolizumab (KEYTRUDA®)
- Where
- 25 sites in United States, Australia and 6 more
- Volunteers
- 160 people
- Sponsor
- Medicenna Therapeutics, Inc.
Breast Carcinoma, Cervical Carcinoma
Support Program for Adoption of Cancer Screening Interventions at a Rural Community-Based Organization
This pilot trial study uses a structural support program for adoption of cancer screening interventions at a rural community-based organization.
- Conditions
- Breast Carcinoma, Cervical Carcinoma, Colorectal Carcinoma, Malignant Solid Neoplasm
- Trial name
- NCT04208724
- Testing
- Training, Cancer Screening intervention, Survey Administration
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Adenocarcinoma, Adenocystic Carcinoma
The Registry of Oncology Outcomes Associated With Testing and Treatment
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation.
- Conditions
- Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer
- Trial name
- ROOT (NCT04028479)
- Testing
- Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Taproot Health
Breast Cancer Female
Developing an Internet-Delivered Sexual Health Program for Breast Cancer Survivors, SHINE Trial
The goal of this clinical trial is to develop an effective internet-delivered program to help breast cancer survivors manage cancer-related sexual concerns.
- Trial name
- SHINE (NCT06216574)
- Testing
- Internet-based Intervention
- Where
- 236 sites in United States
- Volunteers
- 340 people
- Sponsor
- Wake Forest University Health Sciences
Non-small Cell Lung Cancer, Esophageal Cancer
Radiation-induced Toxicity of the Heart
Late side effects in radio(chemo)therapy [R(CH)T] pose a critical limitation to patients' overall survival and quality of life. Even though toxicities of the heart are highly relevant for patients with cancer in the thoracic…
- Conditions
- Non-small Cell Lung Cancer, Esophageal Cancer, Breast Cancer Female
- Trial name
- CorTox (NCT06986291)
- Testing
- Imaging and biomarkers
- Where
- Germany
- Volunteers
- 325 people
- Sponsor
- Technische Universität Dresden
Neoplasm, Colorectal, Neoplasm, Breast
Development, Implementation and Evaluation of an Individual Decision Aid in Swedish Cancer Screening Programs
Background: Sweden has a long tradition of organized national population-based screening programs. Participation rates differ between programs and regions, are relatively high in some groups, but lower in other.
- Conditions
- Neoplasm, Colorectal, Neoplasm, Breast, Neoplasm, Ovarian
- Trial name
- BESTa (NCT05512260)
- Testing
- Individual decision aid (iDA)
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Melanoma (Excluding Uveal Melanoma), Cervical Carcinoma
A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3)
This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity…
- Conditions
- Melanoma (Excluding Uveal Melanoma), Cervical Carcinoma, Pancreatic Carcinoma, Breast Carcinoma That is Estrogen Receptor, Progesterone Receptor, and Her2 Negative
- Trial name
- DUET-3 (NCT03752398)
- Testing
- XmAb®23104, Yervoy® (ipilimumab)
- Where
- 18 sites in United States
- Volunteers
- 198 people
- Sponsor
- Xencor, Inc.
Breast Cancer Female
Omega-3 and Vitamin D Supplementation in Breast Cancer Women
Breast cancer (BC) is the most common malignant disease, which is fifth leading cause of cancer mortality worldwide. Poor nutritional status is one of the common physical symptoms found among cancer patients, in which it is…
- Trial name
- NCT05331807
- Testing
- Omega-3 FA, Vitamin D, Combined Omega-3 and Vitamin D Supplementation
- Where
- Palestinian Territories
- Volunteers
- 88 people
- Sponsor
- Universiti Sains Malaysia
Anxiety, Stress
A New Mindfulness Intervention Called Mindfulness Based Swinging Technique (MBST) for Women With Breast Cancer
It is hypothesised to find that the new mindfulness intervention of Mindfulness Based Swinging Technique (MBST) for Women With Breast Cancer is an effective therapeutic intervention to be applied in breast cancer population.
- Conditions
- Anxiety, Stress, Self Efficacy, Depression
- Trial name
- NCT03985267
- Testing
- Mindfulness based Swinging Effect Intervention
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- University of Barcelona
Breast Neoplasm Female, Quality of Life
PRO Survivorship Concerns ITA
Breast cancer survivors typically experience fatigue, pain, insomnia, depression, anxiety, difficulty in concentrating, memory impairment, body image problems, vaginal dryness, interest in sex decreasing, hot flashes, gain…
- Conditions
- Breast Neoplasm Female, Quality of Life, Psychological Distress
- Trial name
- PRO (NCT06080607)
- Testing
- Patient Reported Outcome (PRO)
- Where
- 2 sites in Italy
- Volunteers
- 280 people
- Sponsor
- Regina Elena Cancer Institute
Vaginal Atrophy, Breast Cancer Female
Histological Modifications of Postmenopausal Vaginal Mucosa After Repeated Carbon Dioxide (CO2) Laser Treatment
To assess the long-term histological and clinical efficacy of MonaLisa Touch procedure for the management of the Genitourinary Syndrome of Menopause (GSM) in postmenopausal female patients.
- Conditions
- Vaginal Atrophy, Breast Cancer Female, Dyspareunia
- Trial name
- REPLAMOD (NCT04868812)
- Testing
- SmartXide 2 V 2 LR, MonaLisa Touch, DEKA, Florence, Italy
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS San Raffaele