Clinical trials: Malignant Pleural Effusion
Malignant Neoplasm, Malignant Respiratory Tract Neoplasm
Rapid On Site Evaluation of Pleural Touch Preparations in Diagnosing Malignant Pleural Effusion in Patients Undergoing Pleuroscopy
This trial studies how well rapid on site evaluation of pleural touch preparations works in diagnosing cancerous fluid in between the linings of the lungs (malignant pleural effusion) in patients undergoing a pleuroscopy.
- Conditions
- Malignant Neoplasm, Malignant Respiratory Tract Neoplasm, Malignant Thoracic Neoplasm
- Trial name
- NCT03868579
- Testing
- Biopsy, Medical Chart Review, Thoracoscopy
- Where
- 4 sites in United States, Cyprus
- Volunteers
- 97 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Pleural Effusion
Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population
Patients with cancer may experience problems with their breathing due to a fluid accumulation around their lungs called malignant pleural effusion (MPE).
- Trial name
- OPUS (NCT01411202)
- Testing
- Doxycycline, normal saline
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Hospital Research Institute
Malignant Pleural Effusion
Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusion
The purpose of this study is to compare the experiences of subjects who drain malignant (cancerous) pleural effusions (fluid) from around their lung(s) in a more frequent manner using a talc instilled via tunneled pleural…
- Trial name
- NCT04792970
- Testing
- Talc
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Malignant Pleural Effusion
Using Thoracic Ultrasound to Predict Pleurodesis Success in Malignant Pleural Effusions: a Pilot Study
The observational pilot study at the Churchill Hospital, funded by Oxford Respiratory Trials Unit, will assess the feasibility and efficacy of thoracic ultrasound (TUS) assessment in patients undergoing talc pleurodesis via…
- Trial name
- NCT02625675
- Testing
- Ultrasound scan
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Oxford
Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer
Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
This randomized phase II trial is studying how well giving docetaxel together with either cetuximab or bortezomib works as first-line therapy in treating patients with stage III or stage IV non-small cell lung cancer.
- Conditions
- Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer, Large Cell Lung Cancer, Malignant Pleural Effusion
- Trial name
- NCT00118183
- Testing
- docetaxel, cetuximab, bortezomib
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Cancer Institute (NCI)
Pulmonary Disease, Postoperative Respiratory Complications
Screening of Postoperative Pulmonary Complications by Electrical Impedance Tomography
The purpose of this study is to determine whether Electrical Impedance Tomography can be used as sensitive and specific predictor in the detection of postoperative pulmonary complications (e.g.
- Conditions
- Pulmonary Disease, Postoperative Respiratory Complications, Malignant Neoplasm of Stomach, Liver Diseases
- Trial name
- NCT02337673
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Johannes Gutenberg University Mainz
Lung Cancer
Intra-pleural Administration of GL-ONC1, a Genetically Modified Vaccinia Virus, in Patients With Malignant Pleural Effusion: Primary, Metastases and Mesothelioma
The purpose of this study is to test the safety of the GL-ONC1 vaccinia virus at different dose levels. The investigators want to find out what effects, good and/or bad, it has on the patient and the malignant pleural effusion.
- Trial name
- NCT01766739
- Testing
- GL-ONC1
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pleural Effusion, Malignant, Prognosis
Longitudinal Follow up of Patients With Pleural Effusion
This study aims to evaluate the clinical course of patients diagnosed with pleural effusion and determine various clinical factors and biomarkers associated that can predict the diagnosis and clinical outcome and prognosis of…
- Trial name
- NCT04670562
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Bundang Hospital
Pleural Effusion, Pleural Effusion, Malignant
PMCF Study of the CE-marked Drainova® ArgentiC Catheter
The goal of this observational study is to learn about the performance of the drainova® ArgentiC Catheter in clinical routine, which is used to treat fluid accumulations in hollow body structures.
- Conditions
- Pleural Effusion, Pleural Effusion, Malignant, Ascites, Ascites, Malignant
- Trial name
- NCT06436807
- Testing
- Indwelling catheter
- Where
- 12 sites in Germany
- Volunteers
- 169 people
- Sponsor
- ewimed GmbH
Carcinoma, Non-Small-Cell Lung
Ph I:Bevacizumab + Chemotherapy in Pts w/Malig Pleural Effusion Due to Adv NSCLC
Your lung cancer has caused fluid to build up in the space around your lung. This fluid is called a malignant pleural effusion. This fluid takes up space in your chest, and prevents your lung from fully filling with air.
- Trial name
- NCT00250978
- Testing
- bevacizumab with chemotherapy, Pleur-XTM catheter placement
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pleural Effusion, Malignant
Impact of Aggressive Versus Standard Drainage Regimen Using a Long Term Indwelling Pleural Catheter
Purpose and Objective: The purpose of this study is to determine if the rate of spontaneous pleurodesis using the Pleurx® catheter could be increased by simply increasing the frequency of pleural drainage and, if so, whether…
- Trial name
- ASAP (NCT00978939)
- Testing
- Standard Drainage Instructions, Aggressive Drainage Instructions
- Where
- 6 sites in United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Malignant Pleural Effusion, Non-small Cell Lung Cancer
Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study.
Oncological treatment of patients with disseminated non-small cell lung cancer (NSCLC) is depending on the status of programmed death-ligand 1 (PD-L1), anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR)…
- Trial name
- NCT04806412
- Testing
- meassurement of PD-L1, ALK, EGFR
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Naestved Hospital
Malignant Pleural Effusion, Malignant Mesothelioma
Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease
This research study aims to evaluate the safety and effectiveness of a novel immunotherapy, Fast TIL, an Adoptive Cellular Therapeutic (ACT), to fight cancer that has spread to the pleura or pleural mesothelioma.
- Conditions
- Malignant Pleural Effusion, Malignant Mesothelioma, Pleural Effusion, Malignant, Metastasis to Pleura
- Trial name
- (RIOT 4A) (NCT07192900)
- Testing
- locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- David Bartlett, MD
Lung Cancer, Non-Small Cell
A Phase II Study of AK112 (PD1/VEGF Bispecific) in Combination with Chemotherapy in Patients with NSCLC
This is a phase II study. All patients are stage IV non-squamas non-small cell lung cancer(NSCLC) with malignant pleura effusion, Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
- Trial name
- NCT06769295
- Testing
- AK112
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Sichuan University
Non-Small Cell Lung Cancer
A Study of Cetuximab and Bevacizumab in Combination With Paclitaxel and Carboplatin in Stage IIIb/IV NSCLC
The primary objective of this study will be to determine the progression free survival of patients with stage IIIb/IV non-small cell lung cancer (NSCLC) treated with dual agent monoclonal antibody therapy consisting of cetuximab…
- Trial name
- NCT00343291
- Testing
- Cetuximab, Bevacizumab, Paclitaxel
- Where
- 43 sites in United States
- Volunteers
- 121 people
- Sponsor
- Eli Lilly and Company
Advanced Cancer, Pleural Effusion
Intrapleural Catheter Daily Versus Three Times a Week Drainage
The goal of this clinical research study is to learn if draining the IPC every day is better at than draining it 3 times a week.
- Trial name
- NCT00761618
- Testing
- Intrapleural catheter (IPC) drained, IPC Placement, Chest X-Ray
- Where
- United States
- Volunteers
- 257 people
- Sponsor
- M.D. Anderson Cancer Center
Pleural Effusion, Malignant, Lung Cancer Stage IV
Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion
Malignant pleural effusion (MPE) is a very common medical condition, especially among patients with disseminated cancers. Chest drain insertion aims to drain the pleural fluid collection and relieve dyspnea.
- Conditions
- Pleural Effusion, Malignant, Lung Cancer Stage IV, Chest Tubes
- Trial name
- NCT04669223
- Testing
- Seldinger chest drain insertion
- Where
- Hong Kong
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Non Small Cell Lung Cancer
Efficacy and Safety Study of Medical Thoracoscope Cryotherapy Combined Standard First-line Treatment of Advanced Non-small Cell Lung Cancer and Malignant Pleural Effusion
This study intends to investigate the efficacy and safety of medical thoracoscopic cryotherapy combined with standard first-line treatment of advanced non-small cell lung cancer with malignant pleural effusion through a…
- Trial name
- NCT05291403
- Testing
- Medical thoracoscopic cryotherapy combined with standard first-line therapy for advanced non-cell lung cancer, Sequential intrathoracic injection of cisplatin/erythromycin combined with standard first-line therapy for advanced non-cell lung cancer, Standard first-line therapy for advanced non-cell lung cancer without intrathoracic treatment
- Where
- China
- Volunteers
- 141 people
- Sponsor
- Qianfoshan Hospital
Pleural Effusion, Malignant
Management of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis
The primary goal of this study is to compare well-defined pleural effusion management success outcomes in patients with malignant or paramalignant pleural effusions who were treated with Indwelling pleural catheter insertion…
- Trial name
- NCT03781908
- Testing
- Silver Nitrate, Indwelling Pleural Catheter
- Volunteers
- 50 people
- Sponsor
- Assiut University
Malignant Mesothelioma, Metastatic Cancer
Mesothelin and Osteopontin as Diagnostic Markers in Patients With Mesothelioma or Atypical Mesothelial Hyperplasia
RATIONALE: Studying levels of mesothelin and osteopontin in samples of blood from patients with mesothelioma or atypical mesothelial hyperplasia may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00899613
- Testing
- laboratory biomarker analysis, study of high risk factors
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Caen