Clinical trials: Malignant Solid Tumours
Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma
CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma
The objective of this study is to assess the safety and efficacy of mecbotamab vedotin (BA3011) in solid tumors.
- Trial name
- NCT03425279
- Testing
- CAB-AXL-ADC, PD-1 inhibitor
- Where
- 40 sites in United States, Hong Kong and 1 more
- Volunteers
- 245 people
- Sponsor
- BioAtla, Inc.
Metastatic Solid Tumors
Study of QLC5513 in Combination With Epalolimab Tovolimab (QL1706) ± Platinum in Patients With Advanced or Metastatic Malignant Solid Tumors
The goal of this Phase Ib/II interventional study is to evaluate the safety, tolerability, pharmacokinetics and efficacy of QLC5513 combined with QL1706± platinum in the treatment of patients with advanced or metastatic malignant…
- Trial name
- NCT07272590
- Testing
- QLC5513 IV infusion, QL1706, IV infusion, platinum, IV infusion
- Volunteers
- 290 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm
The Impact of COVID-19 on Pulmonary Procedures
This study investigates the changes in practice by pulmonary procedural programs across the United States as they faced the coronavirus pandemic.
- Conditions
- COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT05022446
- Testing
- Survey Administration
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Solution-Focused Brief Therapy for Support of Psychological Distress in Adolescent and Young Adult Cancer Survivors
This clinical trial evaluates the how well a virtually delivered solution-focused brief therapy (SFBT-C) works to decrease adolescent and young adult cancer survivors' psychological distress in comparison to enhanced…
- Trial name
- NCT06941324
- Testing
- Behavioral Intervention, Best Practice, Communication Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan Rogel Cancer Center
Solid Tumor
A Study of RC148 As a Single Agent and Combination Therapy in Patients with Locally Advanced Unresectable or Metastatic Malignant Solid Tumors
The primary objective of Phase I of this trial is to evaluate the safety, tolerability, maximum tolerated dose (MTD)/maximum administered dose (MAD) of RC148 in patients with locally advanced unresectable or metastatic solid…
- Trial name
- NCT06016062
- Testing
- RC148 Monotherapy, RC148+docetaxel Combination Therapy, RC148+RC48 Combination Therapy
- Where
- 31 sites in China
- Volunteers
- 221 people
- Sponsor
- RemeGen Co., Ltd.
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Evaluation of an Education Program to Increase Knowledge and Participation in Clinical Trials Among Racial/Ethnic and Rural Populations
This clinical trial evaluates a culturally tailored educational outreach intervention for increasing clinical trial knowledge, referral, and participation among racial/ethnic minority and rural populations.
- Trial name
- NCT06112002
- Testing
- Educational Intervention, Health Education, Survey Administration
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cutaneous Tumor, Malignant Solid Tumor
Study to Evaluate JCXH-211 as Monotherapy in Patients With Malignant Solid Tumors
: A Phase 1 Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of JCXH-211 Intratumoral Injection in Patients with Malignant Solid Tumors
- Trial name
- NCT05727839
- Testing
- JCXH-211 Injection
- Where
- 2 sites in United States, China
- Volunteers
- 19 people
- Sponsor
- Immorna Biotherapeutics, Inc.
Advanced Malignant Solid Neoplasm, Bile Duct Carcinoma
Afatinib Dimaleate and Capecitabine in Treating Patients With Advanced Refractory Solid Tumors, Pancreatic Cancer or Biliary Cancer
This phase I/Ib trial studies the side effects and best dose of afatinib dimaleate when given together with capecitabine in treating patients with solid tumors, pancreatic cancer, or biliary cancer that has spread to other places…
- Conditions
- Advanced Malignant Solid Neoplasm, Bile Duct Carcinoma, Recurrent Malignant Solid Neoplasm, Recurrent Pancreatic Carcinoma
- Trial name
- NCT02451553
- Testing
- Afatinib Dimaleate, Capecitabine, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Washington
Malignant Lymphomas, Solid Tumors
Allogeneic Natural Killer (NK) Cell Therapy in Patients With Lymphoma or Solid Tumor
Allogeneic natural killer (NK) cells (MG4101) were manufactured from normal healthy donor who underwent leukapheresis. These cells were processed based on a novel method for ex vivo activation and expansion using an irradiated…
- Trial name
- MG4101 (NCT01212341)
- Testing
- Allogeneic NK cells
- Where
- South Korea
- Volunteers
- 18 people
- Sponsor
- Seoul National University Hospital
Stage III Cutaneous Melanoma, Stage IV Cutaneous Melanoma
Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies
This phase I trial studies the best dose and side effects of abexinostat and how well it works with given together with pembrolizumab in treating participants with microsatellite instability (MSI) solid tumors that have spread to…
- Conditions
- Stage III Cutaneous Melanoma, Stage IV Cutaneous Melanoma, Locally Advanced Melanoma, Locally Advanced Solid Neoplasm
- Trial name
- NCT03590054
- Testing
- Abexinostat, Pembrolizumab
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Rahul Aggarwal
Malignant Solid Tumour
Vorinostat in Combination With Vinorelbine in Patients With Advanced Cancer
This is a multi-center, open-label non-randomized dose-escalation trial of vorinostat given in combination with vinorelbine. Cohorts will be treated with a fixed dose of vinorelbine (25mg/m²/week continuously, representing the…
- Trial name
- NCT00801151
- Testing
- Zolinza (vorinostat), vinorelbine
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Institut Claudius Regaud
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Vincristine Pharmacokinetics in Infants
This pilot trial compares drug exposure levels using a new method for dosing vincristine in infants and young children compared to the standard dosing method based on body surface area (BSA) in older children.
- Trial name
- NCT05359237
- Testing
- Biospecimen Collection, Vincristine
- Where
- 29 sites in United States, Australia and 1 more
- Volunteers
- 83 people
- Sponsor
- Children's Oncology Group
Refractory Malignant Solid Neoplasm, Osteosarcoma
AOH1996 for the Treatment of Refractory Solid Tumors
This phase I trial studies the side effects and best dose of AOH1996 in treating patients with solid tumors that do not respond to treatment (refractory).
- Conditions
- Refractory Malignant Solid Neoplasm, Osteosarcoma, Leiomyosarcomas, Synovial Sarcomas
- Trial name
- NCT05227326
- Testing
- PCNA Inhibitor AOH1996
- Where
- 3 sites in United States
- Volunteers
- 92 people
- Sponsor
- City of Hope Medical Center
Malignant Solid Tumor - Malignant Nervous System Neoplasm
Safety and Efficacy of Cabazitaxel in Pediatric Patients With Refractory Solid Tumors Including Central Nervous System Tumors
Primary Objectives: Phase 1 Part: To determine the dose limiting toxicity (DLT) and the maximum tolerated dose (MTD) of cabazitaxel as a single agent in pediatric participants with recurrent or refractory solid tumors including…
- Trial name
- NCT01751308
- Testing
- Cabazitaxel (XRP6258)
- Where
- 13 sites in United States, Canada
- Volunteers
- 39 people
- Sponsor
- Sanofi
Advanced Solid Tumors
A Study to Evaluate the Efficacy and Safety of QL1706 Injection in Patients With Solid Tumors
This a multi-center, open-label, non-randomized phaseⅠb trail. The purpose of this study was to evaluate the efficacy and safety of QL1706 in patients with advanced solid tumors and to investigate the immunogenicity and…
- Trial name
- NCT05171790
- Testing
- QL1706 injection
- Where
- China
- Volunteers
- 419 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing BVD-523FB (Ulixertinib) as Potentially Targeted Treatment in Cancers With Genetic Changes (MATCH - Subprotocol Z1L)
This phase II MATCH treatment trial tests how well BVD-523FB (ulixertinib) works in treating patients with cancer that has certain genetic changes.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Refractory Lymphoma, Refractory Malignant Solid Neoplasm
- Trial name
- NCT06400225
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Neoplasms Malignant
A Study of AK112, a PD-1/VEGF Bispecific Antibody, for Advanced Solid Tumors
This study is to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD) and anti-tumor activity of AK112, a PD-1/VEGF bispecific antibody, as a single agent in adult subjects with…
- Trial name
- NCT04047290
- Testing
- AK112
- Where
- 7 sites in Australia
- Volunteers
- 80 people
- Sponsor
- Akesobio Australia Pty Ltd
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
A Wearable Biosensor Patch for Non-Invasive Monitoring for Patients Undergoing Abdominal or Chest Surgery
This clinical trial tests the feasibility and safety of a wearable biosensor patch for non-invasive monitoring for patients undergoing abdominal or chest surgery.
- Trial name
- NCT07612085
- Testing
- Biospecimen Collection, Electronic Health Record Review, Interview
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Advanced Malignant Solid Tumors
A Study of Axl Inhibitor FC084CSA in Patients With Advanced Malignant Solid Tumors
This is a phase I clinical study to evaluate safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of Axl inhibitor FC084CSA in patients with advanced malignant solid tumors who have failed standard…
- Trial name
- NCT06231550
- Testing
- FC084CSA tablets
- Where
- China
- Volunteers
- 21 people
- Sponsor
- FindCure Biosciences (ZhongShan) Co., Ltd.
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Evaluation of Early Identification of Cognitive Side Effects of Immunotherapy
This clinical trial evaluates the use of a tool kit, Stress, Affect, Language and Speech Analysis (SALSA), for early identification of cognitive side effects of immunotherapy compared to the standard of care assessment.
- Trial name
- NCT06414278
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
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