Clinical trials: Malnutrition, Severe Acute
Stunting, Severe Acute Malnutrition
Changes in Nerve Electro Physiologic Properties in Children Before and After Correction of Malnutrition
The goal of this clinical trail study is to measure neurophysiologic parameters to assess the effect of malnutrition on the peripheral nervous system and their response to treatment in three categories (SAM, severe wasting, and…
- Conditions
- Stunting, Severe Acute Malnutrition, Wasting
- Trial name
- NCT05891457
- Testing
- Nutritional Intervention
- Where
- Bangladesh
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Malnutrition
L-Carnitine Supplementation, Rate of Weight Gain and EED in Children With SAM
Background: Burden: Globally, an estimated 14.3 million under-5 children are severely malnourished. Two-thirds of them live in Asian countries, including Bangladesh.
- Trial name
- NCT05083637
- Testing
- L- carnitine oral solution
- Where
- Bangladesh
- Volunteers
- 98 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Severe Acute Malnutrition, Moderate Acute Malnutrition (MAM)
Regular Growth Monitoring (RGM) of Young Children in Guinea-Bissau
Wasting (severe thinness) is a common and serious problem among young children in rural Guinea-Bissau. Community Health Agents (CHAs) can help prevent malnutrition by regularly measuring children's growth and advising families on…
- Trial name
- NCT07584395
- Testing
- Regular Growth Monitoring (RGM) by Community Health Agents
- Where
- Guinea-Bissau
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
Old Age; Cachexia, Dietary Habits
The Nutritionist's Educational Intervention on the Protein Intake in Hospitalized Elderly People
The food intake is often compromised in the elderly, and during hospitalization, dietary restrictions may be imposed, making them more susceptible to the risk of malnutrition and sarcopenia.
- Conditions
- Old Age; Cachexia, Dietary Habits, Sarcopenia, Protein Malnutrition
- Trial name
- NCT05502445
- Testing
- educational intervention
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Hospital Israelita Albert Einstein
Severe Acute Malnutrition
Modified Dosage for Severe Acute Malnutrition
Protocols for the community-based management of acute malnutrition (CMAM) have not changed significantly for more than 20 years, with relatively complex treatment protocols and persistent supply chain challenges that have limited…
- Trial name
- MODAM-SAM (NCT06061484)
- Testing
- ready-to-use therapeutic food (RUTF), Amoxicillin
- Where
- 3 sites in Ethiopia
- Volunteers
- 2,400 people
- Sponsor
- Action Against Hunger USA
Severe Acute Malnutrition in Childhood
Severe Acute Malnutrition and Child Development Clinical Trial in Mwanza
This is a randomized clinical trial to learn whether ready-to-use therapeutic foods enriched with choline and docosahexaenoic acid (DHA) together with psychosocial stimulating activities work well to improve child development in…
- Trial name
- BRIGHTSAM (NCT06781918)
- Testing
- Ready to Use Therapeutic Food (RUTF), Psychosocial stimulation
- Where
- Tanzania
- Volunteers
- 800 people
- Sponsor
- National Institute for Medical Research, Tanzania
Acute Malnutrition, Severe, Malnutrition, Child
Expanding Coverage of Severe Acute Malnutrition (SAM) Treatment in Kenya
Child wasting is a type of malnutrition which occurs when a child becomes too thin. This medical condition increases the risk of becoming sick or dying.
- Conditions
- Acute Malnutrition, Severe, Malnutrition, Child, Wasting
- Trial name
- R-SWITCH (NCT06441305)
- Testing
- SWITCH intervention package
- Where
- Kenya
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Uncomplicated Severe Acute Malnutrition
Effects of Three Feeding Regimens on Recovery of Uncomplicated Severely Acute Malnourished Children
This project aims to assess the efficacy of three options under consideration in India for home management of Severe Acute Malnutrition (SAM).
- Trial name
- SAMPOORNA (NCT01705769)
- Testing
- Ready to Use Therapeutic Food-Centrally produced, Ready to Use Therapeutic Food-Locally produced, High energy and micronutrient rich foods
- Where
- 3 sites in India
- Volunteers
- 911 people
- Sponsor
- Society for Applied Studies
Malnutrition
Optimising Antibiotic Treatment for Sick Malnourished Children
Children with severe malnutrition who are admitted sick to hospitals have a high mortality, usually because of infection. All children with severe malnutrition admitted to hospitals are treated with antibiotics.
- Trial name
- FLACSAM-PK (NCT02746276)
- Testing
- Ceftriaxone, Metronidazole
- Where
- Kenya
- Volunteers
- 81 people
- Sponsor
- University of Oxford
Iron Absorption, Iron Deficiencies
Maximizing the Benefits of Iron in Ready-to-Use Therapeutic Foods for Malnourished Children in Kenya
Reports from the Kenya Red Cross Society (KRCS) in Kwale County, southern Kenya, indicate a limited impact of Ready-to-Use Therapeutic Foods (RUTFs) on malnutrition or anemia.
- Conditions
- Iron Absorption, Iron Deficiencies, Severly Acutely Malnourished Children, Malnutrition in Children
- Trial name
- SAMI (NCT07315295)
- Testing
- Iron absorption from RUTF on Day 0, Treatment with RUTF for 80 days, Iron absorption from RUTF on Day 20
- Where
- 2 sites in Kenya, Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- ETH Zurich
Severe Acute Malnutrition
Therapeutic Approaches to Malnutrition Enteropathy
The TAME study will evaluate four new approaches which will be compared against the standard care currently in use in the treatment of malnutrition enteropathy in children with severe acute malnutrition.
- Trial name
- TAME (NCT03716115)
- Testing
- Colostrum high protein powder (Neovite), N-Acetyl Glucosamine (GInNAC), Teduglutide
- Where
- 3 sites in Zambia, Zimbabwe
- Volunteers
- 125 people
- Sponsor
- Queen Mary University of London
Marasmus
Effectiveness of Safe Drinking Water in Treatment of Severe Acute Malnutrition (Pakistan)
This study builds evidence on the importance of using safe drinking water during the nutritional treatment of children affected by Severe Acute Malnutrition (SAM).
- Trial name
- NCT02751476
- Testing
- Point of Use (PoU) water treatment flocculent disinfectant., Point of Use (PoU) water treatment chlorine disinfectant, Point of Use (PoU) ceramic water filter
- Volunteers
- 820 people
- Sponsor
- Action Contre la Faim
Protein Malnutrition, Vitamin Deficiency
Evaluation of Protein Intake and Micronutrient Supplementation After Bariatric Surgery
Obesity is a chronic disease in which accumulation of excess body fat can result in impaired health. In cases of severe obesity, weight loss surgery can be necessary as a treatment.
- Conditions
- Protein Malnutrition, Vitamin Deficiency, Mineral Deficiency, Trace Element Deficiency
- Trial name
- BOP (NCT04587076)
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- University Medicine Greifswald
Child Nutrition Disorders
Nutritional Intervention For The Treatment Of Uncomplicated SAM
nutritional intervention with ready to use therapeutic food (plumpy nut. by Unicef) and Prebiotics supplimentation ( Galactooligosaccarides).
- Trial name
- SAM (NCT05390437)
- Testing
- Nutritional intervention with Ready to use theraputic food (RUTF) and prebiotic GOS (galacto oligosaccharides) in combination
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Sanaullah Iqbal
Severe Acute Malnutrition in Childhood
Development and Field Testing of Ready-to-use-therapeutic Foods Made of Local Ingredients in Bangladesh for SAM Children
Around 0.5 million under-five children are currently suffering from severe acute malnutrition (SAM) in Bangladesh and are at risk of death. Children with SAM and complications should be treated in a health care facility.
- Trial name
- NCT01889329
- Testing
- RUTF-1, RUTF-2, Plumpynut
- Where
- Bangladesh
- Volunteers
- 490 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Children, Malnutrition
Evaluation of Energy Expenditure, Body Composition and Recovery Rates in Children With Severe Acute Malnutrition
This project is being conducted with an aim to find out energy expenditure, body composition and recovery rates in children with severe acute malnutrition (SAM) receiving community-based nutritional rehabilitation therapy
- Trial name
- NCT01144806
- Testing
- Nutrition education, RUTF
- Where
- 2 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Aga Khan University
Microbiota, Complementary Food
Community-based Clinical Trial With Microbiota Directed Complementary Foods (MDCFs) Made of Locally Available Food Ingredients for the Management of Children With Post-severe Acute Malnutrition Moderate Acute Malnutrition (Post-SAM MAM)
Background (brief): 1. Burden: A total of 52 million children under 5 are suffering from acute malnutrition globally, of whom 33 million suffer from moderate acute malnutrition (MAM).
- Conditions
- Microbiota, Complementary Food, Nutrition
- Trial name
- NCT04015986
- Testing
- Microbiota Directed Complementary Food-2, Ready to Use Supplementary Food
- Where
- Bangladesh
- Volunteers
- 124 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Acute Malnutrition in Childhood, Wasting
Treatment of Acute Malnutrition in Outpatient Care Services in Venezuela: a Prospective Cohort Research
The goal of this observational study is to compare the effectiveness, safety, and efficiency of the simplified protocol, which includes the following three modifications: a) use of a single treatment product (RUTF), b) reduced…
- Conditions
- Acute Malnutrition in Childhood, Wasting, Child Malnutrition
- Trial name
- NCT06287827
- Testing
- Simplified protocol, Standard protocol
- Where
- 4 sites in Venezuela
- Volunteers
- 299 people
- Sponsor
- UNICEF - Venezuela
Severe Acute Malnutrition
RECIPE BASED F100 INTERVENTION FOR NUTRITIONAL EFFICACY IN SAM (REFINE-SAM )
This open-label randomized controlled trial evaluates the efficacy and safety of multiple formulations of the F-100 therapeutic feed during the rehabilitation phase among children aged 6-59 months with SAM, in comparison to…
- Trial name
- REFINE-SAM (NCT07130877)
- Testing
- WHO F100, WHO RECIPE BASED F100
- Where
- 2 sites in Pakistan
- Volunteers
- 114 people
- Sponsor
- Children's Hospital and Institute of Child Health, Multan