Clinical trials: Malnutrition
Critical Illness, Malnutrition
RCT: Early Feeding After PEG Placement
Randomized controlled trial to establish evidence on which to base timing of enteral feeding after bedside PEG placement in ventilated Trauma and Surgical ICU patients.
- Conditions
- Critical Illness, Malnutrition, Gastrostomy, Procedural Sequelae
- Trial name
- PEG (NCT04110613)
- Testing
- noFast: Start tube feeds within 1 hour of procedure
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Carilion Clinic
Cancer of Stomach, Cancer of Esophagus
GLIM-defined Malnutrition Criteria for Postoperative Outcomes in Patients With Esophagogastric Cancer
The present study aims to investigate the prognostic value of preoperative fat-free mass index for postoperative outcomes in patients undergoing esophagogastric cancer surgery, and to explore the role of the FFMI in the Global…
- Conditions
- Cancer of Stomach, Cancer of Esophagus, Malnutrition, Muscle Loss
- Trial name
- NCT05088304
- Testing
- no intervention
- Volunteers
- 205 people
- Sponsor
- Jinling Hospital, China
Water-Related Diseases
SAFEWATER Health & Behaviour Impact Field Trials; Mexico
At least 1.8 billion people globally use a source of drinking water that is faecally contaminated and thus likely to lead to diarrheal illness: nearly 1,000 children die each day due to water and sanitation-related diarrhoeal…
- Trial name
- NCT04736615
- Testing
- SAFEWATER systems for drinking water disinfection, Behavior change interventions
- Where
- 3 sites in Colombia, Mexico
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Water-Related Diseases
SAFEWATER Health & Behaviour Impact Field Trials; Colombia
At least 1.8 billion people globally use a source of drinking water that is faecally contaminated and thus likely to lead to diarrheal illness: nearly 1,000 children die each day due to water and sanitation-related diarrhoeal…
- Trial name
- SAFEWATER (NCT04829981)
- Testing
- SAFEWATER systems for drinking water disinfection, Behaviour change interventions
- Where
- 3 sites in Colombia, Mexico
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Fetal Alcohol Syndrome, HIV
Neighborhood Alcohol & HIV Prevention in South African Townships (Philani)
The purpose of this study is to test a mother-to-mother intervention during pregnancy and after delivery with mothers in South Africa, most of whom are at risk delivering babies with fetal alcohol syndrome, babies that are…
- Conditions
- Fetal Alcohol Syndrome, HIV, Nutrition Disorders
- Trial name
- NCT00996528
- Testing
- Philani Intervention Program
- Where
- South Africa
- Volunteers
- 1,239 people
- Sponsor
- University of California, Los Angeles
HIV, Partner Violence
Improving South African Government Workers' Capacities to Deliver HIV Interventions
The purpose of this study is to address the United States Office of AIDS Research highest priorities: improving the workforce, reducing health disparities, and addressing HIV comorbidities.
- Conditions
- HIV, Partner Violence, Malnutrition, Alcohol Use/Abuse
- Trial name
- NCT02957799
- Testing
- Accountable Condition, Control Condition
- Where
- 2 sites in South Africa
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Malnutrition, Enteropathy
Identification of Novel Bio-markers for Environmental Enteropathy in Children Using an Evidence Based Approach
EE is increasingly recognized as a key factor underlying malnutrition, weakened immune response and impaired cognitive development in children in developing countries.
- Trial name
- EE (NCT05072834)
- Testing
- Upper Gastrointestinal Endoscopy
- Where
- Pakistan
- Volunteers
- 380 people
- Sponsor
- Aga Khan University
Emergencies, Surgery
Impact of Nutritional Deficit in Emergency Surgery
Patients in emergency settings might become malnourished. There are different ways to identify the group as 'at risk' of malnutrition. There are also several different ways to measure outcomes.
- Conditions
- Emergencies, Surgery, Malnutrition
- Trial name
- INDIcatES (NCT04696367)
- Testing
- Emergency laparotomy
- Where
- 2 sites in United Kingdom
- Volunteers
- 59 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Glucose-Galactose Malabsorption, Enteropathy
Labelled Carbon Sucrose Breath Test (13C-SBT) as a Marker of Environmental Enteropathy
Linear growth failure, a manifestation of chronic undernutrition in early childhood, is a recalcitrant problem in resource constrained settings.
- Conditions
- Glucose-Galactose Malabsorption, Enteropathy, Malnutrition, Child, Intestinal Permeability
- Trial name
- SBT4EE (NCT04109352)
- Where
- 9 sites in Australia, Bangladesh and 6 more
- Volunteers
- 600 people
- Sponsor
- University of Virginia
Nutritional Deficiency, Hospitalism
Back Side of the Moon: Nutritional Therapy
Prospective observational follow-up of Intensive Care Unit (ICU) survivors on the adequacy of nutritional therapy: what is the mean caloric and nitrogen intake and how does their metabolic profile evolve over time? Is…
- Trial name
- NCT03724045
- Testing
- Back Side of the Moon
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitair Ziekenhuis Brussel
HIV-1-infection, Malnutrition, Child
Strategies to Reduce Mortality Among HIV-infected and HIV-exposed Children Admitted With Severe Acute Malnutrition
This study to investigate whether empiric use of an antibiotic with greater antimicrobial sensitivity (ceftriaxone) than standard-of-care (ampicillin plus gentamicin) will reduce mortality among HIV-infected/HEU children admitted…
- Trial name
- REDMOTHIV (NCT05051163)
- Testing
- Ceftriaxone Sodium, Ampicillin, Gentamicin
- Where
- Uganda
- Volunteers
- 300 people
- Sponsor
- Makerere University
Anemia, Chronic Liver Disease
Etiopathogenesis of Anemia in Chronic Liver Disease
Anemia is the most common complication of liver cirrhosis and is seen in 75% of cases. The etiology of anemia in liver disease is diverse and often multi-factorial.
- Trial name
- NCT04622449
- Where
- India
- Volunteers
- 125 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Severe Acute Malnutrition
Therapeutic Approaches to Malnutrition Enteropathy
The TAME study will evaluate four new approaches which will be compared against the standard care currently in use in the treatment of malnutrition enteropathy in children with severe acute malnutrition.
- Trial name
- TAME (NCT03716115)
- Testing
- Colostrum high protein powder (Neovite), N-Acetyl Glucosamine (GInNAC), Teduglutide
- Where
- 3 sites in Zambia, Zimbabwe
- Volunteers
- 125 people
- Sponsor
- Queen Mary University of London
Gastric Cancer, Gastrectomy
Supplemental Parenteral Nutrition During Postgastrectomy in Nutritionally at Risk Patient
If a patient undergoes gastrectomy, which is a kind of major abdominal operation, he/she loses more than 5% of his/her body weight in 2 months after surgery.
- Conditions
- Gastric Cancer, Gastrectomy, Malnutrition
- Trial name
- SUPPORT (NCT04607057)
- Testing
- Parenteral Nutrition Solutions
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Seoul National University Hospital
Poor Nutrition
Using Spices and Herbs to Increase Vegetable Intake Among Urban High School Students
A two-phase, school-based intervention will be conducted at a high school in Baltimore to evaluate whether the addition of spices and herbs to vegetable dishes in the National School Lunch Program (NSLP) can increase vegetable…
- Trial name
- NCT02908854
- Testing
- Adding spices and herbs to school lunch vegetables
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Undernourished, Digestive Cancer
Improving the Quality of Life of Cancer Patients Through a Perioperative and Coordinated Nutrition and Physical Care Program.
Hospitalization, for cancer patients, exposes to a risk of undernutrition which has the effect of significantly increasing infections, pressure ulcers, muscle wasting, loss of autonomy, impaired function and delayed healing.
- Trial name
- PENDICOQ (NCT03670199)
- Testing
- Dietary advice, Physiotherapist intervention, Dietary intervention
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Malnutrition, Child, Enteropathy
Study of Environmental Enteropathy and Malnutrition in Pakistan
Environmental Enteropathy (EE) is an acquired sub-clinical inflammatory gut condition in which alterations in intestinal structure, function, and local and systemic immune activation lead to impaired vaccine responses, decreased…
- Conditions
- Malnutrition, Child, Enteropathy, Vaccine Response Impaired, Stunting
- Trial name
- SEEM (NCT03588013)
- Testing
- Nutritional education, Ready to Use Therapeutic Food, Upper gastrointestinal endoscopy with biopsy
- Where
- Pakistan
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Sepsis, Septic Shock
Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa
Open-label phase 2a Randomized Controlled Trial (RCT) assessing the pharmacokinetics of two different doses of intravenous vitamin C given alongside vitamin B1 in adult medical patients with sepsis and hypotension.
- Conditions
- Sepsis, Septic Shock, HIV
- Trial name
- REVISTA-DOSE (NCT04999137)
- Testing
- Vitamin C, Vitamin B1
- Where
- 2 sites in Uganda
- Volunteers
- 60 people
- Sponsor
- Liverpool School of Tropical Medicine
Critical Illness, Malnutrition
The EFFORT Trial and EFFORT Outcomes Sub-study (EFFORT-Outcomes)
The investigators will evaluate the effects of higher protein/amino acid dosing (≥2.2 g/kg/d) vs usual care of protein/amino acid dosing (≤1.2 g/kg/d) over muscle mass in nutritionally high risk ill patients
- Trial name
- NCT04931940
- Testing
- Usual Care, Higher Protein/Amino Acid Group
- Where
- 2 sites in Australia, Malaysia
- Volunteers
- 142 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Deficiency; Diet, Pregnancy
Prevalence and Risk Factors for Micronutrient Deficiencies During Pregnancy in Cayenne, French Guiana
Micronutrient deficiencies are frequent in pregnant women in French Guiana, a French territory in South America. Micronutrient deficiencies are more frequent in precarious women.
- Trial name
- CarMa (NCT05022979)
- Testing
- Observational only
- Where
- French Guiana
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne