Clinical trials: Mammary Cancer
Advanced Breast Cancer, Metastatic Breast Cancer
A Clinical Trial to Compare Efficacy and Tolerability of Fulvestrant 250mg, 250mg (Plus 250mg Loading Regimen) and 500mg
This study will assess the relationship between fulvestrant dose and efficacy, and determine the dosing regimen as a second line therapy for Japanese postmenopausal women with oestrogen receptor positive advanced breast cancer.
- Trial name
- FINDER I (NCT00305448)
- Testing
- Fulvestrant
- Where
- 35 sites in Japan
- Volunteers
- 143 people
- Sponsor
- AstraZeneca
Breast Cancer
Economic and Social Disparities and Breast Cancer
Precariousness is a multifactorial concept that can be broken down in the form of economic insecurity, and / or social insecurity and / or territorial insecurity.
- Trial name
- DESSEIN (NCT02948478)
- Testing
- Exposed, Non exposed
- Where
- 24 sites in France
- Volunteers
- 936 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Adenocarcinoma, Invasive Breast Carcinoma
Nab-Paclitaxel and Atezolizumab Before Surgery in Treating Patients With Triple Negative Breast Cancer
This phase II trial studies how well nab-paclitaxel and atezolizumab before surgery work in treating patients with triple negative breast cancer (breast cancer cells that do not have estrogen receptors, progesterone receptors, or…
- Conditions
- Breast Adenocarcinoma, Invasive Breast Carcinoma, Triple-Negative Breast Carcinoma
- Trial name
- NCT02530489
- Testing
- Atezolizumab, Nab-paclitaxel
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Breast Cancer
Safety Study of Combined Immunotherapy With Trastuzumab and Cetuximab in Patients With Metastatic Breast Cancer
One important approach to change the natural history of advanced breast cancer is that of designing new combination chemotherapies in which the best drugs already available are used together with new anticancer agents devoid of…
- Trial name
- NCT00367250
- Testing
- Cetuximab, Trastuzumab
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Medical University of Vienna
Breast Cancer
Sunitinib in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer Who Have Tumor Cells in the Bone Marrow
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00824538
- Testing
- sunitinib malate, flow cytometry, immunohistochemistry staining method
- Volunteers
- 13 people
- Sponsor
- University of California, San Francisco
Breast Cancer
Prediction in Silico of Pathological Response in a Prospective Cohort Study of Early Breast Cancer Patients
Breast cancer (BC) is the most common cancer in women in France with nearly 58,500 new cases and 12,150 deaths estimated in 2018 . Two major achievements have been made in the last five years for breast cancer patients.
- Trial name
- NEOEPICURE (NCT05981326)
- Testing
- Biopsy, Blood samples, Questionnaires
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer
Bendamustine and Erlotinib in Treating Patients With Stage IIIB, Stage IIIC, or Stage IV Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as bendamustine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00834678
- Testing
- bendamustine, erlotinib, Maintenance erlotinib
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Vitamin D Deficiency, Chemotherapy Effect
Vitamin D Can Increase Pathological Response of the Breast Cancer Patients Treated With Neoadjuvant Therapy
The aim of the study is to evaluate the relationship between the vitamin D replacement and pathological response in patients undergoing neoadjuvant therapy according to different molecular sub types.
- Conditions
- Vitamin D Deficiency, Chemotherapy Effect, Pathology
- Trial name
- NCT03986268
- Testing
- Vit D
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Florence Nightingale Hospital, Istanbul
Breast Cancer
Exercise Study for Breast Cancer Survivors
This study evaluates the link between muscle health and immune health in breast cancer survivors. Regular exercise is known to improve overall survival in cancer patients but the mechanism is not known.
- Trial name
- NCT04208074
- Testing
- Exercise Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- San Diego Biomedical Research Institute
Breast Cancer
Osteopathy and Prevention of Gastrointestinal Side Effects in Women Treated for Breast Cancer
Adjuvant chemotherapy with the protocol 3 cure of 5-FU + Epirubicine + Cyclophosphamide (FEC100) and 3 cure of Taxotere is a standard treatment in the management of patients with breast cancer and in adjuvant situation.
- Trial name
- PREDIGOSTEO (NCT02840890)
- Testing
- osteopathic technique
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Centre Georges Francois Leclerc
Hereditary Cancer Syndromes, BRCA1 Hereditary Breast and Ovarian Cancer Syndrome
Strategy for Management of Patients With Hereditary Cancer Syndromes (HCS) in a Rural Environment
This study aims to improve cancer prevention and surveillance adherence in patients with Hereditary Cancer Syndromes (HCS), particularly those living in rural areas.
- Conditions
- Hereditary Cancer Syndromes, BRCA1 Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome
- Trial name
- LINC (NCT07381985)
- Testing
- Longitudinal Cancer Genetics Follow-Up Program
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Vermont Medical Center
Metastatic Breast Cancer
Real World Study Using Comprehensive Genomic Data on the Next Treatment Decision Making in Metastatic Breast Cancer
SOLTI 1903 HOPE is a national, real world clinical practice study conducted in patients diagnosed with metastatic breast cancer who are receiving, have just received or will receive treatment for its advanced disease.
- Trial name
- HOPE (NCT04497285)
- Testing
- blood sample collection and collection of tumor tissue block
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- SOLTI Breast Cancer Research Group
Metastatic Breast Cancer
Dimethyldiguanide Combined With Aromatase Inhibitor (AI) in Metastatic Breast Cancer
The addition of dimethyldiguanide might increase the efficacy of AI treatment in metastatic breast cancer.
- Trial name
- NCT01654185
- Testing
- AI plus Dimethyldiguanide, Aromatase Inhibitor
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xichun Hu
Breast Cancer, Locoregional Recurrence
Adjuvant Abemaciclib for Locoregional Recurrence of HR-positive, HER2-negative Breast Cancer (JCOG2313, AURA)
The JCOG2313 trial is a multicenter, randomized, phase III study designed to evaluate the efficacy and safety of adjuvant abemaciclib in combination with endocrine therapy versus endocrine therapy alone in patients with hormone…
- Conditions
- Breast Cancer, Locoregional Recurrence, Abemaciclib, Endocrine Therapy
- Trial name
- AURA (NCT07190443)
- Testing
- Endocrine therapy + Abemaciclib, Endocrine Therapy (ET): letrozole, anastrozole, exemestane, tamoxifen
- Where
- Japan
- Volunteers
- 290 people
- Sponsor
- Japanese Foundation for Cancer Research
Chemotherapy, Breast Cancer, Metastatic
Low-Dose/Metronomic(LDM)Chemotherapy for Metastatic Breast Cancer
Low-dose metronomic(LDM)chemotherapy as well as anti-inflammatory agents and bisphosphonates have shown anti-angiogenic properties on tumor vasculature.
- Trial name
- NCT01067989
- Testing
- Cyclophosphamide, Capecitabine, Methotrexate, Celecoxib, Pamidronate (or Zoledronate)
- Where
- Israel
- Volunteers
- 22 people
- Sponsor
- HaEmek Medical Center, Israel
Breast Cancer, Luminal B
Effect of Physical Exercise on Tumor Proliferation of Luminal B Breast Cancer Patients
Observational study to evaluate the effect of physical exercise prior to surgery and adjuvant systemic treatment in women with newly diagnosed operable hormone receptor(HR)-positive, human epidermal growth factor receptor 2…
- Trial name
- EFIK (NCT03860740)
- Testing
- Exercise, Stretching
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Spanish Breast Cancer Research Group
Breast Cancer, Breast Cancer Screening
Breast Cancer AI Imaging Study
This study aims to develop a social health platform called MammoChat (https://MammoChat.com) that allows patients to share their real-world patient data to a trusted network for development of clinical intelligence to improve…
- Trial name
- NCT06604078
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Breast Cancer
Study of Estrogen Levels in Premenopausal Women Who Have Undergone Surgery for Breast Cancer and Are Receiving Triptorelin and Tamoxifen Citrate or Exemestane on Clinical Trial IBCSG 24-02
RATIONALE: Studying samples of blood from patients with breast cancer in the laboratory may help doctors learn how well triptorelin given together with tamoxifen citrate or exemestane works in lowering estrogen levels.
- Trial name
- SOFT-EST (NCT00975676)
- Testing
- gas chromatography / tandem mass spectometry
- Where
- 24 sites in France, Hungary and 6 more
- Volunteers
- 123 people
- Sponsor
- ETOP IBCSG Partners Foundation
Ductal Carcinoma in Situ
Breast Cancer Chemoprevention by SOM230, an IGF-I Action Inhibitor
This will be a proof of principle clinical trial to evaluate the use of pasireotide (SOM230) in women with ductal carcinoma in situ (DCIS) of the breast.
- Trial name
- NCT01372618
- Testing
- SOM 230 / Pasireotide
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Breast Cancer, Prostate Cancer
68Ga-RM26-RGD PET/CT Imaging in the GRPR and αvβ3 Positive Tumor Patients
Based on the high expression of specific receptors on the surface of diseased tissues and neovascularization, noninvasive targeted molecular imaging can be used to visualize lesions in vitro by combining specific ligands labeled…
- Conditions
- Breast Cancer, Prostate Cancer, Brain Tumor, PET/CT Imaging
- Trial name
- NCT05549024
- Testing
- 68Ga-RM26-RGD, 18F-FDG, 68Ga-RM26
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Peking Union Medical College Hospital
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