Clinical trials: Mammary Cancer
Breast Cancer, Radiation Toxicity
Atrial Fibrillation and Other Cardiac Arrhythmias and Diseases After Radiotherapy for Breast Cancer : Watch Your HeaRT
The goal of this interventional study is to evaluate the risk of atrial fibrillation (AF) and other cardiac arrhythmias and diseases in breast cancer patients treated with radiation therapy (RT).
- Conditions
- Breast Cancer, Radiation Toxicity, Atrial Fibrillation, Cardiac Arrhythmia
- Trial name
- WATCH (NCT06073509)
- Testing
- Screening for atrial fibrillation and other cardiac arrhythmias and diseases
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Sophie JACOB
Breast Cancer, Physical Activity
Physical Activity Intervention to Reduce Functional Health Disparities Among Breast Cancer Survivors
The purpose of this research study is to determine whether a physical activity (exercise) program in the community will improve the functional and overall health status of older women with a history of breast cancer.
- Trial name
- NCT02763228
- Testing
- Aerobic Training - Fixed Schedule, Resistance Training - Fixed Schedule, Walking program
- Where
- 3 sites in United States
- Volunteers
- 218 people
- Sponsor
- Case Comprehensive Cancer Center
Triple Negative Breast Cancer
A Study to Evaluate Gemcitabine Plus Cisplatin in the Treatment of TNBC Patients Following Neoadjuvant Chemotherapy
This is a prospective, open-lable phase II clinical trial evaluating the effectiveness and safety of gemcitabine plus cisplatin as adjuvant treatment for non-pCR TNBC patients after standard neoadjuvant chemotherapy.
- Trial name
- nonpCR GP (NCT04297267)
- Testing
- Gemcitabine, Cisplatin
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Breast Cancer
Rapid Histologic Assessment for Stereotactic Breast Biopsy: Enhancing Early Detection With Miniature Mass Spectrometry and AI
Breast cancer is the leading cancer among Taiwanese women, and it is the second leading cause of cancer-related deaths in women.
- Trial name
- NCT06663228
- Testing
- MMS
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Hereditary Breast and Ovarian Cancer
Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers
BRCA1/2 mutation carriers have a considerably increased risk to develop breast and ovarian cancer during their lifetime. There is evidence from the literature that for sporadic breast cancer disease risk and the course of disease…
- Trial name
- LIBRE (NCT02087592)
- Testing
- Structured exercise training plus mediterranean diet
- Where
- 3 sites in Germany
- Volunteers
- 69 people
- Sponsor
- Technical University of Munich
Breast Cancer
PORTAL: Patient-reported Outcomes After Routine Treatment of Atypical Lesions
This research study is evaluating how patients feel physically and emotionally after a prior breast biopsy for specific breast conditions (including atypical lesions such as atypical ductal hyperplasia (ADH), atypical lobular…
- Trial name
- NCT03070236
- Testing
- Survey
- Where
- 6 sites in United States
- Volunteers
- 912 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Quadratic Phenotypic Optimisation Platform (QPOP) Utilisation to Enhance Selection of Patient Therapy Through Patient Derived Organoids in Breast Cancer
Based on proof-of-concept study, the investigators hypothesise that the QPOP prediction model can be further extended into use in solid tumors.
- Trial name
- QUEST (NCT05177432)
- Testing
- QPOP
- Where
- Singapore
- Volunteers
- 26 people
- Sponsor
- National University Hospital, Singapore
Breast Cancer, Invasive Breast Carcinoma
Adaptive Training Exercise Programs for Improving Cardiorespiratory Fitness After Breast Cancer Treatment, The ACTIVATE Trial
This clinical trial studies the feasibility of implementing various adaptive training exercise programs to improve cardiorespiratory fitness in patients after receiving breast cancer treatment.
- Trial name
- ACTIVATE (NCT04667481)
- Testing
- Aerobic Exercise Intervention, Resistance Exercise Intervention, Exercise Intervention: Digital copies and outline of sessions
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Washington
Breast Cancer
MyHealth: Follow-up After Breast Cancer Treatment
Approximately 24,000 women attend a follow-up care program after end of primary treatment for breast cancer (BC) in Denmark. There is no well-conducted, larger randomized controlled trials (RCT) outlining a gold standard for…
- Trial name
- MyHealth (NCT02949167)
- Testing
- MyHealth
- Where
- Denmark
- Volunteers
- 503 people
- Sponsor
- Danish Cancer Society
Risk Reduction, Mammographic Density Reduction
Low Dose Tamoxifen for Mammographic Density Reduction
KARISMA2 is a randomized, double-blinded, six-armed placebo controlled study to identify a low dose of tamoxifen, with less side-effects and a density reduction non-inferior to the standard dose of 20 mg.
- Trial name
- KARISMA2 (NCT03346200)
- Testing
- Tamoxifen Oral Tablet
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- Per Hall
Breast Cancer, Metastatic Cancer
Immune Therapy in HR-positive/HER2-negative Metastatic Breast Cancer(ENIGMA)-BCTOP-L-M02
This study is a prospective, open-label, phase II clinical study for patients with HR+/HER2- advanced breast cancer.
- Trial name
- NCT05205200
- Testing
- SHR-1316, SHR6390, Nab paclitaxel
- Where
- China
- Volunteers
- 338 people
- Sponsor
- Fudan University
Breast Carcinoma, Estrogen Receptor Positive
68-Ga-RM2 PET/MRI in Imaging Patients With Estrogen Receptor-Positive Breast Cancer
This trial studies how well 68-Ga RM2 works with PET/MRI in imaging patients with estrogen receptor-positive breast cancer. 68-Ga-RM2 is an agent used in diagnostic imaging.
- Trial name
- NCT03831711
- Testing
- Gallium Ga 68-labeled GRPR Antagonist BAY86-7548, Magnetic Resonance Imaging, Positron Emission Tomography
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Andrei Iagaru
Anatomic Stage IV Breast Cancer AJCC v8, Locally Advanced Breast Carcinoma
INCMGA00012 and Pelareorep for the Treatment of Metastatic Triple Negative Breast Cancer, IRENE Study
This is a phase 2 study to evaluate the safety and efficacy of the combination of INCMGA00012 and pelareorep and to see how well they work in treating patients with triple negative breast cancer that has spread to other parts of…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Locally Advanced Breast Carcinoma, Metastatic Triple-Negative Breast Carcinoma, Prognostic Stage IV Breast Cancer AJCC v8
- Trial name
- NCT04445844
- Testing
- Pelareorep, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Mridula George, MD
Breast Cancer, Radiation Toxicity
Pre- or Postoperative Accelerated Radiotherapy
20 non-metastasized breast cancer patients receiving neoadjuvant chemotherapy will be randomized between preop or postop RT. Patients with clinically suspicious axillary lymph nodes will receive a fine needle biopsy.
- Trial name
- POP-ART (NCT03783364)
- Testing
- Radiotherapy
- Where
- 2 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Cancer, Breast Cancer
Investigation of a Digital Healthy Habits Program for Individuals With Breast Cancer
This mixed methods study will involve obtaining user feedback on the first 4 weeks of the Healthy Habits for Cancer (HCC) Program.
- Conditions
- Cancer, Breast Cancer, Obesity, Overweight and Obesity
- Trial name
- NCT04967209
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Noom Inc.
Advanced Glioblastoma, Advanced Colorectal Cancer
A First-in-man Phase I/II Study of Oral ONC201 in Patients With Advanced Cancer
ONC201 is a new potential drug that kills cancer cells but not normal cells in laboratory studies. This clinical trial will be the first evaluation of ONC201 in humans and will enroll patients with advanced cancer.
- Conditions
- Advanced Glioblastoma, Advanced Colorectal Cancer, Advanced Triple-negative Breast Cancer, Advanced Non-small Cell Lung Cancer
- Trial name
- NCT02038699
- Testing
- ONC201
- Where
- United States
- Sponsor
- Jazz Pharmaceuticals
Breast Cancer, Colorectal Cancer
Exercise and Dietary Counseling in Improving Physical Activity, Nutrition, and Quality of Life in Older Long-Term Cancer Survivors Who Are Overweight
RATIONALE: Exercise and dietary counseling may improve physical activity, nutrition, and quality of life in older long-term cancer survivors who are overweight.
- Conditions
- Breast Cancer, Colorectal Cancer, Prostate Cancer
- Trial name
- NCT00303875
- Testing
- behavioral dietary and exercise intervention
- Where
- 2 sites in United States
- Volunteers
- 641 people
- Sponsor
- Duke University
HER-2 Negative Breast Cancer
Albumin-Bound Paclitaxel Combined With Carboplatin as Neoadjuvant Chemotherapy in Luminal B/HER-2 Negative Breast Cancer
This is an open-label, single arm, two-stage Simon Design study for women with LuminalB/HER-2 Negative Breast Cancer treated with Nanoparticle Albumin-Bound Paclitaxel and Carboplatin.
- Trial name
- NCT03799692
- Testing
- Chemotherapy
- Where
- 2 sites in China
- Volunteers
- 78 people
- Sponsor
- Fudan University
Breast Cancer, Pain
CWI and Discharge After Breast Cancer Surgery
The objectives of this work are threefold: 1. To evaluate the analgesic efficacy of CWI in women discharged within 23 hours of major breast cancer surgery 2.
- Trial name
- NCT02897934
- Testing
- Bupivacaine continuous infusion
- Where
- Ireland
- Volunteers
- 10 people
- Sponsor
- University College Cork
Advanced Breast Cancer
Screening Plasma HER2 Amplication by Digital PCR in Advanced Breast Cancer Patients Treated With Trastuzumab and Pyrotinib
The hypothesis of this study is to discover the efficacy and safety of trastuzumab combined with pyrotinib in treating advanced breast cancer with HER2 positive, which is detected by digital PCR.
- Trial name
- NCT05020964
- Testing
- Trastuzumab and Pyrotinib
- Volunteers
- 68 people
- Sponsor
- Chinese Academy of Medical Sciences
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