Clinical trials: Mammary Tumor
Triple Negative Breast Cancer
NeoCARD: Anthracycline-Free Neoadjuvant Chemoimmunotherapy in Triple-Negative Breast Cancer Patients
This is a single-arm Phase II study to assess the efficacy of a 12-18 week neoadjuvant carboplatin, paclitaxel, and pembrolizumab (CPP) regimen in a response-adaptive manner for triple-negative breast cancer (TNBC) patients who…
- Trial name
- NeoCARD (NCT06845319)
- Testing
- Carboplatin, Paclitaxel, Pembrolizumab
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Medical University of South Carolina
Breast Cancer, Breast Cancer Survivors
Rowing-Based Exercise Intervention on Health and Quality of Life in Breast Cancer Survivors
The goal of this clinical trial is to learn if a six-month exercise program that combines rowing, walking, and adapted physical activity (such as yoga or Pilates) can improve health and quality of life in women aged 40 to 65 who…
- Trial name
- ERICE/TSB (NCT07919730)
- Testing
- Behavioral Rowing-based exercise therapy program
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Università Cattolica di Milano
Breast Cancer - Female
Melatonin Supplementation for Cancer-related Fatigue in Patients Receiving Radiotherapy
This is a double-blind, placebo-controlled trial wherein subjects with breast cancer will be randomized to receive either 20 mg oral melatonin or placebo the night before their first radiotherapy (RT), nightly throughout their…
- Trial name
- NCT02332928
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Virginia Commonwealth University
Breast Carcinoma, Breast Ductal Carcinoma in Situ
A Patient Navigation Program for Addressing Disparities in Breast Cancer Care
This clinical trial evaluates a patient navigation program for addressing disparities in breast cancer care. The navigation program is designed to help improve patient knowledge about clinical and supportive care services…
- Trial name
- NCT06350500
- Testing
- Patient Navigation, Questionnaire
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Roswell Park Cancer Institute
Breast Cancer, Palliative Care
The Impact of SPC on Advanced Breast Cancer Patients
The aim of this prospective, observational study is the evaluation of the effectiveness of a 14-day Specialist Palliative Care therapy in participants with advanced breast cancer carried out in a stationary palliative care unit…
- Conditions
- Breast Cancer, Palliative Care, Quality of Life, Cancer, Breast
- Trial name
- NCT03612934
- Testing
- Specialist Palliative Care
- Volunteers
- 144 people
- Sponsor
- Silesian University of Medicine
Cancer, Neoplasms
A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers
This study will investigate OC-001 as monotherapy, and in combination with, Avelumab, in various cancer types
- Conditions
- Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer
- Trial name
- NCT04260802
- Testing
- OC-001, Drug: OC-001 in Combination with Avelumab
- Where
- 5 sites in Canada
- Volunteers
- 73 people
- Sponsor
- Ocellaris Pharma, Inc.
Breast Cancer, Cancer Survivor
Magnesium Oxide in Treating Postmenopausal Women With Hot Flashes and a History of Breast Cancer
RATIONALE: Magnesium oxide may help relieve hot flashes symptoms in women with a history of breast cancer. PURPOSE: This randomized clinical trial studies how well a high-dose or a low-dose of magnesium oxide works compared to…
- Conditions
- Breast Cancer, Cancer Survivor, Hot Flashes
- Trial name
- NCT01439945
- Testing
- magnesium oxide
- Where
- 283 sites in United States
- Volunteers
- 289 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Ovarian Neoplasms, Endometrial Neoplasms
A Study of Sofe-M in Participants With Selected Advanced Solid Tumors
The purpose of this study is to find out whether the study drug, Sofetabart Mipitecan (LY4170156), is safe, tolerable and effective in participants with advanced solid tumors.
- Conditions
- Ovarian Neoplasms, Endometrial Neoplasms, Uterine Cervical Neoplasms, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT06400472
- Testing
- Sofe-M, bevacizumab, carboplatin
- Where
- 25 sites in United States, Australia and 5 more
- Volunteers
- 575 people
- Sponsor
- Eli Lilly and Company
Breastcancer, Phyllodes Breast Tumor
Establishing Technique for PECS2 Catheter Insertion
The investigators are trying to establish an easy technique for insertion of a catheter for continuous infusion while performing pectoral type 2 (serratus) block, as a post operative pain controlling measure for cases undergoing…
- Trial name
- ETCI (NCT03030677)
- Testing
- Pectoralis II block & catheter without Lidocaine dissection, Pectoralis II block & catheter with Lidocaine dissection, catheter insertion
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kasr El Aini Hospital
Breast Cancer
Dose Dense Adjuvant CMF (Cyclophosphamide, Methotrexate, Fluorouracil) at 14 and 10-11 Day Intervals for Women With Early Stage Breast Cancer
CMF (cyclophosphamide, methotrexate, fluorouracil) is used to treat early stage breast cancer. The combination, of these three drugs, has been used for approximately 30 years in the treatment of breast cancer, and has been shown…
- Trial name
- NCT00615901
- Testing
- cyclophosphamide, methotrexate, fluorouracil, PEG-filgrastim
- Where
- 5 sites in United States
- Volunteers
- 38 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Early-stage Breast Cancer
Gut Microbiome, Adverse Effects, and Markers Through MEtabolic Reprogramming
This research is being done to test the feasibility of 24-48 hours of water-only fasting to improve delivery of 4 cycles of chemotherapy in those receiving breast cancer treatment either before or after surgery.
- Trial name
- GAMMER (NCT06536881)
- Testing
- Fasting
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Breast Cancer
Evaluating an Endocrine Therapy Dose-frequency Escalation Strategy and Its Effects on Tolerability and Compliance
The goal of this randomized, pragmatic clinical trial is to evaluate an endocrine therapy dose-frequency escalation strategy and its effects on tolerability and compliance.
- Trial name
- REaCT-TEMPO (NCT05754528)
- Testing
- Standard of care administration of Endocrine therapy, Dose-frequency escalation administration of Endocrine therapy
- Where
- 2 sites in Canada
- Volunteers
- 240 people
- Sponsor
- Ottawa Hospital Research Institute
TNBC - Triple-Negative Breast Cancer
LM-108 in Combination With PD-1 Based Treatment for Patients With Recurrent or Metastatic Triple - Negative Breast Cancer
To evaluate the efficacy and safety of LM108 plus toripalimab plusnab-paclitaxel or eribulin as first-line or post-line treatment in patients with metastatic triple-negative breast cancer.
- Trial name
- NCT06387628
- Testing
- LM-108, Toripalimab, Eribulin
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Fudan University
Breast Cancer, Radiation Toxicity
Pre- or Postoperative Accelerated Radiotherapy
20 non-metastasized breast cancer patients receiving neoadjuvant chemotherapy will be randomized between preop or postop RT. Patients with clinically suspicious axillary lymph nodes will receive a fine needle biopsy.
- Trial name
- POP-ART (NCT03783364)
- Testing
- Radiotherapy
- Where
- 2 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Breast Cancer
Neoadjuvant Therapy With Herceptin and Taxol for Breast Cancer
The purpose of this study is to determine the effectiveness and safety of administering Herceptin in combination with Taxol (paclitaxel) in the treatment of women with HER2-positive, early stage breast cancer prior to surgery.
- Trial name
- NCT00136539
- Testing
- Herceptin, Taxol, Adriamycin
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Harold J. Burstein, MD, PhD
Breast Carcinoma, Recurrent Breast Carcinoma
Bevacizumab in Treating Patients With Metastatic Breast Cancer That Overexpresses HER-2/NEU
This randomized phase III trial studies first-line chemotherapy and trastuzumab to compare how well they work when given with or without bevacizumab in treating patients with breast cancer that overexpresses human epidermal…
- Conditions
- Breast Carcinoma, Recurrent Breast Carcinoma, Stage IV Breast Cancer
- Trial name
- NCT00520975
- Testing
- Bevacizumab, Carboplatin, Paclitaxel
- Where
- 373 sites in United States
- Volunteers
- 96 people
- Sponsor
- National Cancer Institute (NCI)
Quality of Life
Behavioural Changes in Breast Cancer Patients
Exercise training has been established as a feasible and safe intervention during or after neoplastic treatment in breast cancer patients.
- Trial name
- BHVBC (NCT01990430)
- Testing
- Exercise Intervention
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad Politecnica de Madrid
Breast Carcinoma; Magnetic Resonance Imaging；OGSE
Study on the Correlation Between the Quantitative Parameters of Mr Mean Cell Size Imaging and the Histopathological Characteristics of Breast Cancer
Patients with breast masses and suspected breast malignancies by ultrasound / mammography were prospectively included. After routine MRI scanning, all patients underwent average cell size imaging sequence scanning, and finally…
- Trial name
- OGSE (NCT05373628)
- Testing
- Gradient and pulse imaging
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer Surgery, Transcutaneous Electric Nerve Stimulation
Effects of Transcutaneous Electrical Nerve Stimulation on Breast Surgery
The aim of this randomized controlled trial was to evaluate the effects of transcutaneous electrical nerve stimulation (TENS) on postoperative pain, lymphedema development, shoulder range of motion, and quality of life in women…
- Trial name
- NCT06973265
- Testing
- TENS
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Seda Akutay
Benign Breast Disease, Breast Cancer
Prolactin Receptor and Breast Diseases
Prolactin is known to play an important role in breast development and differentiation. Thus proliferative breast diseases are good models to unravel PRl / PRLR function in proliferative processes.
- Trial name
- Prolacsein (NCT00842465)
- Testing
- blood collection for hormonal status analysis, breast Biopsy or surgery, blood collection
- Where
- France
- Volunteers
- 735 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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