Clinical trials: Mammary Tumor
Breast Cancer
A Feasibility and Acceptability Pilot Study Evaluating a Patient-Specific Targeted Intervention Using Patient Navigators or Routine Clinical Care
Project Lets start will provide individual support to breast cancer patients with the goal of reducing delay to chemotherapy initiation.
- Trial name
- NCT05488444
- Testing
- Navigator Phone Calls, Exit Interview
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Exemestane in Combination With Fulvestrant in Postmenopausal Women With Hormone Sensitive Advanced Breast Cancer
The purpose of this trial is to evaluate time to progression in women with hormone responsive advanced breast cancer treated with a combination of exemestane and fulvestrant.
- Trial name
- NCT00201864
- Testing
- Exemestane, Fulvestrant
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Shoulder Pain, Late Effect
An Individualised Treatment vs. a Minimal Program in Women With Late-term Shoulder Impairments After Breast Cancer.
In breast cancer patients late-term upper limb sequelae, such as shoulder pain and impaired shoulder function remain common after primary breast cancer surgery.
- Conditions
- Shoulder Pain, Late Effect, Breast Cancer, Rehabilitation
- Trial name
- NCT05277909
- Testing
- The expert assessment of shoulder impairments and individualised treatment plan, A minimal physiotherapeutic rehabilitation program delivered in a pamphlet
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Vejle Hospital
Lung Cancer, Non Small Cell Lung Cancer (NSCLC)
Study to Assess Food Effect on Pharmacokinetics of Entinostat in Subjects With Breast Cancer or Non-Small Cell Lung Cancer
The purpose of this study is to evaluate the effect of food on the pharmacokinetics (PK) of the experimental drug, entinostat, in women with breast cancer and men and women with non-small cell lung cancer.
- Conditions
- Lung Cancer, Non Small Cell Lung Cancer (NSCLC), Breast Cancer, Estrogen Receptor Breast Cancer
- Trial name
- ENCORE110 (NCT01594398)
- Testing
- entinostat, Erlotinib, Exemestane
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- Syndax Pharmaceuticals
Healthy
Relative Bioavailability Study
This is a BA study comparing the bioavailability of two new capsule formulations and one solution formulation to the isethionate capsule used in phase 1 and 2 trials in healthy volunteers.
- Trial name
- NCT01602887
- Testing
- PD-0332991
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Endometrial Cancer, Cervical Cancer
Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors
The objective of this study is to evaluate the safety, tolerability, and efficacy of BL-M07D1 in patients with HER2 expressing advanced tumors.
- Conditions
- Endometrial Cancer, Cervical Cancer, Ovarian Cancer, Urothelial Carcinoma
- Trial name
- NCT06293898
- Testing
- BL-M07D1
- Where
- 26 sites in United States
- Volunteers
- 280 people
- Sponsor
- SystImmune Inc.
Prostate Cancers, Breast Cancer
Early Phase Study of KESONOTIDE™in Participants With Solid Tumours
This clinical trial is an adaptive study of a novel vimentin inhibitor in cancers. It is an open label, multicentre, single ascending dose level in phase I and cohort exploration in phase II.
- Conditions
- Prostate Cancers, Breast Cancer, Lung Cancers, Ovarian Cancer
- Trial name
- ADVICE (NCT06926075)
- Testing
- A novel hGIIA-Vimentin Inhibitor, Dose expansion
- Where
- 3 sites in Australia
- Volunteers
- 80 people
- Sponsor
- Filamon LTD
Breast Cancer
An All-Oral Combination of Capecitabine and Cyclophosphamide in Patients With Metastatic Breast Cancer (MBC)
The primary objective of this study is to evaluate the time to progression. Secondary objectives are safety, OS and pharmacogenetic analysis. Sixty patients will be enrolled into this study.
- Trial name
- NCT00589901
- Testing
- capecitabine and cyclophosphamide
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Metastatic Breast Cancer, Breast Cancer Stage IV
BRaziLian outcomE for metAStatic breasT Cancer
Given the certain benefit in efficacy of adding CDK 4/6 inhibitor to first line endocrine therapy in metastatic breast cancer HR+ HER2- , the aim of this project is to evaluate whether patients without private health insurance…
- Trial name
- BREAST (NCT05559528)
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Hospital do Coracao
Triple Negative Breast Cancer
MicroRNA Profiles in Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) is an aggressive disease with higher proportion of Blacks affected and in younger age groups.
- Trial name
- TARMAC (NCT04771871)
- Testing
- Epirubicin, Cyclophosphamide, Paclitaxel
- Where
- 4 sites in Nigeria
- Volunteers
- 42 people
- Sponsor
- University College Hospital, Ibadan
Secondary Lymphedema
A Phase I Study With Lymfactin® in the Treatment of Patients With Secondary Lymphedema
Indicated for the Treatment of Secondary Lymphedema Associated with the Treatment of Breast Cancer. Primary objective is to evaluate the safety and tolerability of a single dose of Lymfactin® in patients with secondary lymphedema…
- Trial name
- NCT02994771
- Testing
- Lymfactin® [1 x 10E10 vp], Lymfactin® [1 x 10E11 vp]
- Where
- 3 sites in Finland
- Volunteers
- 15 people
- Sponsor
- Herantis Pharma Plc.
Breast Cancer, Mindfulness
Supporting Women With Breast Cancer to Prepare for Treatment (The Prepare Study)
The purpose of this study is to evaluate if a brief mindfulness intervention before and after surgery would impact patient emotional wellbeing, quality of life, and biomarkers measured before and after surgery by finger prick…
- Trial name
- Prepare (NCT07221071)
- Testing
- Mindfulness Arm
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Chemotherapy-induced Peripheral Neuropathy, Breast Cancer Female
Acupuncture Treatment of Chemotherapy-Induced Peripheral Neuropathy in Women
This pilot study aims to evaluate the feasibility to conduct a study of acupuncture treatment (AT) for Chemotherapy-Induced Peripheral Neuropathy (CIPN) at Huntsman Cancer Institute and to investigate changes in physiological…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Breast Cancer Female, Gynecologic Cancer
- Trial name
- NCT04067544
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Invasive Breast Carcinoma, Sentinel Lymph Node Biopsy (SLNB)
Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in IBC
This study will prospectively determine the feasibility and oncological safety of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NACT) in inflammatory breast cancer patients traditionally considered ineligible…
- Conditions
- Invasive Breast Carcinoma, Sentinel Lymph Node Biopsy (SLNB), Neoadjuvant Chemotherapy
- Trial name
- SYMPHONY (NCT07080944)
- Testing
- SLN identification using technetium-99m, SLN intra-operatory identification with radioguided surgery, Axillary Limph Node Dissection (ALND)
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- European Institute of Oncology
ER+ HER2- Advanced Breast Cancer
Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer.
A Phase 1 Dose Escalation and Expansion Study of AZD9833 Alone or in Combination in Women with ER Positive, HER2 Negative Advanced Breast Cancer (SERENA-1)
- Trial name
- SERENA-1 (NCT03616587)
- Testing
- AZD9833, AZD9833 with palbociclib, AZD9833 with everolimus
- Where
- 17 sites in United States, Spain and 1 more
- Volunteers
- 396 people
- Sponsor
- AstraZeneca
Breast Neoplasms
Choline Quantification in Breast Cancer by MRS
Choline has been found in increased concentration in breast cancer patients. Hypothesis: The choline signal as observed by MRS is sensitive to treatment, and a positive response to treatment will give a reduction in choline…
- Trial name
- NCT00201487
- Sponsor
- Norwegian University of Science and Technology
Cancer, Colon Cancer
Emergence of Chemotherapy Related Hyperglycemia in nOn-diabetic Patients
To assess chemotherapy related hyperglycemia in non-diabetic patients, the investigators will assess the incidence of hyperglycemia and analyze co-medications and risk factors.
- Conditions
- Cancer, Colon Cancer, Breast Cancer, Malignant Lymphoma
- Trial name
- ECHO (NCT03062072)
- Testing
- Chemotherapy
- Where
- 2 sites in South Korea
- Volunteers
- 300 people
- Sponsor
- National Cancer Center, Korea
Stage IB Breast Cancer, Stage II Breast Cancer
Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery
This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energy x rays to kill tumor cells.
- Trial name
- NCT01872975
- Testing
- regional nodal XRT, chestwall XRT, WBI
- Where
- 514 sites in United States, Canada and 5 more
- Volunteers
- 1,636 people
- Sponsor
- NSABP Foundation Inc
Breast Cancer
Understanding and Predicting Breast Cancer Events After Treatment
This study is being done to see if patients receiving chemotherapy for breast cancer affects the heart, the ability to exercise and fatigue when compared to patients who do not have cancer.
- Trial name
- UPBEAT (NCT02791581)
- Testing
- Cardiac MRI
- Where
- 66 sites in United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer
Efficacy and Safety of 500mg of Fulvestrant
Fulvestrant has proven effective in the treatment of hormone receptor positive metastatic breast cancer. The dose used in studies so far has been well tolerated and may be too low for optimal effectiveness.
- Trial name
- NCT00585507
- Testing
- Fulvestrant
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
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