Clinical trials: Management, Risk
Patients at Risk of Hospital Admission
Proactive Health Support
Proactive Health Support is a randomized controlled trial of telephone-based self-management support. The primary aim of the intervention is to reduce hospital admissions and improve quality of life in patients with a high risk…
- Trial name
- NCT03628469
- Testing
- Proactive Health Support
- Where
- Denmark
- Volunteers
- 5,454 people
- Sponsor
- Frederiksberg University Hospital
HIV Infections, Dyslipidemias
Efprezimod Alfa (CD24Fc, MK-7110) Administration to Decrease Low-Density Lipoprotein (LDL) and Inflammation in Human Immunodeficiency Virus (HIV) Patients (CALIBER) (MK-7110-003)
This is a phase 2, randomized, double-blinded, placebo-controlled clinical trial. The intervention drug will be efprezimod alfa (intravenous [IV] infusion).
- Trial name
- CALIBER (NCT03960541)
- Testing
- Efprezimod alfa (human CD24 extracellular domain and human IgG1 Fc fusion protein), Saline Solution
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Oncoimmune, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Hypertension, Cardiovascular Disease
Nurse-led Reminder Program for the Prevention of Cardiovascular Diseases
A number of strategies have been evaluated to improve the prevention and control of the main cardiovascular (CVD) risk factors. Nursing telephonic and tele-counseling individualized lifestyle educational programs were found to…
- Trial name
- NCT01823588
- Testing
- Nurse-led reminder through email.
- Where
- 2 sites in Italy
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Atrial Fibrillation, Behavior
Patient Centered Mobile Health Technology Enabled Atrial Fibrillation Management
The overall objective of this proposal is to evaluate the feasibility of a comprehensive digital atrial fibrillation (AFib) management tool that will empower patients to a) take an active role in learning about AFib management…
- Trial name
- mTECHAFib (NCT05400837)
- Testing
- Corrie Virtual Atrial Fibrillation Management Program
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Johns Hopkins University
Acute Myeloid Leukaemia (AML), Myelodysplastic Syndrome (MDS)
Dose-escalation Study of Oral Administration of S 055746 in Patients With Acute Myeloid Leukaemia or Myelodysplastic Syndrome
The purpose of this study is to determine the safety profile and tolerability of S 055746 in patients with AML, and high or very high risk MDS, in terms of Dose-Limiting Toxicities (DLTs), Maximum Tolerated Dose (MTD) and…
- Trial name
- NCT02920541
- Testing
- S 055746
- Where
- 5 sites in Australia, France
- Volunteers
- 48 people
- Sponsor
- Institut de Recherches Internationales Servier
Obesity Prevention
Better4All Personalized Intervention Pilot Study
The BETTER4U project (Preventing obesity through Biologically and bEhaviorally Tailored inTERventions for you) is funded by the European Union (EU) and involves an international consortium consisting of 28 partners across Europe…
- Trial name
- BETTER4ALL (NCT07120802)
- Testing
- BETTER4U Mobile App and Wearable Use (End-User Group), BETTER4U Intervention Platform Testing (Implementer Group)
- Where
- 7 sites in Cyprus, France and 5 more
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Asthma, Asthma Severe Persistent Uncontrolled
Severe/Uncontrolled Asthma From General Population to Clinical Setting: Update and Follow-up of the RItA Registry
Within the AGAVE project (2010-2014), funded by the 2008 AIFA (Italian Medicines Agency) Call (contract No. FARM8YRYZC), a severe/uncontrolled asthma online Registry (RItA) was implemented to assess the appropriateness of…
- Trial name
- RISER (NCT05114447)
- Testing
- Routine medical care, Telephone interview
- Where
- 4 sites in Italy
- Volunteers
- 422 people
- Sponsor
- University of Pisa
Abdominal Aortic Aneurysm, COVID-19
AAA Rupture Risk Assessment in COVID-19 Pandemic
The acute phase of the COVID-19 pandemic requires a redefinition of healthcare system to increase the number of available intensive care units for COVID-19 patients.
- Trial name
- NCT05197543
- Testing
- Biomechanical rupture risk assessment
- Where
- Czechia
- Volunteers
- 102 people
- Sponsor
- Masaryk University
Coronary Artery Disease
Comparison of Predictive Factors Related to Coronary Artery Disease
In Taiwan, heart disease and cerebrovascular disease ranked the second and third of ten leading causes of death in female in 2007; half of these deaths is due to coronary artery disease (CAD).
- Trial name
- NCT01136343
- Testing
- lifestyle modified project
- Where
- Taiwan
- Volunteers
- 130 people
- Sponsor
- Taipei Medical University WanFang Hospital
Atrial Fibrillation, Anticoagulant-induced Bleeding
Perioperative Management of Factor Xa Inhibitors
This study aims to analyze the safety and effectiveness of the discontinuation/resumption protocol of factor Xa inhibitors before and after invasive procedures/surgeries in non-valvular atrial fibrillation patients who are at…
- Trial name
- PERIXa (NCT05801068)
- Testing
- Factor Xa Inhibitor
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Seoul National University Hospital
Alzheimer's Disease
A Study to Evaluate the Safety and Biomarker Effects of RO7269162 in Participants at Risk for or at the Prodromal Stage of Alzheimer's Disease (AD)
This clinical trial is recruiting people who either are at risk of AD - have build-up of beta-amyloid, but have no clinical symptoms, or with a diagnosis of mild cognitive impairment.
- Trial name
- NCT06402838
- Testing
- RO7269162
- Where
- 46 sites in Chile, Denmark and 7 more
- Volunteers
- 256 people
- Sponsor
- Hoffmann-La Roche
Gastrointestinal Stromal Tumors
Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST)
The aim of this study is to demonstrate that the use of Gleevec in initially non-resectable gastrointestinal stromal tumors can lead to allow complete resection in 20% of cases.
- Trial name
- NCT00290485
- Testing
- Imatinib mesylate
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Students, Nursing
The Effect of Using Clinical Decision Support System in Pressure Injury Risk Management Teaching
The goal of this randomized controlled study is to compare the changes in cognitive, attitudinal and psychomotor domains for pressure injury between nursing students who take model-based structured pressure injury risk management…
- Trial name
- NCT05661214
- Testing
- Teaching
- Volunteers
- 48 people
- Sponsor
- Hacettepe University
Cardiopulmonary Bypass
Prothrombin Complex Concentrate (PCC)
The overall objective of this study is to determine whether ROTEM (rotational thromboelastometry) guided dosing of four-factor prothrombin complex concentrate (4F-PCC) results in superior perioperative bleeding control compared…
- Trial name
- NCT07881393
- Testing
- Four Factor Prothrombin Complex Concentrate, ROTEM (Rotational Thromboelastometry) analyzer (TEM International GmbH)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Prostate Cancer
Internal Radiation Therapy in Treating Patients With Prostate Cancer
RATIONALE: Internal radiation therapy uses radioactive material placed directly into or near a tumor to kill tumor cells. PURPOSE: This clinical trial is studying the side effects and how well internal radiation therapy works in…
- Trial name
- NCT00573833
- Testing
- questionnaire administration, quality-of-life assessment, brachytherapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Kidney Injury, Congenital Heart Disease
Nitric Oxide During Cardiopulmonary Bypass in Neonates to Reduce Risk of Acute Kidney Injury
Acute kidney injury following cardiac surgery for congenital heart defects in children is a major cause of both short- and long-term morbidity and mortality, affecting up to 60% of high risk patients.
- Trial name
- NCT04259684
- Testing
- gases Nitric Oxide (gNO)
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Multiple Myeloma, Plasmacytoma
Frontline Combination CAR-T Cell Therapy for Multiple Myeloma or Plasmacytoma
The aim of this clinical trial is to assess the feasibility, safety, and efficacy of CAR-T cell therapy targeting multiple cancer cell antigens in high-risk multiple myeloma or plasmacytoma as part of a frontline treatment…
- Trial name
- NCT06429150
- Testing
- CAR-T cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Proximal Femur Fracture
Postoperative Pain Relieve for Patients Undergoing Surgical Treatment of Femoral Fracture
The aim of the study is to investigate postoperative pain relief for patients undergoing surgical treatment of proximal femoral fracture using intrathecal administration of morphine.
- Trial name
- NCT05920642
- Testing
- Intrathecal morphine administration, Parenteral administration of analgesics
- Where
- Czechia
- Volunteers
- 82 people
- Sponsor
- University Hospital Ostrava
Migraine
Evaluation of Migraine Management Mobile App Combined With Electrophysiological Measurements for Identification of Migraine Attack Risk and Beneficial Preventive Actions.
Evaluation of migraine management mobile app combined with electrophysiological measurements for identification of migraine attack risk and beneficial preventive actions.
- Trial name
- NCT03083860
- Testing
- BEI
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Brainmarc Ltd.
Medication Errors, Patient Safety
Safety Action Feedback and Engagement (SAFE) Loop
This trial will test whether a new intervention, the Safety Action Feedback and Engagement (SAFE) Loop, enhances nurse incident reporting practices, improves nurses' perceptions of incident reporting, and lowers rates of…
- Trial name
- NCT05381441
- Testing
- Safety Action Feedback and Engagement (SAFE) Loop
- Where
- United States
- Volunteers
- 5,163 people
- Sponsor
- Cedars-Sinai Medical Center