Clinical trials: Management, Risk
Symptomatic Haemorrhoidal Disease Requiring Surgical Management
Randomized Controlled Trial Comparing Transanal Doppler-guided Arterial Ligation With Mucopexy and Stapled Haemorrhoidopexy
This multicentre RCT aims to compare two surgical treatments of haemorrhoidal disease: doppler-guided arterial ligation with mucopexy (DGALM) and stapled haemorrhoidopexy according to Longo (SH).
- Trial name
- LIGALONGO (NCT01240772)
- Testing
- doppler-guided arterial ligation with mucopexy, stapled haemorrhoidopexy according to Longo
- Where
- 22 sites in France
- Volunteers
- 407 people
- Sponsor
- Nantes University Hospital
Fever, Infection
Personalised Risk Assessment in Febrile Illness to Optimise Real-life Management Across the European Union (PERFORM)
Childhood fever is a prevalent problem. Most febrile children who visit hospital improve without treatment, but a minority require treatment, and a few will have severe disease.
- Conditions
- Fever, Infection, Inflammation
- Trial name
- PERFORM (NCT03502993)
- Testing
- Validation of biomarker
- Where
- United Kingdom
- Volunteers
- 7,247 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Loss of Autonomy
Seniors'Health Paths " PAERPA ",
•Background: PAERPA experimentation implemented in the East-Herault region since September 2017 aims to identify fragility and prevent the risk of loss of autonomy in elderly persons older than 60 years by facilitating…
- Trial name
- PAERPA (NCT04165915)
- Where
- France
- Volunteers
- 137 people
- Sponsor
- University Hospital, Montpellier
High-Risk Non-Muscle-Invasive Bladder Cancer
Immunological Response to Intravesical BCG Therapy of Superficial Bladder Cancer by Prior Administration of RUTI®
The RUTIVAC-1 study is a Phase I Clinical Trial designed to evaluate the systemic and mucosal immunological response and provide safety information after the use of RUTI® administration to individuals with NMIBC.
- Trial name
- RUTIVAC-1 (NCT03191578)
- Testing
- RUTI®
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Archivel Farma S.L.
Low Back Pain
Pain Management for Patients With Low Back Pain and Psychosocial Risk Factors in a Hospital Setting.
Patients with low back pain and coexisting psychosocial risk factors have a poorer prognosis in terms of quality of life, disability, sick leave and health care use.
- Trial name
- NCT03141541
- Testing
- Group based pain management intervention
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Central Jutland Regional Hospital
Recurrence, Metastasis
Lymph Node Dissection in High-risk UTUC(Upper Tract Urothelial Carcinoma)
This clinical trial is designed to evaluate the role of lymph node dissection in the prevention of recurrence and metastasis after radical nephroureterectomy for high-risk primary upper tract urothelial carcinoma (UTUC) patients.
- Conditions
- Recurrence, Metastasis, Upper Tract Urothelial Carcinoma, Lymph Node Dissection
- Trial name
- UTUC (NCT03230201)
- Testing
- Lymph node dissection
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Fungus Diseases
PROPHESSOR: AmBisome in Antifungal Primary Prophylaxis Treatment of High Risk Patients Undergoing Allogeneic Stem Cell Transplantation
This pilot study was designed in order to evaluate the safety and efficacy of an AmBisome® loading dose regimen, in a weekly administration schedule during the initial phase of allogeneic stem-cell transplant and in case of…
- Trial name
- NCT00326157
- Testing
- AmBisome
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Gilead Sciences
Weight Loss, Overweight and Obesity
Choosing Healthy Activities and Lifestyle Management Through Portal Support
The study aims to randomize 250 participants to 1 of 2 arms: a.) an Active Intervention Group (based on the Look AHEAD* ILI) or b.) a Comparison Group (based on the Look AHEAD DSE Comparison group) to test the hypothesis that a…
- Conditions
- Weight Loss, Overweight and Obesity, Behavior, Health
- Trial name
- CHAMPS (NCT05410353)
- Testing
- Active Intervention Group, Comparison Group
- Where
- United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Good Prognosis Metastatic Gestational Trophoblastic Tumor, Hydatidiform Mole
Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia
Randomized phase III trial to compare the effectiveness of methotrexate with that of dactinomycin in treating patients who have gestational trophoblastic neoplasia.
- Conditions
- Good Prognosis Metastatic Gestational Trophoblastic Tumor, Hydatidiform Mole, Non-Metastatic Gestational Trophoblastic Tumor, Uterine Corpus Choriocarcinoma
- Trial name
- NCT00003702
- Testing
- Dactinomycin, Methotrexate
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Gynecologic Oncology Group
Misoprostol, Respiratory Distress Syndrome (RDS) of Neonate
Misoprostol Before Caesarean Section
The aim of our study is to evaluate the efficacy of Misoprostol before elective cesarean section in pregnant women with gestational age less than 38 weeks for preventing the occurrence of neonatal respiratory morbidity.
- Conditions
- Misoprostol, Respiratory Distress Syndrome (RDS) of Neonate, Caesarean Section
- Trial name
- Miso/CS (NCT06946914)
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Pregnancy, High Risk, Type 1 Diabetes
Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D)
PRISM-TID is a single center non-inferiority randomized controlled trial of permissive intrapartum glucose management (intervention) versus strict intrapartum glucose management (standard of care) among pregnant individuals with…
- Trial name
- PRISM-T1D (NCT07293715)
- Testing
- Insulin, DEXCOM Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Ohio State University
Preemptive Therapy of Patients At Risk for Acute Kidney Injury Following Cardiac Surgery
Phase 1B/2 Clinical Trial Assessing the Safety, Tolerability and Preliminary Efficacy of the Intravenous Administration of Allogeneic Placental Mesenchymal Cells for the Preemptive Treatment of Patients At Risk for Acute Kidney Injury Following Cardiac Surgery
This clinical trial is designed to evaluate KELI-101 versus placebo for the prevention of acute kidney disease leading to chronic kidney disease in subjects at high risk for acute kidney injury following cardiac surgery.
- Trial name
- MesAKI (NCT06678399)
- Testing
- KELI-101
- Volunteers
- 91 people
- Sponsor
- Kelifarma
Ischemic Stroke, Transient Ischemic Attack
Adapting Tools to Implement Stroke Risk Management to Veterans
The purpose of this study is to develop and evaluate the local adaptation of existing stroke prevention tools into practice. A stroke prevention program is a collection of materials including written materials like pamphlets and…
- Trial name
- TOOLS (NCT00355147)
- Testing
- Physician stroke guideline adherence, Stroke Self Management, Attention Control Group
- Where
- 2 sites in United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development
Mobile Health Apps, Lifestyle Intervention
Effectiveness of an AI-Enabled Mobile Intervention on Lifestyle Behaviors and Maternal-Infant Health
The goal of this pragmatic randomized controlled trial is to evaluate the effectiveness of an AI-enabled mobile health management application ("Better Pregnancy" app), grounded in the Theory of Planned Behavior, in preventing…
- Conditions
- Mobile Health Apps, Lifestyle Intervention, Prevention, Multi-component Based Behavioral Intervention
- Trial name
- NCT07582068
- Testing
- Multi-component lifestyle intervention
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Cardiovascular Diseases, Vesicle
Kinetics of cEVs Over the 24-hour Dosing Interval After Low-dose Aspirin Administration
Extracellular vesicles (EVs) are small vesicles deriving from all cell types during cell activation, involved in transcellular communication, and regarded as predictors of vascular damage and of cardiovascular events.
- Trial name
- NCT05584943
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Skin Basal Cell Carcinoma
Active Surveillance for the Treatment of Low-Risk Basal Cell Carcinoma in Elderly Patients
This clinical trial evaluates whether active surveillance (AS) is a safe and comfortable alternative to standard of care (SOC) treatment for elderly patients with low-risk basal cell carcinoma (LR-BCC).
- Trial name
- NCT06539468
- Testing
- Best Practice, Educational Activity, Patient Observation
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Michigan Rogel Cancer Center
Type 2 Diabetes Mellitus
Type 2 Diabetes: Risk Perceptions and Self-management Behaviour
This pilot randomised controlled trial (RCT) aims to assess the feasibility of using a new type of risk communication intervention for people with Type 2 diabetes mellitus (T2DM) in primary care and to evaluate its potential…
- Trial name
- NCT03840850
- Testing
- Personalized Risk Communication for People with Type 2 Diabetes
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Pregnancy, High Risk
Pharmacokinetics and Pharmacodynamics of Tranexamic Acid in Women Having Caesarean Section Birth [WOMAN-PharmacoTXA]
Intramuscular injection and oral solution of tranexamic acid (TXA) would increase its use in situations where administration of intravenous drugs is difficult.
- Trial name
- NCT04274335
- Testing
- Tranexamic Acid 100Mg/Ml Inj Vil 10Ml, Tranexamic Acid Oral Solution, Tranexamic Acid Injectable Product
- Where
- 2 sites in Pakistan, Zambia
- Volunteers
- 120 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Long QT Syndrome
Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes
Torsades de pointes (TdP) is a potentially fatal ventricular arrhythmia associated with corrected QT (QTc) interval prolongation.
- Trial name
- NCT02513940
- Testing
- Testosterone, Progesterone, Ibutilide
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Indiana University
Depression
TEAM-Red, a Remotely Delivered Self-management Program for Depressed Black Women at Risk for Hypertension
The proposed project is a 24-week prospective randomized controlled trial (RCT) evaluating the effects of TargEted MAnageMent Intervention (TEAM, N=41) vs.
- Trial name
- TEAM-Red (NCT05488782)
- Testing
- TEAM-Red, Waitlist
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Jennifer B. Levin