Clinical trials: Management, Risk
Cardiovascular Diseases, Risk Reduction
Strategy for Cardiovascular Disease Prevention Through Tailored Health Management in Individuals With Elevated Risk
The China PEACE SMARTER trial is a cluster ramdomized trial aiming to assess the effectiveness of village doctor-led tailored health management on risk reduction of high-risk individuals for cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Risk Reduction, Primary Prevention
- Trial name
- SMARTER (NCT05645640)
- Testing
- Village doctor-led tailored health management
- Where
- China
- Volunteers
- 4,533 people
- Sponsor
- China National Center for Cardiovascular Diseases
Leukemia, Myelodysplastic Syndromes
3-AP Followed By Fludarabine In Treating Patients With Relapsed or Refractory Acute or Chronic Leukemia or High-Risk Myelodysplastic Syndrome
RATIONALE: Drugs used in chemotherapy, such as fludarabine, work in different ways to stop cancer cells from dividing so they stop growing or die.
- Conditions
- Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
- Trial name
- NCT00077558
- Testing
- fludarabine phosphate, triapine
- Where
- 4 sites in United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Myocardial Infarction
Examination of the Impact of CalmiGo's Stress Management Device on Vascular Heath and Cardiovascular Disease Risk.
The primary purpose of this study is to determine if there are significant differences with respect to baseline between those randomized to CGo and standard-of-care versus standard-of-care alone after completing 12-weeks of…
- Trial name
- CalmiGo (NCT04521699)
- Testing
- CalmioGO Stress management device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Cancer, Geriatric Syndrome
Risk-Based Geriatric Assessment-Driven Management in Older Patients Starting Chemotherapy
Older patients with cancer are at increased risk of severe chemotherapy-related toxicities due to comorbidities, functional impairments, and geriatric syndromes.
- Conditions
- Cancer, Geriatric Syndrome, Frailty, Chemotherapy Toxicity
- Trial name
- NCT07485634
- Testing
- Geriatric Assessment-Driven Management Algorithm (GA-MA)
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- The University of Hong Kong
Wounds
Clinical Investigation to Evaluate the Safety and Performance of ConnettivinaBio Plus Cream Compared to ConnettivinaBio Cream in the Management of Wounds in Patients at High Risk of Infection
The clinical investigation plan will include a Screening/Baseline visit (V1) in which patients will be screened on the basis of inclusion/exclusion criteria and clinically evaluated.
- Trial name
- NCT04936204
- Testing
- ConnettivinaBio Plus cream, ConnettivinaBio cream
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Chest Disorders
Emergency Thoracic Ultrasound and Clinical Risk Management
Clinical risk assessment and management is mostly relevant in emergency. Thoracic ultrasound (TUS) has been proposed as an easy-option replacement for chest X-ray (CXR) in Emergency diagnosis of pneumonia, pleural effusion and…
- Trial name
- CLINRISKETUS (NCT02985528)
- Testing
- further diagnostic
- Volunteers
- 400 people
- Sponsor
- Guglielmo Trovato, MD, PhD
Atrial Fibrillation Paroxysmal
Atrial Fibrillation Lifestyle Project
The objectives of the investigators are to demonstrate a reduction in frequency and symptoms of AF and improvements in cardiovascular risk factors following a lifestyle intervention in patients with paroxysmal AF.
- Trial name
- ALP (NCT03724383)
- Testing
- Risk Factor Management Consult, Diet Classes, Stress Management Classes
- Where
- 7 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Teddi Orenstein Lyall
Coronary Artery Disease
Risk-guided Disease managEment Plan to prevEnt CAD in Patients Treated With Previous Cancer
REDEEM-CAD is a prospective multi-centre study of CAD risk evaluation and management in cancer survivors 40-70 years with chemotherapy or radiotherapy >5 years ago.
- Trial name
- REDEEM-CAD (NCT05366153)
- Testing
- Coronary CT
- Where
- 2 sites in Australia
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Baker Heart and Diabetes Institute
Schizophrenia, Schizoaffective Disorder
Measuring the Effect of Remote Monitoring of Treatment Adherence on the Risk of Re-admission of Ambulatory Schizophrenic Patients
Schizophrenia is a chronic debilitating mental disorder, characterised by a relapsing remitting course. Although anti-psychotics can prevent relapse, its effect on schizophrenia outcome remains very limited, mainly due to very…
- Trial name
- NCT01729572
- Testing
- Tele-medicine monitoring of medication adherence
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Shalvata Mental Health Center
Chronic Low-back Pain (cLBP)
Combining Brain Stimulation and Physiotherapy for the Management of Chronic Low Back Pain
Chronic low back pain (CLBP) is a major health challenge in Canada, leading to substantial disability and socioeconomic burden, particularly among Veterans. In military Veterans, LBP is the most common chronic pain condition.
- Trial name
- NCT06999772
- Testing
- Active rTMS, Psychologically-informed physiotherapy (PiP), Usual physiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 96 people
- Sponsor
- Laval University
Blood Pressure, Intraoperative Hypotension
Perioperative Personalized Blood Pressure Management: IMPROVE-multi
Rates of major complications and mortality in the first weeks after surgery remain very high: postoperative mortality is still around 2% in central Europe and the United States.
- Conditions
- Blood Pressure, Intraoperative Hypotension, Postoperative Complications, Surgery
- Trial name
- IMPROVE (NCT05416944)
- Testing
- Personalized blood pressure management
- Where
- Germany
- Volunteers
- 1,272 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Lifestyle Intervention, Non Communicable Chronic Diseases
Evaluation of the WARIFA App and Its Impact on Healthy Lifestyle
The goal of this study is to assess the effect of the WARIFA app on the adoption of healthy lifestyle behaviours related to Non-communicable diseases (NCDs), as well as in the management of Type 1 Diabetes (T1D).
- Conditions
- Lifestyle Intervention, Non Communicable Chronic Diseases, Type 1 Diabetes (T1D)
- Trial name
- NCT06918444
- Testing
- WARIFA app with AI, WARIFA app without AI
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Instituto Universitario de Investigaciones Biomédicas y Sanitarias (iUIBS) de la Universidad de Las
Cardiovascular Diseases, Heart Failure, Systolic
HeartMate App-Based Remote Monitoring for Cardiovascular Risk Factor Management
This exploratory pilot randomized controlled trial evaluates whether a HeartMate application-based remote patient monitoring (RPM) and digital cardiac rehabilitation program improves cardiovascular, functional, and psychological…
- Conditions
- Cardiovascular Diseases, Heart Failure, Systolic, Coronary Artery Disease, Heart Valve Diseases
- Trial name
- NCT07721584
- Testing
- HeartMate App-Based Remote Cardiac Rehabilitation Program, Usual Care with HeartMate App-Based rPPG Measurement Only
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Obstructive Sleep Apnea
Oxygen Supplementation Study in Obstructive Sleep Apnea (OSA) Patients
Hypotheses: 1. Postoperative oxygen therapy significantly improves postoperative oxygenation in OSA surgical patients. 2. Postoperative oxygen therapy do not significantly increase the number of apnea episodes and the duration of…
- Trial name
- NCT01552304
- Testing
- Oxygen therapy, Control group
- Where
- Canada
- Volunteers
- 196 people
- Sponsor
- University Health Network, Toronto
Diabetes Mellitus, Type 1, Pregnancy in Diabetics
T1D Pregnancy & Me
T1D Pregnancy \& Me will partner with pregnant participants living with type 1 diabetes (T1D) in the United States to collect real-world data on management of T1D in pregnancy.
- Conditions
- Diabetes Mellitus, Type 1, Pregnancy in Diabetics, Pregnancy, High-Risk, Insulin Dependent Diabetes
- Trial name
- PRAM-T1D (NCT06959316)
- Testing
- Hybrid closed loop insulin delivery system
- Where
- 10 sites in United States
- Volunteers
- 500 people
- Sponsor
- Jaeb Center for Health Research
AMD
Anecortave Acetate Risk-Reduction Trial (AART)
The purpose of this study was to demonstrate that Anecortave Acetate for Depot Suspension (15 mg or 30 mg) is safe and effective in arresting the progression of non-exudative (dry) age-related macular degeneration in patients who…
- Trial name
- NCT00333216
- Testing
- Anecortave Acetate Sterile Suspension, 30 mg/mL, Anecortave Acetate Sterile Suspension, 60 mg/ML, Anecortave Acetate Vehicle
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Alcon Research
Adenocarcinoma of the Prostate, Recurrent Prostate Cancer
Enzalutamide, Radiation Therapy and Hormone Therapy in Treating Patients With Intermediate or High-Risk Prostate Cancer
This phase I trial studies the side effects and best way to give enzalutamide, radiation therapy, and hormone therapy in treating patients with intermediate or high-risk prostate cancer.
- Conditions
- Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage IIB Prostate Cancer, Stage III Prostate Cancer
- Trial name
- NCT02023463
- Testing
- Enzalutamide, Goserelin acetate, Leuprolide acetate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Thomas Jefferson University
MASLD, Cardiovascular (CV) Risk
Integrated Ultrasound-Derived Fat Fraction and 2D/4D HeartAI for Cardiovascular Risk Management in Patients With MASLD
This prospective observational cohort study aims to evaluate the association between liver fat fraction measured by ultrasound-derived fat fraction (UDFF) and cardiac functional parameters assessed by 2D and 4D HeartAI in adult…
- Conditions
- MASLD, Cardiovascular (CV) Risk, Subclinical Cardiovascular Impairments
- Trial name
- MUCHAI (NCT07545343)
- Where
- China
- Volunteers
- 700 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Neuroblastoma
High-Risk Neuroblastoma Chemotherapy Without G-CSF
Patients will be asked to participate in this study because patients have been diagnosed with high-risk neuroblastoma, a common childhood cancer which has aggressive features. If left untreated, high-risk neuroblastoma is fatal.
- Trial name
- SPRING (NCT02786719)
- Testing
- Topotecan, Cyclophosphamide, Cisplatin
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Baylor College of Medicine
Endometrium Cancer
A.I and Machine Learning Based Risk Prediction Model to Improve the Clinical Management of Endometrial Cancer.
Prediction of preoperative endometrial biopsy: the evolution from hyperplasia to cancer, the prognosis and the risk of recurrence.
- Trial name
- NCT06841653
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Regina Elena Cancer Institute