Clinical trials: Management, Risk
Melanoma
Pilot Study for the Evaluation of the Efficacy of Vaccination With Autologous Tumor Cells Plus Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) - in - Adjuvant, Followed by Systemic Low-dose-interleukin-2 (IL-2) Administration, in Patients With High Risk Melanoma
This study is an open-label, pilot study of an autologous tumor cell vaccine.
- Trial name
- MEL37 (NCT00912418)
- Testing
- autologous tumor cells plus GM-CSF-in Adjuvant
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Craig L Slingluff, Jr
Atherosclerotic Cardiovascular Disease
VictORION-INCLUSION: Evaluating Inclisiran for Cholesterol Managment in Heart Disease
VictORION-INCLUSION (V-INCLUSION) seeks to evaluate the effectiveness of inclisiran as an innovative therapy with the potential to help bridge care gaps in historically understudied and undertreated populations by leveraging…
- Trial name
- V-INCLUSION (NCT06249165)
- Testing
- Inclisiran
- Where
- 23 sites in United States
- Volunteers
- 130 people
- Sponsor
- Duke University
Atherosclerotic Cardiovascular Disease (ASCVD), Coronary Heart Disease (CHD)
VICTORION-ASCERTAIN: Implementation Study (v-ASCERTAIN)
The goal of this study is to understand and compare an alternative model of care in comparison to the usual model of care in include male and female participants ≥18 years of age with a history of ASCVD (hear and blood vessels…
- Conditions
- Atherosclerotic Cardiovascular Disease (ASCVD), Coronary Heart Disease (CHD), Cerebrovascular Disease, Peripheral Arterial Disease (PAD)
- Trial name
- v-ASCERTAIN (NCT05834673)
- Testing
- SMS messages, Telephone-based support calls, GP Education
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- Monash University
Cocaine-Related Disorders, Heroin Dependence
Employment-based Reinforcement of Naltrexone Ingestion and Abstinence
A randomized study is planned over 5 years to evaluate the effectiveness of the Therapeutic Workplace in promoting naltrexone ingestion and abstinence in unemployed opiate-dependent injection drug users.
- Conditions
- Cocaine-Related Disorders, Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00149669
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Johns Hopkins University
Atrial Fibrillation, Obesity and Obesity-related Medical Conditions
Metabolic Surgery for Atrial Fibrillation Elimination
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is estimated that between 3 and 6 million Americans are currently living with AF, while 12 million people in the United States will have AF in 2030.
- Trial name
- METSAFE (NCT07027969)
- Testing
- Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ali Aminian
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Multimodal Risk Factor Graph Mapping, Metabolic Subtyping, and Digital Intelligent Chronic Disease Management for Prediabetes: An Integrated Cohort and Case-Control Clinical Study
This observational study aims to understand the metabolic characteristics and long-term changes in adults with prediabetes and to identify risk and protective factors associated with progression to diabetes or return to normal…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DM-PIONEER (NCT07854002)
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Symptomatic Intracranial Atherosclerotic Stenosis
Drug-Coated Balloon vs Aggressive Medical Management for High-Risk Symptomatic Intracranial Atherosclerotic Stenosis
DR.BEYOND-2 is an investigator-initiated, prospective, multicenter, randomized, open-label, blinded-endpoint, parallel-group clinical trial designed to evaluate the efficacy and safety of drug-coated balloon (DCB) angioplasty…
- Trial name
- DRBEYOND2 (NCT07830277)
- Testing
- Drug-Coated Balloon Angioplasty, Aggressive Medical Management
- Where
- 2 sites in China
- Volunteers
- 570 people
- Sponsor
- Beijing Tiantan Hospital
Dental Caries
Effectiveness of ICCMS in Reducing the Incidence of Dental Caries in Children
The aim of the present study is to evaluate the effectiveness of using the ICCMS (International Caries Classification And Management System)in reducing caries lesions incidence compared to a control group that use different…
- Trial name
- NCT03488056
- Testing
- ICCMS, SESC standard care
- Where
- Brazil
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Peanut Allergy
Canadian Peanut Thresholds Study
An important gap in the management of peanut allergy is that we do not know the threshold dose, below which most peanut allergic individuals will not react.
- Trial name
- NCT01812798
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Coronary Artery Disease
Efficacy Study of Hydroxychloroquine to Treat High-risk Coronary Artery Disease.
The purpose of this study is to evaluate whether treated with hydroxychloroquine could improve therapeutic effect for patients with high-risk coronary artery disease.
- Trial name
- CHANGAN (NCT02874287)
- Testing
- Hydroxychloroquine Sulfate Tablets
- Where
- China
- Volunteers
- 35 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
HIV Infections
Implementation and Assessment of a Medication Therapy Management Program in HIV Patients at High Risk of Adverse Drug Events at Khartoum, Sudan
This clinical trial aims to evaluate the effectiveness and cost-effectiveness of two levels of a pharmacist-led Medication Therapy Management (MTM) program, Basic MTM and Enhanced MTM, compared with usual care for HIV patients at…
- Trial name
- HIV-MTM-SUDAN- (NCT07750834)
- Testing
- Basic MTM, Enhanced MTM
- Where
- Sudan
- Volunteers
- 1,149 people
- Sponsor
- Universiti Sains Malaysia
Quality of Life
Patient-Centred Care for Warfarin Management: A Pilot Study to Transition Care to High Risk Patients
Warfarin remains the only oral anticoagulant effective in preventing stroke and valve thrombi for patients having mechanical heart valves (MHVs).
- Trial name
- NCT03295799
- Testing
- Patient Self-Management
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- University of Alberta
Gambling Disorder, Gambling Problem
Contingency Management to Reinforce Attendance to Cognitive Behavioral Treatment for Gambling Disorder
The aim of this study is to conduct a trial to investigate the effectiveness of adding contingency management treatment (CM) to standard care cognitive behavioral therapy (CBT) for the treatment of gambling disorder to increase…
- Trial name
- NCT07016100
- Testing
- Contingency management, Cognitive behavioral therapy/ treatment as usual
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- East Tennessee State University
Diabetes Mellitus, Type 2, Dyslipidemias
Curcumin's Effect on Diabetic Patients With Atherosclerotic Cardiovascular Risk
The aim of the study is to assess the safety and efficacy of Curcumin supplementation in combination to the conventional therapy in improving the clinical outcomes, oxidative stress and inflammation in diabetic patients with risk…
- Conditions
- Diabetes Mellitus, Type 2, Dyslipidemias, Hypertension
- Trial name
- NCT05753436
- Testing
- Puritans Pride Turmeric curcumin® 500 mg
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Ain Shams University
Ovarian Hyperstimulation Syndrome
Coasting Versus Antagonist Protocol in Patients at High Risk of OHSS
The aim of this work is to study the value of GnRH antagonist subcutaneous administration as an alternative to coasting in prevention of severe OHSS and its impact on embryos quality \& the outcome of ICSI.
- Trial name
- NCT03996434
- Testing
- Gonadotropin, Antagonist
- Where
- 2 sites in Egypt
- Volunteers
- 300 people
- Sponsor
- ClinAmygate
Airway Management
Patient Positioning and Airway Management During ERCP
The aim of this study is to determine the effect of airway management (a set of medical procedures performed to prevent airway blockage and thus ensure an open path between a patient's lungs and the atmosphere) during endoscopic…
- Trial name
- NCT02850887
- Testing
- general endotracheal anesthesia, deep sedation without endotracheal intubation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington University School of Medicine
Preemptive Therapy of Patients At Risk for Acute Kidney Injury Following Cardiac Surgery
Phase 1B/2 Clinical Trial Assessing the Safety, Tolerability and Preliminary Efficacy of the Intravenous Administration of Allogeneic Placental Mesenchymal Cells for the Preemptive Treatment of Patients At Risk for Acute Kidney Injury Following Cardiac Surgery
This clinical trial is designed to evaluate KELI-101 versus placebo for the prevention of acute kidney disease leading to chronic kidney disease in subjects at high risk for acute kidney injury following cardiac surgery.
- Trial name
- MesAKI (NCT06678399)
- Testing
- KELI-101
- Volunteers
- 91 people
- Sponsor
- Kelifarma
Lymphedema
Prevention of Lymphedema Among Breast Cancer Patients Through Implementation of an Integrative Therapy Program (ITP)
Introduction: Breast cancer women who are treated with axillary node dissection are at increased risk for lymphedema - the lifetime risk in these women is estimated at 15-50% and the risk can significantly increase with…
- Trial name
- NCT02528539
- Testing
- ITP
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Huntington Memorial Hospital
Young Subjects With at Risk Mental States
"Stress in At Risk Mental State: Efficacy of Stress Management Cognitive Behavioral Therapy : a Randomized Controlled Trial"
The first psychotic episodes are preceded by a pauci-symptomatic phase from 2 to 4 years during which the psychotic symptoms are present at a subliminal level in severity or in frequency.
- Trial name
- START (NCT02368353)
- Testing
- Cognitive behavioral therapy, Supportive therapy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier St Anne
Body Weight
Preload, Weight Management, Risk of Cardiovascular Disease
Investigators presumed that preload consumers will have more weight reduction and lower risk of cardiovascular disease
- Trial name
- NCT01665339
- Testing
- preload diet, control diet
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences