Clinical trials: Management, Risk
Pain, Anxiety
Readiness for Discharge Following Lobectomy
This study aims to examine the relationship between the patient's perception of readiness for discharge after lobectomy and mobilization rates, frequency of visitation by family and friends, anxiety levels and pain levels.
- Trial name
- NCT00247832
- Testing
- Self-directed motivation, Personal motivational interviewing
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- University of British Columbia
Hypotension
PeRsonalized Blood prEssure Management on Postoperative Complications and Mortality in hIgh-risk Patients Undergoing Major Non-cardiac Surgery
High-risk populations, particularly elderly individuals and patients with cardiovascular comorbidities, exhibit markedly elevated incidences of postoperative myocardial injury (MINS), acute kidney injury (AKI), and mortality.
- Trial name
- PREMIUM (NCT06952387)
- Testing
- Personalized blood pressure management, Routine blood pressure management
- Where
- 7 sites in China
- Volunteers
- 1,624 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Rectal Cancer
Tailored Operative or Non-operative Management for Low-risk Rectal Cancer After Intensive Neoadjuvant Treatment
This study is designed to test the efficacy of tailored operative or non-operative management (NOM) for MRI defined low-risk rectal cancer following neoadjuvant intensity modulated radiotherapy with concurrent capecitabine plus…
- Trial name
- NCT02860234
- Testing
- Oxaliplatin, Capecitabine, intensity modulated radiotherapy
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Peking University Cancer Hospital & Institute
Gastric Ulcer
Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen
This study uses a randomized, double-blind, controlled design to demonstrate that PN400 (esomeprazole and naproxen) is more effective in reducing the occurrence of gastroduodenal ulcers, dyspepsia, and heartburn in subjects at…
- Trial name
- NCT00527787
- Testing
- PN400 (VIMOVO), Naproxen
- Where
- United States
- Volunteers
- 434 people
- Sponsor
- POZEN
Surgery
Intraoperative Fluid Management Based on Arterial Pulse Pressure Variation During High-Risk Surgery
Hypovolaemia and tissue hypoperfusion can pass undetected during and after major surgery. The resulting systemic inflammatory response and organ dysfunction, often not clinically apparent for several days, may lead to increased…
- Trial name
- NCT00479011
- Testing
- fluid management based on arterial pulse pressure variation
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Santa Casa de Passos
Failure to Thrive
Palliative Care Population Management Project for Integrated Care Management Program for High-Risk Patients
The hypothesis of the Serious Illness Care Program (SICP) is that adherence to the Serious Illness Conversation Guide (SICG) portion, the SIGC, will enhance patient understanding and allow control over their own decisions…
- Trial name
- iCMP (NCT02879357)
- Testing
- Training
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- Brigham and Women's Hospital
Diabetic Foot Ulcer (DFU)
Remote Temperature and Visual Monitoring To Help Manage Diabetic Foot Ulcers
This study is a prospective, observational investigation evaluating the effectiveness of Remote ThermoVisual Monitoring (RTVM) in the early detection of diabetic foot ulcers (DFUs) in high-risk populations.
- Trial name
- NCT06782386
- Testing
- OneStep Foot Scanner
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Bluedrop Medical Limited
Dementia, Alzheimer Disease
Implementation of the Care Ecosystem Training Model for Individuals With Dementia in a High-risk, Integrated Care Management
There is growing need for to provide high quality care for persons living with dementia (PLWD) and provide support for care partners in the primary care setting.
- Trial name
- CRESCENT (NCT04556097)
- Testing
- Care Ecosystem
- Where
- United States
- Volunteers
- 524 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
COVID-19, Acute Respiratory Distress Syndrome
DEXamethasone EARLY Administration in Hospitalized Patients With Covid-19 Pneumonia
The aim of this study is to evaluate the efficacy of dexamethasone in hospitalized adults with COVID-19 pneumonia who do not require supplementary oxygen on admission, but have high risk of developing acute respiratory distress…
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome, Pneumonia, Viral
- Trial name
- EARLYDEXCoV2 (NCT04836780)
- Testing
- Dexamethasone
- Where
- 3 sites in Spain
- Volunteers
- 126 people
- Sponsor
- Hospital Universitario Infanta Leonor
Coronary Artery Disease, Antiplatelet Therapy
Minimally Invasive Coronary Artery Bypass Supported by Cangrelor
The purpose of this study is to find out whether it is safe and practical to perform MIDCAB surgery (a minimally invasive heart bypass procedure) while patients receive a continuous cangrelor infusion during the operation.
- Conditions
- Coronary Artery Disease, Antiplatelet Therapy, Minimally Invasive Coronary Revascularization Surgery
- Trial name
- MINOTAUR (NCT07514962)
- Testing
- Cangrelor-guided MIDCAB surgery (for the prospective cases), Aspirin MIDCAB surgery (for the historical controls)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Cardiocentro Ticino
Skin Basal Cell Carcinoma
Active Surveillance for the Treatment of Low-Risk Basal Cell Carcinoma in Elderly Patients
This clinical trial evaluates whether active surveillance (AS) is a safe and comfortable alternative to standard of care (SOC) treatment for elderly patients with low-risk basal cell carcinoma (LR-BCC).
- Trial name
- NCT06539468
- Testing
- Best Practice, Educational Activity, Patient Observation
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Michigan Rogel Cancer Center
Pregnancy, High Risk, Type 1 Diabetes
Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D)
PRISM-TID is a single center non-inferiority randomized controlled trial of permissive intrapartum glucose management (intervention) versus strict intrapartum glucose management (standard of care) among pregnant individuals with…
- Trial name
- PRISM-T1D (NCT07293715)
- Testing
- Insulin, DEXCOM Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Ohio State University
Acute Cholecystitis, Choledocholithiasis
Acute Cholecystitis With Concomitant Choledocholithiasis: Unicentric Study of Prevalence and Predictive Factors
The management of cholelithiasis with choledocolithiasis is extensively known, whereas for Acute Calculous Cholecystitis (ACC) with choledocolithiasis or common bile duct stones (CBDS), a common entity, there is a lack of…
- Trial name
- CHOLEPREV (NCT04739891)
- Volunteers
- 120 people
- Sponsor
- Hospital de Mataró
Cardiovascular Diseases, Heart Diseases
Problem Solving and Cardiovascular Disease Risk Management in Diabetic Blacks
The purpose of this study is to test a measurement tool and a new training intervention for problem solving in self-management of high cardiovascular disease (CVD) risk in African Americans with type 2 diabetes.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Diabetes Mellitus, Type 2, Coronary Disease
- Trial name
- NCT00201110
- Testing
- Problem Solving Skills
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Johns Hopkins University
Melanoma (Skin)
Vaccine Therapy With or Without Imiquimod in Treating Patients Who Have Undergone Surgery for Stage II, Stage III, or Stage IV Melanoma
RATIONALE: Vaccines made from peptides may help the body build an effective immune response to kill tumor cells. Biological therapies, such as imiquimod, may stimulate the immune system in different ways and stop tumor cells from…
- Trial name
- NCT00118313
- Testing
- incomplete Freund's adjuvant, multi-epitope melanoma peptide vaccine, sargramostim
- Where
- United States
- Sponsor
- Craig L Slingluff, Jr
Pre-Eclampsia, Hypertension in Pregnancy
Furosemide vs. Placebo for Severe Antepartum Hypertension
Primary objective: To determine whether the addition of intravenous furosemide with usual antihypertensives is associated with a reduction in mean systolic blood pressure from baseline compared to treatment with placebo plus…
- Conditions
- Pre-Eclampsia, Hypertension in Pregnancy, Pregnancy Complications, Hypertension, Pregnancy-Induced
- Trial name
- NCT04615624
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Melanie Maykin, MD
Adult Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia
Geriatric Assessment & Genetic Profiling to Personalize Therapy in Older Adults With Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is among the most common hematologic malignancies in adults and accounts for approximately 10,000 deaths in the United States every year. AML is commonly diagnosed in sixth or seventh decades of life.
- Conditions
- Adult Acute Myeloid Leukemia, Secondary Acute Myeloid Leukemia, Therapy-Related Acute Myeloid Leukemia
- Trial name
- NCT03226418
- Testing
- Cytarabine, Decitabine, Idarubicin
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Nebraska
Wearable Device, Cardiovascular Disease
HEARTS in Sync + CardioWatch 287-2
The goal of this interventional study is to evaluate the implementation, usability, and clinical outcomes of a wearable medical-grade device in a virtual Cardiac Rehabilitation (CR) program, titled HEARTS in Sync.
- Conditions
- Wearable Device, Cardiovascular Disease, ASCVD Management, CHF - Congestive Heart Failure
- Trial name
- NCT07322510
- Testing
- Remote Patient Monitoring with Corsano CardioWatch 287-2
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Nova Scotia Health Authority
Hiv, Meningitis, Meningococcal
Evaluation of Safety and Immunogenicity of Meningococcal B and Meningococcal ACWY Vaccine in at Risk Population
This study aims to evaluate the immunogenicity, safety and tolerability of co-administration of vaccinations for meningitis B (Bexsero®) and meningitis ACWY (Menveo®) in adults and children aged 10-45 years living with HIV.
- Conditions
- Hiv, Meningitis, Meningococcal, HIV Infections
- Trial name
- ProPositive (NCT03682939)
- Testing
- Bexsero® (meningitis B vaccine), Menveo® (meningitis ACWY vaccine)
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- St George's, University of London
IBD - Inflammatory Bowel Disease
Renal and Urinary Manifestations of Chronic Inflammatory Bowel Diseases.
The association between IBD and kidney diseases is more common than previously thought. However, the data is limited and comes from studies with small sample sizes.
- Trial name
- NCT06814392
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna