Clinical trials: Management, Risk
Bladder (Urothelial, Transitional Cell) Cancer Superficial (Non-Invasive), Transurethral Resection of Bladder Tumor
Evaluation of the Role of Early Second Look TURBT in Management of High Risk Non Muscle Invasive Bladder Cancer
The aim is to evaluate the intraoperative, postoperative and pathologic findings of early second look TURBT and the factors affecting these findings to assess the value of early second TURBT in the management of high risk NMIBC.
- Trial name
- NCT07642102
- Testing
- early second look transurethral resection of bladder tumor
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Gastrointestinal Stromal Tumors, Gastric Subepithelial Tumors
Development of a Multimodal AI System for GIST Management
Background: Gastrointestinal Stromal Tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Accurate pre-operative diagnosis, risk stratification, and genotyping are critical for determining the…
- Conditions
- Gastrointestinal Stromal Tumors, Gastric Subepithelial Tumors, Gastric Leiomyoma, Artificial Intelligence (AI)
- Trial name
- NCT07454967
- Testing
- Multimodal AI Analysis System
- Where
- 9 sites in China
- Volunteers
- 300 people
- Sponsor
- Qun Zhao
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Natural Killer Cells Before and After Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia
This phase I/II studies the side effects and best dose of natural killer cells before and after donor stem cell transplant and to see how well they work in treating patients with acute myeloid leukemia, myelodysplastic syndrome…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Acute Myeloid Leukemia With Gene Mutations, Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive
- Trial name
- NCT01904136
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation, Cyclophosphamide
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- M.D. Anderson Cancer Center
Ventilation Acquired Pneumonia
The Effect of Continuous Management of Suction Cuff Pressure and Subglottic Irrigation Suction on Preventing VALRI Study
Assessing the effectiveness of continuous cuff pressure management combined with subglottic suction irrigation in reducing ventilator-associated lower respiratory tract infections (VALRTI) in mechanically ventilated patients at…
- Trial name
- SCOPE (NCT06867237)
- Testing
- Suction cuff pressure
- Volunteers
- 90 people
- Sponsor
- Shanghai Zhongshan Hospital
Hypertension, Blood Pressure
Young Adult Hypertension Self-Management Clinical Trial
This is a 5-year randomized controlled trial in two large healthcare systems (Madison and Milwaukee, WI) to evaluate MyHEART's (My Hypertension Education And Reaching Target) impact on blood pressure among 310 geographically and…
- Conditions
- Hypertension, Blood Pressure, Lifestyle Risk Reduction
- Trial name
- MyHEART (NCT03158051)
- Testing
- Home Blood Pressure Monitoring, Telephone Health Coaching
- Where
- 2 sites in United States
- Volunteers
- 316 people
- Sponsor
- University of Wisconsin, Madison
Depression, Hemodialysis Complication
Depression Inventory for Maintenance Hemodialysis Patients
Depression is frequently seen among hemodialysis patients; however, it causes an impaired quality of life, a decrease in adherence to treatment, and an increase in hospitalization and mortality rate.
- Conditions
- Depression, Hemodialysis Complication, Management, Risk Behavior
- Trial name
- Depression (NCT06844890)
- Where
- Turkey (Türkiye)
- Volunteers
- 283 people
- Sponsor
- Istanbul University
Gastroduodenal Ulcerations, Erosion
Clinical Trial Evaluating Gastrointestinal Damage Following Administration PL3100 or Naproxen in At-Risk Adults
The purpose of this study is to determine the subchronic gastrointestinal (GI) safety of PL3100 versus Naproxen in normal healthy volunteers.
- Trial name
- NCT01139190
- Testing
- PL3100, Naproxen
- Where
- 2 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- PLx Pharma
Vasomotor Symptoms, Urinary Incontinence
Nurse-led Primary Healthcare Intervention Model in Women's Health Management in Hong Kong
The goal of this randomized clinical trial is to learn if a nurse-led primary healthcare intervention can help improve health management in women adults aged 45 to 64, and to develop an evidence-based primary healthcare model for…
- Conditions
- Vasomotor Symptoms, Urinary Incontinence, Anxiety, Depression - Major Depressive Disorder
- Trial name
- JCDATAZONEWH (NCT06628388)
- Testing
- Nurse-Led Risk-Based 5As Primary Healthcare Model, Minimal Intervention
- Where
- 3 sites in Hong Kong
- Volunteers
- 1,728 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Geriatric Depression
Community-based Rehabilitation Management for Patients With Remitted Geriatric Depression
This study intends to take patients with RGD as objects. Further construct a community-based rehabilitation management (CBRM) program with drug treatment, rehabilitation measures of education, psychology and exercise as its core…
- Trial name
- NCT05610917
- Testing
- CBRM (community-based rehabilitation management), TAR(treatment as routine)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Duan Li
Brain Tumor Adult, Brain Tumor Benign
Analysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial Tumors
Cerebrospinal fluid is a clear fluid that surrounds and protects the brain. During surgery for brain tumors, neurosurgeons often need to open the covering of the brain (the dura) to reach the tumor.
- Conditions
- Brain Tumor Adult, Brain Tumor Benign, CerebroSpinal Fluid (CSF) Leak, Craniotomy
- Trial name
- CSF-IMR (NCT07411690)
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Opioid-use Disorder, Opioid Misuse
Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes
The Care Continuity Program (CCP), a product of Sure Med Compliance, is a novel, online patient self-assessment used by prescribers of opioids to better identify patient risk factors and therapy benefit.
- Conditions
- Opioid-use Disorder, Opioid Misuse, Opioid Use, Chronic Pain
- Trial name
- NCT04945525
- Testing
- Care Continuity Program
- Where
- United States
- Volunteers
- 1,840 people
- Sponsor
- Sure Med Compliance
Diabetes Mellitus
a Risk Assessment and Management Program Using Telecare Consultation Among Patients With Diabetes Mellitus
Telecare consultation, which is defined as a two-way synchronized visual (voice and image) communication between patients and healthcare professionals using telecommunication applications such as Zoom, has become a major trend in…
- Trial name
- NCT05183685
- Testing
- telecare consultation, Usual face to face consultation
- Where
- Hong Kong
- Volunteers
- 780 people
- Sponsor
- The Hong Kong Polytechnic University
HIV Infections, Sinusitis
Preventing Frequent Sinus Infections in HIV-Infected Patients
To evaluate the additional effectiveness of an anti-inflammatory nasal spray ( beclomethasone dipropionate ) and a broad spectrum antibiotic ( cefuroxime axetil ) over decongestant ( Deconsal II ) alone, when these agents are…
- Trial name
- NCT00000752
- Testing
- Pseudoephedrine hydrochloride, Guaifenesin, Cefuroxime axetil
- Where
- 10 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obesity, Weight Loss
Lifestyle Intervention in Overweight Women
The Exercise and Obesity Health Promotion (PESO) program is a randomized controlled trial designed to analyze the effects of a lifestyle intervention in weight management and health-related parameters of overweight and obese…
- Conditions
- Obesity, Weight Loss, Lifestyle, Sedentary, Physical Activity
- Trial name
- PESO (NCT03823898)
- Testing
- Supervised exercise, Lifestyle intervention from baseline to 4 months, Monthly behavioral sessions
- Where
- Portugal
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Change in Brain Perfusion
Brain SPECT Following Cialis (Tadalafil ) Administration
The study will be an open label one and will include 30 patients who underwent ischemic stroke 3 month to 3 years prior to the study. All patients will undergone a baseline brain SPECT perfusion study.
- Trial name
- CIALIS (NCT01374347)
- Volunteers
- 30 people
- Sponsor
- Wolfson Medical Center
Anxiety Disorders and Symptoms Depressive Symptoms, Risk Factors (Rejection, Bullying/Cyberbullying, Addictions, Healthy Lifestyle Habits, Exam Stress Management, Ecoanxiety, Expressed Emotion)
Selective Prevention Transdiagnostic Intervention for At-risk Adolescents With Booster Sessions. (PROCARE+ 2.0)
Emotional disorders such as anxiety and depression are significantly underdiagnosed and undertreated, even though they are some of the most prevalent mental health conditions, especially among young individuals.
- Trial name
- NCT06185049
- Testing
- PROCARE+ (Core intervention with add-on modules) and two booster sessions., PROCARE+ (Core intervention with add-on modules) and one booster session, PROCARE+ (Core intervention with add-on modules) without booster sessions.
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Jaén
Hiv Prevention, Pre-Exposure Prophylaxis (PrEP)
PrEPared-RN, CAN Nurse-Led Management of High-risk Patients for Pre-Exposure Prophylaxis (PrEP)
During the initial encounter, the nurses will complete program enrollment forms (consents and disclosures as approved by IRB), medical history, and risk assessment.
- Trial name
- Prep-RN (NCT06030557)
- Testing
- Truvada
- Where
- 5 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- CAN Community Health
Depression, Inflammation
Simvastatin and Emotional Processing (OxSTEP)
Simvastatin is being employed because it is a 'statin'. As a drug class, statins have broad anti-inflammatory properties. Low-level inflammation is thought to be a potentially important mediator of the effects of psychosocial…
- Trial name
- OxSTEP (NCT04973800)
- Testing
- Simvastatin 20mg
- Where
- United Kingdom
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Asymptomatic Hypertension
Innovative Approaches to Hypertension Management in High-Risk Emergency Department Populations
This single-center, single-arm quasi-experimental study will assess the feasibility and acceptability of a community health worker (CHW)-led intervention to address social determinants of health (SDOH) among emergency department…
- Trial name
- aHTN-Manage (NCT07539597)
- Testing
- Community Health Worker engagement
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Atrial Fibrillation, Anticoagulant-induced Bleeding
Perioperative Management of Factor Xa Inhibitors
This study aims to analyze the safety and effectiveness of the discontinuation/resumption protocol of factor Xa inhibitors before and after invasive procedures/surgeries in non-valvular atrial fibrillation patients who are at…
- Trial name
- PERIXa (NCT05801068)
- Testing
- Factor Xa Inhibitor
- Where
- South Korea
- Volunteers
- 2,500 people
- Sponsor
- Seoul National University Hospital