Clinical trials: Management, Risk
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment.
The goal of this clinical trial is to learn whether a hybrid multidomain lifestyle program can prevent cognitive decline and reduce dementia risk in community-dwelling adults in mid- to late life who are at increased risk of…
- Trial name
- LETHE-AT (NCT07376135)
- Testing
- A tailored hybrid multidomain lifestyle intervention group, Self-guided multimodal lifestyle advice group
- Where
- 3 sites in Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Intubation; Difficult or Failed, Intubation Complication
Adverse Events in the Tracheal Intubation in the Intensive Care Unit
The airway management is essential in the Critical Care setting, both normal and difficult airway patients. Intubation is a risk procedure in which a great number of complications may occur, including death.
- Conditions
- Intubation; Difficult or Failed, Intubation Complication, Intubation
- Trial name
- INTUPROS (NCT03916224)
- Where
- Spain
- Volunteers
- 1,800 people
- Sponsor
- Spanish Network for Research in Infectious Diseases
Oxygen Delivery, Intubation
Environmental Oxygen Levels During Artificial Ventilation and Oxygen Therapy
European Resuscitation Council 2021 Guidelines and Advanced Life Support Provider Courses teach that the oxygen supply must be removed from the patient during defibrillation to the distance of minimum of 1 meter.
- Conditions
- Oxygen Delivery, Intubation, Airway Control, Concentration
- Trial name
- NCT06718361
- Testing
- Oxygen levels measurement (%)
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- David Peran, PhD, FERC
Wound Heal
Postoperative Wounds With Delayed Healing Risk of Clinical Trial Registration
this study aims to optimize the components of TIME CDST based on clinical practice and apply the optimized elements to the management of wounds with delayed healing risk after hip arthroplasty to identify and design the key steps…
- Trial name
- NCT06272097
- Testing
- Intervention program based on TIME-CDST tool led by wound specialist nurses, A routine wound care program
- Volunteers
- 492 people
- Sponsor
- Danni Feng
Chronic Kidney Disease
A Risk Based Approach to Improving Chronic Kidney Disease Management
Aim 1: To assess whether quality of care for stage 3 chronic kidney disease can be substantially improved over 18 months by: Point of care electronic alerts to primary care physicians recommending risk-appropriate care, and…
- Trial name
- NCT01203813
- Testing
- Electronic Decision Support
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Brigham and Women's Hospital
Postinduction Hypotension
Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension
INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk…
- Trial name
- INDUCT-Multi (NCT07538388)
- Testing
- Continuous Norepinephrine Administration
- Where
- 4 sites in Germany
- Volunteers
- 446 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ventricular Tachycardia
Anesthetic Management in Patients Undergoing Epicardial Ablation
The study is a retrospective study and is descriptive in nature. In this study, the investigators aimed to emphasize the importance of anesthesia management by cardiac risk assessment of patients undergoing epicardial ablation…
- Trial name
- NCT06538987
- Testing
- percutaneous epicardial ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Caries,Dental, Tooth Decay
KAP of Dental Practitioners Regarding CRA
The aim of the study is to evaluate the knowledge, attitude, and practice of a group of dental practitioners from Cairo and Riyadh regarding caries risk assessment and management.
- Conditions
- Caries,Dental, Tooth Decay, Tooth Diseases
- Trial name
- NCT05792215
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Cairo University
Opioid Consumption, Postoperative
Precision Pain Management - A Randomized Clinical Trial Assessing the Efficacy of Suzetrigine on Postoperative Analgesia Among Surgical Patients at Higher Risk for Persistent Postoperative Opioid Use (POU)
The purpose of the study is to investigate the efficacy of suzetrigine for treatment of acute postoperative pain among surgical patients identified as high risk for persistent postoperative opioid use (POU).
- Trial name
- NCT07672015
- Testing
- Suzetrigine, Standard Care (in control arm)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Intestinal Obstruction, Intestinal Perforation
Pathophysiology of Perioperative Fluid Management in Emergency Laparotomy
Pathophysiology of perioperative fluid management in patients undergoing emergency laparotomy.
- Conditions
- Intestinal Obstruction, Intestinal Perforation, Anastomotic Leak, Fluid Overload
- Trial name
- NCT03997721
- Where
- Denmark
- Volunteers
- 73 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Obstructive Sleep Apnea
Oxygen Supplementation Study in Obstructive Sleep Apnea (OSA) Patients
Hypotheses: 1. Postoperative oxygen therapy significantly improves postoperative oxygenation in OSA surgical patients. 2. Postoperative oxygen therapy do not significantly increase the number of apnea episodes and the duration of…
- Trial name
- NCT01552304
- Testing
- Oxygen therapy, Control group
- Where
- Canada
- Volunteers
- 196 people
- Sponsor
- University Health Network, Toronto
Malnourished
Nutritional Screening in Older Individuals
Hospital-based case management programs and home hospitalization services following the risk stratification model of Kaiser Permanente and Kings Fund select an estimated 5% of older individuals living in the community who are at…
- Trial name
- NCT03278678
- Volunteers
- 791 people
- Sponsor
- Sanjuan, Silvia Forcano, M.D.
AMD
Anecortave Acetate Risk-Reduction Trial (AART)
The purpose of this study was to demonstrate that Anecortave Acetate for Depot Suspension (15 mg or 30 mg) is safe and effective in arresting the progression of non-exudative (dry) age-related macular degeneration in patients who…
- Trial name
- NCT00333216
- Testing
- Anecortave Acetate Sterile Suspension, 30 mg/mL, Anecortave Acetate Sterile Suspension, 60 mg/ML, Anecortave Acetate Vehicle
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Alcon Research
Postpartum Hemorrhage， Cesarean Section
A Comparative Study Between Rectal and Intrauterine Misoprostol Administration in the Reduction of Blood Loss During and After Elective Cesarean Delivery in Low Risk Women
One hundred forty low risk pregnant women scheduled for elective cesarean delivery were randomized (1:1) into two groups: the intrauterine group (n=70) received 400 μg misoprostol (200 μg at each uterine cornu) after placental…
- Trial name
- NCT07728084
- Testing
- Misoprostol Tabets
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Cairo University
Human Immunodeficiency Virus
Evaluation of Problem Management Plus in Pregnant Women With HIV in Kenya
This study includes secondary quantitative analysis, qualitative methods, and hybrid type 2 implementation-effectiveness pilot trial.
- Trial name
- Tatua (NCT05841797)
- Testing
- In-Person Program Management Plus (PM+), Mobile Program Management Plus (mHealth PM+)
- Where
- Kenya
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Statin, Cardiovascular Risk Factors
Role of Coronary CTA on Lipid Management and Risk Factors Control in an Asymptomatic Chinese Population
The primary objective of this study is to determine whether coronary computed tomography angiography (CCTA) -based coronary heart disease(CHD) prevention strategy improves lipid-lowering treatment and cardiovascular risk factor…
- Conditions
- Statin, Cardiovascular Risk Factors, Primary Prevention, Adherence, Medication
- Trial name
- RESPECT2 (NCT05725096)
- Testing
- Coronary Computed Tomography Angiography, Traditional cardiovascular risk stratification
- Where
- China
- Volunteers
- 3,400 people
- Sponsor
- Zhang longjiang,MD
Obesity, Diabetes
Translating the Diabetes Prevention Program Into a Virtual Lifestyle Management Program
The objective of this study is to evaluate the effectiveness of Virtual Lifestyle Management (VLM) as a behavior modification tool to promote weight loss, healthy eating and physical activity patterns, in the interest of reducing…
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT00867425
- Testing
- Virtual Lifestyle Management
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Hospitalization, Patient Readmission
Intervening With and Improving Care for Patients at Risk for Frequent Hospital Admissions
Patients with frequent hospital admissions account for a disproportionate share of visits and costs. An intervention that can bridge the gap between hospital and community based care for a population of patients with frequent…
- Trial name
- NCT01292096
- Testing
- Provision of extra (care coordination and management) services
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- NYU Langone Health
Diabetes Mellitus, Foot Ulcer
Becaplermin Use and Cancer Risk in a Patient Population of U.S. Veterans With Diabetes
The purpose of this study is to evaluate risk of cancer incidence and mortality associated with the use of REGRANEX (becaplermin) in patients with diabetes who are members of a U.S. Veterans Health Administration.
- Conditions
- Diabetes Mellitus, Foot Ulcer, Diabetic Foot, Diabetic Neuropathies
- Trial name
- NCT01235260
- Testing
- Becaplermin nonusers, Becaplermin users
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
AKI, CHD - Congenital Heart Disease
NO During CPB in Neonates to Reduce Risk of AKI
Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality.
- Conditions
- AKI, CHD - Congenital Heart Disease, Surgery
- Trial name
- NCT04216927
- Testing
- Nitric Oxide, Oxygen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati