Clinical trials: Management, Risk
Renal Transplantation
Efficacy and Safety of Early Versus Delayed Administration of Everolimus in de Novo Renal Transplant Patients
The purpose of this study is to evaluate if the delayed administration of everolimus could reduce the everolimus associated "anti-proliferative complications" (e.g.
- Trial name
- NCT00154297
- Testing
- Everolimus (RAD001)
- Where
- Switzerland
- Volunteers
- 139 people
- Sponsor
- Novartis Pharmaceuticals
Long QT Syndrome
Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes
Torsades de pointes (TdP) is a potentially fatal ventricular arrhythmia associated with corrected QT (QTc) interval prolongation.
- Trial name
- NCT02513940
- Testing
- Testosterone, Progesterone, Ibutilide
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pre-obesity, Obesity
DIGITALIZATION OF PERSONALISED HEALTH RISK MANAGEMENT
The principal objective of the project is: to bring together academic and business research organisations in a joint partnership integrating technological and social innovation, in order to develop proof-of-concept of a scalable…
- Trial name
- DIG4HEALTH (NCT06983431)
- Testing
- technology driven self coaching, Health coaching, Peer coaching
- Where
- Slovakia
- Volunteers
- 320 people
- Sponsor
- Slovak Academy of Sciences
Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression
PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis
Heart disease is the leading cause of death for men, women, and people of most racial and ethnic groups in the United States. This clinical trial will test if screening and early treatment of mild heart disease works.
- Conditions
- Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression, Prevention & Control, Premature Atherosclerosis
- Trial name
- PRE-EMPT (NCT07232069)
- Testing
- Rosuvastatin 20 Mg Oral Tablet, Colchicine 0.5 MG Oral Tablet Once Daily
- Where
- 23 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Duke University
Oral Mucositis Due to Radiation, Radiation Dermatitis
Feasibility and Safety of CareMin650 in Patients at Risk of or Suffering From Oral Mucositis and/or Radiation Dermatitis
The main objective of the present study is to investigate the feasibility, safety and tolerability of CareMin650 in patients with 1) head \& neck cancer at high risk of or suffering from oral mucositis and/or radiation dermatitis…
- Trial name
- SafePBM (NCT03988556)
- Testing
- Photobiomodulation using CareMin650 at 6 Joules (curative intent), Photobiomodulation using CareMin650 at 3 Joules (prophylactic intent)
- Where
- 5 sites in France
- Volunteers
- 72 people
- Sponsor
- NeoMedLight
Bladder Neck Obstruction, Bladder Outlet Obstruction
Effectiveness and Safety of Adipose-derived Regenerative Cells for Reduction of Risk of Bladder Neck Contracture
Autologous adipose-derived regenerative cells (ADRC) will be extracted from lipoaspirate by enzymatic digestion from a portion of the fat harvested from the patient's front abdominal wall.
- Conditions
- Bladder Neck Obstruction, Bladder Outlet Obstruction, Benign Prostatic Hyperplasia, Urinary Bladder Neck Obstruction
- Trial name
- NCT02869061
- Testing
- Liposuction, Transurethral bladder neck resection., ADRC
- Where
- 2 sites in Russia
- Volunteers
- 12 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Low Back Pain
Pain Management for Patients With Low Back Pain and Psychosocial Risk Factors in a Hospital Setting.
Patients with low back pain and coexisting psychosocial risk factors have a poorer prognosis in terms of quality of life, disability, sick leave and health care use.
- Trial name
- NCT03141541
- Testing
- Group based pain management intervention
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Central Jutland Regional Hospital
Mental Disorders, Severe
Transmural Collaborative Care Model for CVRM and Medication Review for Patients Using Antipsychotics
Currently, monitoring of usage and effects of antipsychotic treatment and cardiovascular risk screening in patients with severe mental illness or antipsychotic treatment is not sufficient.
- Trial name
- TACTIC (NCT05647980)
- Testing
- TACTIC
- Where
- Netherlands
- Volunteers
- 480 people
- Sponsor
- Radboud University Medical Center
Suicide
An Implementation Study of Suicide Risk Management Among Discharged Psychiatric Patients
The post-discharge suicide risk among psychiatric patients is significantly higher than it among patients with other diseases and general population.
- Trial name
- NCT04907669
- Testing
- Brief contact intervention
- Where
- China
- Volunteers
- 498 people
- Sponsor
- Shenzhen Kangning Hospital
Hemodialysis, Heart Failure
Risk Factors and Application of Risk Management Strategies in Hemodialysis Patients Complicated With Heart Failure
Age, hyperglycemia, inflammation, and comorbidities (hypertension, diabetes, coronary disease) independently increase HF risk in hemodialysis patients.
- Trial name
- NCT06959927
- Testing
- Standard Care Group, Risk-Stratified Management Group
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Guiren Hou
Mental Health Disorder
StayOK - an Innovative Measuring Instrument for the Early Identification and Treatment of Psychosocial Risks
The validity and the sensitivity of different measures implemented in the web application StayOk are investigated. The measures are used primarily for the assessment and the early identification of psychosocial risks.
- Trial name
- StayOK (NCT03213327)
- Testing
- StayOk web application
- Where
- Switzerland
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Zurich University of Applied Sciences
Human Papillomavirus Infection
Evaluating Clearance of High-Risk HPV and Safety After Administration of ABI-2280 Vaginal Inserts
This is a blinded study to assess safety, tolerability, and efficacy of ABI-2280 vaginal inserts in participants diagnosed with persistent cervical hrHPV infection.
- Trial name
- NCT06491446
- Testing
- ABI-2280
- Where
- 24 sites in Australia, Kenya and 2 more
- Volunteers
- 141 people
- Sponsor
- Antiva Biosciences
Administration of Increased Dose of GnRH Antagonist for Coasting for Decreasing the Risk for Ovarian Hyperstimulation Syndrome( OHSS)
Administration of Increased Dose of GnRH Antagonist for Coasting for Decreasing the Risk for Ovarian Hyperstimulation Syndrome( OHSS)
Coasting is one of the means to reduce the risk of OHSS for patients at risk for severe OHSS. During coasting gonadotrophin administration is withheld until serum E2 levels drop to a range considered safe.
- Trial name
- NCT01109888
- Testing
- Cetrotide
- Sponsor
- Wolfson Medical Center
Patients at High Risk of Medicine-related Problems
Pharmacist-led Medicines Management Outpatient Service
It widely accepted that a number of medication related problems can occur after the patient has been discharged from the hospital.
- Trial name
- MMC (NCT01534559)
- Testing
- Medicines Management Outpatient service
- Where
- United Kingdom
- Volunteers
- 62 people
- Sponsor
- Queen's University, Belfast
Barotrauma Epidemiology
Diver Ear, Nose and Throat Barotrauma Epidemiology
Ear, nose and throat barotrauma are the most frequently encountered accidents during diving. One study related to recreational diving reports that ENT barotrauma concern 10% of dives with experimented divers and 30% with novice…
- Trial name
- BTORL PAF (NCT04647591)
- Testing
- Questionnaires
- Where
- 7 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Antibiotic Prescription
Management and Outcome of Fever in Children in Europe
This is an observational study assessing the management and outcome of children presenting to Emergency Departments (ED) with fever across Europe.
- Trial name
- MOFICHE (NCT05221437)
- Testing
- antibiotic prescription
- Volunteers
- 38,480 people
- Sponsor
- Imperial College London
HIV, Cardiovascular Disease
HealthMap: an Interactive Health Plan Randomised Trial to Prevent Cardiovascular Disease in People With HIV
The purpose of this study is to improve the health status of people living with HIV in Australia. The overall goal is to rigorously evaluate the impact of interactive health plans and self-management support on chronic condition…
- Trial name
- NCT02178930
- Testing
- Integrated self management support
- Where
- 14 sites in Australia
- Volunteers
- 731 people
- Sponsor
- Karen Klassen
Multimoda Lultasound, Thyroid Cancer
Multimodality US Based on Angio Planewave Ultrasensitive Imaging and Shear Wave Elastography to Evaluate the Malignancy Risk Value of Thyroid Nodules
The goal of this clinical trial is to explore the value of a multimodal ultrasound model based on Angio Planewave Ultrasensitive Imaging, Shear Wave Elastography and grayscale ultrasound in the differential diagnosis of benign…
- Conditions
- Multimoda Lultasound, Thyroid Cancer, Microvascular Classification
- Trial name
- NCT06530771
- Testing
- ultrasound
- Where
- China
- Volunteers
- 720 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Cardiovascular Diseases
Internet Based Vascular Risk Factor Intervention and Self Management Study
The objective of the study is to evaluate the efficacy and cost-effectiveness of an internet based vascular risk factor program on top of usual care compared to usual care alone for treatment of vascular risk factors in patients…
- Trial name
- IRIS (NCT00785031)
- Testing
- internet based vascular risk factor intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 330 people
- Sponsor
- UMC Utrecht
Covid-19 (SARS-CoV-2)
Ambulatory Management of Moderate to High Risk COVID-19 (SARS-CoV-2) Patients - The Coronavirus Related Outpatient Work Navigators (CROWN) Protocol
Descriptive report of the Northwell CROWN program for ambulatory treatment of COVID-19 (SARS-CoV-2) patients with moderate to high risk features
- Trial name
- CROWN (NCT04476602)
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- Northwell Health