Clinical trials: Management, Risk
Chronic Lung Disease
Prevention of Chronic Lung Disease (CLD - Prevention Study)
Primary endpoint: prospectively identify potential biomarkers able to predict the severe course of pulmonary funcion in the first 12 months of life and realize a new profile to early identify hugh risk newborns Secondary…
- Trial name
- NCT06559670
- Testing
- Blood sampling
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cardiovascular Disease
Medication Management and Culture of Safety
There will be no significant decrease in the use of low dose acetylsalicylic acid (ASA) therapy for primary prevention across the three intervention arms from baseline to completion of the project.
- Trial name
- MM (NCT01247454)
- Testing
- academic detailing, Electronic Health Record (EHR) prompt, EHR prompt and patient prompt
- Where
- United States
- Volunteers
- 7,000 people
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes, Gestational Diabetes
Randomized Trial to Evaluate the Effectiveness of Nurse Case Management
The management of high-risk pregnancies require substantial use of medical resources. Our goal is to determine the effectiveness of a nurse case management program in which case managers are assigned to patients with high-risk…
- Conditions
- Type 2 Diabetes, Gestational Diabetes, Hypertension, Preterm Delivery
- Trial name
- NCT00295256
- Testing
- nurse case manager
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Hereditary Cancer Syndromes, Clinical Decision Support
Closing the GAPS: Guideline Adherence, Prevention and Surveillance in Hereditary Cancer
The goal of this clinical trial is to see if a software platform can improve cancer screening in young adults with genetic risk for cancer. The trial will also help improve the software platform (Nest).
- Trial name
- NCT06654466
- Testing
- Nest, an electronic medical record (EMR)-integrated software platform to deliver longitudinal, genetics-based care at scale.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nest Genomics
COVID-19 Pandemic, Vulnerable Subjects
Perceived Impact of the COVID-19 Pandemic on Medical Management and Symptoms in a High Risk Group
The Swiss population underwent a period of confinement related to the COVID-19 pandemic (March 16 to May 11, 2020) decided by the Swiss Federal Government.
- Conditions
- COVID-19 Pandemic, Vulnerable Subjects, Long-term Non-invasive Ventilation
- Trial name
- NCT04477473
- Testing
- Questionnaire-based observational study
- Where
- Switzerland
- Volunteers
- 66 people
- Sponsor
- University Hospital, Geneva
Overweight or Obesity, Physical Activities
An Innovative Care Model Integrating Mobile Health Support to Promote Weight Management in Adults With Overweight or Obesity
The objective of this clinical trial is to evaluate whether an innovative care model integrating mobile health (mHealth) support improves weight management in adults with overweight or obesity.
- Conditions
- Overweight or Obesity, Physical Activities, Healthy Diet, Weight Change
- Trial name
- NCT06996431
- Testing
- EMA-based weight management intervention, Minimal Intervention
- Where
- 3 sites in Hong Kong
- Volunteers
- 876 people
- Sponsor
- The University of Hong Kong
Hypertension, Diabetes Mellitus, Type 2
Effectiveness of a Case Management Model for Patients With Hypertension and Type II Diabetes in Chile
The purpose of this study is to evaluate whether a new model of health care for chronic patients, based on Case Management and guided by a nurse which targets the patient´s risk, is more effective than usual care at Primary…
- Trial name
- NCT02762695
- Testing
- Case Management, Usual Care
- Where
- Chile
- Volunteers
- 616 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Cardiac Transplant Failure, Cardiac Transplant Rejection
Outcomes AlloMap Registry: the Long-term Management and Outcomes of Heart Transplant Recipients With AlloMap Testing
The objective of this registry is to observe short and long term clinical outcomes in heart transplant recipients who receive regular AlloMap testing as part of allograft rejection surveillance.
- Conditions
- Cardiac Transplant Failure, Cardiac Transplant Rejection, Heart Diseases
- Trial name
- OAR (NCT01833195)
- Where
- 36 sites in United States
- Volunteers
- 2,444 people, healthy volunteers welcome
- Sponsor
- CareDx
Hypothermia Following Anesthesia
Incidence and Risk Factors of Intraoperative Hypothermia in Adult Patients After Protocol Implementation
Inadvertent intraoperative hypothermia is one of the most common complications in patients undergoing anesthesia. This condition is strongly associated with several adverse clinical.
- Trial name
- NCT07470801
- Where
- Thailand
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Type 2 Diabetes
Continuous Glucose Monitoring for High-Risk Type 2 Diabetes in the Hospital (Cyber GEMS)
Given the known serious consequences of uncontrolled blood sugars during hospitalization, this research plans to study an alternative seamlessly integrated continuous glucose monitoring (CGM) system in the hospital to test a…
- Trial name
- Cyber GEMS (NCT05307237)
- Testing
- Dexcom G6 Continous Glucose Monitoring Management, Usual Care - Blinded Continuous Glucose Monitoring Management
- Where
- United States
- Volunteers
- 518 people
- Sponsor
- Scripps Whittier Diabetes Institute
Diabetes, Hypertension
Implementation of an Integrated Primary Care Network for Prevention and Management of Cardiometabolic Risks
CONTEXTE: L'Agence de la santé et des services sociaux de Montréal (ASSS) invited our research team to evaluate the implementation of an integrated and interdisciplinary primary care network for prevention and management of…
- Trial name
- RCM (NCT01326130)
- Testing
- Chronic care management 1-6
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- Public Health Department, Montreal
Weight Loss
Risk Management Plan (RMP) Survey for Purchasers of Alli® (60 mg Orlistat) in the European Union.
Following results from the first survey that forms part of the EU RMP for Alli® (RMP survey 1; WEUSRTP3350), several amendments to the information included on the pack carton for Alli® (orlistat 60 mg) were recommended.
- Trial name
- NCT02141230
- Testing
- Alli® 60 mg
- Sponsor
- GlaxoSmithKline
Arthroplasty, Replacement, Shoulder
Intravenous Dexamethasone Administration in Patients Undergoing Total Shoulder Arthroplasty
The aim of the study is to evaluate if intravenous steroid supplementation can provide advantages over routine analgesia protocols in terms of post-operative symptoms (pain and nausea), length of hospital stay, shoulder range of…
- Trial name
- NCT04507412
- Testing
- dexamethasone
- Where
- Switzerland
- Volunteers
- 74 people
- Sponsor
- Christian Candrian
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), Hypercholerolemia
Cardiovascular-kidney-metabolic (CKM)-Guided Therapy for Patients After Acute Coronary Syndrome
Patients with a history of myocardial infarction are at significantly increased risk of recurrent cardiovascular events. Despite established clinical guidelines, secondary preventive care is often initiated too late, inadequate…
- Conditions
- Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), Hypercholerolemia, Hypertension, Diabete Mellitus
- Trial name
- SLIM-3 (NCT07773272)
- Testing
- Rapid ESC-guideline based secondary prevention following myocardial infaction
- Where
- Netherlands
- Volunteers
- 1,215 people
- Sponsor
- Zuyderland Medisch Centrum
Diabetes Mellitus, Type 2
Effectiveness of a High-risk Diabetic Patients Program
The purpose of this study is to determine whether case management for type 2 diabetic patients with target-organ damage improves quality of care compared to usual care.
- Trial name
- NCT01051245
- Testing
- Case manager counseling, Usual care
- Where
- Argentina
- Volunteers
- 223 people
- Sponsor
- Hospital Italiano de Buenos Aires
Chronic Venous Disease
VEIN Health - CVD Prevalence and Characteristics
Epidemiology Study to learn prevalence and characteristics of CVD at Primary and Specialized healthcare level
- Trial name
- NCT04901845
- Testing
- No intervention provided
- Volunteers
- 10,000 people
- Sponsor
- Bokhua Memorial Cardiovascular Center
Postoperative Delirium
Manual vs Automated Anesthesia : Impact On The Incidence Of POCD
This study will be the first study to report the combined use of three independent closed-loop systems together to assist clinicians in titrating anesthesia, analgesia, fluid and optimize ventilation in frailty old patients…
- Trial name
- NCT03148730
- Testing
- closed-loop group
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Erasme University Hospital
Total Knee Replacement
A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation
We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols.
- Trial name
- NCT04432012
- Testing
- Dexamethasone Sodium Phosphate 4 mg/ml intravenous, Dexamethasone Sodium Phosphate 4 mg/ml intra-articular
- Where
- Switzerland
- Volunteers
- 159 people
- Sponsor
- Christian Candrian
Pneumococcal Infections
A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults at Increased Risk for Pneumococcal Disease (V114-017/PNEU-DAY)
This study is designed to 1) describe the safety, tolerability, and immunogenicity of V114 and Prevnar 13™ in pneumococcal vaccine-naïve adults at increased risk for pneumococcal disease and to 2) describe the safety…
- Trial name
- NCT03547167
- Testing
- V114, Prevnar 13™, PNEUMOVAX™23
- Where
- 78 sites in United States, Australia and 5 more
- Volunteers
- 1,515 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Covid19, Thrombosis Embolism
COVID-19 Registry to Assess Frequency, Risk Factors, Management, and Outcomes of Arterial and Venous Thromboembolic Complications
Novel coronavirus 2019 (COVID-19) has emerged as a major international public health concern. While much of the morbidity and mortality associated with COVID-19 has been attributed to acute respiratory distress syndrome (ARDS) or…
- Conditions
- Covid19, Thrombosis Embolism, DVT, Pulmonary Embolism
- Trial name
- CORONA-VTE NET (NCT04535128)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 11,000 people
- Sponsor
- Brigham and Women's Hospital