Clinical trials: Management, Risk
Risk Management, Primary Health Care
Assessment of a Multifaceted Risk Management Program in French Multiprofessional Offices in Primary Care
Avoidable care associated incidents are relatively frequent in primary care. In France for example, avoidable incidents rate is estimated to 22/1000 medical acts from general practitioners.
- Conditions
- Risk Management, Primary Health Care, Patient Safety
- Trial name
- PRisM (NCT02403388)
- Testing
- PRisM
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Pancreatic Cancer, Diabetes
Artificial Intelligence-based Early Screening of Pancreatic Cancer and High Risk Tracing (ESPRIT-AI)
Pancreatic cancer is one of the most fatal malignancies with a 5-year survival rate of only ~6%[1]. The reasons for this high mortality rate can be attributed to several factors, of which perhaps the most important is delayed…
- Conditions
- Pancreatic Cancer, Diabetes, Familial Pancreatic Cancer, Pancreatic Cystic Neoplasm
- Trial name
- ESPRIT-AI (NCT04743479)
- Testing
- high-resolution MRI/CT examinations
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Changhai Hospital
Hypothermia; Anesthesia, Body Temperature Changes
Hypothermia Risk Prediction Combined With Active Insulation Management in Geriatric Surgery
To evaluate the effectiveness and safety of hypothermia risk prediction combined with active warming management to reduce intraoperative hypothermia in elderly patients undergoing elective general anesthesia, improve the quality…
- Trial name
- NCT05430997
- Testing
- IOB Warming Unit (WU505) + Inflatable Warming Blanket, cover with a quilt from the neck to both feet
- Where
- China
- Volunteers
- 1,360 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Food Allergy
Integrated Approaches to Food Allergen and Allergy Risk Management
Patients with history of a food allergy to hazelnut, walnut or celeriac will undergo food provocation with a dose of the allergenic food to which 5% of the respective food allergic population (ED05) has been calculated to respond…
- Trial name
- iFAAM (NCT02295397)
- Testing
- food
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Neuroblastoma
High-Risk Neuroblastoma Chemotherapy Without G-CSF
Patients will be asked to participate in this study because patients have been diagnosed with high-risk neuroblastoma, a common childhood cancer which has aggressive features. If left untreated, high-risk neuroblastoma is fatal.
- Trial name
- SPRING (NCT02786719)
- Testing
- Topotecan, Cyclophosphamide, Cisplatin
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Baylor College of Medicine
Heart Failure
Risk-guided Disease Management Plan to Prevent Heart Failure in Patients Treated With Previous Chemotherapy (REDEEM)
This is a prospective study in which a process of identifying and reducing heart failure (HF) risk will be applied to cancer survivors >55 years old with chemotherapy >5 years ago.
- Trial name
- NCT04962711
- Testing
- Heart Failure intervention (Cardio-Oncology Disease Management Plan (CO-DMP), Usual care
- Where
- Australia
- Volunteers
- 685 people, healthy volunteers welcome
- Sponsor
- Baker Heart and Diabetes Institute
Substance Use Disorder (SUD), Opioid Use Disorders
Recovery Management Checkup Scalability and Sustainability Hybrid Experiment
Individuals who are involved in the criminal-legal system (CLS) are at high risk of drug-related overdose; they also face significant barriers to engaging in substance use disorder (SUD) treatment and recovery support services.
- Conditions
- Substance Use Disorder (SUD), Opioid Use Disorders, Stimulant Overdose, Overdose Risk
- Trial name
- RMC-SS (NCT07873944)
- Testing
- Recovery Management Checkups (RMC) delivered by community-based agencies (RMC adopters), Recovery Management Checkups (RMC) delivered by staff under the research team (RMC by research staff)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Chestnut Health Systems
Colorectal Disorders
Does a Central Venous Line Reduce Perioperative Fluid Administration?
'Hypothesis-generating' study to assess whether the presence of a central venous line significantly affects the volumes of fluid infused perioperatively in major elective colorectal surgery
- Trial name
- NCT03985111
- Testing
- Central Venous Catheter
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Barts & The London NHS Trust
Alcohol Abuse
Telephone Disease Management At-Risk Drinking (TDM II)
The aim of this study is to test for improvements in treatment outcomes for primary care patients with at-risk drinking when cared for using telephone disease management (TDM) compared to those treated with usual care.
- Trial name
- NCT00123409
- Testing
- Telephone disease management, Usual Care
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- US Department of Veterans Affairs
Knee Osteoarthritis, Task Performance and Analysis
Knee Osteoarthritis, Motor Control, Risk of Falls and Virtual Reality
The goal of this clinical trial is to learn about knee osteoarthritis, functionality, and risk of falls in community-dwelling adults aged 60 years and older.
- Conditions
- Knee Osteoarthritis, Task Performance and Analysis, Accidental Falls, Virtual Reality
- Trial name
- NCT06362785
- Testing
- Virtual Reality, Therapeutic exercise
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Submucosal Esophageal Adenocarcinoma, Barrett Esophagus
Prospective Endoscopic Follow-up of Patients With Submucosal and High Risk Mucosal Esophageal Adenocarcinoma
Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or…
- Conditions
- Submucosal Esophageal Adenocarcinoma, Barrett Esophagus, High-risk Mucosal Esophageal Adenocarcinoma
- Trial name
- PREFER (NCT03222635)
- Testing
- Endoscopic follow-up
- Where
- 20 sites in Australia, Belgium and 4 more
- Volunteers
- 225 people
- Sponsor
- Amsterdam UMC
COVID-19
Passive Immunotherapy In Patients With SARS CoV-2
Plasma from convalescent individuals (convalescent plasma, CP) has been used for more than a hundred years for the treatment of infectious diseases.
- Trial name
- CoV-PlasGal (NCT05578391)
- Testing
- Convalescent plasma
- Where
- Spain
- Volunteers
- 61 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Melanoma
Effect of Proactive Management of Side Effects on Treatment Compliance in Malignant Melanoma Patients on High-dose Intron A Therapy (Study P04600)
Patients with malignant melanoma who had undergone surgery will receive adjuvant treatment with high-dose Intron A for one year.
- Trial name
- NCT00723710
- Testing
- Intron A (interferon alfa-2b; SCH 30500)
- Volunteers
- 299 people
- Sponsor
- Merck Sharp & Dohme LLC
Sepsis
Safety and Efficacy of Early Administration of Dexamethasone in High-risk Sepsis
The purpose of this study is to investigate the safety and efficacy of early administration of two different doses of dexamethasone in high risk septic patients.
- Trial name
- NCT05136560
- Testing
- Dexamethasone
- Where
- 2 sites in South Korea
- Volunteers
- 102 people
- Sponsor
- CHA University
Depression, Obesity
Research Aimed at Improving Both Mood and Weight
The RAINBOW study is an NIH R01-funded randomized controlled trial to evaluate the clinical and cost effectiveness and implementation potential of a primary care integrated multicondition intervention program to help improve mood…
- Trial name
- RAINBOW-ENGAGE (NCT02246413)
- Testing
- RAINBOW Intervention Program
- Where
- 2 sites in United States
- Volunteers
- 409 people
- Sponsor
- Palo Alto Medical Foundation
Atrial Fibrillation
Study in Atrial Fibrillation (AF) Patients at High Risk of Stroke
The GARDENIA registry will collect real-world clinical data on the anticoagulant strategies in patients with AF at elevated risk of stroke but also elevated risk of bleeding.
- Trial name
- GARDENIA (NCT05421533)
- Where
- 96 sites in United States, Argentina and 10 more
- Volunteers
- 705 people
- Sponsor
- Anthos Therapeutics, Inc.
Hip Fractures (ICD-10 72.01-72.2)
Risk Early Warning Management for Postoperative Hip Fracture Rehabilitation and Delirium Prevention in Elderly Patients
This clinical study aims to evaluate the effectiveness of a perioperative risk early warning management strategy in patients undergoing surgical treatment for hip fractures.
- Trial name
- NCT06966947
- Testing
- Risk Early Warning Management, Standard Perioperative Care
- Where
- China
- Volunteers
- 284 people
- Sponsor
- People's Hospital Affiliated to Hubei University of Medicine
Diabetes, Gestational, PreDiabetes
A Pragmatic Approach to Lower Diabetes Risk After Gestational Diabetes
This study is testing whether daily metformin for 1 year postpartum can reduce risk of diabetes in patients who had gestational diabetes.
- Conditions
- Diabetes, Gestational, PreDiabetes, Diabetes Mellitus, Type 2
- Trial name
- NCT05280496
- Testing
- Metformin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tufts Medical Center
Atrial Fibrillation, Behavior
Mobile Health Technology-Enabled AFib Management
The overall objective of this proposal is to evaluate the effect on quality of life of a comprehensive digital atrial fibrillation (AFib) management tool that will empower patients to a) take an active role in learning about AFib…
- Trial name
- mTECH Afib (NCT06500988)
- Testing
- Corrie Virtual Atrial Fibrillation Management Program
- Where
- 2 sites in United States
- Volunteers
- 248 people
- Sponsor
- Johns Hopkins University
Cardiovascular Diseases, Hyperlipidemia
Home-based Exercise for Management of HIV-associated Cardiovascular Disease Risk
Because of advances in drug treatment, people living with HIV/AIDS (PLWHA) are living longer, but are also at greater risk for cardiovascular disease (CVD) and diabetes.
- Conditions
- Cardiovascular Diseases, Hyperlipidemia, Obesity
- Trial name
- NCT01377064
- Testing
- Physical Activity Group, Standard Care Group
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of South Carolina