Clinical trials: Mandible Tumor
Mandibular Tumor
Assessment of Accuracy and Aesthetics Following Automated Mandibular Defect Reconstruction Using AI
The Aim of the study is to evaluate Accuracy of automated mandibular defect reconstruction using Artificial intelligence and assessing impact on aesthetic and occlusion outcomes using patient-specific reconstruction plates.
- Trial name
- NCT06945692
- Testing
- patient specific reconstruction plates
- Volunteers
- 4 people
- Sponsor
- Cairo University
Traumatic Bone Cyst
Use of PRP in Treatment of Mandibular Traumatic Bone Cyst
The traumatic bone cyst (TBC) is an infrequent nonepithelial lined cavity of the jaws, which was first expressed by lucassin 1929, the lesion has attracted a great deal of interest in the dental literature, but its pathogenesis…
- Trial name
- TBC (NCT01944410)
- Testing
- PRP injection
- Where
- Iran
- Volunteers
- 12 people
- Sponsor
- Shiraz University of Medical Sciences
Oral Squamous Cell Carcinoma
A Prospective, Single-arm Phase II Clinical Trial of Tislelizumab Combined With Platinum Doublet Neoadjuvant Therapy to Improve Mandibular Preservation in Resectable Locally Advanced Oral Squamous Cell Carcinoma.
Given the feasibility of induction chemotherapy in oral cancer and the encouraging remission rates achieved, we explore the clinical application prospects of using tislelizumab in combination with traditional standard…
- Trial name
- B2023-153 (NCT06130007)
- Testing
- Three-Week Treatment Regimen with Trastuzumab in Combination with Docetaxel and Platinum Triple Therapy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Xuekui Liu
Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma
Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)
The study is an open-label phase I/II clinical trial. The study will enroll patients to receive neoadjuvant SBRT plus 1 or 2 doses of neoadjuvant pembrolizumab with concurrent ficerafusp alfa (4 doses) prior to definitive…
- Trial name
- NCT07552558
- Testing
- Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Washington University School of Medicine
Odontogenic Tumors, Odontoma
Computer Guided Buccal Cortical Plate Separation for Removal of Calcified Benign Odontogenic Tumors Affecting Mandibular Angle Region
Computer guided buccal cortical plate separation was performed for ten patients using patient specific osteotomy locating guides and pre-bent plates.
- Trial name
- NCT05329974
- Testing
- Computer guided buccal cortical plate separation
- Where
- 2 sites in Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mandible Tumor
Mandibular Reconstruction Bone Plate
The purpose of this study is to evaluate the reliability of using mandibular osteosynthesis a 2.3mm reconstruction bone plate in the maintenance of the space, contour, and mandibular bone preservation during marginal mandibular…
- Trial name
- NCT06099431
- Testing
- Mandibular marginal resection and reconstruction, mandibular osteosynthesis a 2.3mm reconstruction bone plate
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tanta University
Head and Neck Cancer, Oral Cancer
Improved Implant for Reconstruction Purposes After Mandibular Resection
Study design: A single center non-randomized, prospective clinical feasibility study. Study population: Study population is composed of 10 patients ineligible for a free-flap bone reconstruction.
- Trial name
- RifRam (NCT05153733)
- Testing
- RIFRAM implant
- Where
- Netherlands
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
Temporomandibular Joint Disorders
Laser Therapy on TMJ Disorders After Head and Neck Cancer.
Temporomandibular disorder (TMD) is a term describing musculoskeletal conditions of the face, jaw and temporal regions. TMD is frequently associated with pain and/or dysfunction such as impaired jaw function, pain in the…
- Trial name
- NCT05868460
- Testing
- High intensity laser, traditional physical therapy exercise program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Oropharynx Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma
Study Comparing Fibula Free-flap MR With or Without PVP in Patients With OOPC
This is a national multicenter, randomized, stratified, open label study, aiming to compare mandibular reconstruction (MR) with or without preoperative virtual planning (PVP), in patients with oral/oropharyngeal cancer (OOPC).
- Trial name
- CURVE (NCT04725396)
- Testing
- Mandibular Reconstruction (MR) with Preoperative Virtual Planning (PVP)., Conventional Mandibular Reconstruction (MR without PVP)
- Where
- 10 sites in France
- Volunteers
- 132 people
- Sponsor
- UNICANCER