Clinical trials: Manic Disorder
Bipolar I Disorder
Evaluation of Efficacy and Safety of Iloperidone in the Acute Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder
The aim of this study is to investigate the efficacy, safety, and tolerability of iloperidone compared with placebo in treating acute manic or mixed episodes associated with Bipolar I Disorder.
- Trial name
- NCT04819776
- Testing
- Iloperidone
- Where
- 27 sites in United States, Bulgaria and 1 more
- Volunteers
- 417 people
- Sponsor
- Vanda Pharmaceuticals
Bipolar Disorder, Depression
Antidepressant Therapy in Treating Bipolar Type II Major Depression
This study will compare the safety and effectiveness of antidepressant therapy versus mood stabilizing therapy in treating people with bipolar type II major depression.
- Trial name
- NCT00602537
- Testing
- Venlafaxine, Lithium Carbonate
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Pennsylvania
Bipolar Disorder, Mania
Peroxisomal Defects and Familial Risk for Bipolar Disorder
The purpose of this study is to screen for peroxisome defects in child and adolescent offspring of Bipolar Disorder I (BD-I) parents at different stages of risk for transitioning to mania and following the onset of mania.
- Trial name
- NCT01237379
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Bipolar Spectrum Disorder With Moderate-to- Severe Hypomania or Mild Mania
Study of Divalproex Extended Release Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomania or Mild Mania
The purpose of this research study is to evaluate the safety, tolerability, and efficacy of divalproex extended release compared to placebo (sugar pill without medication) in the treatment of bipolar disorder with moderate to…
- Trial name
- NCT00278772
- Testing
- Divalproex
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Lindner Center of HOPE
Bipolar Disorder, Alcoholism
Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder
The purpose of this study is determine whether the use of topiramate is effective in the treatment of alcohol dependence (i.e. decreases drinking) in patients with bipolar disorder.
- Conditions
- Bipolar Disorder, Alcoholism, Alcohol Dependence
- Trial name
- NCT00572117
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Mania
Allopurinol for Mania: A Randomized Trial Administering Allopurinol vs. Placebo as add-on to Mood Stabilizers and/or Antipsychotics in Patients in a Bipolar Manic Episode
The objective of the study is to evaluate the efficacy of allopurinol, compared to placebo, as add-on to mood stabilizers and/or antipsychotic in the treatment of patients with bipolar disorder, in a manic episode.
- Trial name
- NCT01092221
- Testing
- Allopurinol
- Where
- 24 sites in Israel, Romania
- Volunteers
- 180 people
- Sponsor
- Sheba Medical Center
Bipolar Disorder
FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder
This study will assess the effects of bipolar disorder on brain activity and will determine if medication changes the brain activity in people with bipolar disorder.
- Trial name
- NCT00596622
- Testing
- Lithium
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Indiana University
Bipolar Disorder
Study of Aripiprazole in Patients With Bipolar I Disorder
The purpose of this research study is to compare the efficacy of aripiprazole with placebo in combination with lithium or valproate monotherapy, in the treatment of bipolar I patients with manic or mixed episodes.
- Trial name
- NCT00257972
- Testing
- aripiprazole
- Where
- 90 sites in United States, Australia and 15 more
- Volunteers
- 400 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Bipolar I Disorder
A Multicenter Investigative Study of the Safety and Efficacy of Long-term Administration of Aripiprazole in Combination With Mood Stabilizer for the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episode
To assess the safety and efficacy of long-term administration of aripiprazole in combination with mood stabilizer (lithium or valproate) in an unblinded manner in patients with Bipolar I Disorder experiencing a manic or mixed…
- Trial name
- NCT00606229
- Testing
- Aripiprazole
- Where
- 5 sites in Japan
- Volunteers
- 41 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Mania, Hypomania
Bipolar Intervention Study: Cognitive Interpersonal Therapy
There is a need to develop a better understanding of the early phase of bipolar disorder, and to develop and evaluate effective psychosocial interventions that assist people in this phase.
- Conditions
- Mania, Hypomania, Bipolar Affective Disorder
- Trial name
- BISCIT (NCT01315028)
- Testing
- Cognitive Interpersonal Therapy, Treatment As Usual
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Bipolar Disorder
Treatment of Geriatric Bipolar Mood Disorders: A Pilot Study
The purpose of this study is to collect pilot data on the feasibility of recruiting, eliciting informed consent, assessing, treating, and following patients aged 60 and older with bipolar mood disorders.
- Trial name
- NCT00177567
- Testing
- lithium carbonate, Depakote-ER, risperidone
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Unipolar Depression, Bipolar Depression
Voice Changes During ECT
Depressed patients talk differently when they are depressed compared to when they are well. But it is hard to actually measure what the differences are.
- Conditions
- Unipolar Depression, Bipolar Depression, Bipolar Disorder, Manic
- Trial name
- VAPRE (NCT04420793)
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Bipolar Disorder
Olanzapine Versus Placebo in the Treatment of Mania in Adolescents With Bipolar I Disorder
The purpose of this study is to determine the efficacy (how well the drug works), safety, and any side effects of olanzapine compared to placebo in the treatment of mania in bipolar disorder in adolescents.
- Trial name
- NCT00050206
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Eli Lilly and Company
Bipolar Disorder
Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania
Background: Bipolar disorder is one of the most common mental illnesses affecting 1%-4% of the population, and one of the leading causes of worldwide disability.
- Trial name
- NCT01893229
- Testing
- Lithium, Valproate, Oxcarbazepine
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Guiyun Xu
Bipolar Disorder
Pilot Study of Levetiracetam (Keppra® (Registered Trademark)) for Bipolar Illness
This study will explore the possible effectiveness of levetiracetam in patients with bipolar illness who have not responded adequately to standard treatments. Levetiracetam was recently approved to treat seizures.
- Trial name
- NCT00015769
- Testing
- levetiracetam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bipolar I Disorder
Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode
Hypothesis: Continuation of an atypical antipsychotic medication in combination with a Mood Stabilizer, following remission from an acute manic episode, lowers the rates of relapse and recurrence of mood episodes compared to…
- Trial name
- NCT01977300
- Testing
- Valproate, Lithium, Risperidone
- Where
- Canada
- Volunteers
- 159 people
- Sponsor
- University of British Columbia
Bipolar Disorder
Abilify in Bipolar Disorder for 24 Weeks Treatment Effectiveness
To demonstrate the difference between Abilify with Depakote vs. Placebo with Depakote in 24-week treatment in patients with remission status after Abilify with Depakote in the 6-week study of acute mania in patients with bipolar…
- Trial name
- SMART-M (NCT00545675)
- Testing
- Abilify(aripiprazole), Depakote (divalproate)
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Bipolar Disorder
Effects of Pentazocine on Manic Symptoms
The opiate neurotransmitter system is thought to be involved in many abnormal mood states. Some researchers have suggested that changes in this system may trigger the switch to/from manic and depressive states in bipolar…
- Trial name
- NCT00125931
- Testing
- Talwin Nx
- Volunteers
- 10 people
- Sponsor
- Mclean Hospital
Bipolar Disorder, New Occurred Episode
Management of Index Episode in Patients With Bipolar Disorder Treated by Seroquel XR
The primary purpose of the study is to explore management of symptomatology in patients with bipolar disorder that experience a new manic,depressive or mixed episode and are treated with Seroquel XR monotherapy/adjuctive, in…
- Trial name
- NCT01029145
- Where
- 30 sites in Romania
- Volunteers
- 537 people
- Sponsor
- AstraZeneca
Mania, Hypomania
Trial of Citicoline Therapy in Patients With Mania or Hypomania and Cocaine Abuse/Dependence
The purpose of this research is to determine if a citicoline supplement is associated with a reduction in cocaine use and craving in patients with bipolar disorder (a mental disorder marked by alternating periods of mania and…
- Conditions
- Mania, Hypomania, Cocaine Abuse, Cocaine Dependence
- Trial name
- NCT00223236
- Testing
- Citicoline
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Texas Southwestern Medical Center