Clinical trials: Margin, Tumor-Free
Advanced Solid Tumor, Clear Cell Renal Cell Carcinoma
Study of CHS-388 (Formerly Known as SRF388) in Patients With Advanced Solid Tumors
This is a Phase 1/1b, open-label, first-in-human, dose-escalation and expansion study of CHS-388, a monoclonal antibody that targets IL-27, as a monotherapy and in combination in patients with solid tumors.
- Conditions
- Advanced Solid Tumor, Clear Cell Renal Cell Carcinoma, Hepatocellular Carcinoma, Non-small Cell Lung Cancer
- Trial name
- NCT04374877
- Testing
- CHS-388, Pembrolizumab, Toripalimab
- Where
- 23 sites in United States, Singapore and 1 more
- Volunteers
- 145 people
- Sponsor
- Coherus Oncology, Inc.
Clear Cell Renal Cell Carcinoma
Modulation of the Bone Immune Microenvironment Following Cabozantinib Treatment of Bone Metastatic Clear Cell Renal Cell Carcinoma: Proof of Concept Study
The goal of our study is to explore how treatments affect the bone immune microenvironment and determine the best treatment options for patients with metastatic kidney cancer to the bone.
- Trial name
- NCT07187869
- Testing
- Cabozantinib, Nivolumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Neoadjuvant Therapy of Non-metastatic Locally Advanced Renal Cell Carcinoma
Toripalimab Combined With Axitinib as Neoadjuvant Therapy in Patients With Non-metastatic Locally Advanced Nonmetastatic Clear Cell Renal Cell Carcinoma
This study is design to prospectively investigate the safety and efficacy of Toripalimab combined with Axitinib in downsizing tumors in patients with nonmetastatic biopsy-proven clear cell renal cell carcinoma.
- Trial name
- NCT04118855
- Testing
- Toripalimab, Axitinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Non Clear Cell Renal Cell Carcinoma (nccRCC)
A Trial to Evaluate Efficacy and Safety of Lenvatinib in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Non Clear Cell Renal Cell Carcinoma (nccRCC) Who Have Not Received Any Chemotherapy for Advanced Disease
This is a single-arm, multicenter, Phase 2 study of lenvatinib in combination with everolimus in participants with unresectable advanced or metastatic non clear cell renal cell carcinoma (nccRCC) who have not received any…
- Trial name
- NCT02915783
- Testing
- lenvatinib, everolimus
- Where
- 8 sites in United States
- Volunteers
- 41 people
- Sponsor
- Eisai Inc.
Quality Improvement, Quality of Recovery From Anaesthesia
The Impact of Fasting Duration on Quality of Recovery After Cesarean Section
This study will evaluate the effect of fasting duration and elective c-section start time on the overall quality of recovery. Patients will be seen 24 hours after surgery to answer 11 questions on their overall recovery after…
- Conditions
- Quality Improvement, Quality of Recovery From Anaesthesia, Cesarean Section, Fasting ( 6H for Solid ; 2H for Clear Fluid )
- Trial name
- NCT06701929
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Jewish General Hospital
Clear Aligner Therapy
Effect of Clear Aligner Wear Protocol on External Root Resorption
The aim of this two-arm randomized clinical trial was to compare the effect of 7-day and 14-day orthodontic clear aligner wear protocols on external apical root resorption (EARR) and pain perception
- Trial name
- NCT07522216
- Testing
- Differnt orthodontic clear aligner wearing protocols (7-day versus 14-day wearing protocols
- Where
- Jordan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Sepsis
CLEAR Sepsis Clinical Study
To investigate the relationship between initial ClearSight™ derived hemodynamic parameters and outcomes (death, ongoing organ dysfunction or delayed ICU admission) in patients with acute infection and possible sepsis, with a…
- Trial name
- CLEAR Sepsis (NCT03231956)
- Testing
- ClearSight™ / EV1000NI Clinical Platform
- Where
- 5 sites in United States
- Volunteers
- 182 people
- Sponsor
- Edwards Lifesciences
Malocclusion, Class I/II, Crowding, Tooth
Treatment Outcome of Clear Aligner and Traditional Fixed Appliances in Four Premolar Extraction Cases
Patients with severe crowding requiring the extraction of four premolars will be enrolled in this study. The degree of apical root resorption associated with using the clear aligner technique compared with vestibular fixed…
- Trial name
- NCT07236775
- Testing
- Clear Aligners, Traditional fixed appliances
- Where
- Syria
- Volunteers
- 40 people
- Sponsor
- Damascus University
Advanced Solid Tumor, Metastatic Solid Tumor
GI-101/GI-101A as a Single Agent or in Combination With Pembrolizumab or Lenvatinib in Advanced Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and therapeutic activity of GI-101/GI-101A as a single agent or in combination with pembrolizumab or lenvatinib over a range of advanced and/or…
- Conditions
- Advanced Solid Tumor, Metastatic Solid Tumor, Cervical Cancer, Urothelial Carcinoma
- Trial name
- NCT04977453
- Testing
- GI-101, Pembrolizumab (KEYTRUDA®), Lenvatinib
- Where
- 13 sites in United States, South Korea
- Volunteers
- 317 people
- Sponsor
- GI Innovation, Inc.
Brenner Tumor, Fallopian Tube Cancer
Paclitaxel, Bevacizumab And Adjuvant Intraperitoneal Carboplatin in Treating Patients Who Had Initial Debulking Surgery for Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
This phase I trial is studying the side effects and best dose of adjuvant intraperitoneal carboplatin when given together with paclitaxel and bevacizumab in treating patients who have undergone debulking surgery for stage II …
- Conditions
- Brenner Tumor, Fallopian Tube Cancer, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Endometrioid Adenocarcinoma
- Trial name
- NCT00079430
- Testing
- adjuvant therapy, paclitaxel, carboplatin
- Where
- 19 sites in United States, Japan
- Volunteers
- 113 people
- Sponsor
- National Cancer Institute (NCI)
Masseter Muscle Activity, Anterior Temporalis Muscle Activity
Orthodontic Clear Aligners Vs Conventional Fixed Appliance's Impact on Muscular Activities Among Adults Using SEMG (Surface Electromyography)
This clinical trial goal is to evaluate the difference in masticatory activities in adult patients treated with clear aligners compared to conventional fixed appliances treatment.
- Trial name
- NCT06699290
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Riyadh Elm University
Hypercholesterolemia, Atherosclerotic Cardiovascular Disease
Assessment of the Long-Term Safety and Efficacy of Bempedoic Acid (CLEAR Harmony OLE)
The purpose of this study is to see if bempedoic acid (ETC-1002) is safe and well-tolerated in patients with high cardiovascular risk and elevated LDL cholesterol that is not adequately controlled by their current therapy.
- Trial name
- NCT03067441
- Testing
- bempedoic acid
- Where
- 3 sites in United States
- Volunteers
- 1,462 people
- Sponsor
- Esperion Therapeutics, Inc.
Malocclusion
Effect of VPro5 Therapy on Clear Aligner Therapy
The investigators hypothesize that brief, daily application of HFA will increase the efficiency of clear aligner treatment by altering PDL metabolism without increasing pain or discomfort.
- Trial name
- NCT03240770
- Testing
- VPro5 device, Deviation from Standard Tray Wear Time (14 Days)
- Where
- 4 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mani Alikhani
Cervical Cancer, Vaginal Cancer
Paclitaxel in Treating Patients With Advanced, Refractory, or Recurrent Cervical or Vaginal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of paclitaxel in treating patients with advanced…
- Trial name
- NCT00002562
- Testing
- paclitaxel
- Where
- 50 sites in United States
- Volunteers
- 25 people
- Sponsor
- Gynecologic Oncology Group
Kidney Cancer
Pilot Study of Denileukin Diftitox Plus High-Dose IL-2 for Patients With Metastatic Renal Cancer
RATIONALE: Combinations of biological substances in denileukin diftitox may be able to carry tumor-killing substances directly to kidney cancer cells. Interleukin-2 may stimulate the white blood cells to kill kidney cancer cells.
- Trial name
- NCT00278369
- Testing
- aldesleukin, denileukin diftitox
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Ovarian Cancer, Primary Peritoneal Cancer
Gleevec and Gemzar in Patients With Epithelial Ovarian Cancer
This study will evaluate the efficacy and tolerability of the combination of Gleevec and Gemzar in patients with ovarian cancer, who have progressed after receiving at least one prior chemotherapy treatment.
- Trial name
- NCT00928642
- Testing
- imatinib mesylate by mouth, Gemcitabine Intravenous
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Ovarian Clear Cell Adenocarcinoma, Recurrent Ovarian Carcinoma
Sunitinib Malate in Treating Patients With Persistent or Recurrent Clear Cell Ovarian Cancer
This phase II trial studies the side effects of sunitinib malate and how well it works in treating patients with ovarian cancer that is persistent or has come back.
- Trial name
- NCT00979992
- Testing
- Laboratory Biomarker Analysis, Sunitinib Malate
- Where
- 97 sites in United States, South Korea
- Volunteers
- 35 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Renal Cell Carcinoma, Translocation Renal Cell Carcinoma
A Study of Abemaciclib and Cabozantinib in People With Clear Cell Renal Cell Carcinoma (ccRCC)
The researchers are doing this study to find out whether the combination of abemaciclib and cabozantinib is a safe and effective treatment for people with metastatic clear cell renal cell carcinoma (ccRCC) and…
- Trial name
- NCT06835972
- Testing
- Abemaciclib, Cabozantinib
- Where
- 8 sites in United States
- Volunteers
- 43 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Communication, Trust
The Effect of Clear Masks in Improving Patient Relationships
To evaluate the effect of wearing masks that hide a surgeon's facial features versus one that shows them. New patients with no prior relationship with the surgeon will be asked questions regarding communication and trust with the…
- Conditions
- Communication, Trust, Covid19, Surgery
- Trial name
- NCT04595695
- Testing
- Transparent mask, Typical surgical covered mask
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of North Carolina, Chapel Hill
VHL Gene Mutation, VHL
MK-3795 (PT2385) for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma (MK-3795-003)
The primary objective of this study is to assess the overall response rate (ORR) of von Hippel-Lindau (VHL) disease-associated clear cell renal cell carcinoma (ccRCC) tumors in VHL participants treated with MK-3795.
- Conditions
- VHL Gene Mutation, VHL, VHL Syndrome, VHL Gene Inactivation
- Trial name
- NCT03108066
- Testing
- MK-3795
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.