Clinical trials: Marijuana Abuse
Alcohol Abuse, Tobacco Use Disorder
Screening to Augment Referral to Treatment- Project START
The investigators propose to use obstetric-gynecological clinics to conduct a randomized clinical trial that would compare two SBIRTS (Screening, Brief Intervention, Referral and Treatment), delivered either by a trained nurse or…
- Conditions
- Alcohol Abuse, Tobacco Use Disorder, Marijuana Abuse, Substance-Related Disorders
- Trial name
- ProjectSTART (NCT01539525)
- Testing
- Motivational Interview, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 439 people
- Sponsor
- Yale University
Schizophrenia, Dual Diagnosis
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment
The first aim of this study is to determine whether a brain reward center (BRC) deficiency in patients with schizophrenia (SCZ) and cannabis use disorder (CUD) will be normalized when patients are given cannabis or dronabinol.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00946348
- Testing
- Dronabinol, Cannabis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Parkinson Disease
A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease
The major purpose of this study is to assess the efficacy of CBD on motor symptoms of Parkinson's Disease (PD), and secondarily to study the safety and tolerability of CBD and other efficacy, particularly regarding tremor in PD.
- Trial name
- NCT03582137
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Colorado, Denver
Marijuana Abuse
The Effect of Prescription Medications in Marijuana Users
A subset of heavy marijuana users have trouble quitting marijuana use and the number of those seeking treatment for problems related to marijuana is increasing.
- Trial name
- NCT00893074
- Testing
- Dronabinol 30mg/day, Dronabinol 60mg/day, Dronabinol 120mg/day
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Positron Emission Tomography
Brain Nicotine Receptor Density in Veteran Smokers
Cigarette smoking is more prevalent among Veterans (27%) than the general U.S. population (21%). Smoking is common among people who use marijuana or caffeine heavily, and the use of menthol cigarettes is becoming increasingly…
- Trial name
- BNRDVS (NCT01721473)
- Testing
- positron emission tomography scan
- Where
- 2 sites in United States
- Volunteers
- 184 people
- Sponsor
- VA Office of Research and Development
Insomnia, Alcohol Use, Unspecified
Research Evaluating Sleep & Trends for Universal Prevention
This study is designed to develop an integrated intervention to reduce alcohol and marijuana use and consequences and improve sleep among young adults with comorbid heavy episodic drinking, marijuana use, and sleep impairment.
- Conditions
- Insomnia, Alcohol Use, Unspecified, Marijuana Use
- Trial name
- REST-UP (NCT04783519)
- Testing
- Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans- STUDY 2
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid cannabidiol (CBD; Epidiolex) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use
- Trial name
- NCT04036968
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Neuropathic Pain, Reflex Sympathetic Dystrophy
Effects of Vaporized Marijuana on Neuropathic Pain
This study theorized that a low dose of vaporized cannabis could alleviate nerve injury pain.
- Conditions
- Neuropathic Pain, Reflex Sympathetic Dystrophy, Peripheral Neuropathy, Post-herpetic Neuralgia
- Trial name
- NCT01037088
- Testing
- Mild dose cannabis, Low dose cannabis, Cannabis
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Davis
Marijuana Abuse, Attention Deficit Disorder With Hyperactivity
Atomoxetine Treatment for ADHD and Marijuana Dependence
The aim of the study is to determine if atomoxetine treatment combined with motivational enhancement therapy is effective in reducing marijuana use in adult individuals with attention-deficit hyperactivity disorder and marijuana…
- Trial name
- NCT00360269
- Testing
- Atomoxetine, Motivational enhancement therapy
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Medical University of South Carolina
Marijuana Smoking
Effect of Quetiapine on Marijuana Withdrawal and Relapse
The objective of this study is to investigate the interaction between marijuana and quetiapine, with the goal of using this information to improve marijuana treatment outcome.
- Trial name
- NCT00743366
- Testing
- Marijuana, Quetiapine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cannabis Dependence, Cannabis Withdrawal
Gabapentin Treatment of Cannabis Dependence
This is a clinical study to evaluate the efficacy of the medication gabapentin in treating persons with cannabis dependence.
- Conditions
- Cannabis Dependence, Cannabis Withdrawal, Cognitive Deficits
- Trial name
- NCT00974376
- Testing
- gabapentin 1200mg/day, Manual-guided behavioral counseling
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Scripps Research Institute
Opioid Overdose
Vaped Marijuana to Attenuate Naloxone-Precipitated Withdrawal
The goal of the proposed, proof-of-concept study is to test the combined effects of vaporized marijuana [Delta-9-tetrahydracannabinol (THC)] with NLX as a proof of concept towards the possible development of a combined overdose…
- Trial name
- NCT05114460
- Testing
- Naloxone, Marijuana
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- New York State Psychiatric Institute
Pain, Insomnia
Effect of Medical Marijuana on Neurocognition and Escalation of Use
This study will use a randomized controlled design to test whether patients who use medical marijuana, compared to a waitlist control group, experience a change in health outcomes (relief of symptoms, or adverse health outcomes…
- Conditions
- Pain, Insomnia, Depression, Anxiety
- Trial name
- MMNE (NCT03224468)
- Testing
- Medical Marijuana
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Cannabis Dependence, Marijuana Dependence
Combined Pharmacotherapy for Cannabis Dependency
The purpose of this study is to see if Lofexidine in combination with Marinol is superior to placebo in achieving abstinence, reducing cannabis use and reducing withdrawal in cannabis-dependent patients seeking treatment for…
- Trial name
- D-LUCS (NCT01020019)
- Testing
- Dronabinol, Lofexidine
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Abuse, Cannabis Dependence
Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
Cannabis use is a significant public health concern that disproportionately affect youth. Although promising psychosocial interventions are being developed, most youth do not benefit from these interventions alone.
- Trial name
- NCT01110434
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Brown University
Marijuana Use Disorder
Effects of Smoked Marijuana on Risk Taking and Decision Making Tasks
The purpose of this study is to investigate the effects of smoked marijuana on both risk taking and decision making tasks.
- Trial name
- NCT00373399
- Testing
- Inactive Marijuana (0% THC), Low THC marijuana (1.8 %THC), High THC marijuana (3.9% THC)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Anxiety, Anxiety Disorders
Anxiety, Inflammation, Stress, and Cannabinoids
This study investigates whether the anxiolytic effects and anti-inflammatory properties of cannabis vary as a function of the ratio of CBD to THC, with the goal that these effects may shed light on the mixed data linking cannabis…
- Conditions
- Anxiety, Anxiety Disorders, Anxiety Generalized, Anxiety Chronic
- Trial name
- NCT03491384
- Testing
- Cannabis (smoked flower, ingested edible)
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- University of Colorado, Boulder
Cannabis, Low Back Pain
Trial of Dronabinol and Vaporized Cannabis in Chronic Low Back Pain
This study will involve treating low back pain associated with nerve injury with oral delta-9-tetrahydrocannabinol (Δ9-THC) or whole plant cannabis for eight weeks.
- Conditions
- Cannabis, Low Back Pain, Neuropathic Pain
- Trial name
- NCT02460692
- Testing
- dronabinol, Vaporized Cannabis 3.7% THC/5.6% CBD
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of California, San Diego
Health Risk Behaviors, Risk Reduction Behavior
Enhancing Quality in Protective Strategies
The most successful young adult alcohol or marijuana interventions involve the provision of accurate, nonjudgmental personalized feedback, but notably the inclusion and effectiveness of protective behavioral strategies (PBS)…
- Trial name
- EQUIP (NCT04978129)
- Testing
- Online and Text Messaging Intervention
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center