Clinical trials: Marijuana Smoking
Cannabis Withdrawal
Efficacy of PP-01 in Mitigating Cannabis Withdrawal Symptoms in Adults With Cannabis Use Disorder
This study is a randomized, double-blind, placebo and active-controlled, multicenter trial conducted to evaluate whether PP-01 mitigates the withdrawal symptoms associated with discontinuing cannabis in participants with moderate…
- Trial name
- NCT07644052
- Testing
- PP-01, Nabilone
- Where
- 22 sites in United States
- Volunteers
- 420 people
- Sponsor
- PleoPharma, Inc.
Cannabis Use, THC
Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults
The goal of this interventional study is to determine the impact of high potency THC product use on cognitive function of young adults aged 21-25.
- Conditions
- Cannabis Use, THC, Marijuana Use, Cognitive Impairment
- Trial name
- THC-YA (NCT06077292)
- Testing
- 15% THC Potency Reduction, 35% THC Potency Reduction
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Opioid Use, Pain
Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain
This study will use a randomized controlled design to test whether medical marijuana use by adults on high-dose chronic opioid therapy (COT) for chronic non-cancer pain is associated with reduced opioid dose and improved pain…
- Conditions
- Opioid Use, Pain, Marijuana Use
- Trial name
- NCT04827992
- Testing
- Cannabis, Prescription Opioid Taper Support (POTS)
- Where
- 3 sites in United States
- Volunteers
- 87 people
- Sponsor
- Massachusetts General Hospital
Alcohol Use, Marijuana Use
Development and Testing of a Smartphone Application to Reduce Substance Use and Sexual Risk Among Homeless Young Adults
A pilot trial (N=60) will be conducted to test the feasibility and preliminary effectiveness of OnTrack (a smartphone application to self-monitor substance use and sexual behaviors among homeless young adults) plus a brief…
- Conditions
- Alcohol Use, Marijuana Use, Sexual Behavior
- Trial name
- NCT02530645
- Testing
- OnTrack, Treatment as Usual, Brief Motivational Interviewing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York State Psychiatric Institute
Marijuana Use, Cannabis Use
THC + CBD and Memory Study
Memory deficits are one of the most consistently observed cognitive effects of marijuana use. There is evidence that some decrements attributable to the primary psychoactive ingredient, delta-9-tetrahydrocannabinol (THC), may be…
- Conditions
- Marijuana Use, Cannabis Use, Cannabis Intoxication
- Trial name
- NCT04855526
- Testing
- High THC/No CBD Marihuana, High THC/High CBD Marihuana, No THC/No CBD Marihuana
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Tobacco Use Disorder, Tobacco Use Cessation
Cannabis-Tobacco Co-Use Treatment Study
The purpose of the RECLAIM study is to evaluate the effectiveness of varenicline (sometimes known as Chantix) compared to placebo (an inactive substance) for the treatment of cigarettes and cannabis (marijuana).
- Conditions
- Tobacco Use Disorder, Tobacco Use Cessation, Cannabis Use, Cannabis Use Disorder
- Trial name
- RECLAIM (NCT06883162)
- Testing
- Varenicline, Counseling, Psychosocial modules
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Insomnia, Alcohol Use
Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)
This study is designed to evaluate an integrated intervention to reduce alcohol and marijuana use and consequences and improve sleep among young adults with comorbid heavy episodic drinking, marijuana use, and sleep impairment.
- Conditions
- Insomnia, Alcohol Use, Marijuana Use
- Trial name
- NCT06736444
- Testing
- Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS), Attention Control
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Washington
Marijuana Use
Improving Brief Marijuana Interventions With a Behavioral Economic Supplement
The purpose of this study is to evaluate the efficacy of a Substance-Free Activity Session (SFAS) as a supplement to a brief motivation intervention (BMI) in reducing marijuana use and drug-related consequences in college student
- Trial name
- BLUE-J (NCT02837315)
- Testing
- Brief Motivational Intervention (BMI), Substance-Free Activity Session (SFAS), Relaxation Session
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- University of Memphis
Opioid-use Disorder, Acceptability of Health Care
Patients' Attitudes Toward and Experiences With Buprenorphine Treatment
This study will disseminate five surveys collecting individual's attitudes and experiences during buprenorphine treatment for Opioid Use Disorder during the COVID-19 pandemic.
- Conditions
- Opioid-use Disorder, Acceptability of Health Care, Opioid-Related Disorders
- Trial name
- NCT05121428
- Where
- United States
- Volunteers
- 817 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Cannabis Abuse, Cannabis Dependence
Quiting Marijuana Use: Self-report Study of Quitting Straegies and Withdrawal Symptoms
Background: Marijuana is the most widely used illicit drug in the world, yet relatively little is known about users who try to quit without formal treatment ( spontaneous quitting).
- Trial name
- NCT01603992
- Where
- 3 sites in United States
- Volunteers
- 822 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Behavioral Economics, Cannabis Smoking
Using Novel Behavioral Economic Measures to Characterize Dual Marijuana and Tobacco Use in Young Adults
The multi session experimental study aims to determine dual use patterns of marijuana and tobacco by assessing the impact of price and availability of marijuana and tobacco using a cross price elasticity of demand task.
- Conditions
- Behavioral Economics, Cannabis Smoking, Tobacco Smoking
- Trial name
- MATEY (NCT07398443)
- Testing
- Cue Reactivity
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Brown University
Cannabis Dependence
A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana
This study is investigating how N-Acetylcysteine (NAC), an over-the-counter medication, will reduce marijuana use when combined with Contingency Management, a behavioral treatment.
- Trial name
- NCT01005810
- Testing
- N-Acetylcysteine, Contingency Management
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Medical University of South Carolina
Nicotine Dependence, Tobacco Use Disorder
E-cigarette Cessation in Adults Who Co-use Cannabis
The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis.
- Trial name
- VapeCAT (NCT06688539)
- Testing
- Varenicline Pill, Contingency management, Counseling
- Where
- 3 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy Volunteers
Safety and Pharmacokinetics of Smoked Cannabis in Healthy Patients
No actual human data for pharmacokinetics, metabolism, safety, pharmacodynamics, nor efficacy parameters are available for inhaled medical cannabis.
- Trial name
- NCT04314804
- Testing
- PPP001
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tetra Bio-Pharma
Medical Cannabis
Medical Marijuana and Open Road Driving Task
Medical marijuana use among adults 50 and older has more than doubled in the past decade with exponential increases projected in this demographic by 2050, and prescription opioids are one of the most common treatments for pain…
- Trial name
- ROADACE (NCT06995937)
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Florida State University
Tobacco Use Disorder, Cannabis Use Disorder
Varenicline for the Treatment of Cannabis and Tobacco Use Disorders in Veterans
After initial eligibility screening, Veterans who use both cannabis and tobacco will be randomly assigned to receive either varenicline (Chantix) or placebo for 12 weeks.
- Trial name
- Vet Cat (NCT05294263)
- Testing
- Varenicline
- Where
- United States
- Sponsor
- VA Office of Research and Development
Insomnia, Alcohol Use, Unspecified
Research Evaluating Sleep & Trends for Universal Prevention
This study is designed to develop an integrated intervention to reduce alcohol and marijuana use and consequences and improve sleep among young adults with comorbid heavy episodic drinking, marijuana use, and sleep impairment.
- Conditions
- Insomnia, Alcohol Use, Unspecified, Marijuana Use
- Trial name
- REST-UP (NCT04783519)
- Testing
- Brief Behavioral Therapy for Insomnia (BBTI), Brief Alcohol Screening and Intervention for College Students (BASICS)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol Use, Marijuana Use
Emerging Adults Who Use Alcohol and Marijuana
The purpose of this study is to if a brief motivational intervention, compared to health education sessions, reduces alcohol and marijuana use and is related to fewer sexually transmitted infections (STI)in emerging adults who…
- Conditions
- Alcohol Use, Marijuana Use, Sexually Transmitted Infections
- Trial name
- HEAT (NCT01473719)
- Testing
- motivational intervention, health education
- Where
- United States
- Volunteers
- 566 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Cigarette Smoking, Marijuana Abuse
Mobile Contingency Management for Marijuana and Tobacco Cessation
The purpose of this pilot project is to pilot-test a combined cannabis and smoking cessation treatment. The intervention combines mobile technology with behavioral strategies, counseling, and medications.
- Trial name
- NCT02869451
- Testing
- bupropion, transdermal nicotine patch, Nicotine polacrilex
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Vaping
Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents
Social media based intervention to support teens in their efforts to quit vaping.
- Trial name
- NCT04707911
- Testing
- Social Media Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco