Clinical trials: Marijuana Usage
Cannabis Use
Cannabis Use and Epigenetic Alterations in Human Male Sperm Cells
This is a follow-up project to a proof-of-concept study to determine if Cannabis use in male humans is associated with changes in deoxyribonucleic acid (DNA) methylation profile of sperm.
- Trial name
- NCT03614637
- Testing
- Cannabis use abstinence for 11 weeks
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Duke University
Epilepsy, Unspecified, Refractory (Medically)
The Use of Medicinal Cannabinoids as Adjunctive Treatment for Medically Refractory Epilepsy
Many families of children with medically refractory epilepsy are choosing to use medicinal cannabinoids (MCBD) as an adjunctive alternative treatment option. The safety, tolerability and efficacy of these products are not known.
- Trial name
- NCT02523183
- Testing
- Medical Cannabis
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Cancer
The Use of Cannabis (Marijuana) and Cannabidiol (CBD) Among Cancer Patients: A Pilot Study
To collect information about how patients in the pain management clinic use cannabis/CBD, including how often it is used, why it is used (for example, to manage pain or other symptoms), and where patients get their information on…
- Trial name
- NCT05836857
- Testing
- Cannabis (Marijuana), Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Cannabis Use
Novel Approaches to Assessing Cannabis Impaired Driving (NAACID)
Researchers at the University of Colorado Anschutz Medical Campus, Colorado School of Public Health, and Injury \& Violence Prevention Center want to learn more about how people are affected by cannabis in different ways.
- Trial name
- NAACID (NCT06255054)
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- Colorado School of Public Health
Alcohol; Use, Problem, Marijuana Usage
Project RAD: A Brief Intervention for Young Adult Alcohol or Marijuana Users
This is a pilot study of the feasibility, acceptability, and effectiveness of a brief, one-session intervention for a diverse sample of 44 young adults who report alcohol binge drinking or marijuana use in the past month.
- Trial name
- NCT03801096
- Testing
- Narrative Based Therapuetic Assessment (NbTa), Health Education Control Condition (HE)
- Volunteers
- 44 people
- Sponsor
- University of Houston
Cannabis Use Disorder
Effects of THC on Alcohol Consumption and Neural Correlates of Reward
Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use.
- Trial name
- NCT06446479
- Testing
- Dronabinol Pill
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cannabis Use Disorder
Cannabis Reduction and Functional Outcomes
This study evaluates the effects of cannabis use reduction among adults diagnosed with cannabis use disorder (CUD). Participants will undergo an 8-week intervention combining motivational interviewing, computerized cognitive…
- Trial name
- NCT07218471
- Testing
- CBT4CBT (Computerized Cognitive Behavioral Therapy), Motivational Interviewing, Contingency Management
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder
CBD for the Treatment of Alcohol Use Disorder
This is a double-blind, placebo-controlled, parallel group study designed to assess the efficacy of full spectrum cannabidiol (CBD) and broad spectrum CBD, compared to a placebo control (PC), to reduce drinking in participants…
- Trial name
- NCT04873453
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Colorado, Denver
Marijuana Abuse
The Effect of Prescription Medications in Marijuana Users
A subset of heavy marijuana users have trouble quitting marijuana use and the number of those seeking treatment for problems related to marijuana is increasing.
- Trial name
- NCT00893074
- Testing
- Dronabinol 30mg/day, Dronabinol 60mg/day, Dronabinol 120mg/day
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alcohol Drinking, Marijuana Smoking
Brief Counseling to Reduce Injuries Among Emergency Department Patients Who Report Alcohol and Substance Use
The purpose of this study is to determine the effectiveness of two brief counseling sessions delivered to emergency department (ED) patients who report conjoint alcohol and marijuana use, in reducing injuries and other negative…
- Trial name
- NCT00547963
- Testing
- brief counseling
- Where
- United States
- Volunteers
- 554 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Eating Disorders, Cannabis Use
A Brief Cannabis Use Psychoeducation Intervention for Eating Disorder Patients
The goal of this clinical trial is to learn if providing eating disorder patients with education about the consequences of cannabis (marijuana) use on mental health, gastrointestinal symptoms, eating disorder symptoms, and eating…
- Trial name
- NCT07387965
- Testing
- Psychoeducation about risks of cannabis use
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Cannabis Use
Acute Effects of Cannabis on Cognition and Affect
This study will examine how a moderate dose of THC affects mood and cognitive functioning in regular cannabis users. The study uses a double-blind, placebo-controlled, crossover design, meaning each participant will complete two…
- Trial name
- NCT07296874
- Testing
- THC 20mg
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Washington State University
Cannabis Use, Opioid Consumption
A Comparison of Post-Operative Analgesia Requirements In Recreational Cannabis Users Versus Cannabis Naïve Inflammatory Bowel Disease Patients
Cannabis is a drug that is widely used for recreational purpose. In most patients undergoing surgery, opioids are the most widely used mode of pain relief, during and following surgery.
- Trial name
- NCT04055662
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Mount Sinai Hospital, Canada
Mental Health Disorder, Substance Abuse Drug
Tobacco Cessation Among Smokers Under Alcohol and/or Cannabis Treatment
Aims: To identify the predictors associated with smoking cessation in smokers under treatment for alcohol and/or cannabis treated in drug treatment centers (DTC).
- Conditions
- Mental Health Disorder, Substance Abuse Drug, Alcohol Abuse, Cannabis Use
- Trial name
- ACT-ATAC (NCT04841655)
- Where
- 2 sites in Spain
- Volunteers
- 1,625 people
- Sponsor
- Institut Català d'Oncologia
Bipolar I Disorder, Bipolar II Disorder
Gabapentin for Bipolar & Cannabis Use Disorders
The proposed 2-week, double-blind, crossover, proof of concept study aims to measure and manipulate core neurochemical (i.e., dysregulated brain GABA/glutamate homeostasis) and neurobehavioral (i.e., elevated impulsivity)…
- Conditions
- Bipolar I Disorder, Bipolar II Disorder, Cannabis Use Disorder, Substance Use Disorders
- Trial name
- NCT03334721
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Medical University of South Carolina
Fibromyalgia, Pain Management
Use of Cannabis Oil in Fibromyalgia
Recently, medical cannabis has been shown to be effective in chronic pain conditions such as osteoarthritis, neuropathic pain, and other chronic non-cancer pain.
- Conditions
- Fibromyalgia, Pain Management, Cannabis, Retrospective Studies
- Trial name
- FIBRO-CB (NCT07194018)
- Testing
- Use of cannabis oil
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Schizophrenia, Cannabis-Induced Disorder
Examining tDCS Effect on Cannabis Use Disorder in Patients With Schizophrenia
Cannabis use disorder is a frequent comorbidity of schizophrenia, associated with increased symptoms and less adherence to therapy.
- Trial name
- CANNAPSYSTIM (NCT04871048)
- Testing
- Transcranial direct current stimulation (tDCS) active, Transcranial direct current stimulation (tDCS) non active
- Where
- 8 sites in France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Melanoma
Evaluating the Effects of Cannabis Use and Circulating Cannabinoids on Tumor Infiltrating Lymphocytes in Malignant Melanoma
The goal of this proposal is to determine how cannabinoid use affects the tumor immune microenvironment (TME) of melanoma by correlating TILs with reported cannabinoid use and circulating plasma cannabinoids.
- Trial name
- NCT05520294
- Testing
- High-performance liquid chromatography-tandem mass spectrometry assays
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Colorado, Denver
Cannabis Use Disorder, Cannabis Dependence
N-acetylcysteine for the Treatment of Cannabis Dependence: Working Mechanisms
This study investigates the effects of repeated NAC administration on glutamate concentrations in the anterior cingulate cortex (ACC), on neurocognitive functioning, and on neuro-inflammatory parameters in adult…
- Trial name
- NCT03221231
- Testing
- N-acetylcysteine, Magnetic Resonance Imaging, Neurocognitive measures
- Where
- Belgium
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Cannabis Smoking, Oxidative Stress
Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response
This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.
- Trial name
- NCT02480283
- Testing
- Bronchoscopy, Chest X-ray, Venipuncture
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver