Clinical trials: Marijuana Use, open to volunteers
Cannabis Use, Sleep
Cannabis Effects on Sleep, Circadian Rhythms, and Light Sensitivity in Young Adults
The goal of this study is to learn how cannabis use and discontinuation affect sleep, circadian rhythms, and sensitivity to light. The main questions it aims to answer are: 1.
- Conditions
- Cannabis Use, Sleep, Circadian Rhythm
- Trial name
- CASCILS (NCT06743373)
- Testing
- Cannabis Discontinuation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cannabis Use, Cannabis Smoking
Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking
This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic…
- Conditions
- Cannabis Use, Cannabis Smoking, Marijuana Smoking, Marijuana Usage
- Trial name
- NCT03909477
- Testing
- Hyperpolarized Xenon-129 MRI of the lungs, Computed Tomography (CT), Pulmonary Function Tests (PFTs)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Cannabis Use, Cannabis Use Disorder
Transcranial Magnetic Stimulation for Adolescents and Young Adults With Cannabis Use Disorder
This pilot study will investigate the potential of repetitive transcranial magnetic stimulation (rTMS) to strengthen a neural circuit critical for maintaining abstinence in adolescents and youth with cannabis use disorder (CUD).
- Trial name
- NCT07634835
- Testing
- Magstim SuperRapid2
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Cannabis Use Disorder
Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder
There has been a considerable rise in cannabis consumption in recent years, with estimates of 200 million individual users globally.
- Trial name
- NCT05859347
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Centre for Addiction and Mental Health
Cannabis Use Disorder, Severe
Cannabis and Processing Emotions Study
The goal of this study is to test a causal neural mechanism of cannabis use-related problem recognition in individuals with severe cannabis use disorder using a non-invasive form of neuromodulation called transcranial magnetic…
- Trial name
- CAPE (NCT06907979)
- Testing
- TMS - Active iTBS, TMS - Active cTBS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Auburn University
Cannabis Use Disorder
A Study of Cannabidiol in Young Adult Cannabis Users
The investigators will study the harm-reducing effect of hemp-derived CBD in non-treatment-seeking emerging adults who use cannabis regularly.
- Trial name
- NCT06569394
- Testing
- Broad Spectrum Cannabidiol (bsCBD) 400 mg
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Colorado, Denver
Cannabis
Age Differences in the Effects of Cannabis on Simulated Driving
Epidemiological studies suggest that the use of cannabis is associated with an increase in the risk of motor vehicle collisions. It is also known that younger users may be at increased risk for motor vehicle collisions.
- Trial name
- ADCUF (NCT04325958)
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Chronic Pain Patients, Medical Cannabis Users
Medical Cannabis and Behavior
This study will assess cognition, neural function, and drug exposure in chronic pain patients who have been prescribed medical cannabis and will differentiate outcomes based on use of specific CBD-dominant versus THC-dominant…
- Trial name
- NCT06808048
- Testing
- Cognitive testing, Task-based fMRI measure of face-name and verbal learning
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Minnesota
Cannabis Use Disorder
Effects of THC on Alcohol Consumption and Neural Correlates of Reward
Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use.
- Trial name
- NCT06446479
- Testing
- Dronabinol Pill
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cannabis Use Disorder
Cannabis Reduction and Functional Outcomes
This study evaluates the effects of cannabis use reduction among adults diagnosed with cannabis use disorder (CUD). Participants will undergo an 8-week intervention combining motivational interviewing, computerized cognitive…
- Trial name
- NCT07218471
- Testing
- CBT4CBT (Computerized Cognitive Behavioral Therapy), Motivational Interviewing, Contingency Management
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Medical University of South Carolina
Eating Disorders, Cannabis Use
A Brief Cannabis Use Psychoeducation Intervention for Eating Disorder Patients
The goal of this clinical trial is to learn if providing eating disorder patients with education about the consequences of cannabis (marijuana) use on mental health, gastrointestinal symptoms, eating disorder symptoms, and eating…
- Trial name
- NCT07387965
- Testing
- Psychoeducation about risks of cannabis use
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Cannabis Use
Acute Effects of Cannabis on Cognition and Affect
This study will examine how a moderate dose of THC affects mood and cognitive functioning in regular cannabis users. The study uses a double-blind, placebo-controlled, crossover design, meaning each participant will complete two…
- Trial name
- NCT07296874
- Testing
- THC 20mg
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Washington State University
Schizophrenia, Cannabis-Induced Disorder
Examining tDCS Effect on Cannabis Use Disorder in Patients With Schizophrenia
Cannabis use disorder is a frequent comorbidity of schizophrenia, associated with increased symptoms and less adherence to therapy.
- Trial name
- CANNAPSYSTIM (NCT04871048)
- Testing
- Transcranial direct current stimulation (tDCS) active, Transcranial direct current stimulation (tDCS) non active
- Where
- 8 sites in France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cannabis Smoking, Oxidative Stress
Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response
This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.
- Trial name
- NCT02480283
- Testing
- Bronchoscopy, Chest X-ray, Venipuncture
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Psychotic Disorders, Cannabis Use Disorder
RCT Comparing Avatar Intervention to Supportive Intervention to Reduce Cannabis Use in Patients With Psychotic Disorders
The goal of this clinical trial is to conduct a single-blind randomized controlled trial to verify whether the Avatar Intervention has greater efficacy over supportive intervention to reduce cannabis use in patients with…
- Conditions
- Psychotic Disorders, Cannabis Use Disorder, Mental Health Disorder
- Trial name
- AC2 (NCT05704582)
- Testing
- Avatar Intervention, Addiction supportive intervention
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Cannabis Use Disorder
Applying Neuromodulation to Boost the Efficacy of Motivational Interviewing
The goal of this clinical trial is to learn how adding brain stimulation to a brief counseling session affects adults with cannabis use disorder.
- Trial name
- NCT07787572
- Testing
- transcranial alternating current stimulation, Motivational interviewing (MI)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- The Mind Research Network
Depression, Cannabis Use Disorder
The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity…
- Conditions
- Depression, Cannabis Use Disorder, HIV
- Trial name
- NCT05453513
- Testing
- MRI Study
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- University of Miami
Alcohol Drinking, Cannabis Use
Cannabis' Impact on Alcohol Consumption
This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which…
- Conditions
- Alcohol Drinking, Cannabis Use, Cannabis, Alcohol Use Disorder
- Trial name
- NCT05389930
- Testing
- THC-dominant cannabis, CBD-dominant cannabis, Alcohol
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Brown University
Cannabis Use, Major Depressive Disorder
Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in Depression
The prevalence of major depressive disorder (MDD) is ~5.0%, and rates of co-occurring SUDs in these patients approach 40-50%. Specifically, rates of co-morbid cannabis use disorder (CUD) in patients with MDD are elevated 2-3 fold…
- Conditions
- Cannabis Use, Major Depressive Disorder, Cognitive Impairment
- Trial name
- NCT04935619
- Testing
- Contingency Reinforcement, Non-Contingency Reinforcement
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Centre for Addiction and Mental Health
Cannabis Use, Stress
Perceptual Influences From Smoking Cannabis: an Experimental Study
The purpose of the study is to better understand the effects of cannabis in relation to mental and physical states including its relationship with mood, cognition, perception including the experience of temperature and pain, and…
- Trial name
- PISCES (NCT06588582)
- Testing
- Water Temperature Variation - WW, Water Temperature Variation - CW
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder